Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
Muller, Alexander J, DuHadaway, James B, Donover, P Scott, Sutanto-Ward, Erika, Prendergast, George C·2005·Nature Medicine
DOI 10.1038/nm1196
Cited by (999)
Items 701–800 of 999
- Ligand and Substrate Migration in Human Indoleamine 2,3-DioxygenaseElena Nickel, Karin Nienhaus, Changyuan Lu, Syun‐Ru Yeh, Gerd Ulrich Nienhaus · 2009 · Journal of Biological Chemistry
- Targeting the kynurenine pathway in gliomas: Insights into pathogenesis, therapeutic targets, and clinical advancesMikolaj M. Krupa, Tomasz Pienkowski, Anna Tankiewicz‐Kwedlo, Tomasz Łysoń · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Addressing Natural Killer Cell Dysfunction and Plasticity in Cell-Based Cancer TherapeuticsKassandra M. Coyle, Lindsey G. Hawke, Mark L. Ormiston · 2023 · Cancers
- Indoleamine-2,3 dioxygenase: a fate-changer of the tumor microenvironmentParviz Azimnasab-sorkhabi, Maryam Soltani-asl, Túlio Teruo Yoshinaga, M.L. Dagli, Cristina de Oliveira Massoco, José Roberto Kfoury · 2023 · Molecular Biology Reports
- Effects of IFN- γ And Stat1 on Gene Expression, Growth, And Survival in Non-Small Cell Lung Cancer CellsJiannong Li, Bin Yu, Lanxi Song, Steven A. Eschrich, Eric B. Haura · 2007 · Journal of Interferon & Cytokine Research
- BRUSELAS: HPC Generic and Customizable Software Architecture for 3D Ligand-Based Virtual Screening of Large Molecular DatabasesAntonio Jesús Banegas‐Luna, José P. Cerón‐Carrasco, Savíns Puertas Martín, Horacio Pérez‐Sánchez · 2019 · Journal of Chemical Information and Modeling
- Altered Tryptophan Metabolism as a Paradigm for Good and Bad Aspects of Immune Privilege in Chronic Inflammatory DiseasesLingqian Li, Lei Huang, Henrique de Paula Lemos, Mario R. Mautino, Andrew L. Mellor · 2012 · Frontiers in Immunology
- Antigen-Specific Antitumor Responses Induced by OX40 Agonist Are Enhanced by the IDO Inhibitor IndoximodZuzana Berrong, Mikayel Mkrtichyan, Shamim Ahmad, Mason Webb, Eslam T. Mohamed, Okoev Gg, Adelaida Matevosyan, Rajeev Kumar Shrimali, Rasha Abu Eid, Scott A. Hammond et al. · 2018 · Cancer Immunology Research
- Addendum: Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injuryAlexei Degterev, Zhihong Huang, Michael Boyce, Yaqiao Li, Prakash G. Jagtap, Noboru Mizushima, Gregory D. Cuny, Timothy John Mitchison, Michael A. Moskowitz, Junying Yuan · 2013 · Nature Chemical Biology
- Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisationXi Jin Xu, Jie Ren, Yinghe Ma, Hongting Liu, Quanjin Rong, Yifan Feng, Yameng Wang, Yu Cheng, Ruijia Ge, Zhiyu Li et al. · 2019 · Journal of Enzyme Inhibition and Medicinal Chemistry
- Immuno-Metabolic Modulation of Liver Oncogenesis by the Tryptophan MetabolismVéronique Trézéguet, Hala Fatrouni, Aksam J. Merched · 2021 · Cells
- Effect of metabolism on the immune microenvironment of breast cancerYingming Zhou, Hu Wang, Yi Luo, Biguang Tuo, Xuemei Liu, Taolang Li · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Low dose Zebularine treatment enhances immunogenicity of tumor cellsHua Liu, Zhong‐Tian Xue, Hans Olov Sjögren, Leif G. Salford, Bengt Widegren · 2007 · Cancer Letters
- Inhibition of indoleamine 2,3-dioxygenase by thielavin derivatives from a soil fungus, Coniochaeta sp. 10F058Jun‐Pil Jang, Jae‐Hyuk Jang, Mijin Oh, Sangkeun Son, Seung Min Kim, Hye-Min Kim, Kee‐Sun Shin, Hyuncheol Oh, Nak‐Kyun Soung, Young‐Soo Hong et al. · 2013 · The Journal of Antibiotics
- Altered tryptophan metabolism in human meningiomaNoble Kumar Talari, Manas Kumar Panigrahi, Sailaja Madigubba, Sundaram Challa, Prakash Babu Phanithi · 2016 · Journal of Neuro-Oncology
- Tumor Associated Macrophages as Therapeutic Targets for Breast CancerLiyan Lao, Siting Fan, Erwei Song · 2017 · Advances in experimental medicine and biology
- Eicosapentaenoic acid reduces indoleamine 2,3-dioxygenase 1 expression in tumor cellsChih-Chiang Wang, Chih‐Jen Yang, Li-Hsien Wu, Han-Chen Lin, Zhi‐Hong Wen, Che‐Hsin Lee · 2018 · International Journal of Medical Sciences
- AHI-1: a novel signaling protein and potential therapeutic target in human leukemia and brain disordersSharmin Esmailzadeh, Xiaoyan Jiang · 2011 · Oncotarget
- Dendritic cell immunotherapy for breast cancerAlberto Pinzón‐Charry, Christopher Schmidt, José Alejandro López · 2006 · Expert Opinion on Biological Therapy
- Bin1 Interacts with and Restrains the DNA End-Binding Protein Complex KuRamalingam, Arivudainambi, Farmer, George E., Stamato, Thomas, Prendergast, George C. · 2007 · Cell Cycle
- Bin1 Attenuation Suppresses Experimental Colitis by Enforcing Intestinal Barrier FunctionMee Young Chang, Janette Boulden, Mary Carmen Valenzano, Alejandro Peralta Soler, Alexander J. Muller, James M. Mullin, George C. Prendergast · 2012 · Digestive Diseases and Sciences
- Clinical Development of Combination Strategies in Immunotherapy: are We Ready for More Than One Investigational Product in an Early Clinical Trial?José Luis Perez‐Gracia, Pedro Berraondo, Iván Martínez‐Forero, Carlos Alfaro, Natalia Suárez, Alfonso Gúrpide, Bruno Sangro, Sandra Hervás‐Stubbs, Carmen Ochoa, José Antonio Melero et al. · 2009 · Immunotherapy
- Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activitiesRan Bi, Xinni Yang, Haofeng Zhou, Li‐Yan Peng, Jiangxin Liu, Qin‐Shi Zhao · 2022 · Phytochemistry
- Recent developments in chemodrug-loaded nanomedicines and their application in combination cancer immunotherapyNayeon Shim, Hanhee Cho, Seong Ik Jeon, Kwangmeyung Kim · 2023 · Journal of Pharmaceutical Investigation
- The role of metabolic reprogramming in immune escape of triple-negative breast cancerRuochen Bao, Hongtao Qu, Baifeng Li, Kai Cheng, Yandong Miao, Jiangtao Wang · 2024 · Frontiers in Immunology
- Development of 1-N-11C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-TryptophanLin Xie, Jun Maeda, Katsushi Kumata, Joji Yui, Yiding Zhang, Akiko Hatori, Nobuki Nengaki, Hidekatsu Wakizaka, Masayuki Fujinaga, Tomoteru Yamasaki et al. · 2015 · Scientific Reports
- Expression of CXCR-4 and IDO in human colorectal cancer: An immunohistochemical approachMasaichi Ogawa, Michiaki Watanabe, Takuo Hasegawa, Kohei Ichihara, Kazuhiko Yoshida, Katsuhiko K. Yanaga · 2017 · Molecular and Clinical Oncology
- PD-L1 and IDO1 are potential targets for treatment in patients with primary diffuse large B-cell lymphoma of the CNSMaysaa Abdulla, Andrei Alexsson, Christer Sundström, Claes Ladenvall, Larry Mansouri, Cecilia Lindskog, Mattias Berglund, Lucia B. Cavelier, Gunilla Enblad, Peter Hollander et al. · 2021 · Acta Oncologica
- Population Pharmacokinetic and Pharmacodynamic Modeling of Epacadostat in Patients With Advanced Solid MalignanciesJack G. Shi, Kevin Bowman, Xuejun Chen, Janet E. Maleski, Lance Howard Leopold, Swamy Yeleswaram · 2016 · The Journal of Clinical Pharmacology
- Variations in genes involved in immune response checkpoints and association with outcomes in patients with resected colorectal liver metastasesStefan Stremitzer, Yu Sunakawa, Wei Yan Zhang, Dongyun Yang, Y Ning, Sebastian Stintzing, Ana Sebio, Shinichi Yamauchi, S. Matsusaka, Rita Elie El-Khoueiry et al. · 2015 · The Pharmacogenomics Journal
- Noncarrier naked antigen-specific DNA vaccine generates potent antigen-specific immunologic responses and antitumor effectsC-A Chen, M‐C Chang, W-Z Sun, Y-L Chen, Y-C Chiang, C-Y. Hsieh, S M Chen, Po‐Ni Hsiao, W-F Cheng · 2009 · Gene Therapy
- Immune system modulation in patients with malignant and benign breast disorders: tryptophan degradation and serum neopterin.G. Girgin, Tevfik Tolga Sahin, D. Fuchs, H. Kasuya, O. Yuksel, E. Tekin, T. Baydar · 2009 · International Journal of Biological Markers
- Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasisYufei Hui, Xue Jiao, Li Yang, Dejin Lu, Yanbo Han, Wen Yang, Yanli Cao, Yuxi Miao, Shiqiang Gong, Minjie Wei · 2025 · Acta Pharmaceutica Sinica B
- Immune modulatory vaccines targeting tumor microenvironment antigens: recent advances in oncology and beyondMads Hald Andersen · 2026 · Signal Transduction and Targeted Therapy
- Inter‐ and intrapatient heterogeneity of indoleamine 2,3‐dioxygenase expression in primary and metastatic melanoma cells and the tumour microenvironmentT. Gide, B. Allanson, A. Menzies, P. Ferguson, J. Madore, R. Saw, John F. Thompson, G. Long, J. Wilmott, R. Scolyer · 2019 · Histopathology
- The One Health Consortium: Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Combination With a Checkpoint Inhibitor in Canine Patients With Sporadic High Grade GliomasMelissa R. Chambers, R. Timothy Bentley, David K. Crossman, Jeremy B. Foote, Jennifer W. Koehler, James M. Markert, Nidal Bassam Omar, Simon R. Platt, Dwight Mitchell Self, Andy Shores et al. · 2020 · Frontiers in Surgery
- A Cisplatin‐Loaded Immunochemotherapeutic Nanohybrid Bearing Immune Checkpoint Inhibitors for Enhanced Cervical Cancer TherapyNa Wang, Zhigang Wang, Zoufeng Xu, Xianfeng Chen, Guangyu Zhu · 2018 · Angewandte Chemie
- Metabolic reprograming of cancer as a therapeutic targetTatsuhiko Furukawa, Sho Tabata, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Akihide Tanimoto · 2022 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Reprogrammed IDO-Induced Immunosuppressive Microenvironment Synergizes with Immunogenic Magnetothermodynamics for Improved Cancer TherapyXun Wang, Bin Yan, Hugang Li, Jianlan Yuan, Jingyi Guo, Siyao Wang, Penggao Dai, Xiaoli Liu · 2024 · ACS Applied Materials & Interfaces
- SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK/STAT1 signaling pathway in gallbladder carcinoma cellsPeng Zhang, Guanmin Jiang, Jian Gao, Lingling Li, Jun Du, Xingyuan Jiao · 2012 · Oncology Reports
- Expression and function analysis of indoleamine 2 and 3-dioxygenase in bladder urothelial carcinoma.Chenggang Yang, Yongchun Zhou, Lijuan Zhang, Congguo Jin, Mei Li, Lijuan Ye · 2015 · Europe PMC (PubMed Central)
- Methodology of drug screening and target identification for new necroptosis inhibitorsPengchao Pan, Zhenyu Cai, Chunlin Zhuang, Xiaofei Chen, Yifeng Chai · 2018 · Journal of Pharmaceutical Analysis
- Prognostic and clinico-pathological significance of BIN1 in breast cancerSubbroto Kumar Saha, Md. Ashraful Kader, Kazi Abdus Samad, Krishno Chandra Biswas, Md. Ataur Rahman, Md. Anowar Khasru Parvez, Md. Shahedur Rahman · 2020 · Informatics in Medicine Unlocked
- Kynurenine 3‐monooxygenase ( KMO ), and signal transducer and activator of transcription 3 ( STAT3 ) expression is involved in tumour proliferation and predicts poor survival in canine melanomaI‐Li Liu, Ting‐Fang Chung, Wei‐Hsiang Huang, Chia‐Hui Hsu, Cheng‐Chi Liu, Yi‐Han Chiu, Kuo‐Chin Huang, Albert Taiching Liao, Chen‐Si Lin · 2020 · Veterinary and Comparative Oncology
- The Kynurenine PathwayYiquan Chen, Gilles Guillemi · 2012 · InTech eBooks
- Identification of Substituted 1 H ‐Indazoles as Potent Inhibitors for Immunosuppressive Enzyme Indoleamine 2,3‐Dioxygenase 1Nirmalya Pradhan, Saurav Sekhar Paul, Suman Jyoti Deka, Ashalata Roy, Vishal Trivedi, Debasis Manna · 2017 · ChemistrySelect
- Gene expression of indoleamine and tryptophan dioxygenases and three long non-coding RNAs in breast cancerSoudeh Ghafouri‐Fard, Zahra Taherian‐Esfahani, Sepideh Dashti, Vahid Kholghi Oskooei, Mohammad Naser Taheri, Majid Samsami · 2020 · Experimental and Molecular Pathology
- Tryptophan Metabolism in Obesity: The Indoleamine 2,3-Dioxygenase-1 Activity and Therapeutic OptionsAyşe Başak Engin, Atilla Engin · 2024 · Advances in experimental medicine and biology
- Calcium Channel Blocker Lacidipine Promotes Antitumor Immunity by Reprogramming Tryptophan MetabolismYuwen Sheng, Chong Qiao, Zhonghui Zhang, Xiaoke Shi, Linhan Yang, Ruiying Xi, Jialing Yu, Wanli Liu, Guolin Zhang, Fei Wang · 2024 · Advanced Science
- Kynurenine pathway enzyme KMO in cancer progression: A tip of the IcebergSo‐Yeon Park, Jeong‐Seok Nam · 2020 · EBioMedicine
- Insights into Therapy: Tryptophan Oxidation and HIV InfectionMichael F. Murray · 2010 · Science Translational Medicine
- Determination of Kynurnine and Tryptophan, Biomarkers of Indoleamine 2,3-Dioxygenase by LC–MS/MS in Plasma and TumorWenyan Wang, Xuhui Zhuang, Wenrong Liu, Lina Dong, Heyuan Sun, Guangying Du, Liang Ye · 2018 · Bioanalysis
- Modulation of Tumor Tolerance in Primary Central Nervous System MalignanciesTheodore S. Johnson, David H. Munn, Bernard L. Maria · 2012 · Clinical and Developmental Immunology
- Contribution of IDO to human respiratory syncytial virus infectionFelipe M. Benavente, Jorge A. Soto, Magdalena S. Pizarro-Ortega, Karen Böhmwald, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis · 2019 · Journal of Leukocyte Biology
- CpG‐related SNPs in the MS4A region have a dose‐dependent effect on risk of late–onset Alzheimer diseaseYiyi Ma, Gyungah Jun, Jaeyoon Chung, Xiaoling Zhang, Brian W. Kunkle, Adam Christian Naj, Charles C. White, David Alan Bennett, Philip L. De Jager, Richard P Mayeux et al. · 2019 · Aging Cell
- Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapyRoberta Cillari, Rita C. Acúrcio, Andreia Pereira Barateiro, Helena F. Florindo, Nicolò Mauro, Gennara Cavallaro · 2025 · Journal of Controlled Release
- IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic LeukemiaSelcen Öztürk, Verena Kalter, Philipp M. Roessner, Murat Sünbül, Martina Seiffert · 2021 · Cancers
- Heterogeneity of the tumor immune microenvironment and clinical interventionsZheng Jin, Qin Zhou, Jianan Cheng, Qingzhu Jia, Bo Zhu · 2023 · Frontiers of Medicine
- Myelodysplastic Syndromes: Recent Advancements in Risk Stratification and Unmet Therapeutic ChallengesRafael L. Bejar, Ramon Velasquez Tiu, Mikkael Aaron Sekeres, Rami S. Komrokji · 2013 · American Society of Clinical Oncology Educational Book
- Induction of indoleamine-2,3 dioxygenase in bone marrow stromal cells inhibits myeloma cell growthSabine Pfeifer, Martin Schreder, Arnold Bolomsky, Sebastian Graffi, Dietmar Fuchs, Surinder Singh Sahota, Heinz Ludwig, Niklas Zojer · 2012 · Journal of Cancer Research and Clinical Oncology
- Microtubule inhibitors containing immunostimulatory agents promote cancer immunochemotherapy by inhibiting tubulin polymerization and tryptophan-2,3-dioxygenaseShixian Hua, Feihong Chen, Shaohua Gou · 2019 · European Journal of Medicinal Chemistry
- Collagen-Anchored Interleukin-2 and Interleukin-12 Safely Reprogram the Tumor Microenvironment in Canine Soft-Tissue SarcomasJordan A. Stinson, Allison M. Sheen, Noor Momin, Jordan Hampel, Rebecca Bernstein, Rebecca L. Kamerer, Bahaa A. Fadl-Alla, Jonathan Samuelson, Elizabeth Fink, Timothy M. Fan et al. · 2023 · Clinical Cancer Research
- IDO1 Promotes the Progression of NSCLC by Regulating the Polarization of M2 MacrophagesXiao Chen, Jie Yao, Mengyu Zhang, Rui Li, Xiao Liu, Yi-Qing Qu · 2023 · International Journal of General Medicine
- Novel Colitis Immunotherapy Targets Bin1 and Improves Colon Cell Barrier FunctionSunil Thomas, Joanna M. Mercado, James B. DuHadaway, Kate DiGuilio, James M. Mullin, George C. Prendergast · 2015 · Digestive Diseases and Sciences
- Specific In Situ Detection of Murine Indoleamine 2, 3‐ D ioxygenaseSunil Thomas, James B. DuHadaway, George C. Prendergast, Lisa D. Laury‐Kleintop · 2013 · Journal of Cellular Biochemistry
- Tumor-associated macrophages (TAMs) as new target in anticancer therapyAlberto Mantovani, Chiara Porta, Luca Rubino, Paola Allavena, Antonio Sica · 2006 · Drug Discovery Today Therapeutic Strategies
- Marine Bioactive Compounds from CnidariansJoana Rocha, Ricardo Calado, Miguel Costa Leal · 2015 · Springer eBooks
- Mutations in components of antiviral or microbial defense as a basis for breast cancerBernard Friedenson · 2013 · Functional & Integrative Genomics
- Cancer Clonal Theory, Immune Escape, and Their Evolving Roles in Cancer Multi-Agent TherapeuticsJonathan L. Messerschmidt, Prianka Bhattacharya, Gerald L. Messerschmidt · 2017 · Current Oncology Reports
- Function and dysfunction of dendritic cells in autoimmune rheumatic diseasesSergio Rutella, Raimondo DE CRISTOFARO, Gianfranco Ferraccioli · 2009 · Human Immunology
- Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in GliomasApril C.L. Bostian, Robert Lawton Eoff · 2016 · Chemical Research in Toxicology
- Heme-based dioxygenases: Structure, function and dynamicsZachary Geeraerts, Izumi Ishigami, Yuan Gao, Syun‐Ru Yeh · 2024 · Journal of Inorganic Biochemistry
- Suppression of Immunodominant Antitumor and Antiviral CD8+ T Cell Responses by Indoleamine 2,3-DioxygenaseMateusz Rytelewski, Courtney Erin Meilleur, Maryam Atef Yekta, Peter Anthony Szabo, Nitan Garg, Todd D. Schell, Anthony M. Jevnikar, Shayan Sharif, Bhagirath Singh, S. M. Mansour Haeryfar · 2014 · PLoS ONE
- The potential role of indoleamine 2,3 dioxygenase (IDO) as a predictive and therapeutic target for diabetes treatment: a mythical truthBabak Baban, William Todd Penberthy, Mahmood S. Mozaffari · 2010 · The EPMA Journal
- Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine modelElisa Wirthgen, Ellen Kanitz, Margret Tuchscherer, Armin Tuchscherer, Grażyna Domańska, Werner Weitschies, Anne Seidlitz, Eberhard Scheuch, Winfried Otten · 2015 · EXPERIMENTAL ANIMALS
- Substrate binding in human indoleamine 2,3-dioxygenase 1: A spectroscopic analysisKarin Nienhaus, Elena Nickel, Gerd Ulrich Nienhaus · 2017 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Expression of Indoleamine 2,3-Dioxygenase Gene Is a Feature of Poorly Differentiated Non-muscle-invasive Urothelial Cell Bladder CarcinomasTvrtko Hudolin, Chantal Mengus, Julie Coulot, Željko Kaštelan, Ahmad El‐Saleh, Giulio C. Spagnoli · 2017 · Anticancer Research
- Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluationNing Wang, Jie Zhang, Qiao Li, Hui Zhong Xu, Geng Chen, Zhiyong Li, Difa Liu, Xin Yang · 2019 · Fitoterapia
- Discovery of IDO1 and DNA dual targeting antitumor agentsKun Fang, Shanchao Wu, Guoqiang Dong, Ying Wu, Shuqiang Chen, Jianhe Liu, Wei Wang, Chunquan Sheng · 2017 · Organic & Biomolecular Chemistry
- Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1Jiali Wang, Yunlong Jia, Tianxu Liu, Xinyan Liu, Shuxian Yin, Jiaqi Chen, Xiaoqing Xu, Yi Zhang, Lihua Liu · 2025 · Journal of Experimental & Clinical Cancer Research
- Die hard: necroptosis and its impact on age-dependent neuroinflammatory diseasesKaitlan Smith, Meagan Colie, Trinity Moore, Jonathan Cummings Schisler · 2024 · Frontiers in Cell Death
- Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting StrategiesKarl O. Holmberg, Anna Borgenvik, Miao Zhao, G Giraud, Fredrik J. Swartling · 2024 · Cancers
- Necroptosis: a significant and promising target for intervention of cardiovascular diseaseYanwei Ji, Xinyu Wen, He-Peng Tang, Wating Su, Zhongyuan Xia, Shaoqing Lei · 2025 · Biochemical Pharmacology
- Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer ImmunotherapyAlisha Holtzhausen, Fei Linda Zhao, Kathy S. Evans, Brent Allen Hanks · 2014 · Frontiers in Immunology
- Design, synthesis and bioevaluation of novel 6-substituted aminoindazole derivatives as anticancer agentsNgo Xuan Hoang, Van-Hai Hoang, Thi-Thu-Trang Luu, Hung Nguyen Luu, Thien Ngo, Duong Van Hieu, Nguyen Huu Long, Le Viet Anh, Sơn Tùng Ngô, Yen Thi Kim Nguyen et al. · 2020 · RSC Advances
- Comprehensive polar metabolomics and lipidomics profiling discriminates the transformed from the non-transformed state in colon tissue and cell linesCaroline Rombouts, Margot De Spiegeleer, Lieven Van Meulebroek, Lynn Vanhaecke, Winnok Harald De Vos · 2021 · Scientific Reports
- High Expression of Indoleamine 2, 3-Dioxygenase in Adenosquamous Lung Carcinoma Correlates with Favorable Patient OutcomeWenjuan Ma, Hao Duan, Rongxin Zhang, Xing Wang, Haineng Xu, Qianghua Zhou, Li Zhang · 2019 · Journal of Cancer
- Off-tumor IDO1 target engagements determine the cancer-immune set point and predict the immunotherapeutic efficacyLin Xie, Kuan Hu, Yanhong Duo, Takashi Shimokawa, Katsushi Kumata, Yiding Zhang, Cuiping Jiang, Lulu Zhang, Nobuki Nengaki, Hidekatsu Wakizaka et al. · 2021 · Journal for ImmunoTherapy of Cancer
- Turn Off the IDO: Will Clinical Trials Be Successful?Sergey V. Novitskiy, Harold L. Moses · 2012 · Cancer Discovery
- IDO and outcomes in ovarian cancerBrad H. Nelson · 2009 · Gynecologic Oncology
- Targeting the tumor microenvironment by liposomal Epacadostat in combination with liposomal gp100 vaccineSahar Tahaghoghi-Hajghorbani, Mona Yazdani, Amin Reza Nikpoor, Mahdi Hatamipour, Abolghasem Ajami, Mahmoud Reza Jaafari, Ali Badiee, Alireza Rafiei · 2023 · Scientific Reports
- Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor EffectsRi-Zhen Huang, Qiaoling Liang, Xiao-Teng Jing, Ke Wang, Huiyong Zhang, Heng‐Shan Wang, Xian‐Li Ma, Jian-Hua Wei, Ye Zhang · 2023 · Molecules
- Dual‐Targeting Nanoliposome Improves Proinflammatory Immunomodulation of the Tumor MicroenvironmentZili Gu, Candido G. Da Silva, Sen Ma, Qi Liu, Timo Schomann, FERRY A. OSSENDORP, Luis Javier Cruz · 2023 · Advanced Healthcare Materials
- Necroptosis in Pneumonia: Therapeutic Strategies and Future PerspectivesXiuzhen Mei, Yuchen Zhang, Shu Wang, Hui Wang, Rong Chen, Ke Ma, Yue Yang, Ping Jiang, Zhixin Feng, Chao Zhang et al. · 2024 · Viruses
- Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal ToleranceDelia Hoffmann, Tereza Dvořáková, Florence Schramme, Vincent Stroobant, Benoit J. Van den Eynde · 2020 · Frontiers in Immunology
- Single-Cell Sequencing of Malignant Ascites Reveals Transcriptomic Remodeling of the Tumor Microenvironment during the Progression of Epithelial Ovarian CancerYiqun Li, Wenjie Wang, Danyun Wang, Liuchao Zhang, Xizhi Wang, Jia He, Lei Cao, Kang Li, Hongyu Xie · 2022 · Genes
- Immunotherapy for MelanomaJustin T. Moyers, Isabella C. Glitza Oliva · 2021 · Advances in experimental medicine and biology
- Indoleamine 2,3-Dioxygenase (IDO) Downregulates the Cell Surface Expression of the CD4 MoleculeGuanyou Huang, Yao-Ying Zeng, Pei‐Yan Liang, Zhou Congrong, Shuyun Zhao, Xiu−Yan Huang, Ling‐Fei Wu, Xian‐Hui He · 2012 · International Journal of Molecular Sciences
- The immunoregulatory function of indoleamine 2, 3 dioxygenase and its application in allotransplantation.Reza B. Jalili, Farshad Forouzandeh, Mohammad Ali Bahar, Aziz Ghahary · 2007 · PubMed
- Chemical Tools and Materials for Biological/Medicinal ApplicationsXuehai Yan, Jan C. M. van Hest · 2018 · Chemistry - An Asian Journal