Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

Giustacchini, Alice, Thongjuea, Supat, Barkas, Nikolaos, Woll, Petter S, Povinelli, Benjamin J, Booth, Christopher A G, Sopp, Paul, Norfo, Ruggiero +12 more·2017·Nature Medicine

Cited by (423)

Items 101–200 of 423

  1. Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance
    Theresa Klümper, Henrike Bruckmueller, Tobias Diewock, Meike Kaehler, Sierk Haenisch, Christiane Pott, Oliver Bruhn, Ingolf Cascorbi · 2020 · Experimental Hematology and Oncology
  2. High-dimension single-cell analysis applied to cancer
    Lili Wang, Kenneth J. Livak, Catherine J. Wu · 2017 · Molecular Aspects of Medicine
  3. Coordinated immune networks in leukemia bone marrow microenvironments distinguish response to cellular therapy
    Katie Maurer, Cameron Y. Park, Shouvik Mani, Mehdi Borji, Florian Raths, Kenneth H. Gouin, Livius Penter, Yinuo Jin, Jia Yi Zhang, Crystal S. Shin et al. · 2025 · Science Immunology
  4. Single-cell RNA sequencing to track novel perspectives in HSC heterogeneity
    Pan Zhang, Xiang Li, Chengwei Pan, Xinmin Zheng, Bohan Hu, Ruiheng Xie, Jialu Hu, Xuequn Shang, Hui Yang · 2022 · Stem Cell Research & Therapy
  5. Learning discriminative and structural samples for rare cell types with deep generative model
    Haiyue Wang, Xiaoke Ma · 2022 · Briefings in Bioinformatics
  6. Hematopoietic stem cell heterogeneity and age-associated platelet bias are evolutionarily conserved
    Merve Aksöz, Grigore Gafencu, Bilyana Stoilova, Mario Buono, Ying Zhang, Sven Turkalj, Yiran Meng, Niels Asger Jakobsen, Marlen Metzner, Sally‐Ann Clark et al. · 2024 · Science Immunology
  7. The bone marrow microenvironment of pre-B acute lymphoblastic leukemia at single-cell resolution
    Denise R. Anderson, Patrycja Skut, Anastasia M. Hughes, Emanuela Ferrari, Jennifer C. Tickner, Jiake Xu, Benjamin H. Mullin, Dave T. P. Tang, Sébastien Malinge, Ursula R. Kees et al. · 2020 · Scientific Reports
  8. Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia
    Allegra A. Petti, Saad M. Khan, Ziheng Xu, Nichole Helton, Catrina C. Fronick, Robert Fulton, Sai M. Ramakrishnan, Sridhar Nonavinkere Srivatsan, Sharon E. Heath, Peter Westervelt et al. · 2021 · Blood Cancer Discovery
  9. Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia
    Anne‐Sophie Bouillon, Mónica S. Ventura Ferreira, Shady Adnan Awad, Johan Richter, Andreas Hochhaus, Volker Kunzmann, Jolanta B. Dengler, Jeroen J. W. M. Janssen, Gert Jan Ossenkoppele, Peter E. Westerweel et al. · 2018 · Blood Advances
  10. Single-cell RNA sequencing and bioinformatics as tools to decipher cancer heterogenicity and mechanisms of drug resistance
    Diletta Rosati, Antonio Giordano · 2021 · Biochemical Pharmacology
  11. Data normalization for addressing the challenges in the analysis of single-cell transcriptomic datasets
    Raquel Cuevas‐Díaz Durán, Haichao Wei, Jiaqian Wu · 2024 · BMC Genomics
  12. The Outside-In Journey of Tissue Transglutaminase in Cancer
    Livia Elena Sima, Daniela Elena Matei, Salvatore Condello · 2022 · Cells
  13. AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia
    Hyllana C. D. Medeiros, Carina Colturato-Kido, Letícia Silva Ferraz, Claudia A. Costa, Vivian Moraes, Edgar Julian Paredes‐Gamero, Ivarne L.S. Tersariol, Tiago Rodrigues · 2019 · Chemico-Biological Interactions
  14. Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
    Bin Zhang, Dandan Zhao, Fang Chen, David Eugene Frankhouser, Huafeng Wang, Khyatiben V. Pathak, Lei Dong, Anakaren Torres, Krystine Garcia‐Mansfield, Yi Zhang et al. · 2023 · Nature Communications
  15. Decoding leukemia at the single-cell level: clonal architecture, classification, microenvironment, and drug resistance
    Jianche Liu, Penglei Jiang, Zezhen Lu, Zebin Yu, Pengxu Qian · 2024 · Experimental Hematology and Oncology
  16. Targeting histone deacetylase SIRT1 selectively eradicates EGFR TKI-resistant cancer stem cells via regulation of mitochondrial oxidative phosphorylation in lung adenocarcinoma
    Jiangtao Sun, Guifang Li, Yiwen Liu, Mingyang Ma, Kaifang Song, Huaxu Li, Daxing Zhu, Xiaojun Tang, Jinyu Kong, Xiang Yuan · 2019 · Neoplasia
  17. Precision medicine in myeloid malignancies
    Jörg Westermann, Lars Bullinger · 2021 · Seminars in Cancer Biology
  18. Clonal architecture evolution in Myeloproliferative Neoplasms: from a driver mutation to a complex heterogeneous mutational and phenotypic landscape
    Nabih Maslah, Lina Benajiba, Stéphane Giraudier, Jean‐Jacques Kiladjian, Bruno Cassinat · 2023 · Leukemia
  19. Arresting of miR-186 and releasing of H19 by DDX43 facilitate tumorigenesis and CML progression
    J. Lin, Ji‐chun Ma, Jun Yang, J.-Y. Yin, X.-X. Chen, Hong Guo, Xiang-mei Wen, T.-J. Zhang, W. Qian, Jun Qian et al. · 2018 · Oncogene
  20. Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors
    Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe et al. · 2022 · Nature Communications
  21. ABC portal: a single-cell database and web server for blood cells
    Xin Gao, Fang Hong, Zhenyu Hu, Zilong Zhang, Lei Yang, Xiaoyun Li, Tao Cheng · 2022 · Nucleic Acids Research
  22. Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome
    Daniel H. Wiseman, Syed Murtuza Baker, Arundhati V Dongre, Kristian Gurashi, Joanna A Storer, Tim C. P. Somervaille, Kiran Batta · 2020 · EBioMedicine
  23. CIPHER-SC: Disease-Gene Association Inference Using Graph Convolution on a Context-Aware Network With Single-Cell Data
    Yiding Zhang, Lyujie Chen, Shao Li · 2020 · IEEE Transactions on Computational Biology and Bioinformatics
  24. The immune landscape in BCR‐ABL negative myeloproliferative neoplasms: inflammation, infections and opportunities for immunotherapy
    Marie Strickland, Lynn Swun Quek, Bethan Psaila · 2021 · British Journal of Haematology
  25. Droplet microfluidics for CTC-based liquid biopsy: a review
    Lin Hong Jiang, Hang Yang, Weiqi Cheng, Zhonghua Ni, Nan Xiang · 2022 · The Analyst
  26. Technical Advances in Single-Cell RNA Sequencing and Applications in Normal and Malignant Hematopoiesis
    Xiangtao Huang, Xi Li, Peizhong Qin, Yao Zhu, Shuangnian Xu, Jieping Chen · 2018 · Frontiers in Oncology
  27. Epigenetic Reprogramming and Emerging Epigenetic Therapies in CML
    Jane Bugler, Ross Kinstrie, Mary T. Scott, David L.P. Vetrie · 2019 · Frontiers in Cell and Developmental Biology
  28. Druggable Biochemical Pathways and Potential Therapeutic Alternatives to Target Leukemic Stem Cells and Eliminate the Residual Disease in Chronic Myeloid Leukemia
    Fabien Muselli, Jean‐François Peyron, Didier Mary · 2019 · International Journal of Molecular Sciences
  29. Remodeling the Bone Marrow Microenvironment – A Proposal for Targeting Pro-inflammatory Contributors in MPN
    Jonas Samuel Jutzi, Ann Mullally · 2020 · Frontiers in Immunology
  30. Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells
    Kevin M. Rattigan, Zuzana Brabcová, Daniele Sarnello, Martha M. Zarou, Kiron Roy, Ryan Shun-Yuen Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf et al. · 2023 · Nature Communications
  31. Declaration of Bcr-Abl1 independence
    Helong Zhao, Michael W. Deininger · 2020 · Leukemia
  32. TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β‑catenin/TCF7/ABC transporter signaling axis
    Hui Zhang, Yonghong Wang, Hao Yang, Zhenglan Huang, Xin Wang, Wenli Feng · 2020 · Oncology Reports
  33. Single-cell RNA Sequencing in Immunology
    Yirui Cao, Yue Qiu, Guo-Wei Tu, Cheng Yang · 2020 · Current Genomics
  34. Overcoming Expressional Drop-outs in Lineage Reconstruction from Single-Cell RNA-Sequencing Data
    Tianshi Lu, Seongoh Park, James J. Zhu, Yunguan Wang, Xiaowei Zhan, Xinlei Wang, Li Wang, Hao Zhu, Tao Wang · 2021 · Cell Reports
  35. Integrating genetic and epigenetic factors in chronic myeloid leukemia risk assessment: toward gene expression-based biomarkers
    Vaidehi Krishnan, Dennis Dong Hwan Kim, Timothy P. Hughes, Susan Branford, S. Tiong Ong · 2021 · Haematologica
  36. Treatment-Free Remission in Chronic Myeloid Leukemia and New Approaches by Targeting Leukemia Stem Cells
    Yilin Chen, Jing Zou, Fanjun Cheng, Wei‐Ming Li · 2021 · Frontiers in Oncology
  37. Advances in histone deacetylase inhibitors in targeting glioblastoma stem cells
    R. Gajendra Reddy, Unis Ahmad Bhat, Sumana Chakravarty, Arvind Kumar · 2020 · Cancer Chemotherapy and Pharmacology
  38. Aberrantly reduced expression of miR-342-5p contributes to CCND1-associated chronic myeloid leukemia progression and imatinib resistance
    Yi‐Ying Wu, Hsing-Fan Lai, Tzu‐Chuan Huang, Yuguang Chen, Ren‐Hua Ye, Ping‐Ying Chang, Shiue‐Wei Lai, Yeu‐Chin Chen, Cho‐Hao Lee, Wei-Nung Liu et al. · 2021 · Cell Death and Disease
  39. Applications of single-cell multi-omics in liver cancer
    Frederik Peeters, Sarah Cappuyns, Marta Piqué‐Gili, Gino Phillips, Chris Verslype, Diether Lambrechts, Jeroen Dekervel · 2024 · JHEP Reports
  40. Isolating Lithologic Versus Tectonic Signals of River Profiles to Test Orogenic Models for the Eastern and Southeastern Carpathians
    Boris Gailleton, Hugh D. Sinclair, Simon M. Mudd, Emma Graf, Liviu C. Matenco · 2021 · Journal of Geophysical Research Earth Surface
  41. LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis
    Hongdan Dai, Jianming Wang, Zhenglan Huang, Hui Zhang, Xin Wang, Qian Li, Wenli Feng · 2021 · Technology in Cancer Research & Treatment
  42. Immune Dysregulation and Infectious Complications in MPN Patients Treated With JAK Inhibitors
    Daniele Cattaneo, Alessandra Iurlo · 2021 · Frontiers in Immunology
  43. Contribution of BCR-ABL molecular variants and leukemic stem cells in response and resistance to tyrosine kinase inhibitors: a review
    Mohammad Al Hamad · 2021 · F1000Research
  44. C/EBPβ is a critical mediator of IFN-α–induced exhaustion of chronic myeloid leukemia stem cells
    Asumi Yokota, Hideyo Hirai, Ryuichi Sato, Hiroko Adachi, Fumiko Sato, Yoshihiro Hayashi, Atsushi Satō, Naoka Kamio, Yasuo Miura, Masakazu Nakano et al. · 2019 · Blood Advances
  45. Single-cell analysis on stromal fibroblasts in the microenvironment of solid tumours
    Marahaini Musa · 2020 · Advances in Medical Sciences
  46. Targeting Leukemia Stem Cells in the Bone Marrow Niche
    Sarah Kathleen Tasian, Martin Bornhäuser, Sergio Rutella · 2018 · Biomedicines
  47. Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity
    Meghan C. Ferrall‐Fairbanks, Markus Ball, Eric Padron, Philipp M. Altrock · 2019 · JCO Clinical Cancer Informatics
  48. Selective translational control by PABPC1 phase separation regulates blast crisis and therapy resistance in chronic myeloid leukaemia
    Chenguang Sun, Xi Xu, Zhongyang Chen, Fanqi Zhou, Wen Jin Wang, Jun-zhu Chen, Mengyao Sun, Fang Wang, Linjia Jiang, Ming Ji et al. · 2025 · Nature Cell Biology
  49. Data mining for mutation-specific targets in acute myeloid leukemia
    Brooks A. Benard, Andrew J. Gentles, Thomas Köhnke, Ravindra Majeti, Danièl Thomas · 2019 · Leukemia
  50. Leukemia Stem Cells as a Potential Target to Achieve Therapy-Free Remission in Chronic Myeloid Leukemia
    Kyoko Ito, Keisuke Ito · 2021 · Cancers
  51. Association of TIM-3 checkpoint receptor expression on T cells with treatment-free remission in chronic myeloid leukemia
    Yazad Irani, Chung Hoow Kok, Jade Clarson, Naranie Shanmuganathan, Susan Branford, David T. O. Yeung, David M. Ross, Timothy P. Hughes, Agnes S. M. Yong · 2023 · Blood Advances
  52. Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia
    Sabrina Inselmann, Ying Wang, Susanne Saußele, Lea V. Fritz, Christin Schütz, Magdalena Huber, Simone Liebler, Thomas Ernst, Dali Cai, Sarah Botschek et al. · 2018 · Cancer Research
  53. A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration
    Jinzhi Lei · 2020 · Journal of Theoretical Biology
  54. Non-Coding RNAs Are Implicit in Chronic Myeloid Leukemia Therapy Resistance
    Alexander Rudich, Ramiro Garzon, Adrienne M. Dorrance · 2022 · International Journal of Molecular Sciences
  55. Continuous map of early hematopoietic stem cell differentiation across human lifetime
    Hana Komic, Tessa Schmachtel, Catia Patricia Simoes, Marius Külp, Weijia Yu, Adrien Jolly, Malin S. Nilsson, Carmen González, Felipe Prósper, Halvard B. Bonig et al. · 2025 · Nature Communications
  56. Autophagy in adult stem cell homeostasis, aging, and disease therapy
    Ke Zhao, Indigo T.C. Chan, Erin H. Y. Tse, Zhiyao Xie, Tom H. Cheung, Yi Arial Zeng · 2025 · Cell Regeneration
  57. Natural Barcodes for Longitudinal Single Cell Tracking of Leukemic and Immune Cell Dynamics
    Livius Penter, Satyen Harish Gohil, Catherine J. Wu · 2022 · Frontiers in Immunology
  58. Comprehensive analysis of the cuproptosis-related gene DLD across cancers: A potential prognostic and immunotherapeutic target
    Weiguang Yang, Qiang Guo, Haiyang Wu, Linjian Tong, Jian Xiao, Yulin Wang, Rui Liu, Lixia Xu, Hua Yan, Zhiming Sun · 2023 · Frontiers in Pharmacology
  59. Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal
    Parto Toofan, Caroline Busch, Heather Morrison, Stephen J. O’Brien, Heather G. Jørgensen, Mhairi Copland, Helen Wheadon · 2018 · Cell Death and Disease
  60. Optimal Gene Filtering for Single-Cell data (OGFSC)—a gene filtering algorithm for single-cell RNA-seq data
    Jie Hao, Wei Cao, Jian Jun Huang, Xin Zou, Ze‐Guang Han · 2018 · Bioinformatics
  61. Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss
    Anwesha Chaudhury, Geoff Miller, Daniel Eichner, John M. Higgins · 2019 · eLife
  62. Leukemic stem cell signatures in Acute myeloid leukemia- targeting the Guardians with novel approaches
    Deepshi Thakral, Ritu Gupta, Aafreen Khan · 2022 · Stem Cell Reviews and Reports
  63. Epigenetic control of immunoevasion in cancer stem cells
    Claudia Galassi, Manel Esteller, Ilio Vitale, Lorenzo Galluzzi · 2024 · Trends in cancer
  64. Infliximab therapy together with tyrosine kinase inhibition targets leukemic stem cells in chronic myeloid leukemia
    Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till A. Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf et al. · 2019 · BMC Cancer
  65. Single-cell sequencing in hematology
    Charlotte K. Brierley, Adam J. Mead · 2019 · Current Opinion in Oncology
  66. Technological advances and computational approaches for alternative splicing analysis in single cells
    Wei Xiong Wen, Adam J. Mead, Supat Thongjuea · 2020 · Computational and Structural Biotechnology Journal
  67. Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML
    Jun Toda, Michiko Ichii, Kenji Oritani, Hirohiko Shibayama, Akira Tanimura, Hideaki Saito, Takafumi Yokota, Daisuke Motooka, Daisuke Okuzaki, Yuichi Kitai et al. · 2020 · Oncogene
  68. Why chronic myeloid leukaemia cannot be cured by tyrosine kinase-inhibitors
    Michele Baccarani, Robert Peter Gale · 2021 · Leukemia
  69. YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation
    Jiadi Lv, Xiaohan Liu, Yabo Zhou, Feiran Cheng, Haoran Chen, Shunshun Li, Dianheng Wang, Li Zhou, Zhenfeng Wang, Nannan Zhou et al. · 2023 · Research
  70. A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I
    Nyam‐Osor Chimge, Min-Hsuan Chen, Cu Nguyen, Yuqi Zhao, Xiwei Wu, Paulina A García-González, Heather Anne N. Ogana, Samantha Hurwitz, Jia-Ling Teo, Xiaolong Chen et al. · 2023 · Current Molecular Pharmacology
  71. MISC: missing imputation for single-cell RNA sequencing data
    Mary Qu Yang, Sherman M. Weissman, William E. Yang, Jialing Zhang, Allon Canaan, Renchu Guan · 2018 · BMC Systems Biology
  72. A combined computational and experimental strategy identifies mutations conferring resistance to drugs targeting the BCR-ABL fusion protein
    Jinxin Liu, Jianfeng Pei, Luhua Lai · 2020 · Communications Biology
  73. Single-Cell Transcriptomics Reveals the Cellular Heterogeneity of Cardiovascular Diseases
    Mengxia Fu, Jiangping Song · 2021 · Frontiers in Cardiovascular Medicine
  74. Unraveling survivin expression in chronic myeloid leukemia: Molecular interactions and clinical implications
    Paula Sabbo Bernardo, Lauana Greicy Tonon Lemos, Gabriela Nestal de Moraes, Raquel Ciuvalschi Maia · 2020 · Blood Reviews
  75. Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia
    Benjamin Demaree, Cyrille L. Delley, Harish N. Vasudevan, Cheryl A.C. Peretz, David Ruff, Catherine Choy Smith, Adam R. Abate · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Therapy Resistance and Disease Progression in CML: Mechanistic Links and Therapeutic Strategies
    John Joson Ng, S. Tiong Ong · 2022 · Current Hematologic Malignancy Reports
  77. Activating p53 abolishes self-renewal of quiescent leukaemic stem cells in residual CML disease
    Mary T. Scott, Wei Liu, Rebecca Mitchell, Cassie J. Clarke, Ross Kinstrie, Felix Warren, Hassan Hussain Almasoudi, Thomas Stevens, Karen M. Dunn, John Pritchard et al. · 2024 · Nature Communications
  78. Understanding cancer from the stem cells up
    Christopher A. Eide, Brian J. Druker · 2017 · Nature Medicine
  79. Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells
    Ramin Radpour, Farzad Forouharkhou · 2018 · World Journal of Stem Cells
  80. Targeting BMP signaling in the bone marrow microenvironment of myeloid leukemia
    Sylvain Lefort, Véronique Maguer‐Satta · 2020 · Biochemical Society Transactions
  81. Recent advances in understanding chronic myeloid leukemia: where do we stand?
    Rahul Kumar, Daniela S. Krause · 2021 · Faculty Reviews
  82. Driving CAR T Stem Cell Targeting in Acute Myeloid Leukemia: The Roads to Success
    Ilaria Marina Michelozzi, Efstratios Kirtsios, Alice Giustacchini · 2021 · Cancers
  83. Autophagy and mitochondrial metabolism: insights into their role and therapeutic potential in chronic myeloid leukaemia
    Pablo Baquero, Amy Dawson, G. Vignir Helgason · 2018 · FEBS Journal
  84. Discontinuation of Tyrosine Kinase Inhibitors in Patients with Chronic Myeloid Leukemia: a Review of the Biological Factors Associated with Treatment-Free Remission
    Ruth Stuckey, Juan Francisco López Rodríguez, María Teresa Gómez‐Casares · 2022 · Current Oncology Reports
  85. The rewired immune microenvironment in leukemia
    Zoe B. Ciantra, Varvara Paraskevopoulou, Iannis Aifantis · 2025 · Nature Immunology
  86. In vitro anti-leukemia activity of dual PI3K/mTOR inhibitor Voxtalisib on HL60 and K562 cells, as well as their multidrug resistance counterparts HL60/ADR and K562/A02 cells
    Lei Zhang, Zhengming Wang, Tungalagtamir Khishignyam, Ting Chen, Chang Zhou, Zhe Zhang, Meihua Jin, Ran Wang, Yuling Qiu, Dexin Kong · 2018 · Biomedicine & Pharmacotherapy
  87. Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis
    Sandra Parenti, Sebastiano Rontauroli, Chiara Carretta, Selene Mallia, Elena Genovese, Chiara Chiereghin, Clelia Peano, Lara Tavernari, Elisa Bianchi, Sebastian Fantini et al. · 2021 · npj Precision Oncology
  88. Single‐cell sequencing in translational cancer research and challenges to meet clinical diagnostic needs
    Ulrich Pfisterer, Julia Bräunig, Per Ludvik Brattås, Markus Heidenblad, Göran Karlsson, Thoas Fioretos · 2021 · Genes Chromosomes and Cancer
  89. Mouse models in the era of large human tumour sequencing studies
    Julian R. de Ruiter, Lodewyk F.A. Wessels, Jos Jonkers · 2018 · Open Biology
  90. Single‐cell RNA sequencing of motoneurons identifies regulators of synaptic wiring in Drosophila embryos
    Jessica Velten, Xuefan Gao, Patrick van Nierop y Sanchez, Katrin Domsch, Rashi Agarwal, Lena Bognar, Malte S. Paulsen, Lars Velten, Ingrid Lohmann · 2022 · Molecular Systems Biology
  91. Cellular hierarchy insights reveal leukemic stem-like cells and early death risk in acute promyelocytic leukemia
    Wen Jin, Yuting Dai, Li Chen, Hong‐Hu Zhu, Fangyi Dong, Hongming Zhu, Guoyu Meng, Junmin Li, Sai‐Juan Chen, Zhu Chen et al. · 2024 · Nature Communications
  92. Single-cell lineage tracing approaches to track kidney cell development and maintenance
    Baul Yoon, Hayoung Kim, Su Woong Jung, Jihwan Park · 2024 · Kidney International
  93. Sex-dependent differences in hematopoietic stem cell aging and leukemogenic potential
    Chun-Xiao Zhang, Taisen Hao, A. Bortoluzzi, Min-Hsuan Chen, Xi-Wei Wu, Jin-Hui Wang, R. Ermel, Young Kim, Shiuan Chen, Wen-Yong Chen · 2024 · Oncogene
  94. How I investigate Clonal cytogenetic abnormalities of undetermined significance
    Guilin Tang, Leonard Jeffrey Medeiros, S. A. Wang · 2018 · International Journal of Laboratory Hematology
  95. Single cell sequencing reveals cell populations that predict primary resistance to imatinib in chronic myeloid leukemia
    Weilong Zhang, Beibei Yang, Linqian Weng, Jiangtao Li, Jiefei Bai, Ting Wang, Jingwen Wang, Jin Ye, Hongmei Jing, Yuchen Jiao et al. · 2020 · Aging
  96. Single-cell technologies and analyses in hematopoiesis and hematological malignancies
    Ignacio Campillo‐Marcos, Damiana Álvarez‐Errico, Regina Antoni Alandes, Elisabetta Mereu, Manel Esteller · 2021 · Experimental Hematology
  97. Processing single-cell RNA-seq datasets using SingCellaR
    Guanlin Wang, Wei Xiong Wen, Adam J. Mead, Anindita Roy, Bethan Psaila, Supat Thongjuea · 2022 · STAR Protocols
  98. Identification of key microRNAs as predictive biomarkers of Nilotinib response in chronic myeloid leukemia: a sub-analysis of the ENESTxtnd clinical trial
    Ryan Yen, Sarah Grasedieck, Andrew Wu, Hanyang Lin, Jiechuang Su, Katharina Rothe, Helen Nakamoto, Donna L. Forrest, Connie J. Eaves, Xiaoyan Jiang · 2022 · Leukemia
  99. Targeting Cancer Stem Cells and Their Niche: Current Therapeutic Implications and Challenges in Pancreatic Cancer
    Jiangang Zhao, Jiahui Li, Hans Schlößer, Felix Popp, Marie Christine Popp, Hakan Alakus, Karl‐Walter Jauch, Christiane J. Bruns, Yue Zhao · 2017 · Stem Cells International
  100. Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
    Luyao Wang, Ye Zhu, Chengying Huang, Qiuming Pan, Junxi Wang, Hongrui Li, Yudi Huang, Guozhong Yi, Zhiyong Li, Songtao Qi et al. · 2025 · Genes & Diseases