Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631 · see citing works

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · see citing works

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143 · see citing works

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137 · see citing works

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129 · see citing works

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., & Akira, S. (2002) · Nature Immunology · doi:10.1038/ni758 · Cited by 2,517 · see citing works

Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

Kurt-Jones, E., Popova, L., Kwinn, L. A., Haynes, L., Jones, L. P., Tripp, R., Walsh, E., Freeman, M., Golenbock, D., Anderson, L., et al. (2000) · Nature Immunology · doi:10.1038/80833 · Cited by 1,842 · see citing works

Innate immunity: impact on the adaptive immune response

Medzhitov, R. M., & Janeway, C. A. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80152-5 · Cited by 1,548 · see citing works

Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 )

Qureshi, S. T., Larivière, L., Leveque, G., Clermont, S., Moore, K. J., Gros, P., & Malo, D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.615 · Cited by 1,525 · see citing works

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

Selmaj, K. W., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,357 · see citing works

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Fitzgerald, K. A., Pålsson‐McDermott, E. M., Bowie, A., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E. K., Dunne, A., Gray, P., Harte, M. T., et al. (2001) · Nature · doi:10.1038/35092578 · Cited by 1,258 · see citing works

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

Zarember, K. A., & Godowski, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.554 · Cited by 1,251 · see citing works

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

Muzio, M., Bosisio, D., Polentarutti, N., D’Amico, G., Stoppacciaro, A., Mancinelli, R., Veer, C. V. ′., Pentón‐Rol, G., Ruco, L., Allavena, P., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5998 · Cited by 1,058 · see citing works

Broad Expression of Toll-Like Receptors in the Human Central Nervous System

Bsibsi, M., Ravid, R., Gveric, D. O., & van Noort, J. M. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.11.1013 · Cited by 1,000 · see citing works

Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2

Compton, T., Kurt‐Jones, E. A., Boehme, K. W., Belko, J., Latz, E., Golenbock, D. T., & Finberg, R. W. (2003) · Journal of Virology · doi:10.1128/jvi.77.8.4588-4596.2003 · Cited by 676 · see citing works

Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

Yang, Y. L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schäfer, R., Kumar, A., Williams, B. R. G., Aguet, M., & Weissmann, C. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00300.x · Cited by 632 · see citing works

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

Ford, A. L., Goodsall, A. L., Hickey, W. F., & Sedgwick, J. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4309 · Cited by 631 · see citing works

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

Visintin, A., Mazzoni, A., Spitzer, J. H., Wyllie, D. H., Dower, S., & Segal, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.249 · Cited by 611 · see citing works

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Miller, S. D., Vanderlugt, C. L., Begolka, W. S., Pao, W., Yauch, R. L., Neville, K. L., Katz-Levy, Y., Carrizosa, A., & Kim, B. S. (1997) · Nature Medicine · doi:10.1038/nm1097-1133 · Cited by 565 · see citing works

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

Balachandran, S., Roberts, P. C., Brown, L. E., Truong, H., Pattnaik, A. K., Archer, D. R., & Barber, G. N. (2000) · Immunity · doi:10.1016/s1074-7613(00)00014-5 · Cited by 527 · see citing works

Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus

Haynes, L. M., Moore, D. D., Kurt‐Jones, E. A., Finberg, R. W., Anderson, L. J., & Tripp, R. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.22.10730-10737.2001 · Cited by 496 · see citing works

Murine retroviruses activate B cells via interaction with toll-like receptor 4

Rassa, J., Meyers, J., Zhang, Y., Kudaravalli, R., & Ross, S. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.042355399 · Cited by 493 · see citing works

Epidemiologic evidence for multiple sclerosis as an infection

Kurtzke, J. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.382 · Cited by 472 · see citing works

Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes

Aloisi, F., Ria, F., & Adorini, L. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01512-1 · Cited by 390 · see citing works

Toll receptors and pathogen resistance

Takeda, K., & Akira, S. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00264.x · Cited by 305 · see citing works

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

Aloisi, F., Ria, F., Penna, G., & Adorini, L. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4671 · Cited by 276 · see citing works

The central nervous system as an immunocompetent organ: role of glial cells in antigen presentation

Shrikant, P., & Benveniste, E. N. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.1819 · Cited by 233 · see citing works

The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease

Lipton, H. L., TWADDLE, G. M., & Jelachich, M. L. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2525-2533.1995 · Cited by 183 · see citing works

Direct Activation of Innate and Antigen-Presenting Functions of Microglia following Infection with Theiler's Virus

Olson, J. K., Girvin, A. M., & Miller, S. D. (2001) · Journal of Virology · doi:10.1128/jvi.75.20.9780-9789.2001 · Cited by 178 · see citing works

Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)

Clatch, R. J., Miller, S. D., Metzner, R., et al. (1990) · Virology · doi:10.1016/0042-6822(90)90249-q · Cited by 175 · see citing works

Immunostimulatory CpG-DNA Activates Murine Microglia

Dalpke, A. H., Schäfer, M. K.-H., Frey, M., Zimmermann, S., Tebbe, J. J., Weihe, E., & Heeg, K. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.4854 · Cited by 161 · see citing works

Oligodendrocytes utilize a matrix metalloproteinase, MMP-9, to extend processes along an astrocyte extracellular matrix

Uhm, J. H., Dooley, N. P., Oh, L. Y. S., & Yong, V. W. (1998) · Glia · doi:10.1002/(sici)1098-1136(199801)22:1 · Cited by 144 · see citing works

Specific Cleavage of the A1 Protein from Myelin with Cathepsin D

Brostoff, S. W., Reuter, W., Hichens, M., et al. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43066-4 · Cited by 133 · see citing works

Lipopolysaccharide Activates the Expression of ISG15-specific Protease UBP43 via Interferon Regulatory Factor 3

Malakhova, O. A., Malakhov, M. P., Hetherington, C. J., & Zhang, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111527200 · Cited by 126 · see citing works

Presentation of proteolipid protein epitopes and B7-1-dependent activation of encephalitogenic T cells by IFN-gamma-activated SJL/J astrocytes.

Tan, L., Gordon, K. B., Mueller, J. P., Matis, L. A., & Miller, S. D. (1998) · PubMed · Cited by 118 · see citing works

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease

Miller, S. D., Gerety, S. J., Kennedy, M. K., et al. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90115-4 · Cited by 115 · see citing works

Purification of Theiler's Murine Encephalomyelitis Virus and Analysis of the Structural Virion Polypeptides: Correlation of the Polypeptide Profile with Virulence

Lipton, H., & Friedmann, A. (1980) · Journal of Virology · doi:10.1128/jvi.33.3.1165-1172.1980 · Cited by 102 · see citing works

Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-γ-Activated SJL/J Astrocytes

Tan, L., Gordon, K. B., Mueller, J. P., Matis, L. A., & Miller, S. D. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4271 · Cited by 96 · see citing works

Efficient technique for immortalization of murine microglial cells relevant for studies in murine models of multiple sclerosis

Olson, J. K., Zamvil, S. S., & Miller, S. D. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00145-6 · Cited by 9 · see citing works

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

Genomic analysis of reactive astrogliosis

Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Astrocytes are active players in cerebral innate immunity

Farina, C., Aloisi, F., & Meinl, E. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.01.005 · Cited by 1,304 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens

Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064 · see citing works

TLR signaling tailors innate immune responses in human microglia and astrocytes

Jack, C. S., Arbour, N., Manusow, J., Montgrain, V., Blain, M., McCrea, E., Shapiro, A., & Antel, J. P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4320 · Cited by 734 · see citing works

Altered Microbiomes Distinguish Alzheimer’s Disease from Amnestic Mild Cognitive Impairment and Health in a Chinese Cohort

Liu, P., Wu, L., Peng, G., Han, Y., Tang, R., Ge, J., Zhang, L., Jia, L., Yue, S., Zhou, K., et al. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.05.008 · Cited by 669 · see citing works

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works

Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy

Muzio, L., Viotti, A., & Martino, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.742065 · Cited by 581 · see citing works

Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain

Aschauer, D. F., Kreuz, S., & Rumpel, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076310 · Cited by 522 · see citing works

Pattern recognition receptors and central nervous system repair

Kigerl, K. A., de Rivero Vaccari, J. P., Dietrich, W. D., Popovich, P. G., & Keane, R. W. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.01.001 · Cited by 490 · see citing works

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

Morales, I., Guzmán-Martínez, L., Cerda-Troncoso, C., Farías, G. A., & Maccioni, R. B. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00112 · Cited by 490 · see citing works

Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease

Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445 · see citing works

The role of microglia in central nervous system immunity and glioma immunology

Yang, I., Han, S. J., Kaur, G., Crane, C., & Parsa, A. T. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.05.006 · Cited by 410 · see citing works

Microglia receptors and their implications in the response to amyloid β for Alzheimer’s disease pathogenesis

Doens, D., & Fernández, P. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-48 · Cited by 348 · see citing works

Toll-like receptors in the pathogenesis of neuroinflammation

Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331 · see citing works

The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?

Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works

The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I:C)

Cunningham, C., Campion, S., Teeling, J., Felton, L., & Perry, V. H. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.12.007 · Cited by 318 · see citing works

Role of Microglia TLRs in Neurodegeneration

Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291 · see citing works

Differential monocyte responses to TLR ligands in children with autism spectrum disorders

Enstrom, A. M., Onore, C. E., Van de Water, J. A., & Ashwood, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.001 · Cited by 294 · see citing works

Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury

Zhao, W., Beers, D. R., Henkel, J. S., Zhang, W., Urushitani, M., Julien, J., & Appel, S. H. (2010) · Glia · doi:10.1002/glia.20919 · Cited by 288 · see citing works

DAMPs as mediators of sterile inflammation in aging-related pathologies

Feldman, N., Rotter-Maskowitz, A., & Okun, E. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.003 · Cited by 283 · see citing works

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

Li, Y., Xia, Y., Yin, S., Wan, F., Hu, J., Kou, L., Sun, Y., Wu, J., Zhou, Q., Huang, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.719807 · Cited by 230 · see citing works

Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses

Chan, Y. K., Wang, S. K., Chu, C. J., Copland, D. A., Letizia, A. J., Costa Verdera, H., Chiang, J. J., Sethi, M., Wang, M. K., Neidermyer, W. J., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abd3438 · Cited by 215 · see citing works

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

Farfara, D., Lifshitz, V., & Frenkel, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00314.x · Cited by 216 · see citing works

Stress-induced neuroinflammation: role of the toll-like receptor-4 pathway

Gárate, I., Garcia-Bueno, B., Madrigal, J. L. M., Caso, J. R., Alou, L., Gomez-Lus, M. L., Micó, J. A., & Leza, J. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.07.005 · Cited by 202 · see citing works

<i>Porphyromonas gingivalis</i> Periodontal Infection and Its Putative Links with Alzheimer’s Disease

Singhrao, S. K., Harding, A., Poole, S., Kesavalu, L., & Crean, S. (2015) · Mediators of Inflammation · doi:10.1155/2015/137357 · Cited by 195 · see citing works

Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation

Xiao, Y., Jin, J., Chang, M., Chang, J.-H., Hu, H., Zhou, X., Brittain, G. C., Stansberg, C., Torkildsen, Ø., Wang, X., et al. (2013) · Nature Medicine · doi:10.1038/nm.3111 · Cited by 184 · see citing works

Etiologies underlying sex differences in autism spectrum disorders

Schaafsma, S. M., & Pfaff, D. W. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.006 · Cited by 178 · see citing works

NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease

Haslund‐Vinding, J., McBean, G., Jaquet, V, & Vilhardt, F. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13425 · Cited by 169 · see citing works

Role of Endothelial TLR4 for Neutrophil Recruitment into Central Nervous System Microvessels in Systemic Inflammation

Zhou, H., Andonegui, G., Wong, C. H. Y., & Kubes, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901309 · Cited by 174 · see citing works

Toll-like Receptors in Defense and Damage of the Central Nervous System

Aravalli, R. N., Peterson, P. K., & Lokensgard, J. R. (2007) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9071-5 · Cited by 173 · see citing works

Toll-like receptors and their therapeutic potential in Parkinson’s disease and α-synucleinopathies

Kouli, A., Horne, C. B., & Williams-Gray, C. H. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.06.042 · Cited by 143 · see citing works

Regulation of microglia development and homeostasis.

Greter, M., & Merad, M. (2013) · Glia · doi:10.1002/glia.22408 · Cited by 141 · see citing works

Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving

Theberge, F. R., Li, X., Kambhampati, S., Pickens, C. L., St. Laurent, R., Bossert, J. M., Baumann, M. H., Hutchinson, M. R., Rice, K. C., Watkins, L. R., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.12.019 · Cited by 119 · see citing works

Management of neuroinflammatory responses to AAV-mediated gene therapies for neurodegenerative diseases

Perez, B. A., Shutterly, A., Chan, Y. K., Byrne, B. J., & Corti, M. (2020) · Brain Sciences · doi:10.3390/brainsci10020119 · Cited by 112 · see citing works

TLR2 and TLR4 in Parkinson’s disease pathogenesis: The environment takes a toll on the gut

Gorecki, A. M., Anyaegbu, C. C., & Anderton, R. S. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00271-0 · Cited by 103 · see citing works

Inflammation and lithium: clues to mechanisms contributing to suicide-linked traits

Beurel, E., & Jope, R. S. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.129 · Cited by 92 · see citing works

The microbiota influences cell death and microglial colonization in the perinatal mouse brain

Castillo-Ruiz, A., Mosley, M., George, A. J., Mussaji, L. F., Fullerton, E. F., Ruszkowski, E. M., Jacobs, A. J., Gewirtz, A. T., Chassaing, B., & Forger, N. G. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.08.027 · Cited by 91 · see citing works

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

Frank, S., Copanaki, E., Burbach, G. J., Müller, U. C., & Deller, T. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.075 · Cited by 86 · see citing works

Blockade of IL-17A/IL-17R Pathway Protected Mice from Sepsis-Associated Encephalopathy by Inhibition of Microglia Activation

Ye, B., Tao, T., Zhao, A., Wen, L., He, X., Liu, Y., Fu, Q., Mi, W., & Lou, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/8461725 · Cited by 83 · see citing works

Modulation of inflammatory cytokines and mitogen-activated protein kinases by acetate in primary astrocytes

Soliman, M. L., Combs, C. K., & Rosenberger, T. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9426-4 · Cited by 84 · see citing works

Inflammasome-Induced IL-1β Secretion in Microglia Is Characterized by Delayed Kinetics and Is Only Partially Dependent on Inflammatory Caspases

Burm, S. M., Zuiderwijk-Sick, E. A., ‘t Jong, A. E. J., van der Putten, C., Veth, J., Kondova, I., & Bajramovic, J. J. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2510-14.2015 · Cited by 82 · see citing works

Innate Immunity in the Central Nervous System: A Missing Piece of the Autoimmune Encephalitis Puzzle?

Wesselingh, R., Butzkueven, H., Buzzard, K., Tarlinton, D., O'Brien, T. J., & Monif, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02066 · Cited by 83 · see citing works

Cofilin mediates LPS-induced microglial cell activation and associated neurotoxicity through activation of NF-κB and JAK-STAT pathway

Alhadidi, Q., & Shah, Z. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0432-7 · Cited by 83 · see citing works

Optimized isolation enables <i>ex vivo</i> analysis of microglia from various central nervous system regions

De Haas, A. H., Boddeke, H. W. G. M., Brouwer, N., & Biber, K. (2007) · Glia · doi:10.1002/glia.20554 · Cited by 81 · see citing works

Emerging pathogenic role of peripheral blood factors following BBB disruption in neurodegenerative disease

Jeon, M.-T., Kim, K.-S., Kim, E. S., Lee, S., Kim, J., Hoe, H.-S., & Kim, D.-G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101333 · Cited by 76 · see citing works

Ischemia/reperfusion induces interferon stimulated gene expression in microglia

McDonough, A., Lee, R. V., Noor, S., Lee, C., Le, T., Iorga, M., Phillips, J. L. H., Murphy, S., Möller, T., & Weinstein, J. R. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0725-17.2017 · Cited by 71 · see citing works

Children with autism spectrum disorders (ASD) who exhibit chronic gastrointestinal (GI) symptoms and marked fluctuation of behavioral symptoms exhibit distinct innate immune abnormalities and transcriptional profiles of peripheral blood (PB) monocytes

Jyonouchi, H., Geng, L., Streck, D. L., & Toruner, G. A. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.07.001 · Cited by 67 · see citing works

Neuroinflammation in Parkinson’s Disease Animal Models: A Cell Stress Response or a Step in Neurodegeneration?

Cebrián, C., Loike, J. D., & Sulzer, D. (2014) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2014_356 · Cited by 65 · see citing works

Innate Immune Response Gene Expression Profiles of N9 Microglia Are Pathogen-Type Specific

McKimmie, C. S., Roy, D., Forster, T., & Fazakerley, J. K. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.012 · Cited by 51 · see citing works

Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues

Chandler, L. C., Barnard, A. R., Caddy, S. L., Patrício, M. I., McClements, M. E., Fu, H., Rada, C., MacLaren, R. E., & Xue, K. (2019) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2019.05.012 · Cited by 50 · see citing works

Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy

Chandler, L., Yusuf, I., McClements, M., Barnard, A., MacLaren, R., & Xue, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144972 · Cited by 49 · see citing works

Dynamic Responses of Microglia in Animal Models of Multiple Sclerosis

Plastini, M. J., Desu, H. L., & Brambilla, R. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00269 · Cited by 48 · see citing works

Characterizing the cellular immune response to subretinal AAV gene therapy in the murine retina

Chandler, L. C., McClements, M. E., Yusuf, I. H., Martinez-Fernandez de la Camara, C., MacLaren, R. E., & Xue, K. (2021) · Molecular Therapy - Methods &amp; Clinical Development · doi:10.1016/j.omtm.2021.05.011 · Cited by 43 · see citing works

Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains

Brudek, T., Winge, K., Agander, T. K., & Pakkenberg, B. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1020-5 · Cited by 43 · see citing works

Roles of HSV-1 infection-induced microglial immune responses in CNS diseases: friends or foes?

Wang, Y., Jia, J., Wang, Y., Li, F., Song, X., Qin, S., Wang, Z., Kitazato, K., & Wang, Y. (2019) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2019.1660615 · Cited by 40 · see citing works

Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults

Albrecht, D. S., Sagare, A., Pachicano, M., Sweeney, M. D., Toga, A., Zlokovic, B., Chui, H., Joe, E., Schneider, L., Morris, J. C., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.01.010 · Cited by 37 · see citing works

Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration

Ernest James Phillips, T., & Maguire, E. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652593 · Cited by 33 · see citing works

The AAV2.7m8 capsid packages a higher degree of heterogeneous vector genomes than AAV2

Cui, M., Su, Q., Yip, M., McGowan, J., Punzo, C., Gao, G., & Tai, P. W. L. (2024) · Gene Therapy · doi:10.1038/s41434-024-00477-7 · Cited by 20 · see citing works

Prothrombin Kringle-2: a potential inflammatory pathogen in the parkinsonian dopaminergic system

Leem, E., Jeong, K. H., Won, S.-Y., Shin, W.-H., & Kim, S. R. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.4.147 · Cited by 16 · see citing works

UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b

Klammer, M. G., Dzaye, O., Wallach, T., Krüger, C., Gaessler, D., Buonfiglioli, A., Derkow, K., Kettenmann, H., Brinkmann, M. M., & Lehnardt, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.715774 · Cited by 6 · see citing works

Immunomodulatory Effect of G2013 (α-L-Guluronic Acid) on the TLR2 and TLR4 in Human Mononuclear Cells

Sharifi, L., Mohsenzadegan, M., Aghamohammadi, A., et al. (2018) · Current Drug Discovery Technologies · doi:10.2174/1570163814666170605111331 · Cited by 20 · see citing works

Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in micePreprint

Shen, Y., Gong, Z., Zhang, S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2594406/v1 · Cited by 2 · see citing works

Bacterial Lipopolysaccharide and IFN-γ Induce Toll-Like Receptor 2 and Toll-Like Receptor 4 Expression in Human Endothelial Cells: Role of NF-κB Activation1

Faure, E., Thomas, L., Xu, H., Medvedev, A., Equils, O., & Arditi, M. (2001) · Journal of Immunology · doi:10.4049/jimmunol.166.3.2018 · Cited by 445 · see citing works

Besides TLR2 and TLR4, NLRP3 is also involved in regulating Escherichia coli infection-induced inflammatory responses in mice

Shen, Y., Gong, Z., Zhang, S., Cao, J., Mao, W., Yao, Y., Zhao, J., Li, Q., Liu, K., Liu, B., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110556 · Cited by 23 · see citing works

Different effects ofP. gingivalisLPS andE. coliLPS on the expression of interleukin-6 in human gingival fibroblasts

Andrukhov, O., Ertlschweiger, S., Moritz, A., et al. (2013) · Acta Odontologica Scandinavica · doi:10.3109/00016357.2013.834535 · Cited by 70 · see citing works