Clonal evolution in cancer

Hallmarks of Cancer: The Next Generation

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Cancer Statistics, 2008

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Stem cells, cancer, and cancer stem cells

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The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.

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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

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Tumour evolution inferred by single-cell sequencing

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

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A Perivascular Niche for Brain Tumor Stem Cells

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

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Efficient tumour formation by single human melanoma cells

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Cancer as an evolutionary and ecological process

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Models, mechanisms and clinical evidence for cancer dormancy

Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,673 · see citing works

Tumor heterogeneity: Causes and consequences

Marusyk, A., & Polyák, K. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.11.002 · Cited by 1,596 · see citing works

Mutation selection and the natural history of cancer

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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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TGFβ: the molecular Jekyll and Hyde of cancer

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

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Parallel progression of primary tumours and metastases

Klein, C. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2627 · Cited by 1,134 · see citing works

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,134 · see citing works

Stem cell concepts renew cancer research.

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Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

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Punctuated equilibrium comes of age

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Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

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Testicular germ-cell tumours in a broader perspective

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Adaptive Therapy

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Comparative lesion sequencing provides insights into tumor evolution

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Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

Mazzone, M., Dettori, D., de Oliveira, R. L., Loges, S., Schmidt, T., Jonckx, B., Tian, Y.-M., Lanahan, A. A., Pollard, P. J., de Almodóvar, C. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.01.020 · Cited by 812 · see citing works

Genetic variegation of clonal architecture and propagating cells in leukaemia

Anderson, K., Lutz, C., van Delft, F. W., Bateman, C. M., Guo, Y., Colman, S., Kempski, H. M., Moorman, A. V., Titley, I., Swansbury, J. G., et al. (2010) · Nature · doi:10.1038/nature09650 · Cited by 803 · see citing works

Accumulation of driver and passenger mutations during tumor progression

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Triple-Negative Breast Cancer: An Unmet Medical Need

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Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment

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Genetic instability and darwinian selection in tumours

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The Frequency of Carcinoma and Intraepithelial Neoplasia of the Prostate in Young Male Patients

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A microenvironmental model of carcinogenesis

Gatenby, R. A., & Gillies, R. J. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2255 · Cited by 725 · see citing works

Signatures of mutation and selection in the cancer genome

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The Increasing Complexity of the Cancer Stem Cell Paradigm

Rosen, J. M., & Jordan, C. T. (2009) · Science · doi:10.1126/science.1171837 · Cited by 699 · see citing works

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

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Exploring the Genomes of Cancer Cells: Progress and Promise

Stratton, M. R. (2011) · Science · doi:10.1126/science.1204040 · Cited by 688 · see citing works

Genetic clonal diversity predicts progression to esophageal adenocarcinoma

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Clonal expansion of p53 mutant cells is associated with brain tumour progression

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The therapeutic promise of the cancer stem cell concept.

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Cancer genomics: from discovery science to personalized medicine

Chin, L., Andersen, J. N., & Futreal, P. A. (2011) · Nature Medicine · doi:10.1038/nm.2323 · Cited by 639 · see citing works

Chromosome translocations and covert leukemic clones are generated during normal fetal development

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Leukemia in twins: lessons in natural history

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Inferring tumor progression from genomic heterogeneityPreprint

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Radiation and the microenvironment – tumorigenesis and therapy

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Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

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DNA Damage-Mediated Induction of a Chemoresistant Niche

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Genetic Interactions in Cancer Progression and Treatment

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Genetic Progression and the Waiting Time to Cancer

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Human cancers express mutator phenotypes: origin, consequences and targeting

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Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

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Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

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Ductal Carcinoma In situ and the Emergence of Diversity during Breast Cancer Evolution

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Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

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Temporal Dissection of Tumorigenesis in Primary Cancers

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Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

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Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

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Selectively Advantageous Mutations and Hitchhikers in Neoplasms

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How and Why Species Multiply

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Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus

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Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

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Metapopulation dynamics and spatial heterogeneity in cancer

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Identifying cancer driver genes in tumor genome sequencing studies

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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

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Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

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Carcinogen-specific induction of genetic instability

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Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

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Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer

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Ecological Therapy for Cancer: Defining Tumors Using an Ecosystem Paradigm Suggests New Opportunities for Novel Cancer Treatments

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Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

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The relationship between growth rate, labelling index and histological type of human solid tumours

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Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

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A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma

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Complex patterns of ETS gene alteration arise during cancer development in the human prostate

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The molecular basis of common and rare fragile sites

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Cancer stem cells: Back to Darwin?

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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

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Clonal Interference and the Periodic Selection of New Beneficial Mutations in Escherichia coli

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Cancer: the evolutionary legacy

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How and Why Species Multiply

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Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia

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SYNTHESIS: Cancer research meets evolutionary biology

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Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research

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Shifting paradigms: the seeds of oncogene addiction

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Cancer

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