A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

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Items 101–200 of 405

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3. NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components
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5. The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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8. β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1
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9. Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm
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11. Molecular markers in ALL: Clinical implications
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12. Super-enhancers in transcriptional regulation and genome organization
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13. The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia
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14. Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
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16. Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia
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17. Super-enhancers maintain renin-expressing cell identity and memory to preserve multi-system homeostasis
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18. SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival
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19. Notch signaling in cancer: Complexity and challenges on the path to clinical translation
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20. Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer
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21. NF-kappaB-dependent lymphoid enhancer co-option promotes renal carcinoma metastasis
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22. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
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24. Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation
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25. Super-enhancers complexes zoom in transcription in cancer
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26. Transcriptionally active enhancers in human cancer cells
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27. RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia
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28. Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells
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29. Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders
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30. RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers
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32. Multi-Omics Analysis Identifies MGA as a Negative Regulator of the MYC Pathway in Lung Adenocarcinoma
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35. DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia
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37. Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation
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42. Intracellular Cholesterol Pools Regulate Oncogenic Signaling and Epigenetic Circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia
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43. Histone Modifications Drive Aberrant Notch3 Expression/Activity and Growth in T-ALL
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53. An Updated Perspective on Current Prognostic and Predictive Biomarkers in Chronic Lymphocytic Leukemia in the Context of Chemoimmunotherapy and Novel Targeted Therapy
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56. Developmental origins shape the paediatric cancer genome
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71. BCOR Binding to MLL-AF9 Is Essential for Leukemia via Altered EYA1, SIX, and MYC Activity
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