The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease
Open accessAbstract
A nonhuman primate model of tuberculosis that closely resembles human disease is urgently needed. We have evaluated the Philippine cynomolgus monkey, Macaca fasicularis, as a model of TB. Cynomolgus monkeys challenged intratracheally with extremely high doses of Mycobacterium tuberculosis (105 or 104 CFU) developed an acute, rapidly progressive, highly fatal multilobar pneumonia. However, monkeys challenged with moderate or low doses of M. tuberculosis (≤103 CFU) developed a chronic, slowly progressive, localized form of pulmonary TB, akin to the disease in humans, that was frequently accompanied by such clinical syndromes as ocular tuberculosis, meningitis and tuberculous spondylitis. A significant proportion of monkeys challenged with 102 or 101 CFU contained the infection in a subclinical state. The Philippine cynomolgus monkey model is an excellent model of chronic TB and provides an opportunity to study subclinical and potentially latent disease in an animal model.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
EXTRAPULMONARY TUBERCULOSIS IN THE UNITED STATES1
FARER, L. S., LOWELL, A. M., & MEADOR, M. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112675 · Cited by 379
Cited by
Persistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
Tuberculosis — metabolism and respiration in the absence of growth
Boshoff, H. I. M., & Barry, C. E. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1065 · Cited by 448
Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
Lin, P. L., Rodgers, M., Smith, L., Bigbee, M., Myers, A., Bigbee, C., Chiosea, I., Capuano, S. V., Fuhrman, C., Klein, E., et al. (2009) · Infection and Immunity · doi:10.1128/iai.00592-09 · Cited by 425
Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection
Tufariello, J. M., Chan, J., & Flynn, J. L. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00741-2 · Cited by 403
Tuberculosis: a problem with persistence
Stewart, G. R., Robertson, B. D., & Young, D. B. (2003) · Nature Reviews Microbiology · doi:10.1038/nrmicro749 · Cited by 386
Metadata
- Authors
- Walsh, G. P., Tan, E. V., Dela Cruz, E. C., Abalos, R. M., Villahermosa, L. G., Young, L. J., Cellona, R. V., Narareno, J. B., & Horwitz, M. A.
- Venue
- Nature Medicine
- Published
- 1996-04
- Volume
- 2
- Issue
- 4
- Pages
- 430-436
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1992452635
- Cited by
- 225
- References
- 1
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease. https://app.cochat.ai/papers/10.1038/nm0496-430
- The paper
- Walsh, G. P., Tan, E. V., Dela Cruz, E. C., Abalos, R. M., Villahermosa, L. G., Young, L. J., Cellona, R. V., Narareno, J. B., & Horwitz, M. A. (1996). The Philippine cynomolgus monkey (Macaca fasicularis) provides a new nonhuman primate model of tuberculosis that resembles human disease. Nature Medicine. https://doi.org/10.1038/nm0496-430
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
