Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Vogl, Thomas, Tenbrock, Klaus, Ludwig, Stephan, Leukert, Nadja, Ehrhardt, Christina, van Zoelen, Marieke A D, Nacken, Wolfgang, Foell, Dirk +3 more·2007·Nature Medicine

DOI 10.1038/nm1638

Cited by (1,001)

Items 401–500 of 1,001

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Shuning Sun, Shi-Hao Ni, Yue Li, Xin Liu, Jianping Deng, Zixin Chen, Huan Li, Wenjun Feng, Yu‐Sheng Huang, Da-Nian Li et al. · 2021 · Cell Death and Disease
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Membrane TLR signaling mechanisms in the gastrointestinal tract during sepsis
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Mélissa Côté, Janelle Drouin‐Ouellet, Francesca Cicchetti, Denis Soulet · 2011 · Brain Behavior and Immunity
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