Cocaine sobers up
Integrity signals
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Disulfiram blocks the enzyme aldehyde dehydrogenase (ALDH).
“Disulfiram blocks the enzyme aldehyde dehydrogenase (ALDH).”
From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [9]
Cites
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.256.11.1449 · Cited by 541 · see citing works
Disulfiram Treatment of Alcoholism: A Veterans Administration Cooperative Study
Fuller, R. K. (1986) · JAMA · doi:10.1001/jama.1986.03380110055026 · Cited by 431 · see citing works
Efficacy of Disulfiram and Cognitive Behavior Therapy in Cocaine-DependentOutpatients
Carroll, K. M., Fenton, L. R., Ball, S. A., Nich, C., Frankforter, T. L., Shi, J. M., & Rounsaville, B. J. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.3.264 · Cited by 410 · see citing works
There and Back Again: A Tale of Norepinephrine and Drug Addiction
Weinshenker, D., & Schroeder, J. P. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301263 · Cited by 347 · see citing works
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Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
Fuller, R. K., Branchey, L., Brightwell, D. R., Derman, R., Emrick, C. D., Iber, F. L., James, K. E., Lacoursiere, R. B., Lee, K. K., & Lowenstam, I. (1986) · PubMed · Cited by 166 · see citing works
Prazosin, an α-1 Adrenergic Antagonist, Reduces Cocaine-Induced Reinstatement of Drug-Seeking
Zhang, X. Y., & Kosten, T. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.003 · Cited by 118 · see citing works
Mechanisms of Disulfiram-induced Cocaine Abstinence: Antabuse and Cocaine Relapse
Gaval‐Cruz, M., & Weinshenker, D. (2009) · Molecular Interventions · doi:10.1124/mi.9.4.6 · Cited by 110 · see citing works
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Bourdélat-Parks, B. N., Anderson, G. M., Donaldson, Z. R., Weiss, J. M., Bonsall, R. W., Emery, M., Liles, L. C., & Weinshenker, D. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0139-8 · Cited by 97 · see citing works
Self-citationStanley, W. C., Li, B., Bonhaus, D. W., Johnson, L. G., Lee, K., Porter, S., Walker, K. A. M., Martinez, G., Eglen, R. M., Whiting, R. L., et al. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701315 · Cited by 93 · see citing works
Suppression of Heavy Drinking and Alcohol Seeking by a Selective ALDH‐2 Inhibitor
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Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities
Chen, C., Ferreira, J. C. B., Gross, E. R., & Mochly‐Rosen, D. (2014) · Physiological Reviews · doi:10.1152/physrev.00017.2013 · Cited by 613 · see citing works
Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis
Skinner, M. D., Lahmek, P., Pham, H., & Aubin, H.-J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087366 · Cited by 347 · see citing works
“On the other hand, different pharmacodynamic rather than psychological mechanisms of action have been proposed to explain the success of disulfiram in cocaine addiction [9,10,11], and in one case report of pathological gambling [12].”
BackgroundPiecing together the puzzle of acetaldehyde as a neuroactive agent
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Pharmacotherapeutic strategies for treating cocaine use disorder—what do we have to offer?
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Current pharmacological treatment approaches for alcohol dependence
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- Authors
- Weinshenker, D.
- Affiliations
- Emory University (US)
- Corresponding author
- Weinshenker, David
- ORCID
- Weinshenker, David
- Venue
- Nature Medicine
- Published
- 2010-09
- Volume
- 16
- Issue
- 9
- Pages
- 969-970
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2052599384
- Cited by
- 15
- References
- 13
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cocaine dependence, dopamine depletion, relapse prevention, alcohol consumption reduction
- MeSH terms
- Aldehyde Dehydrogenase, Mitochondrial, Aldehyde Dehydrogenase, Animals, Disulfiram, Dopamine, Humans, Levodopa, Norepinephrine, Recurrence, Self Administration, Temperance, Cocaine-Related Disorders, Mitochondrial Proteins, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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