Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

Thomas, George V, Tran, Chris, Mellinghoff, Ingo K, Welsbie, Derek S, Chan, Emily, Fueger, Barbara, Czernin, Johannes, Sawyers, Charles L·2006·Nature Medicine

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  31. Everolimus in metastatic renal cell carcinoma: Subgroup analysis of patients with 1 or 2 previous vascular endothelial growth factor receptor-tyrosine kinase inhibitor therapies enrolled in the phase III RECORD-1 study
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  32. mTOR inhibitors in renal cell carcinoma
    Chiara Battelli, Daniel C. Cho · 2011 · Therapy
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    Edward Kenneth Geissler, Hans Jürgen Schlitt, George Thomas · 2008 · American Journal of Transplantation
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    Alberto Maria Martelli, Camilla Evangelisti, Francesca Chiarini, Cecilia Grimaldi, Lucia Manzoli, James Andrew McCubrey · 2009 · Expert Opinion on Investigational Drugs
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    William G. Kaelin · 2009 · Cancer
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    Jing Ying Tan, Puay Leng Lee, Zhimei Li, Xia Jiang, Yaw Chyn Lim, Shing Chuan Hooi, Qiang Yu · 2010 · Cancer Cell
  41. mTOR Inhibitors in Advanced Renal Cell Carcinoma
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  88. Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies
    Benoît Bilanges, David Stokoe · 2007 · Oncogene
  89. Targeting mTOR pathway: A new concept in cancer therapy
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  92. Optimal targeting of the mTORC1 kinase in human cancer
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  93. Clinical impact of targeted therapies in patients with metastatic clear-cell renal cell carcinoma
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  96. Morphoproteomic and molecular concomitants of an overexpressed and activated mTOR pathway in renal cell carcinomas.
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  100. mTOR and cancer: reason for dancing at the crossroads?
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