The promises and challenges of human brain organoids as models of neuropsychiatric disease

Quadrato, Giorgia, Brown, Juliana, Arlotta, Paola·2016·Nature Medicine

DOI 10.1038/nm.4214

Cited by (304)

Items 101–200 of 304

Modelling Alzheimer's disease: Insights fromin vivotoin vitrothree-dimensional culture platforms
Vivek Ranjan, Lifeng Qiu, Eng‐King Tan, Li Zeng, Yilei Zhang · 2018 · Journal of Tissue Engineering and Regenerative Medicine
Negative Symptoms of Schizophrenia and Dopaminergic Transmission: Translational Models and Perspectives Opened by iPSC Techniques
Ginetta Collo, Armida Mucci, Giulia Maria Giordano, Emilio Merlo Pich, Silvana Galderisi · 2020 · Frontiers in Neuroscience
Proteomic signatures of schizophrenia-sourced iPSC-derived neural cells and brain organoids are similar to patients' postmortem brains
Juliana Minardi Nascimento, Verônica Monteiro Saia-Cereda, Giuliana S. Zuccoli, Guilherme Reis‐de‐Oliveira, Victor Corasolla Carregari, Bradley Joseph Smith, Stevens Kastrup Rehen, Daniel Martins‐de‐Souza · 2022 · Cell & Bioscience
Advanced in vitro models: Microglia in action
Cakir, Bilal, Kiral, Ferdi Ridvan, Park, In-Hyun · 2022 · Neuron
Mental health dished up—the use of iPSC models in neuropsychiatric research
Rhiannon Victoria McNeill, Georg Christoph Ziegler, Franziska Radtke, Matthias Nieberler, Klaus‐Peter Lesch, Sarah Kittel‐Schneider · 2020 · Journal of Neural Transmission
Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease
Juliana R. Brown, Giorgia Quadrato, Paola Arlotta · 2018 · Current topics in developmental biology/Current Topics in Developmental Biology
Bioelectrical interfaces with cortical spheroids in three-dimensions
Anna Kalmykov, Jay W. Reddy, Esther Bedoyan, Yingqiao Wang, Raghav Garg, Sahil Kumar Rastogi, Devora Cohen-Karni, Maysamreza Chamanzar, Tzahi Cohen‐Karni · 2021 · Journal of Neural Engineering
Reaching into the toolbox: Stem cell models to study neuropsychiatric disorders
Jack T. Whiteley, Sarah Fernandes, Amandeep Sharma, Ana P. D. Mendes, Vipula Racha, Simone K. Benassi, Maria Carolina Marchetto · 2022 · Stem Cell Reports
Compartmentalized Devices as Tools for Investigation of Human Brain Network Dynamics
Joseph A. Fantuzzo, Ronald P. Hart, Jeffrey D. Zahn, Zhiping P. Pang · 2018 · Developmental Dynamics
Human induced pluripotent stem cell-derived planar neural organoids assembled on synthetic hydrogels
Joydeb Majumder, Elizabeth Torr, Elizabeth A. Aisenbrey, Connie S. Lebakken, Peter F. Favreau, William D Richards, Yanhong Yin, Qiang Chang, William L. Murphy · 2024 · Journal of Tissue Engineering
Brain Organoids: Filling the Need for a Human Model of Neurological Disorder
Philip Jalink, Massimiliano Caiazzo · 2021 · Biology
Imaging three-dimensional brain organoid architecture from meso- to nanoscale across development
Juan Eduardo Rodriguez-Gatica, Vira Iefremova, Liubov Sokhranyaeva, Si Wah Christina Au Yeung, Yannik Breitkreuz, Oliver Brüstle, Martin K. Schwarz, Ulrich Kubitscheck · 2022 · Development
Organoid and Organ-on-a-Chip Systems: New Paradigms for Modeling Neurological and Gastrointestinal Disease
Aslam Abbasi Akhtar, Samuel Sances, Robert J. Barrett, Joshua J. Breunig · 2017 · Current Stem Cell Reports
Central and Peripheral Changes in FOS Expression in Schizophrenia Based on Genome-Wide Gene Expression
Jing Huang, Fangkun Liu, Bolun Wang, Hui Tang, Ziwei Teng, Lehua Li, Yan Qiu, Haishan Wu, Jindong Chen · 2019 · Frontiers in Genetics
Using Human‐Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review
Shiya Lv, Enhui He, Jinping Luo, Yaoyao Liu, Wei Jie Liang, Shihong Xu, Kui Zhang, Yan Feng Yang, Mixia Wang, Yilin Song et al. · 2023 · Advanced Science
Connectome development and a novel extension to the neurodevelopmental model of schizophrenia
Guusje Collin, Matcheri S. Keshavan · 2018 · Dialogues in Clinical Neuroscience
Review of Artificial Intelligence Applications and Algorithms for Brain Organoid Research
Jiayidaer Badai, Qian Bu, Le Zhang · 2020 · Interdisciplinary Sciences Computational Life Sciences
Human Stem Cell Modeling in Neurofibromatosis type 1 (NF1)
Michelle L. Wegscheid, C. Anastasaki, D. Gutmann · 2017 · Experimental Neurology
Modeling the Human Brain With ex vivo Slices and in vitro Organoids for Translational Neuroscience
Giovanna Orlovski Nogueira, Patricia Pestana Garcez, Cédric Bardy, Mark O. Cunningham, Adriano Silva Sebollela · 2022 · Frontiers in Neuroscience
Advances in Cerebral Organoid Systems and their Application in Disease Modeling
Liu, Fangkun, Huang, Jing, Zhang, Liyang, Chen, Jindong, Zeng, Yu, Tang, Yongjian, Liu, Zhixiong · 2019 · Neuroscience
Preclinical Testing Techniques: Paving the Way for New Oncology Screening Approaches
Antonia van Rijt, Evan Stefanek, Karolina Papera Valente · 2023 · Cancers
Taming human brain organoids one cell at a time
Alexander Atamian, Lluís Cordón-Barris, Giorgia Quadrato · 2020 · Seminars in Cell and Developmental Biology
Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets
Greta Pintacuda, Jacqueline M. Martín, Kevin C. Eggan · 2021 · Molecular Autism
Unraveling Human Brain Development and Evolution Using Organoid Models
Sarah Fernandes, Davis Klein, Maria Carolina Marchetto · 2021 · Frontiers in Cell and Developmental Biology
The Interface of Gene Editing with Regenerative Medicine
Veronica E. Farag, Elsie Devey, Kam W. Leong · 2024 · Engineering
Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids
Honghui Zheng, Yilin Feng, Jiyuan Tang, Feifei Yu, Zitian Wang, Jiani Xu, Cheng Hai, Mingyue Jiang, Yifan Cheng, Zhicheng Shao et al. · 2025 · Nature Communications
Screening Platforms for Genetic Epilepsies—Zebrafish, iPSC-Derived Neurons, and Organoids
Aleksandr Shcheglovitov, Randall Theodore Peterson · 2021 · Neurotherapeutics
Knowledge graphs of ethical concerns of cerebral organoids
Lulu Ding, Zhenyu Xiao, Xia Gong, Yaojin Peng · 2022 · Cell Proliferation
Human microglial models to study host–virus interactions
Rachel E. McMillan, Ellen Y. Wang, Aaron F. Carlin, Nicole G. Coufal · 2023 · Experimental Neurology
Cyborg organoids integrated with stretchable nanoelectronics can be functionally mapped during development
Zu-Wan Lin, Wenbo Wang, Ren Liu, Qiang Li, Jaeyong Lee, Charles Hirschler, Jia Liu · 2025 · Nature Protocols
Brain Organoids and Assembloids—From Disease Modeling to Drug Discovery
Aderonke O. Ajongbolo, Sigrid A. Langhans · 2025 · Cells
WWOX-Related Neurodevelopmental Disorders: Models and Future Perspectives
Daniel J. Steinberg, Rami I. Aqeilan · 2021 · Cells
Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders
James J. Fink, Eric S. Levine · 2018 · Frontiers in Neurology
Reality check for organoids in neuroscience
Vivien Marx · 2020 · Nature Methods
Devices and techniques used to obtain and analyze three‐dimensional cell cultures
Gatika Agrawal, Anuradha Ramesh, Pargaonkar Aishwarya, Jennifer Sally Samson, Maddaly Ravi · 2021 · Biotechnology Progress
Development and Disease in a Dish: The Epigenetics of Neurodevelopmental Disorders
Emily M. A. Lewis, Kristen L. Kroll · 2018 · Epigenomics
Brain Organoids: A Promising Living Biobank Resource for Neuroscience Research
Shuang Li, Min Wang, Junmei Zhou · 2020 · Biopreservation and Biobanking
Laser bioprinting of human iPSC-derived neural stem cells and neurons: Effect on cell survival, multipotency, differentiation, and neuronal activity
Lothar Koch, Andrea Deiwick, Jordi Soriano, Boris N. Chichkov · 2023 · International Journal of Bioprinting
Cell reprogramming for oligodendrocytes: A review of protocols and their applications to disease modeling and cell‐based remyelination therapies
McCaughey‐Chapman, Amy, Connor, Bronwen · 2023 · Journal of Neuroscience Research
Animal models for neuropsychiatric disorders: prospects for circuit intervention
Tobias Kaiser, Yang Zhou, Guoping Feng · 2017 · Current Opinion in Neurobiology
Brain Organoids: Expanding Our Understanding of Human Development and Disease
L. E. Bayona Chuye, Alexander J. Dimitri, A. Desai, Christopher R. Handelmann, Yongho Bae, Pedram Johari, Josep Miquel Jornet, Ilona Klejbor, Michal K. Stachowiak, Ewa K. Stachowiak · 2018 · Results and problems in cell differentiation
Microinstrumentation for Brain Organoids
Devan Patel, Saniya Shetty, Chris Acha, Itzy E. Morales Pantoja, Alice Zhao, Derosh George, David H. Gracias · 2024 · Advanced Healthcare Materials
Aging phenotype in AD brain organoids: Track to success and challenges
Muhammad Kamal Hossain, Hyung‐Ryong Kim, Han–Jung Chae · 2024 · Ageing Research Reviews
APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids
Karina K. Meyer-Acosta, Eva Díaz‐Guerra, Parul Varma, Adyasha Aruk, Sara Mirsadeghi, Aranis Muniz Perez, Yousef Rafati, Ali Hosseini, Vanesa Nieto‐Estévez, Michèle Giugliano et al. · 2025 · Stem Cell Reports
Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges
Sara R. Guerreiro, Patrı́cia Maciel · 2023 · Cells
iPSC modeling of rare pediatric disorders
Bethany A. Freel, Jordan N. Sheets, Kevin R. Francis · 2019 · Journal of Neuroscience Methods
The Dilemma of Human Brain Surrogates: Scientific Opportunities, Ethical Concerns
Henry T. Greely · 2020 · Springer eBooks
Chronic exposure to (2 R,6 R)-hydroxynorketamine induces developmental neurotoxicity in hESC-derived cerebral organoids
Zhulin Du, Zhenle Zang, Jing Luo, Tianyao Liu, Ling Yang, Yun Cai, Liuyongwei Wang, Dandan Zhang, Jinghui Zhao, Junwei Gao et al. · 2023 · Journal of Hazardous Materials
In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid
Ki Hong Nam, Sang Ah Yi, Hyun Ji Jang, Jeung‐Whan Han, Jaecheol Lee · 2020 · Archives of Pharmacal Research
Stem cell contributions to neurological disease modeling and personalized medicine
Nicholas Liang, Cleber A. Trujillo, Priscilla Davidson Negraes, Alysson Renato Muotri, Claudiana Lameu, Henning Ulrich · 2017 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
The beneficial effects of chick embryo extract preconditioning on hair follicle stem cells: A promising strategy to generate Schwann cells
Sareh Pandamooz, Benjamin Jurek, Mehdi Dianatpour, Silke Haerteis, Katharina Limm, Peter Josef Oefner, Leila Dargahi, Afshin Borhani‐Haghighi, Jaleel A. Miyan, Mohammad Saied Salehi · 2023 · Cell Proliferation
Chronic Opioid Treatment Arrests Neurodevelopment and Alters Synaptic Activity in Human Midbrain Organoids
Hye Sung Kim, Yang Xiao, Xuejing Chen, Siyu He, Jongwon Im, Moshe J. Willner, Michael O. Finlayson, Cong Xu, Huixiang Zhu, Se Joon Choi et al. · 2024 · Advanced Science
Linking Mitochondrial Dysfunction, Neurotransmitter, and Neural Network Abnormalities and Mania: Elucidating Neurobiological Mechanisms of the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder
Zachary Freyberg, Ana C. Andreazza, Colleen A. McClung, Mary Louise Phillips · 2024 · Biological Psychiatry Cognitive Neuroscience and Neuroimaging
Stem cell-based models and therapies: a key approach into schizophrenia treatment
Bagher A. Larijani, Peyvand Parhizkar Roudsari, Mahdieh Hadavandkhani, Sepideh Alavi-Moghadam, Mostafa Rezaei–Tavirani, Parisa Goodarzi, Forough Azam Sayahpour, Fereshteh Mohamadi-Jahani, Babak Arjmand · 2021 · Cell and Tissue Banking
The abiding relevance of mouse models of rare mutations to psychiatric neuroscience and therapeutics
Joseph A. Gogos, Gregg W. Crabtree, Anastasia Diamantopoulou · 2019 · Schizophrenia Research
Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
Christopher Hoyle, Elena Redondo‐Castro, James Cook, Te-Chen Jenny Tzeng, Stuart McRae Allan, David Brough, Eloïse Lemarchand · 2020 · Immunology
Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes
Bruna da Silveira Paulsen, Silvia Velasco, Amanda J. Kedaigle, Martina Pigoni, Giorgia Quadrato, Anthony J. Deo, Xian Adiconis, Ana Uzquiano, Kwanho Kim, Sean Simmons et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Biological and structural phenotypes associated with neurodevelopmental outcomes in congenital heart disease
Charlotte E. Verrall, Shrujna Patel, Leksi Travitz, Jason H. Tchieu, Russell Clive Dale, Nadine Angele Kasparian, David Scott Winlaw, Gillian M. Blue · 2023 · Translational Pediatrics
Human brain organoid: trends, evolution, and remaining challenges
Minghui Li, Yuhong Yuan, Zongkun Hou, Shilei Hao, Liang Jin, Bochu Wang · 2023 · Neural Regeneration Research
Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity
Prabha Acharya, Sunil Shrestha, Pranav Joshi, Na Young Choi, Vinod Kumar Reddy Lekkala, Soo‐Yeon Kang, Gabriel Ni, Moo‐Yeal Lee · 2024 · Biofabrication
Drug discovery in psychopharmacology: from 2D models to cerebral organoids
A.C. Rossetti, Philipp Koch, Julia Ladewig · 2019 · Dialogues in Clinical Neuroscience
Flexible and stretchable bioelectronics for organoids
Jaeyong Lee, Jia Liu B · 2025 · Med-X
Developing a Multidisciplinary Approach for Engineering Stem Cell Organoids
Marissa E. Wechsler, Mariya Shevchuk, Nicholas A. Peppas · 2019 · Annals of Biomedical Engineering
Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
Madeline Williams, Smrithi Prem, Xiaofeng Zhou, Paul G. Matteson, Percy Luk Yeung, Chi-Wei Lu, Zhiping P. Pang, Linda M. Brzustowicz, James H. Millonig, Emanuel M. DiCicco-Bloom · 2018 · Journal of Visualized Experiments
Pluripotent Stem Cells for Brain Repair: Protocols and Preclinical Applications in Cortical and Hippocampal Pathologies
Claudia Alia, Marco Terrigno, Irene Busti, Federico Cremisi, Matteo Caleo · 2019 · Frontiers in Neuroscience
Three-Dimensional Cell Culture Systems in Pediatric and Adult Brain Tumor Precision Medicine
Nicole C. Riedel, Flavia W. de Faria, Amelie Alfert, Jan M. Bruder, Kornelius Kerl · 2022 · Cancers
Application of colloidal photonic crystals in study of organoids
Kai Huang, Qiwei Li, Yufei Xue, Qiong Wang, Zaozao Chen, Zhongze Gu · 2023 · Advanced Drug Delivery Reviews
Modeling neurodegenerative diseases with brain organoids: from development to disease applications
Teresa Larriba-González, Marina García-Martín, Doddy Denise Ojeda-Hernández, Paula Rincón-Cerrada, Lucía Martín-Blanco, María Soledad Benito‐Martín, Belén Selma-Calvo, Sarah de la Fuente-Martín, Jordi A. Matías‐Guiu, Jorge Matías‐Guiu et al. · 2025 · Frontiers in Cell and Developmental Biology
Functional genomics in stem cell models: considerations and applications
Kaivalya Shevade, Sailaja Peddada, Karl Mader, Laralynne Przybyla · 2023 · Frontiers in Cell and Developmental Biology
Therapeutic Transplantation of Human Central Nervous System Organoids for Neural Reconstruction
Sung Jun Hong, Minsung Bock, Songzi Zhang, Seong Bae An, Inbo Han · 2024 · International Journal of Molecular Sciences
Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research
Alfredo Bellon · 2024 · Translational Psychiatry
Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?
Iya Prytkova, Alison Goate, Ronald P. Hart, Paul A. Slesinger · 2018 · Alcoholism Clinical and Experimental Research
Surface‐Functionalized Self‐Standing Microdevices Exhibit Predictive Localization and Seamless Integration in 3D Neural Spheroids
Aziliz Lecomte, Lidia Giantomasi, Silvia Rancati, Fabio Boi, Gian Nicola Angotzi, Luca Berdondini · 2020 · Advanced Biosystems
Using Stems to Bear Fruit: Deciphering the Role of Alzheimer’s Disease Risk Loci in Human-Induced Pluripotent Stem Cell-Derived Microglia
Edward S. Wickstead · 2023 · Biomedicines
Multiscale engineering of brain organoids for disease modeling
Cong Xu, Alia Alameri, Wei Leong, Emily Johnson, Zaozao Chen, Bin Xu, Kam W. Leong · 2024 · Advanced Drug Delivery Reviews
Quantitative profiling of human brain organoid cell diversity across four protocols and multiple cell lines
Julia Naas, Meritxell Balmaña, Laurenz Holcik, Maria Novatchkova, Lina Dobnikar, Thomas Krausgruber, Sabrina Ladstätter, Christoph Bock, Arndt von Haeseler, Christopher Esk et al. · 2025 · Cell Reports
An assessment of the moral value of neuronal cell models and brain organoids
Sietske A. L. van Till, Mariia V. Maksimova, Ghislaine J. M. W. van Thiel, Eline Maria Bunnik · 2023 · Molecular Psychology Brain Behavior and Society
Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook
Matthew S. Scarnati, Apoorva Halikere, Zhiping P. Pang · 2018 · Alcohol
Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells
Abdurrahman W. Muhtaseb, Jubao Duan · 2022 · Schizophrenia Research
Human iPSC-derived cerebral organoids model features of Leigh Syndrome and reveal abnormal corticogenesis
Alejandra I. Romero-Morales, Gabriella L. Robertson, Anuj Rastogi, Megan L. Rasmussen, Hoor Temuri, Gregory Scott McElroy, Ram Prosad Chakrabarty, Lawrence Hsu, Paula M. Almonacid, Bryan A. Millis et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
Intrinsic Network Activity in Human Brain Organoids
Tal Sharf, Tjitse van der Molen, Elmer Guzman, Stella M.K. Glasauer, Gabriel Luna, Zhouwei Cheng, Morgane Audouard, Kamalini G. Ranasinghe, Kiwamu Kudo, Srikantan S. Nagarajan et al. · 2021 · SSRN Electronic Journal
The Pattern of Copper Release in Copper‐Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models
José I. García-Peiro, Paula Guerrero‐López, Felipe Hornos, José L. Hueso, José Manuel García‐Aznar, Jesús Santamarı́a · 2024 · Small Science
Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold
Takuma Sumi, Hideaki Yamamoto, Ayumi Hirano-Iwata · 2020 · Soft Matter
Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
Ginetta Collo, Laura Cavalleri, Michèle Zoli, Uwe Maskos, Emiliangelo Ratti, Emilio Merlo Pich · 2018 · Frontiers in Pharmacology
Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
Tian, Chunhui, Ao, Zheng, Cerneckis, Jonas, Cai, Hongwei, Chen, Lei, Niu, Hengyao, Takayama, Kazuo, Kim, Jungsu, Shi, Yanhong, Gu, Mingxia et al. · 2025 · Science Advances
Cross-Species Convergence of Brain Transcriptomic and Epigenomic Findings in Posttraumatic Stress Disorder: A Systematic Review
Diana L. Núñez-Ríos, José Jaime Martínez‐Magaña, Sheila T. Nagamatsu, John Harrison Krystal, Karen Martínez, Paola Giusti‐Rodríguez, Janitza L. Montalvo‐Ortiz · 2023 · Complex Psychiatry
Advances and Challenges in Cerebral Organoids Research
Dandan Luo, Jiaqi Xu, Fuyao Liu, Zhen Gu · 2024 · Advanced NanoBiomed Research
Human cerebral organoids: cellular composition and subcellular morphological features
Patricia Mateos-Martínez, Raquel Coronel, Martin Sachse, Rosa González-Sastre, Laura Maeso, María Josefa Rodríguez, María Carmen Terrón, Victoria López-Alonso, Isabel Liste · 2024 · Frontiers in Cellular Neuroscience
Generating and characterizing human telencephalic brain organoids from stem cell-derived single neural rosettes
H. M. Arif Ullah, Qiju Huang, Simone Chiola, Yueqi Wang, Alex Shcheglovitov · 2025 · Nature Protocols
Building in vitro models of the brain to understand the role ofAPOEin Alzheimer’s disease
Rebecca L. Pinals, Li‐Huei Tsai · 2022 · Life Science Alliance
Developing HiPSC Derived Serum Free Embryoid Bodies for the Interrogation of 3-D Stem Cell Cultures Using Physiologically Relevant Assays
André W. Phillips, Jonathan E. Nestor, Michael W. Nestor · 2017 · Journal of Visualized Experiments
From enhanceropathies to the epigenetic manifold underlying human cognition
Alessandro Vitriolo, Michele Gabriele, Giuseppe Testa · 2019 · Human Molecular Genetics
How can preclinical cognitive research further neuropsychiatric drug discovery? Chances and challenges
István Gyertyán · 2020 · Expert Opinion on Drug Discovery
Production of Phenotypically Uniform Human Cerebral Organoids from Pluripotent Stem Cells
Adam Sivitilli, Parisa Ghiasi, Liliana Attisano · 2021 · BIO-PROTOCOL
Cell-line dependency in cerebral organoid induction: cautionary observations in Alzheimer’s disease patient-derived induced pluripotent stem cells
Ju‐Hyun Lee, Geon Yoo, Juhyun Choi, Si-Hyung Park, Hyogeun Shin, Renuka Prasad, Yeunehee Lee, Mee Ryung Ahn, Il‐Joo Cho, Woong Sun · 2022 · Molecular Brain
Emerging Debates About Breakthrough Science: Understanding the Interplay of Values and Cognition in Shaping Attitudes on Human Brain Organoids
Isabel I. Villanueva, Dayeon Eom, Ashley R. Cate, Nicole M. Krause, Dietram A. Scheufele, Dominique Brossard · 2025 · Science Communication
Personalized psychiatry with human iPSCs and neuronal reprogramming
Cédric Bardy, Zarina Greenberg, Seth W. Perry, Júlio Licinio · 2019 · Elsevier eBooks
Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids
Moshe J. Willner, Yang Xiao, Hye Sung Kim, Xuejing Chen, Bin Xu, Kam W. Leong · 2021 · Journal of Tissue Engineering
Cortical spheroids display oscillatory network dynamics
Jessica L. Sevetson, Brian B. Theyel, Diane Hoffman–Kim · 2021 · Lab on a Chip
Human Brain In Vitro Model for Pathogen Infection-Related Neurodegeneration Study
Yuwei Yan, Ann‐Na Cho · 2024 · International Journal of Molecular Sciences