The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Open accessAbstract
Recent studies have revealed that ARID1A, encoding AT-rich interactive domain 1A (SWI-like), is frequently mutated across a variety of human cancers and also has bona fide tumor suppressor properties. Consequently, identification of vulnerabilities conferred by ARID1A mutation would have major relevance for human cancer. Here, using a broad screening approach, we identify ARID1B, an ARID1A homolog whose gene product is mutually exclusive with ARID1A in SWI/SNF complexes, as the number 1 gene preferentially required for the survival of ARID1A-mutant cancer cell lines. We show that loss of ARID1B in ARID1A-deficient backgrounds destabilizes SWI/SNF and impairs proliferation in both cancer cells and primary cells. We also find that ARID1A and ARID1B are frequently co-mutated in cancer but that ARID1A-deficient cancers retain at least one functional ARID1B allele. These results suggest that loss of ARID1A and ARID1B alleles cooperatively promotes cancer formation but also results in a unique functional dependence. The results further identify ARID1B as a potential therapeutic target for ARID1A-mutant cancers.
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Metadata
- Authors
- Helming, K. C., Wang, X., Wilson, B. G., Vazquez, F., Haswell, J. R., Manchester, H. E., Kim, Y., Kryukov, G. V., Ghandi, M., Aguirre, A. J., Jagani, Z., Wang, Z., Garraway, L. A., Hahn, W. C., & Roberts, C. W. M.
- Venue
- Nature Medicine
- Published
- 2014-02-23
- Volume
- 20
- Issue
- 3
- Pages
- 251-254
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2112728955
- Cited by
- 418
- References
- 5
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: ARID1B is a specific vulnerability in ARID1A-mutant cancers. https://app.cochat.ai/papers/10.1038/nm.3480
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- Helming, K. C., Wang, X., Wilson, B. G., Vazquez, F., Haswell, J. R., Manchester, H. E., Kim, Y., Kryukov, G. V., Ghandi, M., Aguirre, A. J., Jagani, Z., Wang, Z., Garraway, L. A., Hahn, W. C., & Roberts, C. W. M. (2014). ARID1B is a specific vulnerability in ARID1A-mutant cancers. Nature Medicine. https://doi.org/10.1038/nm.3480
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