Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
Thomas, George V, Tran, Chris, Mellinghoff, Ingo K, Welsbie, Derek S, Chan, Emily, Fueger, Barbara, Czernin, Johannes, Sawyers, Charles L·2006·Nature Medicine
DOI 10.1038/nm1337
Cited by (605)
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- Mammalian target of rapamycin as a therapeutic target in oncologyRobert T. Abraham, Christina H. Eng · 2008 · Expert Opinion on Therapeutic Targets
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- Approved and Experimental Small‐Molecule Oncology Kinase Inhibitor Drugs: A Mid‐2016 OverviewPeter M. Fischer · 2016 · Medicinal Research Reviews
- RECORD-2: phase II randomized study of everolimus and bevacizumab versus interferon α-2a and bevacizumab as first-line therapy in patients with metastatic renal cell carcinomaAlain Ravaud, Carlos H. Barrios, B. Yа. Alekseev, M.-H. Tay, Sanjiv S. Agarwala, Şuayib Yalçın, C.-C. Lin, Laslo Roman, Michail I. Shkolnik, Oezlem Anak et al. · 2015 · Annals of Oncology
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- Phosphorescent Ir (III) complexes as cellular staining agents for biomedical molecular imagingSana A. Shaikh, Yihan Wang, Fawad Ur Rehman, Hui Jiang, Xuemei Wang · 2020 · Coordination Chemistry Reviews
- Mechanisms of translational deregulation in human tumors and therapeutic intervention strategiesBenoît Bilanges, David Stokoe · 2007 · Oncogene
- Targeting mTOR pathway: A new concept in cancer therapyS.H. Advani · 2010 · Indian Journal of Medical and Paediatric Oncology
- Statin-Dependent Suppression of the Akt/Mammalian Target of Rapamycin Signaling Cascade and Programmed Cell Death 4 Up-Regulation in Renal Cell CarcinomaJennifer Woodard, Antonella Sassano, Nissim Hay, Leonidas C. Platanias · 2008 · Clinical Cancer Research
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- Optimal targeting of the mTORC1 kinase in human cancerHeidi A. Lane, Madlaina Breuleux · 2009 · Current Opinion in Cell Biology
- Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinomaVirginie Nerich, Marion Hugues, Thierry Nai, Ulrich Stein, Thierry Nguyen Tan Hon, Philippe Montcuquet, Tristan Maurina, Guillaume Mouillet, Marie Justine Paillard, Laetitia Borowski et al. · 2014 · OncoTargets and Therapy
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- Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas.Fan Lin, Ping L. Zhang, Ximing J. Yang, Jeffrey W. Prichard, Mingyue Lun, Robert Eldon Brown · 2006 · PubMed
- Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignanciesThomas Elmer Witzig, Scott H. Kaufmann · 2006 · Current Treatment Options in Oncology
- Hypoxia-inducible factor 1 and its role in viral carcinogenesisSean Cuninghame, Robert Jackson, Ingeborg Zehbe · 2014 · Virology
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- mTOR and cancer: reason for dancing at the crossroads?GEORGE V. THOMAS · 2005 · Current Opinion in Genetics & Development