Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 364

The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.

An abundant dysfunctional apolipoprotein A1 in human atheroma

Open access
Huang, Ying, DiDonato, Joseph A, Levison, Bruce S, Schmitt, Dave, Li, Lin, Wu, Yuping, Buffa, Jennifer, Kim, Timothy, Gerstenecker, Gary S, Gu, Xiaodong, Kadiyala, Chandra S, Wang, Zeneng, Culley, Miranda K, Hazen, Jennie E, DiDonato, Anthony J, Fu, Xiaoming, Berisha, Stela Z, Peng, Daoquan, Nguyen, Truc T, Liang, Shaohong, Chuang, Chia-Chi, Cho, Leslie, Plow, Edward F, Fox, Paul L, Gogonea, Valentin, Tang, W H Wilson, Parks, John S, Fisher, Edward A, Smith, Jonathan D, Hazen, Stanley L·2014·Nature Medicine
DOI 10.1038/nm.3459
Open this paper in CoChat — free account

Abstract

Recent studies have indicated that high-density lipoproteins (HDLs) and their major structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are dysfunctional and are extensively oxidized by myeloperoxidase (MPO). In vitro oxidation of either apoA1 or HDL particles by MPO impairs their cholesterol acceptor function. Here, using phage display affinity maturation, we developed a high-affinity monoclonal antibody that specifically recognizes both apoA1 and HDL that have been modified by the MPO-H2O2-Cl− system. An oxindolyl alanine (2-OH-Trp) moiety at Trp72 of apoA1 is the immunogenic epitope. Mutagenesis studies confirmed a critical role for apoA1 Trp72 in MPO-mediated inhibition of the ATP-binding cassette transporter A1 (ABCA1)-dependent cholesterol acceptor activity of apoA1 in vitro and in vivo. ApoA1 containing a 2-OH-Trp72 group (oxTrp72-apoA1) is in low abundance within the circulation but accounts for 20% of the apoA1 in atherosclerosis-laden arteries. OxTrp72-apoA1 recovered from human atheroma or plasma is lipid poor, virtually devoid of cholesterol acceptor activity and demonstrated both a potent proinflammatory activity on endothelial cells and an impaired HDL biogenesis activity in vivo. Elevated oxTrp72-apoA1 levels in subjects presenting to a cardiology clinic (n = 627) were associated with increased cardiovascular disease risk. Circulating oxTrp72-apoA1 levels may serve as a way to monitor a proatherogenic process in the artery wall.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nm.3459

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 64 references

Cited by

See all 364

Metadata

Authors
Huang, Y., DiDonato, J. A., Levison, B. S., Schmitt, D., Li, L., Wu, Y., Buffa, J., Kim, T., Gerstenecker, G. S., Gu, X., Kadiyala, C. S., Wang, Z., Culley, M. K., Hazen, J. E., DiDonato, A. J., Fu, X., Berisha, S. Z., Peng, D., Nguyen, T. T., Liang, S., Chuang, C.-C., Cho, L., Plow, E. F., Fox, P. L., Gogonea, V., Tang, W. H. W., Parks, J. S., Fisher, E. A., Smith, J. D., & Hazen, S. L.
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2014-01-26
Volume
20
Issue
2
Pages
193-203
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm.3459
OpenAlex
W2010686434
Cited by
364
References
64
FWCI
47.19
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: An abundant dysfunctional apolipoprotein A1 in human atheroma. https://app.cochat.ai/papers/10.1038/nm.3459
The paper
Huang, Y., DiDonato, J. A., Levison, B. S., Schmitt, D., Li, L., Wu, Y., Buffa, J., Kim, T., Gerstenecker, G. S., Gu, X., Kadiyala, C. S., Wang, Z., Culley, M. K., Hazen, J. E., DiDonato, A. J., Fu, X., Berisha, S. Z., Peng, D., Nguyen, T. T., . . . Hazen, S. L. (2014). An abundant dysfunctional apolipoprotein A1 in human atheroma. Nature Medicine. https://doi.org/10.1038/nm.3459

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.