Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

Minami, S Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H +5 more·2014·Nature Medicine
DOI 10.1038/nm.3672

Cited by (239)

Items 201–239 of 239

  1. Targeting Granulin Haploinsufficiency in Frontotemporal Dementia: From Genetic Mechanisms to Therapeutics
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  2. Serum progranulin is not associated with rs5848 polymorphism in Korean patients with neurodegenerative diseases
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  3. Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD
    Claire Dudley Clelland, Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad R. Altobelli, Sally E. Salomonsson, Alisha M. Birk, Aradhana Sachdev, Jingjie Zhu, Se-In Lee et al. · 2025 · Communications Biology
  4. Potential effects of progranulin and granulins against retinal photoreceptor cell degeneration.
    Miruto Tanaka, Yoshiki Kuse, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa · 2019 · PubMed Central
  5. GRN mutation spectrum and genotype–phenotype correlation in Chinese dementia patients: data from PUMCH dementia cohort
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  6. Turning microglia neuroprotective: Towards connexin43-specific therapy of Alzheimer’s disease
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  7. Neurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation
    John Michael Replogle, Jordan D. Marks, Martin G. Fernandez, Hebao Yuan, Dahyun Yu, Elizabeth Winters, Vidhya Maheswari Jawahar, Rishi Deshmukh, Renaldo Sutanto, Isabelle Kowal et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  8. A novel c.1468 G > A GRN mutation causes frontotemporal dementia in a Chinese Han family
    Mingrong Xia, Chenhao Gao, Junkui Shang, Dan Li, Ali Yang, Weizhou Zang, Jiewen Zhang · 2025 · European journal of medical research
  9. Proteome-wide association study identifies novel Alzheimer's disease-associated proteins
    Lingyun Sun, Guikang Wei, Feiyang Ji, Yihong Ding, Jiayao Fan, Yue Xu, Chunfeng He, Yuan Zhou, Z. Liu, Zeyu Sun et al. · 2025 · Journal of Alzheimer s Disease
  10. Genetic Interactions of Progranulin Across the ALS-FTD Spectrum and Beyond
    James J Doyle, J. Alex Parker · 2020 · PubMed Central
  11. Viral Vector Therapeutics Against Alzheimer’s Disease
    Magisetty Obulesu · 2019 · Elsevier eBooks
  12. C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition
    Victoria J. Butler, Wilian Augusto Cortopassi, Andrea R. Argouarch, M. Olivia Pierce, Mihir Vohra, Juan A. Osés-Prieto, Fuying Gao, Benjamin Caballero, Shreya Chand, William W. Seeley et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  13. E2F4 as a single multifactorial target against Alzheimer’s disease
    Noelia López‐Sánchez, Morgan Ramón‐Landreau, Cristina Trujillo, Alberto Garrido‐García, José María Frade · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. A Mendelian randomization study identifies proteins involved in neurodegenerative diseases
    Lazaros Belbasis, Sam Morris, Cornelia M. van Duijn, Derrick Bennett, Robin G. Walters · 2024 · medRxiv
  15. Microglia in the Alzheimers brain: a help or a hindrance?
    Craig T. Vollert, Jason L. Eriksen · 2014 · AIMS neuroscience
  16. Autosomal Dominant Frontotemporal Lobar Degeneration: From Genotype to Phenotype
    María Serpente, Daniela Galimberti · 2018 · Springer eBooks
  17. Nemo-like kinase regulates Progranulin levels in the brain through the microglial endocytosis-lysosomal pathway
    Tingting Dong, Hiroshi Kokubu, Terri M. Driessen, Leon Tejwani, Janghoo Lim · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  18. PGRN and Neurodegenerative Diseases Other Than FTLD
    Masato Hosokawa · 2019 · Springer eBooks
  19. Premature termination codon readthrough restores progranulin expression in preclinical models of frontotemporal dementia and neuronal ceroid lipofuscinosis
    Jonathan Frew · 2021 · cIRcle (University of British Columbia)
  20. Cellular Mechanisms of Dementia
    Li Gan · 2017 · Oxford University Press eBooks
  21. Analysis of Adult Hippocampal Neurogenesis in Neurodegenerative disease
    HAN, GANG · 2022
  22. AZP2006 in Progressive Supranuclear Palsy: A Multi-Centre, Randomized, Phase 2a Trial Assessing Safety and Biomarker Outcomes
    Jean‐Christophe Corvol, Mickaël Alexandre Obadia, Caroline Moreau, Louise‐Laure Mariani, Jean‐Philippe Brandel, David Devos, Sara Sambin, Nicolas Carrière, Marie Lebouteux, Graziella Mangone et al. · 2024 · SSRN Electronic Journal
  23. Progranulin preserves mitochondrial health and turnover in neurons under hyperglycemic stress in a p97-dependent manner
    Cass Dedert, Fenglian Xu · 2024 · Research Square
  24. A progranulin gene deletion in frontotemporal lobar degeneration with corticobasal syndrome in a TREDEM case report
    Maurizio Gallucci, Chiara Da Ronch, Matteo Bendini, Vittorio Fiore, Licia Turolla, Moreno Ferrarini, Gian Maria Fabrizi, Pietro Tiraboschi · 2024 · Journal of Alzheimer s Disease Reports
  25. Ablation of progranulin augments microglial activation and accelerates prion progression
    Bei Li, Yiyue Shi, Wenyu Hou, Haoyuan Guan, Jun Li, Tuo Yi, Wei Li, Donglin Cai, Petra Schwarz, Adriano Aguzzi et al. · 2025 · Acta Neuropathologica Communications
  26. Additional file 3 of Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
    Wang, Jing, Simin Lai, Zhou, Ting, Zhihao Xia, Li, Weina, Wenqi Sha, JINGJIE LIU, Chen, Yanjiong · 2024 · Figshare
  27. Additional file 4 of Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
    Wang, Jing, Simin Lai, Zhou, Ting, Zhihao Xia, Li, Weina, Wenqi Sha, Liu, Jingjie, Chen, Yanjiong · 2024 · Figshare
  28. Additional file 1 of Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia
    Michael Kurnellas, Ananya Mitra, Tina Schwabe, Paul, Robert, Andrew E. Arrant, Erik D. Roberson, Michael Ward, Felix L. Yeh, Long, Hua, Arnon Rosenthal · 2024 · Figshare
  29. Additional file 1 of Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
    Wang, Jing, Simin Lai, Zhou, Ting, Zhihao Xia, Li, Weina, Wenqi Sha, Liu, Jingjie, Chen, Yanjiong · 2024 · Figshare
  30. Additional file 2 of Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
    Wang, Jing, Simin Lai, Zhou, Ting, Zhihao Xia, Li, Weina, Wenqi Sha, Liu, Jingjie, Chen, Yanjiong · 2024 · Figshare
  31. Toll-like receptor 9 contributes in microglial activation and lysosomal dysfunction to promote Alzheimer’s disease
    Moïse de Lavergne, Lucie Mazzola, Katrina Podsypanina, Cecilia Estrella, Philippe Verwaerde, Irini Evnouchidou, Guillaume Darrasse-Jèze, Marie‐Claude Potier, Sheela Vyas, Bénédicte Manoury · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  32. Etudes de trois métalloprotéases matricielles, MT1-MMP, MT5-MMP et MMP-12 dans l'amyloïdogenèse et les atteintes inflammatoires et vasculaires associées à la maladie d'Alzheimer
    Amandine Bonnet · 2017 · theses.fr (ABES)
  33. Progranulin deficiency in the brain activates an insulin signaling pathway that may promote neurodegeneration
    Mini P. Sajan, Geetika Aggarwal, Joel Jihwan Hwang, Denise M. Smith, Denise R. Cooper, Mildred Acevedo Duncan, BARBARA CALEEN HANSEN, Andrew D. Nguyen, Robert V. Farese · 2026 · iScience
  34. Progranulin genetic variant rs5848 displays ancestry-specific associations with Alzheimer’s disease
    Benjamin E. Life, Erick I. Navarro‐Delgado, Oriol Fornés, Jan M Friedman, Wyeth W. Wasserman, Keegan D. Korthauer, Blair R. Leavitt · 2026 · Human Genomics
  35. Loss of Lysosomal Proteins Progranulin and Prosaposin Associated with Increased Neurofibrillary Tangle Development in Alzheimer Disease.
    育夫 遠山, Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E SERRANO, Thomas G. Beach, Douglas G. Walker · Institutional Repositories DataBase (IRDB)
  36. Biparatopic affibody engineering enables high-affinity sortilin blockade and progranulin elevation
    Moira Ek, Hanna Lindberg, Stefan Ståhl, John Löfblom · 2026 · New Biotechnology
  37. Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation
    Qinglong Guo, Jing Bi, Yu Fu, 吕松 Lü Song, Haojia Wu, Xi Chen, Yaqi Gong, Carl G. Feng, Guoliang Zhang · 2026 · Cell Reports
  38. From biology to therapy: advances in progranulin-related neurodegenerative diseases
    Sixian Hu, Kairui Qiu, Fangyuan Zhen, Xiaolai Zhou · 2026 · Molecular Neurodegeneration Advances
  39. BindingDB Entry 50011497: Hormone-like conopeptides - new tools for pharmaceutical design.
    BindingDB · 2022 · UC San Diego