Cited by 304Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

The promises and challenges of human brain organoids as models of neuropsychiatric disease

Quadrato, Giorgia, Brown, Juliana, Arlotta, Paola·2016·Nature Medicine

Abstract

Neuropsychiatric disorders such as autism spectrum disorder (ASD), schizophrenia (SCZ) and bipolar disorder (BPD) are of great societal and medical importance, but the complexity of these diseases and the challenges of modeling the development and function of the human brain have made these disorders difficult to study experimentally. The recent development of 3D brain organoids derived from human pluripotent stem cells offers a promising approach for investigating the phenotypic underpinnings of these highly polygenic disorders and for understanding the contribution of individual risk variants and complex genetic background to human pathology. Here we discuss the advantages, limitations and future applications of human brain organoids as in vitro models of neuropsychiatric disease.

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Crossref · 10.1038/nm.4214

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Authors
Quadrato, G., Brown, J., & Arlotta, P.
Affiliations
Harvard University (US)
Corresponding author
Arlotta, Paola
Venue
Nature Medicine
Published
2016-10-26
Volume
22
Issue
11
Pages
1220-1228
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W2545768818
Cited by
304
References
100
Citations by year
2026: 21 · 2025: 29 · 2024: 29 · 2023: 26 · 2022: 27 · 2021: 29 · 2020: 44 · 2019: 38 · 2018: 35 · 2017: 26
FWCI
17.15
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Broad Institute
  • National Institutes of Health
  • Stanley Center for Psychiatric Research, Broad Institute
  • National Institute of Mental Health (R01MH101268)
  • National Institute of Neurological Disorders and Stroke (R01NS078164)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
brain organoids, neuropsychiatric disorders, autism spectrum disorder, schizophrenia, bipolar disorder, human pluripotent stem cells, in vitro disease model, polygenic disease, genetic risk variants, 3D brain models
MeSH terms
Autism Spectrum Disorder, Mental Disorders, Bipolar Disorder, Brain, Humans, Models, Neurological, Models, Psychological, Nerve Net, Organoids, Schizophrenia, Pluripotent Stem Cells, Neurogenesis, Induced Pluripotent Stem Cells, In Vitro Techniques

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