The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model
Open accessAbstract
We previously described that low-dose Mycobacterium tuberculosis infection in cynomolgus macaques results in a spectrum of disease similar to that of human infection: primary disease, latent infection, and reactivation tuberculosis (S. V. Capuano III, D. A. Croix, S. Pawar, A. Zinovik, A. Myers, P. L. Lin, S. Bissel, C. Fuhrman, E. Klein, and J. L. Flynn, Infect. Immun. 71: 5831-5844, 2003). This is the only established model of latent infection, and it provides a unique opportunity to understand host and pathogen differences across of range of disease states. Here, we provide a more extensive and detailed characterization of the gross pathology, microscopic histopathology, and immunologic characteristics of monkeys in each clinical disease category. The data underscore the similarities between human and nonhuman primate M. tuberculosis infection. Furthermore, we describe novel methods of quantifying gross pathology and bacterial burden that distinguish between active disease and latent infection, and we extend the usefulness of this model for comparative studies. Early in infection, an abnormal chest X ray, M. tuberculosis growth by gastric aspirate, and increased mycobacterium-specific gamma interferon (IFN-γ) in peripheral blood mononuclear cells (PBMCs) and bronchoalveolar lavage (BAL) cells were associated with the development of active disease. At necropsy, disease was quantified with respect to pathology and bacterial numbers. Microscopically, a spectrum of granuloma types are seen and differ with disease type. At necropsy, monkeys with active disease had more lung T cells and more IFN-γ from PBMC, BAL, and mediastinal lymph nodes than monkeys with latent infection. Finally, we have observed a spectrum of disease not only in monkeys with active disease but also in those with latent infection that provides insight into human latent tuberculosis.
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Cites
Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent
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Self-citationTuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates
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Self-citationCapuano, S. V., Croix, D. A., Pawar, S., Zinovik, A., Myers, A., Lin, P. L., Bissel, S., Fuhrman, C., Klein, E., & Flynn, J. L. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.5831-5844.2003 · Cited by 479
Self-citationPulmonary Tuberculoma Evaluated by Means of FDG PET: Findings in 10 Cases
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BackgroundInfluentialTuberculosis and the Tubercle Bacillus
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Comparison of two commercial interferon-γ assays for diagnosing Mycobacterium tuberculosis infection
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Cited by
Lin, P. L., Ford, C. B., Coleman, M. T., Myers, A. J., Gawande, R., Ioerger, T., Sacchettini, J., Fortune, S. M., & Flynn, J. L. (2014) · Nature Medicine · doi:10.1038/nm.3412 · Cited by 533
Self-citationTuberculosis: What We Don’t Know Can, and Does, Hurt Us
Russell, D. G., Barry, C. E., & Flynn, J. L. (2010) · Science · doi:10.1126/science.1184784 · Cited by 489
Self-citationFord, C. B., Lin, P. L., Chase, M. R., Shah, R. R., Iartchouk, O., Galagan, J., Mohaideen, N., Ioerger, T. R., Sacchettini, J. C., Lipsitch, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.811 · Cited by 437
Self-citationPrinciples and approaches for reproducible scoring of tissue stains in research
Meyerholz, D. K., & Beck, A. P. (2018) · Laboratory Investigation · doi:10.1038/s41374-018-0057-0 · Cited by 341
HIV-1/ Mycobacterium tuberculosis Coinfection Immunology: How Does HIV-1 Exacerbate Tuberculosis?
Diedrich, C. R., & Flynn, J. L. (2011) · Infection and Immunity · doi:10.1128/iai.01126-10 · Cited by 266
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Metadata
- Authors
- Lin, P. L., Rodgers, M., Smith, L., Bigbee, M., Myers, A., Bigbee, C., Chiosea, I., Capuano, S. V., Fuhrman, C., Klein, E., & Flynn, J. L.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2009-10
- Volume
- 77
- Issue
- 10
- Pages
- 4631-4642
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2121476879
- Cited by
- 425
- References
- 25
- FWCI
- 17.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, P. L., Rodgers, M., Smith, L., Bigbee, M., Myers, A., Bigbee, C., Chiosea, I., Capuano, S. V., Fuhrman, C., Klein, E., & Flynn, J. L. (2009). Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model. Infection and Immunity. https://doi.org/10.1128/iai.00592-09
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