A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
Herranz, Daniel, Ambesi-Impiombato, Alberto, Palomero, Teresa, Schnell, Stephanie A, Belver, Laura, Wendorff, Agnieszka A, Xu, Luyao, Castillo-Martin, Mireia +5 more·2014·Nature Medicine
DOI 10.1038/nm.3665
Cited by (405)
Items 301–400 of 405
- Erythroid Cell Research: 3D Chromatin, Transcription Factors and BeyondCharlotte Andrieu‐Soler, Éric Soler · 2022 · International Journal of Molecular Sciences
- Identification of a Notch transcriptomic signature for breast cancerEike-Benjamin Braune, Felix Geist, Xiaojia Tang, Krishna R. Kalari, Judy Caroline Boughey, Liewei Wang, Roberto Antonio Leon-Ferre, Antonino B. D’Assoro, James N. Ingle, Matthew Philip Goetz et al. · 2024 · Breast Cancer Research
- Efficient chromosomal-scale DNA looping in Escherichia coli using multiple DNA-looping elementsNan Hao, Kim Sneppen, Keith Edward Shearwin, Ian B. Dodd · 2017 · Nucleic Acids Research
- Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemiasBenjamin J. Huang, Anica M. Wandler, Lauren K. Meyer, Monique Dail, Anneleen Daemen, Deepak Sampath, Qing Li, Xinyue Wang, Jasmine C. Y. Wong, Joy Nakitandwe et al. · 2019 · PLoS Genetics
- An oncogenic enhancer enemy (N-Me) in T-ALLDaniel Herranz, Adolfo A. Ferrando · 2015 · Cell Cycle
- Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemiaKalay Bertulfo, Pablo Pérez‐Durán, Hannah I. Miller, Cindy Ma, Alberto Ambesi‐Impiombato, Jeremy B. Samon, Adam L. Mackey, Wen-Hsuan Wendy Lin, Adolfo A. Ferrando, Teresa Palomero · 2025 · Proceedings of the National Academy of Sciences
- DeepMethyGene: a deep-learning model to predict gene expression using DNA methylationsYuyao Yan, Xinyi Chai, Jiajun Liu, Sijia Wang, Wenran Li, Tao Huang · 2025 · BMC Bioinformatics
- RUNX1 colludes with NOTCH1 to reprogram chromatin in T cell acute lymphoblastic leukemiaMd Rashedul Islam, Catherine E. Jenkins, Qi Cao, Jasper Wong, Misha Bilenky, Annaïck Carles, Michelle Moksa, Andrew P. Weng, Martin Hirst · 2023 · iScience
- A helicase-independent role of DHX15 promotes MYC stability and acute leukemia cell survivalQilong Li, Hao Guo, Jin Xu, Xinlu Li, Donghai Wang, Ying Guo, Guoliang Qing, Pieter Van Vlierberghe, Hudan Liu · 2023 · iScience
- Novel oncogenic noncoding mutations in T-ALLSteven Goossens, Pieter Van Vlierberghe · 2017 · Blood
- Sequence of events in prostate cancerKellie A. Cotter, Mark A. Rubin · 2018 · Nature
- A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudilJing Zhang, Shenqiu Zhang, Qiong Shi, Thaddeus D. Allen, Fengming You, Dun Yang · 2021 · PLoS ONE
- Regulatory mechanisms and context-dependent roles of TAL1 in T-cell acute lymphoblastic leukemiaJolynn Zu Lin Ong, Tze King Tan, Lu Wang, Shi Hao Tan, Takaomi Sanda · 2023 · Haematologica
- The Genome in a Three-Dimensional Context: Deciphering the Contribution of Noncoding Mutations at Enhancers to Blood CancerLlorenç Rovirosa, Alberto Ramos-Morales, Biola M. Javierre · 2020 · Frontiers in Immunology
- CARMA1 is required for Notch1-induced NF-κB activation in SIL-TAL1-negative T cell acute lymphoblastic leukemiaNinghan Zhang, Jiawen Xu, Rong Wang, Ting Shuang Pan, Huan-Xin Zhang, Lingling Yin, Yao Yao, Linyan Xu, Shengyun Zhu, Qing‐Yun Wu et al. · 2021 · Journal of Molecular Medicine
- Tackling Acute Lymphoblastic Leukemia—One Fish at a TimeArpan A. Sinha, Gilseung Park, John Kimble Frazer · 2019 · International Journal of Molecular Sciences
- Prognostic Significance of Comprehensive Gene Mutations and Clinical Characteristics in Adult T-Cell Acute Lymphoblastic Leukemia Based on Next-Generation SequencingHua Yin, Mei Hong, Jun Deng, Lan Yao, Chenjing Qian, Yao Teng, Tingting Li, Qiuling Wu · 2022 · Frontiers in Oncology
- A novel oncogenic enhancer of estrogen receptor-positive breast cancerChun‐Jie Bao, Jia‐Lun Duan, Ying Xie, Yixuan Liu, Peishan Li, Jianwei Li, Huihui Zhao, Haitao Guo, Yanchen Men, Yuxin Ren et al. · 2022 · Molecular Therapy — Nucleic Acids
- Identification of ANXA1 as a Novel Upstream Negative Regulator of Notch1 Function in AMLGang Qin Shao, Xi Wang, Yiting Zheng, Junjie Ma, Lei Wang, Zhibin Yan, Zeyu Sun, Shuyuan Zhang, Hongzhang Wu, Yudie Lv et al. · 2024 · Advanced Science
- Super-enhancer PPP1R15B/EIF2A axis characterizes aggressive drug-tolerant persister cells in GlioblastomaHao-Yu Chuang, Cheng‐Hsin Cheng, Fuyou Guo, Vijesh Kumar Yadav, Iat-Hang Fong, Jia‐Wei Lin, Chi‐Tai Yeh · 2025 · Biomedicine & Pharmacotherapy
- The landscape of structural variation in pediatric cancerRobert Greenhalgh, Samuel W. Brady, Wentao Yang, Diane A. Flasch, Michael N. Edmonson, Nadezhda V. Terekhanova, Yanling Liu, Jian Wang, Karol A. Szlachta, Liqing Tian et al. · 2026 · Cancer Cell
- Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemiaHyoju Kim, Tze King Tan, Dean Zi Yang Lee, Xiao Zi Huang, Jolynn Zu Lin Ong, Michelle A. Kelliher, Allen Eng Juh Yeoh, Takaomi Sanda, Shi Hao Tan · 2024 · Leukemia
- Dual Function of Notch Signaling in Cancer: Oncogene and Tumor SuppressorUte Koch, Freddy Radtke · 2018 · Springer eBooks
- Native stem cell transcriptional circuits define cardinal features of high-risk leukemiaQing Wang, Francesco E. Boccalatte, Jason Xu, Giovanni Gambi, Bettina Nadorp, Fatema Akter, Carea Mullin, Ashley F. Melnick, Elizabeth Choe, Anna C. McCarter et al. · 2025 · The Journal of Experimental Medicine
- No Need to Stick Together to Be Connected: Multiple Types of Enhancers’ NetworkingEmanuele Vitale, Mila Gugnoni, Alessia Ciarrocchi · 2021 · Cancers
- Illuminating the Noncoding Genome in Cancer Using Artificial IntelligenceMaría del Mar Álvarez‐Torres, Xi Fu, Raúl Rabadán · 2025 · Cancer Research
- Probing the limits of cis-acting gene regulation using a model of allelic imbalance quantitative trait lociCathal Seoighe, Seán Connaire, Mehak Chopra · 2025 · PLoS Genetics
- Targeted Metabolomics of Tissue and Plasma Identifies Biomarkers in Mice with NOTCH1-Dependent T-Cell Acute Lymphoblastic LeukemiaValeria Tosello, Ludovica Di Martino, Erich Piovan · 2024 · International Journal of Molecular Sciences
- Mechanisms of enhancer‐driven oncogene activationJoyce Vriend, Ruud Delwel, Dorien Pastoors · 2025 · International Journal of Cancer
- Pathobiology of Acute Lymphoblastic LeukemiaMelissa Burns, Scott A. Armstrong, Alejandro Gutiérrez · 2017 · Elsevier eBooks
- Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemiaShulan Tian, Henan Zhang, Pan Zhang, Michael T. Kalmbach, Jeong‐Heon Lee, Tamás Ördög, Paul Joseph Hampel, Timothy G. Call, Thomas Elmer Witzig, Neil E. Kay et al. · 2021 · Scientific Reports
- MYC Expression Is Associated With p53 Expression and TP53 Aberration and Predicts Poor Overall Survival in Acute Lymphoblastic Leukemia/LymphomaLinlin Gao, Brent Harbaugh, Kevin Parr, Payal J. Patel, Shivani Golem, Da Zhang, Janet M. Woodroof, Wei Cui · 2021 · American Journal of Clinical Pathology
- Super-enhancers: Implications in gastric cancerYizhou Huang, Yanfei Huo, Linying Huang, Long Zhang, Yanxiu Zheng, Nasha Zhang, Ming Wen Ou Yang · 2024 · Mutation Research/Reviews in Mutation Research
- Enhancer and superenhancer regulation and its disruption in cancerYotam Drier · 2020 · Current Opinion in Systems Biology
- A ROS‐Responsive Dual‐Targeting Drug Nanocarrier Serving as a GSI Synergist and Ferroptosis Sensitizer for T‐Cell Acute Lymphoblastic LeukemiaRuinan Jia, Yang Liu, Jilong Xiao, Yuan Xia, Xin Zhao, Huixian Ma, Jingjing Ye, Zhiyue Zhang, Tao Sun, Chunyan Ji · 2025 · Advanced Science
- T-cell Dysfunction upon Expression of MYC with Altered Phosphorylation at Threonine 58 and Serine 62Colin J. Daniel, Carl Pelz, Xiaoyan Wang, Michael W. Munks, Aaron Ko, Dhaarini Murugan, Sarah A. Byers, Eleonora Juarez, Karyn L. Taylor, Guang Fan et al. · 2022 · Molecular Cancer Research
- Progression of Notch signaling regulation of B cells under radiation exposureXin Shu, Jie Wang, Huihong Zeng, Lijian Shao · 2024 · Frontiers in Immunology
- Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus Talimogene Laherparepvec with Small Molecule InhibitorsStavros Sotiriadis, Julia Beil, Susanne Berchtold, Irina Smirnow, Andrea Schenk, Ulrich M. Lauer · 2024 · Viruses
- Integrating rapamycin with novel PI3K/Akt/mTOR inhibitor microRNAs on NOTCH1-driven T-cell acute lymphoblastic leukemia (T-ALL)Fateme Arjmand, Samaneh Shojaei, Mitra Khalili, Hossein Dinmohammadi, Behzad Poopak, Samira Mohammadi‐Yeganeh, Yousef Mortazavi · 2023 · Bioimpacts
- Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemiaXiaoman Shao, Rui Yokomori, Jolynn Zu Lin Ong, Haoqing Shen, Dennis Kappei, Leilei Chen, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda · 2024 · Leukemia
- Novel Targeted Therapies for T-Cell MalignanciesMelania Tesio · 2022 · Cancers
- An Integrated Workflow to Study the Promoter-Centric Spatio-Temporal Genome Architecture in Scarce Cell PopulationsLlorenç Rovirosa, Laureano Tomás-Daza, Blanca Urmeneta, Alfonso Valencia, Biola M. Javierre · 2023 · Journal of Visualized Experiments
- Neo‐enhancers in T‐cell acute lymphoblastic Leukaemia (T‐ ALL ) and beyondCharlotte L. Smith, Vahid Asnafi, Aurore Touzart · 2025 · International Journal of Cancer
- The ESCRT protein CHMP5 promotes T cell leukemia by enabling BRD4-p300-dependent transcriptionKatharine Umphred-Wilson, Shashikala Ratnayake, Qianzi Tang, Rui Wang, Sneha Ghosh Chaudhary, Ballachanda N. Devaiah, Josephine Trichka, Jan Wiśniewski, Lan Zhou, Qingrong Chen et al. · 2025 · Nature Communications
- Epigenetics, Enhancers, and CancerJames J. Morrow, Peter C. Scacheri · 2016 · Energy balance and cancer
- Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B- cell Lymphoma Authors and affiliations:Yotam Drier, Holly J. Whitton, Matthew J. Cotton, Jasleen Kaur, Robbyn Issner, Shawn M. Gillespie, Charles B. Epstein, Valentina Nardi, Aliyah R. Sohani, Ephraim P. Hochberg et al. · 2015
- Notch Functions in T Cell DevelopmentVedran Radojčić, Ivan P. Maillard · 2016 · Elsevier eBooks
- MYC overexpression leads to increased chromatin interactions at superenhancers and c-Myc binding sitesYi Xiang See, Kaijing Chen, Melissa J. Fullwood · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Bone marrow progenitor-like cells against leukemia cureSarah Elitzur, Shai Izraeli · 2024 · Nature Cancer
- PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulatorsSunny Periyasamy, Thyla Jarrett, Joe Truong, Rachid Skouta · 2026 · Journal of Enzyme Inhibition and Medicinal Chemistry
- MYC-induced USP10 stabilizes SOX4 to promote thymocyte proliferation and leukemia onset in miceMengdi Zhang, Hanrui Wu, Xiaoxi Lin, Fan Zhao, Qiaolin Deng, Linrong Lu, Xia Li, Xiang Chen, Hong Liu, Paul E. Love et al. · 2026 · Nature Communications
- Genomic Insights into the Biology of T-lineage Acute Lymphoblastic LeukemiaPetri Pölönen, David T. Teachey, Charles Grenfell Mullighan · 2026 · Blood Cancer Discovery
- Brownian Bridging of Chromatin States in Leukemic CellsMacarena Calero, Eduardo del Arco, Marta Amores-Sánchez, Diego Herráez‐Aguilar, E. Garcia-Sanchez, África González‐Murillo, Jaanam Lalchandani, Niccolò Caselli, Jesús F. Castillo, Antonio J. Caamaño et al. · 2026 · PRX Life
- Natural-product polypharmacology in acute lymphoblastic leukemia: a state-of-the-art reviewJinlian Wang, Jun Wang, Fang Wang, Ying Zhou, Huan Wang, Xinyu Tang, Liu R, Hui Huang, Xin Xie, X Li · 2026 · Phytomedicine
- Thymocyte transformation enhancedGayle Pageau Pouliot, Alejandro Gutiérrez · 2014 · Nature Medicine
- Targeting the Noncoding Genome: Superenhancers Meet Their KryptoniteEric Wang, Iannis Aifantis · 2017 · Cancer Discovery
- Notch in Human Cancers—A Complex TaleHao Guo, Ting Xie, Hudan Liu · 2021 · Elsevier eBooks
- TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemiaL. Lauwereins, Q. Van Thillo, S. Demeyer, N. Mentens, S. Provost, K. Jacobs, O. Gielen, Lien Boogaerts, C. de Bock, G. Andrieu et al. · 2025 · Leukemia
- Deregulation of the non-coding genome in leukemiaSusanna Teppo, Merja Heinäniemi, Olli Lohi · 2017 · RNA Biology
- Notch Signaling in T-Cell Acute Lymphoblastic Leukemia and Other Hematologic MalignanciesCatherine Hoofd, Vincenzo Giambra, Andrew P. Weng · 2018 · Springer eBooks
- Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashionRosanne J. Spolski, Peng Li, Vivek Chandra, Boyoung Shin, Chengyu Liu, Jangsuk Oh, Min Ren, Yutaka Enomoto, Erin E. West, Stephen M. Christensen et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Dosage Amplification Dictates Oncogenic Regulation by the NKX2-1 Lineage Factor in Lung AdenocarcinomaJohn L. Pulice, Matthew M. Meyerson · 2023 · SSRN Electronic Journal
- Epigenetic Rewiring of Enhancer–Promoter Interactions in Cancer: Mechanisms and Therapeutic ImplicationsChoppavarapu, Lavanya, Nosirov, Bakhtiyor, Kahn, Michael, Jin, Victor X. · 2026 · Cancers
- Genetic Characterization of Pediatric T-cell Acute Lymphoblastic LeukemiaKristina Karrman · 2014 · Lund University Publications (Lund University)
- Leukemic Stem Cells in Acute Lymphoblastic LeukemiaUgo Testa · 2015 · Springer eBooks
- Molecular Origin of Childhood Acute Lymphoblastic LeukemiaEsmé Waanders, Marjolijn C.J. Jongmans, Charles Grenfell Mullighan · 2016 · Springer eBooks
- Caracterización clínica y biológica del proceso de transformación de los sindromes linfoproligferativos indolentes: análisis histológico, fenotípico y molecularSara Alonso Álvarez · 2016
- Int“Dll”igent control of T-cell pathology in GVHDMarkus Düchler · 2018 · Blood
- Computational exploration of cancer genomesJoakim W. Karlsson · 2019 · Gothenburg University Publications Electronic Archive (Gothenburg University)
- Mice deficient of Myc super-enhancer region reveal a differential control mechanism between normal and pathological growthKashyap Dave, Inderpreet Sur, Jian Yan, Jilin Zhang, Eevi Kaasinen, Fan Zhong, Leander Blaas, Xiaoze Li, Robert Månsson, Jussi Taipale · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
- Ennet: construction of potential cancer-driving networks based on somatic enhancer mutations onlyYa Cui, Yiwei Niu, Xueyi Teng, Dan Wang, Huaxia Luo, Peng Zhang, Wei Wu, Shunmin He, Jianjun Luo, Runsheng Chen · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
- Preventing cancer by long-term partial Myc suppressionNicole M. Sodir, Luca Pellegrinet, Roderik M. Kortlever, Yong-Won Kwon, Shinseog Kim, Daniel A. Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Trevor D. Littlewood et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- [The role and research progress of NOTCH1 in T-cell acute lymphoblastic leukemia].Shanshan Guo, J Q Mi, Jiayi Wang · 2021 · PubMed Central
- Disinfection of drinking water using high-intensity pulsed lightY. Lamont, Tao Wang, John G. Anderson, S.J. MacGregor, Neil J. Rowan · 2002
- The Combination Transition Development of Mongolian Music from the Perspective of Music CombinationMeng Dongqi · 2019
- Planificación financiera y de marketing para alcanzar la rentabilidadHarold W. Fox · 1976 · Alta dirección
- Genetic Mechanisms in T-Cell Acute Lymphoblastic LeukemiaFrancesca Gianni, Adolfo A. Ferrando · 2022 · Springer eBooks
- Mechanisms underlying transcription factor deregulation in acute lymphoblastic leukemiaJan Cools · 2018 · HemaSphere
- Genome-Wide Approaches to Defining Macrophage Identity and FunctionGregory J. Fonseca, Jason S. Seidman, Christopher K. Glass · 2017 · ASM Press eBooks
- New subtypes of oncogenic deregulation in childhood T-ALLPetri Pölönen, Marten Dooper · 2022
- Molecular genetic abnormalities in patients with T-cell acute lymphoblastic leukemia: a literature reviewAnastasia N. Vasileva, Olga A. Aleshina, Бидерман Белла Вениаминовна, Andrey Borisovich Sudarikov · 2022 · Oncohematology
- Data from Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer TherapyFatemeh Amjadi‐Moheb, Alireza Paniri, Haleh Akhavan‐Niaki · 2023
- Genomic Landscape of Acute Lymphoblastic Leukemia (ALL): Insights to Leukemogenesis, Prognostications, and TreatmentSin Chun-fung · 2023 · Springer eBooks
- Research progress on the application of CRISPR/Cas9 technology in breast cancer treatmentYuxin Cai · 2023 · Theoretical and Natural Science
- The ESCRT protein CHMP5 promotes T cell leukemia by controlling BRD4-p300-dependent transcriptionKatharine Umphred-Wilson, Shashikala Ratnayake, Qianzi Tang, Rui Wang, Ballachanda N. Devaiah, Lan Zhou, Qingrong Chen, Daoud M. Meerzaman, Dinah S. Singer, Stanley Adoro · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Notch Functions in T Cell DevelopmentManjula Kamath, Juan Carlos Zúñiga‐Pflücker · 2024 · Elsevier eBooks
- A novel murine syngeneic CD8 peripheral T-cell lymphoma model with preclinical applicationsLarry Milshteyn, Anton Luis Villamejor, Akil Abid Merchant, Joseph Cornelius Lownik · 2024 · Leukemia & lymphoma/Leukemia and lymphoma
- Genetic and Epigenetic Profiles in T-ALLBüşra Erarslan Uysal, Andreas E. Kulozik · 2024 · Pediatric oncology
- HemaCisDB: An Interactive Database for Analyzing Cis -regulatory Elements Across Hematopoietic MalignanciesXinping Cai, Qianru Zhang, Bolin Liu, Lu Sun, Yuxuan Liu · 2024 · Genomics Proteomics & Bioinformatics
- Competitive signaling and cellular communications in myocardial infarction responseVishnu Nair, Christian Demitri, Finosh Gnanaprakasam Thankam · 2025 · Molecular Biology Reports
- Role and Therapeutic Implication of Notch Signaling Pathway in CancerSuhail Shafi Lone, Mosin Saleem Khan, Sabhiya Majid, Waseem Qureshi · 2025 · Springer eBooks
- Functional enhancers: concept, screening, and validationHongli Lin, Fei Chen, Jialiang Huang · 2025 · Scientia Sinica Vitae
- Targeting the Liquid–Liquid Separation Region of c‐Maf for Treating Chromosomal Translocations in Multiple MyelomaZe Wang, Mengjie Guo, Xichao Yu, Yi Sun, Haowen Bai, Lianxin Zhou, Zihao Liu, Hongming Huang, Chong Wang, Hong Liu et al. · 2025 · MedComm
- Effects of topological domain disruption on transcriptional regulation are chromatin context dependentÁngel Josué Cerecedo-Castillo, Diana Itzé Mojica-Santamaría, Hober Nelson Núñez-Martínez, Carlos Alberto Peralta‐Álvarez, Gustavo Tapia-Urzúa, Georgina Guerrero, Rodrigo G. Arzate‐Mejía, Félix Recillas Targa · 2026 · Epigenetics & Chromatin
- BARTsc identifies key transcriptional regulators from single-cell omics dataHongpan Zhang, Lei Kang, Jingyi Wang, Kathleen Liang, Zhenjia Wang, Kexin Xu, Chongzhi Zang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- The functional and spatial organization of chromatin during Thymocyte developmentYousra Ben Zouari · 2018
- Etude de l’importance de la kinase LCK, des radeaux lipidiques et de la sécrétion autocrine de l’interleukine 7 dans les leucémies aiguës lymphoblastiques T, via des modèles de souris humaniséesAnne Buffière · 2019
- Leucémies aigüs lymphoblastiques T (LAL-T) et dérégulation épigénétiqueAurore Touzart · 2018
- Caractérisation des enhancers dérégulés dans la leucémie aiguë lymphoblastique de type TAlexandre P. España · 2019
- Study of impact of Pten-loss in leukemic development of T cell : boolean modelling and transcriptomic analysis at single-cell resolutionSaran Pankaew · 2022 · theses.fr (ABES)