In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

Kishimoto, Hiroyuki, Kojima, Toru, Watanabe, Yuichi, Kagawa, Shunsuke, Fujiwara, Toshiya, Uno, Futoshi, Teraishi, Fuminori, Kyo, Satoru +5 more·2006·Nature Medicine
DOI 10.1038/nm1404

Cited by (178)

Items 101–178 of 178

  1. Multidisciplinary oncolytic virotherapy for gastrointestinal cancer
    Toshiyoshi Fujiwara · 2019 · Annals of Gastroenterological Surgery
  2. Experimental models to study lymphatic and blood vascular metastasis
    Lu Chen, Byron C. Hann, Lily Wu · 2011 · Journal of Surgical Oncology
  3. Lentivirus-Based DsRed-2-Transfected Pancreatic Cancer Cells for Deep In Vivo Imaging of Metastatic Disease
    Jiahua Zhou, Zeqian Yu, Susu Zhao, Liang Hu, Jie Zheng, De-Tong Yang, Michael Bouvet, Robert M. Hoffman · 2008 · Journal of Surgical Research
  4. A Cooperatively Activatable, DNA‐based Fluorescent Reporter for Imaging of Correlated Enzymatic Activities
    Zetan Fan, Jian Zhao, Xin Chai, Lele Li · 2021 · Angewandte Chemie
  5. Development of an oral cancer recurrence mouse model after surgical resection
    Simon · 2010 · International Journal of Oncology
  6. Anti-tumor effects of telomelysin for head and neck squamous cell carcinoma
    Fujita Fujita · 1994 · Oncology Reports
  7. Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment
    Hiroshi Tazawa, Kunitoshi Shigeyasu, Kazuhiro Noma, Shunsuke Kagawa, Fuminori Sakurai, Hiroyuki Mizuguchi, Hisataka Kobayashi, Takeshi Imamura, Toshiyoshi Fujiwara · 2022 · Cancer Science
  8. Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment
    Shuya Yano, Hiroshi Tazawa, Hiroyuki Kishimoto, Shunsuke Kagawa, Toshiyoshi Fujiwara, Robert M. Hoffman · 2021 · International Journal of Molecular Sciences
  9. Cancer imaging: Gene transcription-based imaging and therapeutic systems
    Hyo-Eun Carrie Bhang, Martin G. Pomper · 2012 · The International Journal of Biochemistry & Cell Biology
  10. Telomerase-Specific Oncolytic Virotherapy for Human Cancer with the hTERT Promoter
    Toshiyoshi Fujiwara, Noriaki Tanaka · 2008 · Uirusu
  11. Telomerase-specific virotherapy for human squamous cell carcinoma
    Toshiyoshi Fujiwara · 2009 · Expert Opinion on Biological Therapy
  12. A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus
    Tsuyoshi Sasaki, Hiroshi Tazawa, Joe Hasei, Shuhei Osaki, Toshiyuki Kunisada, Aki Yoshida, Yosuke Hashimoto, Shuya Yano, Ryuichi Yoshida, Shunsuke Kagawa et al. · 2012 · Gene Therapy
  13. Tumor-specific delivery of biologics by a novel T-cell line HOZOT
    Teppei Onishi, Hiroshi Tazawa, Yuuri Hashimoto, Makoto Takeuchi, Takeshi Otani, Shuji Nakamura, Fuminori Sakurai, Hiroyuki Mizuguchi, Hiroyuki Kishimoto, Yuzo Umeda et al. · 2016 · Scientific Reports
  14. Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis
    Jin Woo Choi, Pilhan Kim, Jun Ki Kim, Yi Rang Kim, Dai Fukumura, Seok Hyun Yun · 2015 · Theranostics
  15. Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer
    Satoru Kikuchi, Hiroyuki Kishimoto, Hiroshi Tazawa, Yuuri Hashimoto, Shinji Kuroda, Masahiko Nishizaki, Takeshi Nagasaka, Yasuhiro Shirakawa, Shunsuke Kagawa, Yasuo Urata et al. · 2014 · Molecular Therapy
  16. Combination of pet imaging with viral vectors for identification of cancer metastases
    Peter Brader, Richard J. Wong, Gilad Horowitz, Ziv Gil · 2011 · Advanced Drug Delivery Reviews
  17. Diagnostic and therapeutic application of telomerase-specific oncolytic adenoviral agents
    Toshiyoshi Fujiwara · 2007 · Frontiers in bioscience
  18. Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines
    Daisuke Sato, Yuji Kurihara, Seiji Kondo, Tatsuo Shirota, Yasuo Urata, Toshiyoshi Fujiwara, Satoru Shintani · 2013 · Oncology Reports
  19. A novel gene expression system for detecting viable bladder cancer cells
    Masami Watanabe · 2012 · International Journal of Oncology
  20. Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models
    Shuya Yano, Kiyoto Takehara, Hiroyuki Kishimoto, Yasuo Urata, Shunsuke Kagawa, Michael Bouvet, Toshiyoshi Fujiwara, Robert M. Hoffman · 2015 · Oncotarget
  21. Tumor interstitial fluid and gastric cancer metastasis: An experimental study to verify the hypothesis of “tumor-phlegm microenvironment”
    Da-zhi Sun, Jianpeng Jiao, JU Da-wei, Min Ye, Xuan Zhang, Jingyu Xu, Lu Ye, Jin He, Pin-kang Wei, Minghui Yang · 2012 · Chinese Journal of Integrative Medicine
  22. Antiviral activity of cidofovir against telomerase-specific replication-selective oncolytic adenovirus, OBP-301 (Telomelysin)
    Masaaki Ouchi, Hitoshi Kawamura, Yasuo Urata, Toshiyoshi Fujiwara · 2008 · Investigational New Drugs
  23. Gene and virotherapy for hematological malignancies
    Evidio Domingo‐Musibay, Masato Yamamoto · 2016 · International Journal of Hematology
  24. Functional remodeling of intraperitoneal macrophages by oncolytic adenovirus restores anti-tumor immunity for peritoneal metastasis of gastric cancer
    Motoyasu Tabuchi, Satoru Kikuchi, Hiroshi Tazawa, Tomohiro Okura, Toshihiro Ogawa, Ema Mitsui, Yuta Une, Shinji Kuroda, Hiroki Sato, Kazuhiro Noma et al. · 2024 · Molecular Therapy Oncology
  25. The Development of Transcription-Regulated Adenoviral Vectors with High Cancer-Selective Imaging Capabilities
    Ziyue Karen Jiang, Makoto Sato, Lily Wu · 2012 · Advances in cancer research
  26. Imaging and Adenoviral Gene Therapy
    Jillian R. Richter, Benjamin B. Kasten, Kurt R. Zinn · 2016 · Elsevier eBooks
  27. Molecular Bio-Imaging Probe for Non-Invasive Differentiation Between Human Leiomyoma Versus Leiomyosarcoma
    Shahinaz M. Shalaby, Mostafa Khater, Archana Laknaur, Ali S. Arbab, Ayman A. Al-Hendy · 2020 · Reproductive Sciences
  28. Optimization of an E1A Gene Expression Cassette in an Oncolytic Adenovirus for Efficient Tumor Cell Killing Activity
    Fuminori Sakurai, Fumitaka Nishimae, Kosuke Takayama, Hiroyuki Mizuguchi · 2021 · Anticancer Research
  29. Robust cancer-specific gene expression by a novel cassette with hTERT and CMV promoter elements
    Masakiyo Sakaguchi, Takuya Sadahira, Hideo Ueki, Rie Kinoshita, Hitoshi Murata, Ken-ichi Yamamoto, Junichiro Futami, Yasutomo Nasu, Kazuhiko Ochiai, Hiromi Kumon et al. · 2017 · Oncology Reports
  30. A Molecular Imaging System Based on Both Transcriptional and Genomic Amplification to Detect Prostate Cancer Cells In Vivo
    Frédéric Pouliot, Makoto Sato, Ziyue Karen Jiang, Steve Huyn, Breanne D.W. Karanikolas, Lily Wu · 2012 · Molecular Therapy
  31. Telomelysin shows potent antitumor activity through apoptotic and non‐apoptotic cell death in soft tissue sarcoma cells
    Gui‐Dong Li, Hiroyuki Kawashima, Akira Ogose, Takashi Ariizumi, Tetsuo Hotta, Ryozo Kuwano, Yasuo Urata, Toshiyoshi Fujiwara, Naoto Endo · 2013 · Cancer Science
  32. Rapamycin Enhances Adenovirus-Mediated Cancer Imaging and Therapy in Pre-Immunized Murine Hosts
    Ziyue Karen Jiang, Mai Johnson, Diana L. Moughon, Jennifer Kuo, Makoto Sato, Lily Wu · 2013 · PLoS ONE
  33. Meganuclease-mediated Virus Self-cleavage Facilitates Tumor-specific Virus Replication
    Engin Gürlevik, Peter Schache, Anneliese Goez, Arnold Kloos, Norman Woller, Nina Armbrecht, Michael Peter Manns, Stefan Kubicka, Florian Kühnel · 2013 · Molecular Therapy
  34. Shedding (Killer) Light on Tumors
    Robert M. Hoffman, Michael Bouvet · 2012 · Seminars in Thoracic and Cardiovascular Surgery
  35. Multimodal Key Anti-Oncolytic Therapeutics Are Effective In Cancer Treatment?
    Luyi Ye, Meng Gao, Yue Chen, Yuting Zhu, Jilong Wang, Z W Wang · 2025 · International Journal of Nanomedicine
  36. p53-armed oncolytic adenovirus induces apoptosis in pancreatic cancer-associated stellate cells via macropinocytosis
    Takeyoshi Nishiyama, Hiroshi Tazawa, Yasuo Nagai, Ryohei Shoji, Yoshinori Kajiwara, Naoyuki Hashimoto, Yosuke Takahashi, Satoru Kikuchi, Shinji Kuroda, Toshiaki Ohara et al. · 2025 · Cancer Gene Therapy
  37. Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus
    Koji Uotani, Hiroshi Tazawa, Joe Hasei, Tomohiro Fujiwara, Aki Yoshida, Yasuaki Yamakawa, Toshinori Omori, Kazuhisa Sugiu, Tadashi Komatsubara, Hiroya Kondo et al. · 2024 · PLoS ONE
  38. Fluorescent cell-selective ablation using an adaptive photodynamic method
    Yi Rang Kim, Jun Ki Kim, Jin Woo Choi · 2017 · Chemical Communications
  39. Development of Recombinant Adenovirus Carrying MicroRNA-regulated Gene Expression System
    Fuminori Sakurai, Hiroyuki Mizuguchi · 2010 · YAKUGAKU ZASSHI
  40. A dopamine antagonist, domperidone enhances the replication of an oncolytic adenovirus in human tumour cells
    Fumitaka Nishimae, Fuminori Sakurai, Ryosuke Ono, Rika Onishi, Kosuke Takayama, Hiroyuki Mizuguchi · 2022 · Journal of General Virology
  41. Enzymatic Cascade-Powered Urinary Diagnostics for Visual Cancer Monitoring
    Linlin Wang, Ruiyue Chen, Zhiyong Liu, Dongtao Zhou, Yanyin Zhang, Chao Teng, Bangshun He, Yi Yin, Yanfeng Gao, Jingjing Yang et al. · 2026 · ACS Nano
  42. Targeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer
    Toshiyoshi Fujiwara · 2010 · Springer eBooks
  43. Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer
    Toshiyoshi Fujiwara, Yasuo Urata, Noriaki Tanaka · 2009 · Humana Press eBooks
  44. Therapeutic Sentinel Lymph Node Imaging
    Stefan S. Kachala, Elliot L. Servais, Bernard J. Park, Valerie W. Rusch, Prasad S. Adusumilli · 2009 · Seminars in Thoracic and Cardiovascular Surgery
  45. Lentivirus-Based DsRed-2-Transfected Pancreatic Cancer Cells for Deep In Vivo Imaging of Metastatic Disease
    Zeqian Yu, Jiahua Zhou, Robert M. Hoffman · 2012 · Methods in molecular biology
  46. Collagen depletion by pirfenidone enhances antitumor effect of oncolytic adenovirus against peritoneal metastases of gastric cancer
    Tomohiro Okura, Satoru Kikuchi, Hiroshi Tazawa, Yu Mikane, Nobuhiko Kanaya, Ema Mitsui, Yuta Une, Kunitoshi Shigeyasu, Toshiaki Ohara, Shinji Kuroda et al. · 2025 · Molecular Therapy Oncology
  47. Imaging the hallmarks of cancer
    Jan Grimm, Fabian M. Kiessling, Kevin Michael Brindle, Douglas Hanahan, Sanjay Kumar Jain, Philippe Lambin, Twan Lammers, King C. Li, I. Jolanda de Vries, Wolfgang Weber et al. · 2026 · Nature reviews. Cancer
  48. Laparoscopic Fluorescence Imaging for Identification and Resection of Pancreatic and Hepatobiliary Cancer
    Michael Bouvet, Robert M. Hoffman · 2013 · Frontiers of gastrointestinal research
  49. Development of a Detection System for Circulating Tumor Cells in Peripheral Blood Using a Next Generation Conditionally-replicating Adenovirus
    Fuminori Sakurai, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi · 2013 · YAKUGAKU ZASSHI
  50. A Novel Liquid Biopsy Strategy to Detect Small Amounts of Cancer Cells Using Cancer-Specific Replication Adenoviruses
    Masahiro Takakura, Emi Takata, Toshiyuki Sasagawa · 2020 · Journal of Clinical Medicine
  51. p21 cιp/WAF is a key regulator of long‐term radiation damage in mesenchyme‐derived tissues
    Babak J. MenTara, Tomer Avraham, Marc A. Soares, John G. Fernandez, Alan Yan, Jamie C. Zampell, Victor Piana de Andrade, Andrew P. Cordeiro, Cristina M. Sorrento · 2010 · The FASEB Journal
  52. Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models
    Ziyue Karen Jiang · 2013 · eScholarship (California Digital Library)
  53. Replication-competent adenovirus 11p vector as a new oncolytic agent
    Jim Silver · 2011 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  54. Telomerase-specific virotherapy targeting lymph node micrometastasis of human cancer
    Toru Kojima, Yuichi Watanabe, Yuuri Hashimoto, Shinji Kuroda, Yasumoto Yamasaki, Shuya Yano, Hiroshi Tazawa, Futoshi Uno, Shunsuke Kagawa, Noriaki Tanaka et al. · 2013 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  55. Development of innovative therapies for gastrointestinal cancer
    Toshiyoshi Fujiwara · 2010 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  56. Development of novel detecting systems and therapies for micro cancer using replication-competent oncolytic adenovirus
    Toru Kojima, Yuuri Hashimoto, Shunsuke Kagawa, Noriaki Tanaka, Yasuo Urata, Toshiyoshi Fujiwara · 2010 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  57. Radiosensitization by telomerase-dependent oncolytic adenovirus
    Shinji Kuroda, Toshiya Fujiwara, Yasuhiro Shirakawa, Yasumoto Yamasaki, Syuya Yano, Futoshi Uno, Hiroshi Tazawa, Yuuri Hashimoto, Yuichi Watanabe, Kazuhiro Noma et al. · 2011 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  58. In Vivo Imaging of Human Cancer with Telomerase-Specific Replication-Selective Adenovirus
    Toshiyoshi Fujiwara · 2012 · Methods in molecular biology
  59. Gene Therapy: Technologies and Applications
    Ryuichi Morishita, Hironori Nakagami A · 2013
  60. The 2015 Incentive Award of the Okayama Medical Association in Cancer Research (2015 Hayashibara Prize and Yamada Prize)
    Kunitoshi Shigeyasu · 2016 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  61. Gene therapy for cancer treatment
    Shunsuke Kagawa, Toshiyoshi Fujiwara · 2013
  62. The Use of Patient-Derived Orthotopic Xenograft (PDOX) Models to Develop Curative Fluorescence-Guided Surgery of Cancer
    Robert M. Hoffman, Yukihiko Hiroshima, Shuya Yano, Cristina Angela Metildi, Michael Bouvet · 2017 · Molecular and translational medicine
  63. Comparison of fluorescence-labeling strategies of colon cancer for fluorescence-guided surgery of liver metastasis in orthotopic mouse models
    Robert M. Hoffman, Takashi Murakami, Shuya Yano, Yukihiko Hiroshima, Hiroto Nishino, Michael Bouvet · 2020 · Elsevier eBooks
  64. The 2016 Incentive Award of the Okayama Medical Association in Cancer Research (2016 Hayashibara Prize and Yamada Prize)
    Satoru Kikuchi · 2012 · Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
  65. Functional Molecular Imaging of Prostate Cancer Lymph Node Metastases: Adenovirus-Mediated Lymph Node Detection
    Saul J. Priceman, Jeremy B. Burton, Lily Wu · 2009 · Humana Press eBooks
  66. Faculty Opinions recommendation of In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation.
    Igor Štagljar, Jamie D. Snider · 2009 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  67. Data from Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences
    Kumiko Sugio, Fuminori Sakurai, Kazufumi Katayama, Katsuhisa Tashiro, Hayato Matsui, Kenji Kawabata, Atsushi Kawase, Masahiro Iwaki, Takao Hayakawa, Toshiyoshi Fujiwara et al. · 2023
  68. Data from Malignant Pleural Mesothelioma–Targeted CREBBP/EP300 Inhibitory Protein 1 Promoter System for Gene Therapy and Virotherapy
    Takuya Fukazawa, Junji Matsuoka, Yoshio Naomoto, Yutaka Maeda, Mary L. Durbin, Noriaki Tanaka · 2023
  69. Data from Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences
    Kumiko Sugio, Fuminori Sakurai, Kazufumi Katayama, Katsuhisa Tashiro, Hayato Matsui, Kenji Kawabata, Atsushi Kawase, Masahiro Iwaki, Takao Hayakawa, Toshiyoshi Fujiwara et al. · 2023
  70. Data from Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer
    Ryo Sakai, Shunsuke Kagawa, Yasumoto Yamasaki, Toru Kojima, Futoshi Uno, Yuuri Hashimoto, Yuichi Watanabe, Yasuo Urata, Noriaki Tanaka, Toshiyoshi Fujiwara · 2023
  71. Data from Preclinical Evaluation of Differentially Targeting Dual Virotherapy for Human Solid Cancer
    Ryo Sakai, Shunsuke Kagawa, Yasumoto Yamasaki, Toru Kojima, Futoshi Uno, Yuuri Hashimoto, Yuichi Watanabe, Yasuo Urata, Noriaki Tanaka, Toshiyoshi Fujiwara · 2023
  72. Additional file 4 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Ryuichi Yoshida, Tazawa, Hiroshi et al. · 2021 · Figshare
  73. Additional file 6 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Ryuichi Yoshida, Tazawa, Hiroshi et al. · 2021 · Figshare
  74. Additional file 3 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Yoshida, Ryuichi, Tazawa, Hiroshi et al. · 2021 · Figshare
  75. Additional file 2 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Ryuichi Yoshida, Tazawa, Hiroshi et al. · 2021 · Figshare
  76. Additional file 1 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Ryuichi Yoshida, Tazawa, Hiroshi et al. · 2021 · Figshare
  77. Additional file 5 of Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation
    Atene Ito, Kagawa, Shunsuke, Sakamoto, Shuichi, Kazuya Kuwada, Hiroki Kajioka, Yoshimoto, Masashi, Satoru Kikuchi, Kuroda, Shinji, Ryuichi Yoshida, Tazawa, Hiroshi et al. · 2021 · Figshare
  78. Mitochondrial inhibition enhances the sensitivity of pancreatic ductal adenocarcinoma cells to oncolytic adenovirus
    Ryohei Shoji, Hiroshi Tazawa, Shinji Kuroda, Takeyoshi Nishiyama, Yoshinori Kajiwara, Motohiko Yamada, Yasuo Nagai, Hiroaki Inoue, Naoyuki Hashimoto, Satoru Kikuchi et al. · 2026 · Molecular Therapy Oncology