Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Chung, Kenny K.K., Zhang, Yi, Lim, Kah Leong, Tanaka, Yuji, Huang, Hui, Gao, Jun, Ross, Christopher A., Dawson, Valina L., Dawson, Ted M.·2001·Nature Medicine
DOI 10.1038/nm1001-1144

Cited by (744)

Items 601–700 of 744

  1. Identification and characterization of a novel endogenous murine parkin mutation
    Chenere P. Ramsey, Benoit I. Giasson · 2010 · Journal of Neurochemistry
  2. Parkin is expressed in vascular endothelial cells
    Wakako Tamo, Tadaatsu Imaizumi, Kunikazu Tanji, Hidemi Yoshida, Shingo Takanashi, Koichi Wakabayashi, Ryōsuke Takahashi, Nobutaka Hattori, Kei Satoh · 2007 · Neuroscience Letters
  3. Minimotifs dysfunction is pervasive in neurodegenerative disorders
    Surbhi Sharma, Richard J. Young, Jingchun Chen, Xiangning Chen, Edwin C. T. Oh, Martin R. Schiller · 2018 · Alzheimer s & Dementia Translational Research & Clinical Interventions
  4. Splicing variants of porcine synphilin-1
    Knud Larsen, Lone Bruhn Madsen, Leila Farajzadeh, Christian Bendixen · 2015 · Meta Gene
  5. Genetic Factors in Parkinsons Disease and Potential Therapeutic Targets
    Jian Feng · 2003 · Current Neuropharmacology
  6. ISG15‐dependent Regulation
    Arthur L. Haas · 2006 · Wiley eBooks
  7. PRKN/parkin-mediated control of SNCA (synuclein alpha) and chaperone-mediated autophagy are defective in cellular, mice models and Parkinson disease-affected brains
    Lígia Ramos dos Santos, Eric Duplan, Juliane Debord, G. Fremont, Julien Minniti, Inger Lauritzen, Eugénie Mutez, Coline Leghay, Marie‐Christine Chartier‐Harlin, Frédéric Checler et al. · 2026 · Autophagy
  8. AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in drosophila
    Jingnan Liu, Xiaobo Wang, Rui Ma, Tianxia Li, Gongbo Guo, Bo Ning, Timothy H. Moran, Wanli W. Smith · 2020 · Journal of Cell Science
  9. Selected genetically engineered models relevant to human neurodegenerative disease
    Donald L. Price, David Borchelt, Michael K. Lee, Philip C. Wong · 2005 · Cambridge University Press eBooks
  10. Genetic aspects of Parkinson's disease
    Yoshikuni Mizuno, Nobutaka Hattori, Hideki Mochizuki · 2007 · Handbook of clinical neurology
  11. Biochemical and immunological aspects of protein aggregation in neurodegenerative diseases
    Fatemeh Shojaei, Naemeh Tavakolinia, Adeleh Divsalar, Thomas Haertlé, Ali Akbar Saboury, Mohsen Nemat‐Gorgani, Maria P. Abbracchio · 2014 · Journal of the Iranian Chemical Society
  12. Microglial activation in a mouse model of α-synuclein overexpression
    Kathleen A. Maguire‐Zeiss, Xiaomin Su, Howard J. Federoff · 2008 · Elsevier eBooks
  13. Genetics of Parkinson's Disease—An Overview
    Christine Klein · 2009 · Blue books of neurology
  14. Cellular and Molecular Mechanisms Underlying Parkinson’s Disease: The Role of Molecular Chaperones
    Pamela J. McLean · 2008 · Springer eBooks
  15. Neurodegeneration caused by ER stress?
    Ryōsuke Takahashi · 2004 · Folia Pharmacologica Japonica
  16. RING Fingers and Relatives: Determinators of Protein Fate
    Kevin L. Lorick, Yien Che Tsai, Yili Yang, Allan M. Weissman · 2007 · Wiley eBooks
  17. Genetics of Parkinson's Disease
    KK Sinha · 2005 · Jaypee Brothers Medical Publishers (P) Ltd. eBooks
  18. Characteristic fingerprint spectrum of α-synuclein mutants on terahertz time-domain spectroscopy
    Xiaofang Zhao, Chenlong Yang, Xin Chen, Yu Sun, Weihai Liu, Qinggang Ge, Jun Yang · 2024 · Biophysical Journal
  19. Rare Copy Number Variants Intersecting Parkinson’s-associated Genes in a Cohort of children With Autism Spectrum Disorders
    Alina Erbescu, Sorina Mihaela Papuc, Magdalena Budișteanu, Maria Dobre, Catrinel Iliescu, Mihail Eugen Hinescu, Aurora Arghir, Monica Teodora Neagu · 2025 · Neuroscience Insights
  20. Synphilin-1 modulates alpha-synuclein assembly, release and uptake
    Diana F. Lázaro, Triana Amen, Ellen Gerhardt, Chengyuan Song, Ryan Burns, Niels Kruse, Patrícia I. Santos, Dragomir Milovanović, Günter U. Höglinger, Brit Mollenhauer et al. · 2025 · npj Parkinson s Disease
  21. C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.
    Ebany J. Martinez‐Finley, Sudipta Chakraborty, Sam Caito, Stephanie J.B. Fretham, Michael Aschner · 2012 · PubMed
  22. Co-occurrence of Parkinson’s disease and Retinitis Pigmentosa: A genetic and in silico analysis
    Archana Dwivedi, Anand Kumar, Mohammed Faruq, Varun Kumar Singh, Nidhi Dwivedi, Kamaljeet Singh, Ibrahim Hussain, Swati Parida, Gaurab Kumar Jha, Niraj Kumar et al. · 2024 · Neuroscience
  23. Synphilin-1A is a Phosphoprotein Phosphatase 1-Interacting Protein and Affects PPP1 Sorting to Subcellular Compartments
    Emanuel Ferreira‐Fernandes, Sara L. C. Esteves, Luís Korrodi‐Gregório, Georg H. Lüers, Vera Mónica Almeida Afreixo, Margarida Fardilha, Odete A. B. da Cruz e Silva · 2014 · Journal of Molecular Neuroscience
  24. Progress in Familial Parkinson's Disease.
    Yoshikuni Mizuno, Nobutaka Hattori, Shuichi Asakawa, Hideki Shimura, Hideo Mori, Nobuyuki Shimizu · 2000 · Journal of Clinical Biochemistry and Nutrition
  25. CCK Response Deficiency in Synphilin-1 Transgenic Mice
    Wanli W. Smith, Megan Smith, Dejun Yang, Pique P. Choi, Alexander A. Moghadam, Tianxia Li, Timothy H. Moran · 2015 · PLoS ONE
  26. Genetics Of Parkinson’s Disease
    Sathya R. Sriram, Ted M. Dawson, Valina Lynn Dawson · 2005 · Neurological disease and therapy
  27. The M458L missense mutation disrupts the catalytic properties of Parkin
    Yun‐Ju Do, Seo Young Yun, Min‐Young Park, Eunhee Kim · 2017 · FEBS Letters
  28. Ubiquitin Mediated Posttranslational Modification of Proteins Involved in Various Signaling Diseases
    VALLURI ANITHA LAVANYA, Shazia Jamal, Neesar Ahmed · 2019 · Elsevier eBooks
  29. Animal models of Parkinson's review
    Wenjie You · 2021 · AIP conference proceedings
  30. Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity
    M. Bonin, F. P. Marx, Sabine Kautzmann, Olaf Rieß, Rejko Krüger · 2008 · Journal of Neural Transmission
  31. Genetics of parkinsonism
    Thomas Gasser · 2005 · Cambridge University Press eBooks
  32. Molecular Chaperones and the Ubiquitin–Proteasome System
    Cam Patterson, Jörg Höhfeld · 2005 · Wiley eBooks
  33. Regulatory Role of ADGRL3, PARK2, and CNTNAP2 in Neurodevelopmental Disorders
    Vidya Murugesan, Senthilkumar Rajagopal · 2022 · Nutritional neurosciences
  34. Canonical and alternate mechanisms that regulate ubiquitylation by the E3 ligase parkin
    Nicoletta T. Basilone, V.S.C. Pimenta, Gary S. Shaw · 2025 · Biochemical Society Transactions
  35. Exploring Indole-Based Molecules as Novel Therapeutics for Parkinson’s Disease: A Comprehensive Review
    Ritam Mondal, Deepika Paliwal, Aman Thakur, Saurabh Sharma, Niranjan Kaushik · 2025 · Mini-Reviews in Medicinal Chemistry
  36. E3 ubiquitin ligases in neurodegenerative diseases
    Duan Lu Hou, Josephine Ho, Tuchen Guan, Xiao-Xue Dong, Li Zeng, Laurie H. Sanders, Y Wu, Eng‐King Tan, Zhi Dong Zhou · 2026 · Military Medical Research
  37. Probiotics protect against progressive deterioration of motor functions and Parkinson's disease
    Reena Kumari, Mitali Makwana, Subrota Hati · 2024 · Elsevier eBooks
  38. Ubiquitin ligase signalling networks shape presynaptic development, function and disease
    Melissa A. Borgen, Brock J. Grill · 2024 · The Journal of Physiology
  39. Neurodegenerative Diseases: Insights from Drosophila and Mouse Models
    Juan Botas · 2003 · Research and perspectives in neurosciences
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  41. Parkin and Parkinson’s Disease
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  42. Strategies for Inhibiting Protein Aggregation: Therapeutic Approaches to Protein-Aggregation Diseases
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    Manju Tewari, Hriday Shanker Pandey, Pankaj Seth · 2017 · Springer eBooks
  45. Malfunctions in synaptic membrane trafficking in early pathology of Parkinson’s disease: New molecular clues
    Elena Sopova, Olga M. Korenkova, Oleg Shupliakov · 2017 · Biological Communications
  46. Parkinsonism
    Vincenzo Bonifati · 2012 · Cambridge University Press eBooks
  47. Aging and Parkinson’s Disease: Pathological Insight on Model Mice
    Shigeto Sato, Nobutaka Hattori · 2022 · Springer eBooks
  48. Apoptosis in Neurodegenerative Diseases
    Qiuli Liang, Jianhua Zhang · 2009 · Humana Press eBooks
  49. Ubiquitin and Protein Degradation in Synapse Function
    Thomas D. Helton, Michael Ehlers · 2008 · Springer eBooks
  50. Parkin Mutations (Park 2)
    Yoshikuni Mizuno, Nobutaka Hattori, Hiroyo Yoshino, Shuichi Asakawa, Shinsei Minoshima, Nobuyoshi Shimizu, Toshiaki Suzuki, Tomoki Chiba, Keiji Tanaka · 2003 · Elsevier eBooks
  51. Putting a PARKINg brake on neurodegeneration
    Bingwei Lu · 2003 · Molecular Psychiatry
  52. Insight Into Parkinson's Disease Using Yeast as a Model to Evaluate the Role of Autophagy Genes in alpha-Synuclein Toxicity
    Ray S. Choi · 2010 · Eukaryon
  53. Direct Interaction Between Two Parkinson-related Protein Parkin and PINK1*
    Xuejing Wang, Jifeng Guo, Hong Ning Jiang, Lu Shen, Beisha Tang · 2010 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
  54. The use of cell-free systems to characterize parkinson's disease-related gene products
    Jean‐Christophe Rochet, Jeremy L. Schieler · 2008 · Elsevier eBooks
  55. Update on Parkinson's Disease Genetics
    Rejko Krüger, Daniela Berg, O. Riess, Peter Riederer · 2007 · Springer eBooks
  56. Molecular Chaperones and the Ubiquitin–Proteasome System
    Cam Patterson, Jörg Höhfeld · 2008 · Wiley eBooks
  57. Parkinson Disease
    Taku Hatano, Nobutaka Hattori · 2011 · Wiley eBooks
  58. Modelling Parkinson’s Disease Pre-Clinically: A Novel Virus-Fibril Inducible Mouse Model Exploring Disease Characteristics and Therapeutic Intervention via Metabotropic Glutamate Receptor 5 Negative Allosteric Modulation
    Samantha C. Bureau · 2022 · Carleton University's Institutional Repository (MacOdrum Library, Carleton University)
  59. Funktionelle Charakterisierung von Mutationen im Synphilin-1- und Parkin-Gen bei der Parkinson-Krankheit : Bedeutung von Proteinaggregation und des Ubiquitin-Proteasomen-Systems für die Pathogenese der Parkinson-Krankheit
    Frank P. Marx · 2004
  60. Mutant ubiquitin and the proteasome in Alzheimer's disease
    Femke M. S. de Vrij · 2005 · UvA-DARE (University of Amsterdam)
  61. THE ROLE OF DOPAMINE OXIDATION IN DOPAMINE-INDUCED TOXICITY, INITIATION OF ENDOPLASMIC RETICULUM STRESS, AND POTENTIATION OF ROTENONE-INDUCED TOXICITY IN DIFFERENTIATED PC12 CELLS
    April A. Dukes · 2007 · D-Scholarship@Pitt (University of Pittsburgh)
  62. Kovalente und nicht-kovalente Interaktion ligandengesteuerter Ionenkanäle mit Ubiquitin in Xenopus-laevis-Oozyten
    Chakravertty, Anastasia · 2006 · RWTH Publications (RWTH Aachen)
  63. Alpha-synuclein phosphorylation role on Parkinson’s disease
    Filipa Magalhães Silva · 2013 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  64. The role of kalirin-7 in the pathogenesis of Parkinson disease and Huntington disease
    Yu-Chun Tsai · 2012
  65. Bone marrow cells differentiation to neurons in the rat brain using Serotonin and GABA:Their role on glutamate receptors, IP3, cAMP and cGMP functional regulation in unilateral Parkinsonism induced by 6-hydroxydopamine
    Mohan Sobhana Nandhu, C.S. Paulose · 2011 · Dyuthi Digital Repository (Cochin University of Science and Technology)
  66. Autosomal recessive, early-onset Parkinson’s disease
    Vincenzo Bonifati · 2003 · RePub (Erasmus University Rotterdam)
  67. Parkin and Neurodegeneration
    Sathya R. Sriram, Valina Lynn Dawson, Ted M. Dawson · 2007 · Wiley eBooks
  68. Novel Proteins in α-Synucleinopathies
    Christine Lund Kragh, Poul Henning Jensen · 2008 · Focus on structural biology
  69. Protein misfolding and cellular defense mechanisms in neurodegenerative diseases
    Michael Y. Sherman, Alfred Lewis Goldberg · 2005 · Cambridge University Press eBooks
  70. Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases
    Tomohiro Nakamura, Stuart A. Lipton · 2011 · Wiley eBooks
  71. The Molecular Pathway to Neurodegeneration in Parkin‐Related Parkinsonism
    Ryōsuke Takahashi · 2007 · Wiley eBooks
  72. Effects of Aggregated Alpha-Synuclein on Cultured Neuronal Cells
    David W. Freeman · 2015 · Loyola eCommons (Loyola University of Chicago)
  73. PARK2: Parkin Mutations Responsible for Familial Parkinson's Disease
    Nobutaka Hattori, Taku Hatano, Yutaka Machida, Shigeto Sato, Shinichiro Kubo · 2009 · Blue books of neurology
  74. The Proteasome, Protein Aggregation, and Neurodegeneration
    S. Wilk · 2007 · Springer eBooks
  75. Involvement of S-Nitrosylation in Neurodegeneration
    Yihang Li, Kenny K. K. Chung · 2010 · Springer eBooks
  76. Wnt/beta-catenin signaling in midbrain dopaminergic neurons
    Nina Rawal · 2006 · Figshare
  77. Protein Oxidation Triggers the Unfolded Protein Response and Neuronal Injury in Chemically Induced Parkinson Disease
    Alison I. Bernstein, Karen L. O’Malley · 2009 · Contemporary clinical neuroscience
  78. Overview of cell-free systems for the study of parkinson's disease
    Chun Zhou · 2008 · Elsevier eBooks
  79. Role of striatal-enriched protein tyrosine phosphatase STEP in the nigrostriatal pathway
    Rita Alexandra Videira · 2012 · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
  80. Characterization of phosphorylation-dependent interactions involving neurofibromin 2 (NF2, merlin) isoforms and the Parkinson protein 7 (PARK7, DJ1)
    Josephine M. Worseck · 2012 · edoc Publication server (Humboldt University of Berlin)
  81. In Search of an Immunobiomarker for Parkinson’s Disease
    Linda Chang · 2012 · Journal of Neuroimmune Pharmacology
  82. The Study of The Interaction Between Parkin and OGCP*
    Chun-Yu WANG, Li Hua Cao, Beisha Tang, Hainan Zhang, Jifeng Guo, Dan He, Shusheng Liao, Jianguang Tang, Xinxiang Yan, Liming Tan · 2010 · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
  83. Investigation of the genetic aetiology of Parkinson's disease in South Africa
    Rowena J. Keyser · 2011 · SUNScholar (Stellenbosch University)
  84. CHARACTERIZATION AND FUNCTIONAL ANALYSIS OF USP14
    Stephen L. Crimmins · 2007
  85. Mechanism of action of autosomal recessive juvenile parkinsonism gene mutations
    Anna Sandebring · 2010 · Figshare
  86. The role of the ubiquitin-proteasome system in neurodegenerative disorders
    Lisette G. G. C. Verhoef · 2006 · Figshare
  87. Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie
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  88. The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies
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  89. First in Molecular Medicine Review Series
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  90. Folding, function and subcellular localization of parkin
    Julia S. Schlehe · 2008
  91. Ubiquitination by Parkin — Implications in Parkinson’s Disease
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  92. Mechanistic Studies of the E3 Ubiquitin Ligases SCF(Fbx4) and Parkin
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  93. Identification of parkin interactions: implications for Parkinson’s disease
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  94. Aus dem Institut für Humangenetik der Universität Tübingen Ärztlicher Direktor: Professor Dr. O. Rieß Abteilung für Medizinische Genetik Abteilungsleiter: Professor Dr. O. Rieß Mutationsanalyse und Haplotypenvergleich in CDCrel-1 und GPR37 bei Patienten mit Morbus Parkinson
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  97. Visions & Reflections (Minireview) Synphilin-1 isoforms in Parkinsons disease: regulation by phosphorylation and ubiquitylation
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  98. Parkin Misfolding, Dysfunction, and Degradation in Parkinson's Disease
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  99. PAPEL DE LA PROTEÍNA PARKINA EN LA FUNCIÓN CELULAR DE LAS NEURONAS DOPAMINÉRGICAS. SUSCEPTIBILIDAD A LA MUERTE CELULAR
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