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The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.

Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection: Implications for antiviral therapy

Pantaleo, Giuseppe, Cohen, Oren J., Schacker, Timothy, Vaccarezza, Mauro, Graziosi, Cecilia, Rizzardi, G. Paolo, Kahn, James, Fox, Cecil H., Schnittman, Steven M., Schwartz, David H., Corey, Lawrence, Fauci, Anthony S.·1998·Nature Medicine
DOI 10.1038/nm0398-341
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Abstract

Evolutionary patterns of virus replication and distribution in lymphoid tissue during the early phases of HIV infection have not been delineated. Lymph node (LN) biopsies were excised from patients at different times after the estimated time of primary infection. Within 3 months of the acute viral syndrome, HIV was mostly present in individual virus-expressing cells in LNs; trapping of virions in the follicular dendritic cell (FDC) network was minimal or absent, but was the predominant form of HIV detected in LNs of subjects with chronic infection, either recent (4-20 months after primary infection) or long-term (>2-3 years after primary infection). Plasma viremia was significantly higher in patients during the first 3 months than in those recently infected; however, there were no significant differences in the number of virus-expressing cells per square millimeter of LN tissue in these two groups. Numbers of virus-expressing cells in lymphoid tissue were significantly lower in the subjects with long-term infection than in the other two groups. Therefore, during the transition from primary to chronic HIV infection, the level of HIV replication in lymphoid tissue remains elevated despite the fact that viremia is significantly downregulated. These findings have implications for therapeutic strategies in primary HIV infection and in recent seroconvertors.

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Crossref · 10.1038/nm0398-341

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  • Lymphadenopathy and HIV accumulation in patient lymph nodes at early stages suggest close lymphocyte contacts may facilitate virus transmission.

    “Indeed, observation of lymphadenopathy and HIV accumulation in the patient’s lymph nodes at the early stages of the disease [127,128] suggest that close lymphocyte contacts may facilitate virus transmission.”

    From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [128]

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Research works printed but not linked: 1

  1. Chakrabarti, L., et al. Early stages of simian immunodeficiency virus infection in lymph nodes. Am. J. Pathol. 144, 1226–34 (1994).

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Metadata

Authors
Pantaleo, G., Cohen, O. J., Schacker, T., Vaccarezza, M., Graziosi, C., Rizzardi, G. P., Kahn, J., Fox, C. H., Schnittman, S. M., Schwartz, D. H., Corey, L., & Fauci, A. S.
Affiliations
  • Centre Hospitalier Universitaire Vaudois (CH)
  • National Institutes of Health (US)
  • University of Minnesota (US)
  • San Francisco General Hospital (US)
  • Johns Hopkins University (US)
  • University of Washington (US)
ORCID
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
1998-03
Volume
4
Issue
3
Pages
341-345
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/nm0398-341
OpenAlex
W2038904774
Cited by
132
References
23
Citations by year
2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 1 · 2012: 8
FWCI
4.48
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi di Cassino (submittedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
primary HIV infection, HIV replication, lymph nodes, follicular dendritic cells, plasma viremia, chronic HIV infection, seroconversion, antiviral therapy, viral load
MeSH terms
Acute Disease, Biopsy, Chronic Disease, Dendritic Cells, HIV, Humans, Lymph Nodes, RNA, Viral, Viremia, Virus Replication, HIV Infections, Disease Progression

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