Metformin Activates a Duodenal Ampk-Dependent Pathway to Lower Hepatic Glucose Production in Rats

Duca, Frank A, Côté, Clémence D, Rasmussen, Brittany A, Zadeh-Tahmasebi, Melika, Rutter, Guy A, Filippi, Beatrice M, Lam, Tony K T·2015·Nature Medicine

Cited by (402)

Items 101–200 of 402

  1. Polysaccharides extracted from Phellinus linteus ameliorate high-fat high-fructose diet induced insulin resistance in mice
    Han Feng, Shijie Zhang, Jennifer Man‐Fan Wan, Lifeng Gui, Mengcheng Ruan, Na Li, Hongyu Zhang, Zhiguo Liu, Hualin Wang · 2018 · Carbohydrate Polymers
  2. Involvement of glucagon‐like peptide‐1 in the glucose‐lowering effect of metformin
    Emilie Bahne, Morten Hansen, Andreas Brønden, David Peick Sonne, Tina Vilsbøll, Filip Krag Knop · 2016 · Diabetes Obesity and Metabolism
  3. Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus
    Madsen, Kasper S, Chi, Yuan, Metzendorf, Maria-Inti, Richter, Bernd, Hemmingsen, Bianca · 2019 · Cochrane Database of Systematic Reviews
  4. Metformin is Associated with Decreased 30-Day Mortality Among Nursing Home Residents Infected with SARS-CoV2
    Michelle Lally, Philip Tsoukas, Christopher W. Halladay, Emily O’Neill, Stefan Gravenstein, James L. Rudolph · 2020 · Journal of the American Medical Directors Association
  5. A microbial amino-acid-conjugated bile acid, tryptophan-cholic acid, improves glucose homeostasis via the orphan receptor MRGPRE
    Jun Lin, Qixing Nie, Jie Cheng, Ya-Ni Zhong, Tianyao Zhang, Xiuying Zhang, Xiaoyan Ge, Yong Ding, Canyang Niu, Yuhua Gao et al. · 2025 · Cell
  6. Mulberry leaf active components alleviate type 2 diabetes and its liver and kidney injury in db/db mice through insulin receptor and TGF-β/Smads signaling pathway
    Liwen Zhang, Shulan Su, Kevin Yue Zhu, Jianming Guo, Sheng Guo, Dawei Qian, Zhen Ouyang, Jin‐Ao Duan · 2019 · Biomedicine & Pharmacotherapy
  7. Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling
    Kang‐Hoon Kim, In‐Seung Lee, Ji Young Park, Yumi Kim, Eun-Jin An, Hyeung-Jin Jang · 2018 · Frontiers in Pharmacology
  8. Research progress on Sirtuins (SIRTs) family modulators
    Mingkai Chen, Junfei Tan, Zihan Jin, Tingting Jiang, Jiabiao Wu, Xiaolong Yu · 2024 · Biomedicine & Pharmacotherapy
  9. Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?
    Tian Xiang Li, Shuai Jiang, Zhi Ping Yang, Zhiqiang Ma, Wei Yi, Dongjin Wang, Yang Yang · 2016 · Cellular and Molecular Life Sciences
  10. Health benefits of late-onset metformin treatment every other week in mice
    Alfaras, Irene, Mitchell, Sarah J., Mora, Hector, Lugo, Darisbeth Rosario, Warren, Alessandra, Navas-Enamorado, Ignacio, Hoffmann, Vickie, Hine, Christopher, Mitchell, James R., Le Couteur, David G. et al. · 2017 · npj Aging and Mechanisms of Disease
  11. Regulation of systemic metabolism by the autonomic nervous system consisting of afferent and efferent innervation.
    Junta Imai, H. Katagiri · 2021 · International Immunology
  12. Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes
    Adam R. Konopka, Raul Ruiz Esponda, Matthew M. Robinson, Matthew L. Johnson, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Fredric Edward Wondisford, Ian R. Lanza, K. Sreekumaran Nair · 2016 · Cell Reports
  13. Metformin Impairs Spatial Memory and Visual Acuity in Old Male Mice
    Nopporn Thangthaeng, Margaret A. Rutledge, Jessica M. Wong, Philip H. Vann, Michael J. Forster, Nathalie Sumien · 2017 · Aging and Disease
  14. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion
    Panaro, Brandon L., Yusta, Bernardo, Matthews, Dianne, Koehler, Jacqueline A., Song, Youngmi, Sandoval, Darleen A., Drucker, Daniel J. · 2020 · Molecular Metabolism
  15. Metformin inhibits intracranial aneurysm formation and progression by regulating vascular smooth muscle cell phenotype switching via the AMPK/ACC pathway
    Sichen Li, Yuan Shi, Peixi Liu, Yaying Song, Yingjun Liu, Lingwen Ying, Kai Quan, Yu Guo, Zhiyuan Fan, Wei Ping Zhu · 2020 · Journal of Neuroinflammation
  16. Understanding the action mechanisms of metformin in the gastrointestinal tract
    Meihui Cheng, Lili Ren, Xianxian Jia, Jianwei Wang, Bin Cong · 2024 · Frontiers in Pharmacology
  17. Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats
    Jeong Rim Ko, Dae Yun Seo, Tae Nyun Kim, Se Hwan Park, Hyo‐Bum Kwak, Kyung Soo Ko, Byoung Doo Rhee, Jin Han · 2019 · Journal of Clinical Medicine
  18. Dietary Polyphenols to Combat Nonalcoholic Fatty Liver Disease via the Gut–Brain–Liver Axis: A Review of Possible Mechanisms
    Zhenyu Wang, Maomao Zeng, Zhaojun Wang, Fang Qin, Jie Chen, Zhiyong He · 2021 · Journal of Agricultural and Food Chemistry
  19. AMP-activated protein kinase: a therapeutic target in intestinal diseases
    Xiaofei Sun, Meijun J. Zhu · 2017 · Open Biology
  20. Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm
    Kiran Chaudhari, Jianmei Wang, Yong Xu, Ali Winters, Linshu Wang, Xiaowei Dong, Eric Y. Cheng, Ran Liu, Shao-Hua Yang · 2020 · PLoS ONE
  21. New Insights Into the Anti-Diabetic Actions of Metformin: From the Liver to the Gut
    Wu, Tongzhi, Horowitz, Michael, Rayner, Christopher K. · 2017 · Expert Review of Gastroenterology & Hepatology
  22. Mitochondrial dynamics in exercise physiology
    Tomohiro Tanaka, Akiyuki Nishimura, Kazuhiro Nishiyama, Takumi Goto, Takuro Numaga‐Tomita, Motohiro Nishida · 2019 · Pflügers Archiv - European Journal of Physiology
  23. An agonist of a zinc-sensing receptor GPR39 enhances tight junction assembly in intestinal epithelial cells via an AMPK-dependent mechanism
    Pawin Pongkorpsakol, Chavin Buasakdi, Thanyatorn Chantivas, Varanuj Chatsudthipong, Chatchai Muanprasat · 2018 · European Journal of Pharmacology
  24. AMPK activation can delay aging
    Andreea Lucia Stancu · 2015 · Discoveries
  25. Metformin monotherapy for adults with type 2 diabetes mellitus
    Filip Gnesin, Anne Cathrine B. Thuesen, Lise Katrine Aronsen Kähler, Sten Madsbad, Bianca Hemmingsen · 2020 · Cochrane Database of Systematic Reviews
  26. TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin Toxicity
    Chao‐Yung Wang, Chun‐Chi Chen, Mei-Hsiu Lin, Huiting Su, Ming-Yun Ho, Jih‐Kai Yeh, Ming‐Lung Tsai, Ching‐Lin Hsieh, Ming‐Shien Wen · 2020 · Biology
  27. Metformin Alters Locomotor and Cognitive Function and Brain Metabolism in Normoglycemic Mice
    Wenjun Li, Kiran Chaudhari, Ritu A. Shetty, Ali Winters, Xiaofei Gao, Zeping Hu, Woo‐Ping Ge, Nathalie Sumien, Michael J. Forster, Ran Liu et al. · 2019 · Aging and Disease
  28. Insulin secretagogues for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus
    Bianca Hemmingsen, David Peick Sonne, Maria‐Inti Metzendorf, Bernd Richter · 2016 · Cochrane Database of Systematic Reviews
  29. Enhanced Release of Glucose Into the Intraluminal Space of the Intestine Associated With Metformin Treatment as Revealed by [18F]Fluorodeoxyglucose PET-MRI
    Yasuko Morita, Munenobu Nogami, Kazuhiko Sakaguchi, Yuko Okada, Yushi Hirota, Kenji Sugawara, Yoshikazu Tamori, Feibi Zeng, Takamichi Murakami, Wataru Ogawa · 2020 · Diabetes Care
  30. Recent advances in anti-inflammation via AMPK activation
    Yi-Hua Xu, Lan Bai, Xin-Wei Yang, Jian-Li Huang, Jie Wang, Xian-Bo Wu, Jianyou Shi · 2024 · Heliyon
  31. Glucoregulatory Relevance of Small Intestinal Nutrient Sensing in Physiology, Bariatric Surgery, and Pharmacology
    Frank Anthony Duca, Paige V. Bauer, Sophie C. Hamr, Tony K.T. Lam · 2015 · Cell Metabolism
  32. Activation of Short and Long Chain Fatty Acid Sensing Machinery in the Ileum Lowers Glucose Production in Vivo
    Melika Zadeh‐Tahmasebi, Frank Anthony Duca, Brittany A. Rasmussen, Paige V. Bauer, Clémence D. Côté, B Filippi, Tony K.T. Lam · 2016 · Journal of Biological Chemistry
  33. Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production
    Emily Tubbs, Annika S. Axelsson, Guillaume Vial, Claes B. Wollheim, Jennifer Rieusset, Anders H. Rosengren · 2017 · Molecular and Cellular Endocrinology
  34. Chitosan oligosaccharide regulates AMPK and STAT1 pathways synergistically to mediate PD-L1 expression for cancer chemoimmunotherapy
    Jiashe Chen, Zaigang Zhou, Chunjuan Zheng, Yu Liu, Ruiqi Hao, Xiaolin Ji, Qiaoer Xi, Jianliang Shen, Zhiming Li · 2021 · Carbohydrate Polymers
  35. Metformin Enhances Osteogenesis and Suppresses Adipogenesis of Human Chorionic Villous Mesenchymal Stem Cells
    Qiaoli Gu, Yanzheng Gu, Huilin Yang, Qin Shi · 2016 · The Tohoku Journal of Experimental Medicine
  36. Duodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry
    Mengliu Yang, Jinzhi Wang, Shaobo Wu, Lei Yuan, Xiaodong Zhao, Chaohong Liu, Jing Xie, Yanjun Jia, Yerui Lai, Allan Z. Zhao et al. · 2017 · Cell Death and Disease
  37. Physiological and therapeutic regulation of glucose homeostasis by upper small intestinal PepT1-mediated protein sensing
    Helen J. Dranse, T.M. Zaved Waise, Sophie C. Hamr, Paige V. Bauer, Mona A. Abraham, Brittany A. Rasmussen, Tony K.T. Lam · 2018 · Nature Communications
  38. Attenuation of diethylnitrosamine (DEN) – Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles
    Deepika Singh, Manvendra Pratap Singh, Ekta Yadav, Neha Falls, Deependra Singh Dangi, Vikas Kumar, Pramod Wasudeo Ramteke, Amita Verma · 2018 · Biomedicine & Pharmacotherapy
  39. Molecular mechanisms of action of metformin: latest advances and therapeutic implications
    Hong Zhu, Zhenquan Jia, Yunbo Robert Li, Igor Danelisen · 2023 · Clinical and Experimental Medicine
  40. Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease
    Triggle, Chris R., Ding, Hong, Marei, Isra, Anderson, Todd J., Hollenberg, Morley D. · 2020 · Canadian Journal of Physiology and Pharmacology
  41. Metformin: review of epidemiology and mechanisms of action in pancreatic cancer
    Guido Eibl, Enrique Rozengurt · 2021 · Cancer and Metastasis Reviews
  42. Comparative effects of proximal and distal small intestinal administration of metformin on plasma glucose and glucagon‐like peptide‐1, and gastric emptying after oral glucose, in type 2 diabetes
    Malcolm J. Borg, Michelle J. Bound, Jacqueline Grivell, Zilin Sun, Karen L. Jones, Michael Horowitz, Christopher Keith Rayner, Tongzhi Wu · 2018 · Diabetes Obesity and Metabolism
  43. Metformin attenuates cadmium-induced neuronal apoptosis in vitro via blocking ROS-dependent PP5/AMPK-JNK signaling pathway
    Xiaoling Chen, Wen Wu, Baoming Gong, Long Hou, Xiaoqing Dong, Chong Xu, Rui Zhao, Qianyun Yu, Zhihan Zhou, Shile Huang et al. · 2020 · Neuropharmacology
  44. Reg3γ: current understanding and future therapeutic opportunities in metabolic disease
    Jae Hoon Shin, Nadejda Bozadjieva-Kramer, Randy J. Seeley · 2023 · Experimental & Molecular Medicine
  45. Curcumin attenuates collagen-induced inflammatory response through the “gut-brain axis”
    Yannong Dou, Jinque Luo, Xin Wu, Zhifeng Wei, Bei Tong, Juntao Yu, Ting Wang, Xinyu Zhang, Yan Yang, Xusheng Yuan et al. · 2018 · Journal of Neuroinflammation
  46. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks
    Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, Ying Hu, Lin He, Chien‐Min Hung, Erin Quan Toyama, Debbie S. Ross, Björn F. Lillemeier, Lewis C. Cantley et al. · 2019 · Cell Reports
  47. Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
    Yong Chen, Qiu Fujuan, Beijia Yu, Yanjuan Chen, Fangfang Zuo, Xiaoyu Zhu, Kutty Selva Nandakumar, Changhong Xiao · 2020 · Molecular Therapy — Methods & Clinical Development
  48. Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke
    Wanchao Yang, Tingting Li, Qiang Wan, Xin Zhang, Yuan Xiao, Liying Sun, Yurong Zhang, Xiang-Nan Liu · 2022 · Neural Regeneration Research
  49. Reactive Oxygen Species/Reactive Nitrogen Species as Messengers in the Gut: Impact on Physiology and Metabolic Disorders
    Anne Abot, Steven G. Fried, Patrice D. Cani, Claude Knauf · 2021 · Antioxidants and Redox Signaling
  50. Mechanisms of metformin action: In and out of the gut
    Takahiro Minamii, Munenobu Nogami, Wataru Ogawa · 2018 · Journal of Diabetes Investigation
  51. Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?
    Juhong Yang, Reiko Nishihara, Xuehong Zhang, Shuji Ogino, Zhi Rong Qian · 2017 · Journal of Diabetes and its Complications
  52. An Innovative Short-Clustered Maltodextrin as Starch Substitute for Ameliorating Postprandial Glucose Homeostasis
    Haocun Kong, Luxi Yu, Zhengbiao Gu, Caiming Li, Li Cheng, Yan Hong, Zhaofeng Li · 2020 · Journal of Agricultural and Food Chemistry
  53. Metformin causes a futile intestinal–hepatic cycle which increases energy expenditure and slows down development of a type 2 diabetes-like state
    Philipp Schommers, Anna Thurau, Insa Bultmann-Mellin, Maria Guschlbauer, Andreas R. Klatt, Jan Rozman, Martin Klingenspor, Martin Hrabě de Angelis, Jens Alber, Dirk Gründemann et al. · 2017 · Molecular Metabolism
  54. Single-Dose Metformin Enhances Bile Acid–Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes
    Andreas Brønden, Anders Albèr, Ulrich Rohde, Jens Frederik Rehfeld, Jens Juul Holst, Tina Vilsbøll, Filip Krag Knop · 2017 · The Journal of Clinical Endocrinology & Metabolism
  55. Metformin for early comorbid glucose dysregulation and schizophrenia spectrum disorders: a pilot double-blind randomized clinical trial
    Agarwal, Sri Mahavir, Panda, Roshni, Costa-Dookhan, Kenya A., MacKenzie, Nicole E., Treen, Quinn Casuccio, Caravaggio, Fernando, Hashim, Eyesha, Leung, General, Kirpalani, Anish, Matheson, Kelly et al. · 2021 · Translational Psychiatry
  56. The Gut Microbiota-Related Antihyperglycemic Effect of Metformin
    Izabela Szymczak-Pajor, Józef Drzewoski, Małgorzata Kozłowska, Jan Krekora, Agnieszka Śliwińska · 2025 · Pharmaceuticals
  57. Postprandial glucose‐lowering effect of premeal consumption of protein‐enriched, dietary fiber‐fortified bar in individuals with type 2 diabetes mellitus or normal glucose tolerance
    Jae Hyun Bae, Lee-Kyung Kim, Se-Hee Min, Chang Ho Ahn, Young Min Cho · 2018 · Journal of Diabetes Investigation
  58. Silibinin decreases hepatic glucose production through the activation of gut–brain–liver axis in diabetic rats
    Fanxing Xu, Jingyu Yang, Hiroko Negishi, Yue Sun, Dahong Li, Xianxian Zhang, Toshihiko Hayashi, Ming Gao, Katsumi Ikeda, Takashi Ikejima · 2018 · Food & Function
  59. Metformin and cognition from the perspectives of sex, age, and disease
    Kiran Chaudhari, Conner D. Reynolds, Shao-Hua Yang · 2020 · GeroScience
  60. The Effects of Metformin on the Gut Microbiota of Patients with Type 2 Diabetes: A Two-Center, Quasi-Experimental Study
    Hanako Nakajima, Fumie Takewaki, Yoshitaka Hashimoto, Shizuo Kajiyama, Saori Majima, Hiroshi Okada, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi et al. · 2020 · Life
  61. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα
    Min Yan, Huan Qi, Tian Xia, Xinjie Zhao, Wen Wang, Zhichao Wang, Chang Lu, Zhen Ning, Huan Chen, Tongming Li et al. · 2018 · Metabolism
  62. Metformin prevents PFKFB3‑related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway
    Cijun Tang, Ji Ping Xu, Hai-Yan Ye, Xuebin Wang · 2021 · Experimental and Therapeutic Medicine
  63. AMPK inhibits liver gluconeogenesis: fact or fiction?
    Manuel Johanns, Louis Hue, Mark H. Rider · 2023 · Biochemical Journal
  64. Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota
    Yue Wang, Xianxian Jia, Bin Cong · 2024 · Frontiers in Microbiology
  65. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney
    Michael Søberg Christensen, Jonas Jensen, Steen Jakobsen, Niels Jessen, Jørgen Frøkiær, Bruce E. Kemp, Allison L. Marciszyn, Hui Li, Núria M. Pastor‐Soler, Kenneth R. Hallows et al. · 2016 · Scientific Reports
  66. Metformin attenuated endotoxin-induced acute myocarditis via activating AMPK
    Gang Liu, Kejia Wu, Li Zhang, Jie Dai, Wei Huang, Ling Lin, Pu Ge, Fuling Luo, Han Lei · 2017 · International Immunopharmacology
  67. The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome
    Lan Luo, Xiaoli Zhuang, Lin Fu, Ziyuan Dong, Shuyuan Yi, Kan Wang, Yu Jiang, Ju Zhao, Xiaofang Yang, Feilong Hei · 2024 · Clinical and Translational Medicine
  68. Photobiomodulation reduces hepatic lipogenesis and enhances insulin sensitivity through activation of CaMKKβ/AMPK signaling pathway
    Shuang Guo, Longlong Gong, Qi Shen, Da Xing · 2020 · Journal of Photochemistry and Photobiology B Biology
  69. Adipose tissue ageing: implications for metabolic health and lifespan
    Guan Wang, Anying Song, Qiong A Wang · 2025 · Nature Reviews Endocrinology
  70. The direct targets of metformin in diabetes and beyond
    Luxia Yao, Lei Wang, Runshuai Zhang, Alexander A. Soukas, Lianfeng Wu · 2024 · Trends in Endocrinology and Metabolism
  71. Cucurbitacin B Suppresses Hyperglycemia Associated with a High Sugar Diet and Promotes Sleep in Drosophila melanogaster
    Jiun Sang, Subash Dhakal, Youngseok Lee · 2021 · Molecules and Cells
  72. Neuropeptide Y Overexpressing Female and Male Mice Show Divergent Metabolic but Not Gut Microbial Responses to Prenatal Metformin Exposure
    Salomäki-Myftari, Henriikka, Vähätalo, Laura H., Ailanen, Liisa, Pietilä, Sami, Laiho, Asta, Hänninen, Arno, Pursiheimo, Juha-Pekka, Munukka, Eveliina, Rintala, Anniina, Savontaus, Eriika et al. · 2016 · PLOS ONE
  73. Metformin reprograms tryptophan metabolism via gut microbiome-derived bile acid metabolites to ameliorate depression-Like behaviors in mice
    Xiaoxian Xie, Wenwen Li, Ze Xiong, Junyu Xu, Tailin Liao, Lei Sun, Haoshen Xu, Mengya Zhang, Jiafeng Zhou, Wenzheng Xiong et al. · 2024 · Brain Behavior and Immunity
  74. Improved glycemic control with minimal systemic metformin exposure: Effects of Metformin Delayed-Release (Metformin DR) targeting the lower bowel over 16 weeks in a randomized trial in subjects with type 2 diabetes
    Robert R. Henry, Juan P. Frías, Brandon Walsh, Sharon Skare, John Hemming, Colleen M. Burns, Thomas A. Bicsak, Alain Baron, Mark S. Fineman · 2018 · PLoS ONE
  75. Fighting Diabetes Mellitus: Pharmacological and Non-pharmacological Approaches
    Xin Wang, Jinhong Kang, Qing Liu, Tao Tong, Helong Quan · 2020 · Current Pharmaceutical Design
  76. The Relationship between Frequently Used Glucose-Lowering Agents and Gut Microbiota in Type 2 Diabetes Mellitus
    You Lv, Xue Yan Zhao, Weiying Guo, Ying Gao, Shuo Yang, Zhuo Li, Guixia Wang · 2018 · Journal of Diabetes Research
  77. A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study
    Hyewon Chung, Jaeseong Oh, Seo Hyun Yoon, Kyung‐Sang Yu, Joo‐Youn Cho, Jae‐Yong Chung · 2018 · PLoS ONE
  78. Urolithin A Attenuates Diabetes‐Associated Cognitive Impairment by Ameliorating Intestinal Barrier Dysfunction via N‐glycan Biosynthesis Pathway
    Yao Xiao, Kailin Li, Ji Bian, Hang Liu, Xiaotong Zhai, Emad M. El-Omar, Lin Han, Lan Gong, Min Wang · 2022 · Molecular Nutrition & Food Research
  79. Three structural features of functional food components and herbal medicine with amyloid β42 anti-aggregation properties
    Murakami, Kazuma, Irie, Kazuhiro · 2019 · Molecules
  80. Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes
    Yuxin Huang, Xudan Lou, Cuiping Jiang, Xueying Ji, Xiaoming Tao, Jiao Sun, Zhijun Bao · 2022 · Frontiers in Endocrinology
  81. Inhibition of tumor energy pathways for targeted esophagus cancer therapy
    Abbas Shafaee, Davood Zarei Dastyar, Jalil Pirayesh Islamian, Milad Hatamian · 2015 · Metabolism
  82. Liraglutide and Metformin alone or combined therapy for type 2 diabetes patients complicated with coronary artery disease
    Ying Liu, Xia Jiang, Xin Chen · 2017 · Lipids in Health and Disease
  83. Obligatory Role of AMPK Activation and Antioxidant Defense Pathway in the Regulatory Effects of Metformin on Cellular Protection and Prevention of Lens Opacity
    Bhavana Chhunchha, Eri Kubo, Dhirendra P. Singh · 2022 · Cells
  84. Metformin
    Meng Hee Tan, Hussain Alquraini, Kara Mizokami‐Stout, Mark MacEachern · 2016 · Endocrinology and Metabolism Clinics of North America
  85. Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway
    Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li et al. · 2019 · Cell Communication and Signaling
  86. Icariin treatment reduces blood glucose levels in type�2 diabetic rats and protects pancreatic function
    Xin Li, Yun‑Xiao Wang, Ping Shi, Yan‐Ping Liu, Ting Li, Shuqin Liu, Chen‐Jing Wang, Le‐Xin Wang, Yu Cao · 2020 · Experimental and Therapeutic Medicine
  87. Deletion of intestinal epithelial AMP-activated protein kinase alters distal colon permeability but not glucose homeostasis
    Séverine Olivier, Camille Pochard, Hanna Ilchmann-Diounou, Vanessa Castillo, Jordane Divoux, Joshua A. Alcantara, Jocelyne Leclerc, Sandra Guilmeau, Camille Huet, Wafa Charifi et al. · 2021 · Molecular Metabolism
  88. The Emerging Role of Metformin in the Treatment of Hepatocellular Carcinoma: Is There Any Value in Repurposing Metformin for HCC Immunotherapy?
    Stavros P. Papadakos, Daniele Ferraro, Gabriele Carbone, Adam Enver Frampton, Giovanni Vennarecci, Stylianos Kykalos, Dimitriοs Schizas, Stamatios E Theocharis, Nikolaos Machairas · 2023 · Cancers
  89. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
    Jessica T.Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank Anthony Duca, B Filippi, Owen T. M. Chan, Tony K.T. Lam · 2016 · Nature Communications
  90. Of mice and men: Is there a future for metformin in the treatment of hepatic steatosis?
    Charlotte Green, Thomas Marjot, Jeremy Tomlinson, Leanne Hodson · 2018 · Diabetes Obesity and Metabolism
  91. Effect of Metformin on Antipsychotic-Induced Metabolic Dysfunction: The Potential Role of Gut-Brain Axis
    Chao Luo, Xu Wang, Hanxue Huang, Xiao‐Yuan Mao, Hong‐Hao Zhou, Zhaoqian Liu · 2019 · Frontiers in Pharmacology
  92. 14, 15‐EET alleviates neurological impairment through maintaining mitochondrial dynamics equilibrium via AMPK / SIRT1 / FoxO1 signal pathways in mice with cerebral ischemia reperfusion
    Jing Yan Tang, Yiang Chen, Jingyuan Li, Shuo Yan, Zenan Wang, Xinyu Deng, Ke Feng, Yanshuo Zhang, Chun‐Rong Chen, Huixia Geng et al. · 2023 · CNS Neuroscience & Therapeutics
  93. Dual actions of Netrin-1 on islet insulin secretion and immune modulation
    Shan Gao, Xiuyuan Zhang, Yibo Qin, Shixin Xu, Ju Zhang, Zhihong Wang, Weiwei Wang, Deling Kong, Chen Li · 2016 · Clinical Science
  94. Therapeutic Target Identification and Drug Discovery Driven by Chemical Proteomics
    Mingjie Zou, Haiyuan Zhou, Letian Gu, Jingzi Zhang, Lei Fang · 2024 · Biology
  95. Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons
    Zhang, Yong-mei, Zong, Hai-chao, Qi, Ying-bei, Chang, Liu-liu, Gao, Ya-nan, Zhou, Ting, Yin, Tao, Liu, Meng, Pan, Kai-jun, Chen, Wen-gang et al. · 2023 · Molecular Psychiatry
  96. Lactate Levels with Chronic Metformin Use: A Narrative Review
    Weiyi Huang, Ronald Lynel Castelino, Gregory Mark Peterson · 2017 · Clinical Drug Investigation
  97. Interactions Between Therapeutics for Metabolic Disease, Cardiovascular Risk Factors, and Gut Microbiota
    Qiyou Ding, Jiaxing Tian, Min Li, Fengmei Lian, Linhua Zhao, Xiuxiu Wei, Lin Han, Yujiao Zheng, Zezheng Gao, Haoyu Yang et al. · 2020 · Frontiers in Cellular and Infection Microbiology
  98. Targeting Myotonic Dystrophy Type 1 with Metformin
    Mikel García-Puga, Ander Saenz‐Antoñanzas, Ander Matheu, Adolfo López de Munaín · 2022 · International Journal of Molecular Sciences
  99. The Gastrointestinal Tract as Prime Site for Cardiometabolic Protection by Dietary Polyphenols
    José A. Villa-Rodríguez, Idolo Ifie, Gustavo Adolfo González-Aguilar, Diana E. Roopchand · 2019 · Advances in Nutrition
  100. Glucagon‐like Peptide‐2 and the Regulation of Intestinal Growth and Function
    Patricia Lee Brubaker · 2018 · Comprehensive physiology