Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Miller, Stephen D.; Vanderlugt, Carol L.; Begolka, Wendy Smith; Pao, Winnie; Yauch, Robert L.; Neville, Katherine L.; Katz-Levy, Yael; Carrizosa, Ana; Kim, Byung S.

doi:10.1038/nm1097-1133

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Multiple sclerosis (MS) is a T cell-mediated autoimmune demyelinating disease, which may be initiated by a virus infection. Theiler's murine encephalomyelitis virus (TMEV), a natural mouse pathogen, is a picornavirus that induces a chronic, CD4+ T cell-mediated demyelinating disease with a clinic…