Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

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2. Progranulin levels in blood in Alzheimer's disease and mild cognitive impairment
   Yonatan A. Cooper, Daniel C. Nachun, Deepika Reddy Dokuru, Zhongan Yang, Anna M. Karydas, Ginette Serrero, Binbin Yue, Alzheimer’s Disease Neuroimaging Initiative, Adam L. Boxer, Bruce L. Miller et al. · 2018 · Annals of Clinical and Translational Neurology
3. Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations
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4. Cerebrospinal fluid progranulin is associated with increased cortical thickness in early stages of Alzheimer's disease
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5. Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
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6. Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy
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7. Cerebrospinal Fluid Progranulin, but Not Serum Progranulin, Is Reduced in GRN-Negative Frontotemporal Dementia
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8. Progranulin and GPNMB: interactions in endo-lysosome function and inflammation in neurodegenerative disease
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9. Advances in the Understanding of the Correlation Between Neuroinflammation and Microglia in Alzheimer’s Disease
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10. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice
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11. Delivering progranulin to neuronal lysosomes protects against excitotoxicity
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12. The Microglial Response to Neurodegenerative Disease
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13. Endosomal Trafficking in Alzheimer's Disease, Parkinson's Disease, and Neuronal Ceroid Lipofuscinosis
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14. Progranulin mutations in clinical and neuropathological Alzheimer's disease
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15. Immune dysfunction in Alzheimer disease
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16. Alzheimer’s Disease Research Using Human Microglia
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17. Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1
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18. The Role of PGRN in Alzheimer’s Disease
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19. PPARδ agonist GW0742 ameliorates Aβ1–42-induced hippocampal neurotoxicity in mice
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20. Mendelian randomization identifies proteins involved in neurodegenerative diseases
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21. Progranulin as a therapeutic target for dementia
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22. Hormone-like conopeptides – new tools for pharmaceutical design
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23. Progranulin deficiency in the brain: the interplay between neuronal and non-neuronal cells
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24. Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
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25. Lysosomal Dysfunction and Other Pathomechanisms in FTLD: Evidence from Progranulin Genetics and Biology
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26. Progranulin Administration Attenuates β-Amyloid Deposition in the Hippocampus of 5xFAD Mice Through Modulating BACE1 Expression and Microglial Phagocytosis
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27. APP‐derived peptides reflect neurodegeneration in frontotemporal dementia
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28. Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis
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29. Progranulin haploinsufficiency reduces amyloid beta deposition in Alzheimer’s disease model mice
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30. Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS
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31. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses
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32. Progranulinopathy: A diverse realm of disorders linked to progranulin imbalances
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33. Identification of potential therapeutic targets for Alzheimer's disease from the proteomes of plasma and cerebrospinal fluid in a multicenter Mendelian randomization study
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34. Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation
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35. Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease
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36. Targeting Progranulin as an Immuno-Neurology Therapeutic Approach
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37. Genome-wide meta-analysis identifies novel determinants of circulating serum progranulin
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38. Serum progranulin levels are associated with frailty in middle-aged individuals
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39. Microglial Reactivity Correlates with Presynaptic Loss Independent of β‐Amyloid and Tau
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40. In Vivo Detection of Changes Related to Cortical Columnar Organization and Neuroinflammation Across the AD Continuum
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41. Microglia increases the proliferation of retinal precursor cells during postnatal development.
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42. Brain-Derived Glia Maturation Factor β Participates in Lung Injury Induced by Acute Cerebral Ischemia by Increasing ROS in Endothelial Cells
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43. Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets
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44. Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study
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47. Protein network analysis reveals selectively vulnerable regions and biological processes in FTD
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48. Approaches to develop therapeutics to treat frontotemporal dementia
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49. Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review
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50. Raster image cross-correlation analysis for spatiotemporal visualization of intracellular degradation activities against exogenous DNAs
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51. Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists
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52. Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
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53. The role of endolysosomal progranulin and TMEM106B in neurodegenerative diseases
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54. Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics
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55. Progranulin Promotes Functional Recovery in Rats with Acute Spinal Cord Injury via Autophagy-Induced Anti-inflammatory Microglial Polarization
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56. Chemical and genetic rescue of in vivo progranulin-deficient lysosomal and autophagic defects.
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57. Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia
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58. The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels
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59. Neuroimmune dysfunction in frontotemporal dementia: Insights from progranulin and C9orf72 deficiency
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60. Innate Anti-microbial and Anti-chemotaxis Properties of Progranulin in an Acute Otitis Media Mouse Model
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61. Progranulin Preserves Autophagy Flux and Mitochondrial Function in Rat Cortical Neurons Under High Glucose Stress
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62. Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets
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63. Understanding the role of progranulin in Alzheimer's disease
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64. Neuroinflammation modulates the association of PGRN with cerebral amyloid-β burden
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65. Potential Value of Cerebrospinal Fluid Progranulin in the Identification of Postoperative Delirium in Geriatrics Patients Undergoing Knee Replacement: The Perioperative Neurocognitive Disorder and Biomarker LifestylE Study
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66. Short-Term Effects of Microglia-Specific Mitochondrial Dysfunction on Amyloidosis in Transgenic Models of Alzheimer’s Disease
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67. Clinical and radiological features of posterior cortical atrophy (PCA) in a GRN mutation carrier: a case report
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68. Progranulin function and regulation in the CNS
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69. Multiple Molecular Pathways Are Influenced by Progranulin in a Neuronal Cell Model–A Parallel Omics Approach
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70. A Mutant Variant of E2F4 Triggers Multifactorial Therapeutic Effects in 5xFAD Mice
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71. PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases
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72. Progranulin protects against the tissue damage of acute ischaemic stroke: Figure 1
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73. A Multi-Dimensional Comparison of Alzheimer’s Disease Neurodegenerative Biomarkers
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74. Investigational therapeutics for the treatment of progressive supranuclear palsy
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75. An anti-sortilin affibody-peptide fusion inhibits sortilin-mediated progranulin degradation
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76. Genetically programmed changes in transcription of the novel progranulin regulator
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77. GRN Missense Variants and Familial Alzheimer’s Disease: Two Case Reports
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78. The progranulin cleavage product granulin 3 exerts a dominant negative effect on animal fitness
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79. Neurodegenerative Disease Conditions and Genomic Treatment for Better Health
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81. Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis
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82. Relationships of PGRN with sTREM2 in AD continuum and non-AD pathophysiology and their reciprocal roles in modulating amyloid pathology: two population-based study
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83. Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors
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84. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice
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85. Progranulin Protects against Hyperglycemia-Induced Neuronal Dysfunction through GSK3β Signaling
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86. Stability of Progranulin Under Pre-Analytical Conditions in Serum and Cerebrospinal Fluid
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87. Progranulin and neuropathological features of Alzheimer’s disease: longitudinal study
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90. Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia
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