The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The sepsis seesaw: tilting toward immunosuppression
Open accessAbstract
The immune response goes haywire during sepsis, a deadly condition triggered by infection. Richard S. Hotchkiss and his colleagues take the focus off of the prevailing view that the key aspect of this response is an exuberant inflammatory reaction. They assess recent human studies bolstering the notion that immunosuppression is also a major contributor to the disease. Many people with sepsis succumb to cardiac dysfunction, a process examined by Peter Ward. He showcases the factors that cause cardiomyocyte contractility to wane during the disease.
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Citations
Cites
CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance
Griffith, T. S., Yu, X., Herndon, J. M., Green, D. R., & Ferguson, T. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80305-2 · Cited by 382
Self-citation
Cited by
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
Endotoxin tolerance: new mechanisms, molecules and clinical significance
Biswas, S. K., & Lopez-Collazo, E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.009 · Cited by 1,318
The immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
Pillay, J., Kamp, V. M., van Hoffen, E., Visser, T., Tak, T., Lammers, J.-W., Ulfman, L. H., Leenen, L. P., Pickkers, P., & Koenderman, L. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57990 · Cited by 828
Gentile, L. F., Cuenca, A. G., Efron, P. A., Ang, D., Bihorac, A., McKinley, B. A., Moldawer, L. L., & Moore, F. A. (2012) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0b013e318256e000 · Cited by 801
Metadata
- Authors
- Hotchkiss, R. S., Coopersmith, C. M., McDunn, J. E., & Ferguson, T. A.
- Venue
- Nature Medicine
- Published
- 2009-05
- Volume
- 15
- Issue
- 5
- Pages
- 496-497
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2056411965
- Cited by
- 574
- References
- 1
- FWCI
- 24.26
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
