Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
Thomas, George V, Tran, Chris, Mellinghoff, Ingo K, Welsbie, Derek S, Chan, Emily, Fueger, Barbara, Czernin, Johannes, Sawyers, Charles L·2006·Nature Medicine
DOI 10.1038/nm1337
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- The Mammalian Target of Rapamycin Kinase and Tumor Growth InhibitionAnne Boulay, Heidi A. Lane · 2007 · Springer eBooks
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- Temsirolimus for advanced renal cell carcinomaLothar Bergmann, Luise Maute, M. Guschmann · 2013 · Expert Review of Anticancer Therapy
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- mTOR inhibition sensitizes gastric cancer to alkylating chemotherapy in vivo.Daniel Cejka, Matthias Preusser, Thorsten Fuereder, Wolfgang Sieghart, Johannes M. Werzowa, Sabine Strommer, Volker Wacheck · 2008 · PubMed
- Role of the ubiquitin proteasome system in renal cell carcinomaPaul Gettys Corn · 2007 · BMC Biochemistry
- Comparison of temsirolimus pharmacokinetics in patients with renal cell carcinoma not receiving dialysis and those receiving hemodialysis: A case seriesGianluigi Lunardi, Andrea Armirotti, Maurizio Nicodemo, Lucia Cavallini, Gianluca Damonte, Maria Ornella Vannozzi, Marco Venturini · 2009 · Clinical Therapeutics
- Resistance to angiogenesis inhibitors in renal cell carcinoma.Ila Tamaskar, Jaspreet Dhillon, Роберто Пили · 2011 · PubMed
- A Phase Ib Study of Combined VEGFR and mTOR Inhibition With Vatalanib and Everolimus in Patients With Advanced Renal Cell CarcinomaRhonda Lynn Bitting, Patrick N Healy, Patricia A. Creel, James D. Turnbull, Karla K. Morris, Sarah Yenser Wood, Herbert I. Hurwitz, Mark D. Starr, Andrew B. Nixon, Andrew J. Armstrong et al. · 2013 · Clinical Genitourinary Cancer
- AMPK activation—protean potential for boosting healthspanMark Frederick McCarty · 2013 · AGE
- Therapeutic challenges in renal cell carcinoma.Justin C. Penticuff, Natasha Kyprianou · 2015 · Europe PMC (PubMed Central)
- Minocycline attenuates hypoxia-inducible factor-1α expression correlated with modulation of p53 and AKT/mTOR/p70S6K/4E-BP1 pathway in ovarian cancer: in vitro and in vivo studies.Parvin Ataie-Kachoie, Mohammad H. Pourgholami, Farnaz Bahrami-B, Samina Badar, David Lawson Morris · 2015 · Europe PMC (PubMed Central)
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- The von Hippel–Lindau Tumor Suppressor ProteinWilliam G. Kaelin · 2018 · Annual Review of Cancer Biology
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- Update on First-Line Combination Treatment Approaches in Metastatic Clear-Cell Renal Cell CarcinomaBryce Raymon Christensen, Yasmin Hajja, Vadim S. Koshkin, Pedro Coelho Barata · 2021 · Current Treatment Options in Oncology