The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Open accessAbstract
Genetic heterogeneity contributes to clinical outcome and progression of most tumors, but little is known about allelic diversity for epigenetic compartments, and almost no data exist for acute myeloid leukemia (AML). We examined epigenetic heterogeneity as assessed by cytosine methylation within defined genomic loci with four CpGs (epialleles), somatic mutations, and transcriptomes of AML patient samples at serial time points. We observed that epigenetic allele burden is linked to inferior outcome and varies considerably during disease progression. Epigenetic and genetic allelic burden and patterning followed different patterns and kinetics during disease progression. We observed a subset of AMLs with high epiallele and low somatic mutation burden at diagnosis, a subset with high somatic mutation and lower epiallele burdens at diagnosis, and a subset with a mixed profile, suggesting distinct modes of tumor heterogeneity. Genes linked to promoter-associated epiallele shifts during tumor progression showed increased single-cell transcriptional variance and differential expression, suggesting functional impact on gene regulation. Thus, genetic and epigenetic heterogeneity can occur with distinct kinetics likely to affect the biological and clinical features of tumors.
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Oral Azacitidine Maintenance Therapy for Acute Myeloid Leukemia in First Remission
Wei, A. H., Döhner, H., Pocock, C., Montesinos, P., Afanasyev, B., Dombret, H., Ravandi, F., Sayar, H., Jang, J.-H., Porkka, K., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2004444 · Cited by 445
Self-citationImmune signature drives leukemia escape and relapse after hematopoietic cell transplantation
Toffalori, C., Zito, L., Gambacorta, V., Riba, M., Oliveira, G., Bucci, G., Barcella, M., Spinelli, O., Greco, R., Crucitti, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0400-z · Cited by 401
Metadata
- Authors
- Li, S., Garrett-Bakelman, F. E., Chung, S. S., Sanders, M. A., Hricik, T., Rapaport, F., Patel, J., Dillon, R., Vijay, P., Brown, A. L., Perl, A. E., Cannon, J., Bullinger, L., Luger, S., Becker, M., Lewis, I. D., To, L. B., Delwel, R., Löwenberg, B., Döhner, H., Döhner, K., Guzman, M. L., Hassane, D. C., Roboz, G. J., Grimwade, D., Valk, P. J. M., D'Andrea, R. J., Carroll, M., Park, C. Y., Neuberg, D., Levine, R., Melnick, A. M., & Mason, C. E.
- Venue
- Nature Medicine
- Published
- 2016-06-20
- Volume
- 22
- Issue
- 7
- Pages
- 792-799
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2426586472
- Cited by
- 387
- References
- 20
- FWCI
- 33.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Li, S., Garrett-Bakelman, F. E., Chung, S. S., Sanders, M. A., Hricik, T., Rapaport, F., Patel, J., Dillon, R., Vijay, P., Brown, A. L., Perl, A. E., Cannon, J., Bullinger, L., Luger, S., Becker, M., Lewis, I. D., To, L. B., Delwel, R., Löwenberg, B., . . . Mason, C. E. (2016). Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia. Nature Medicine. https://doi.org/10.1038/nm.4125
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
