Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

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3. Toll-like Receptor
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5. In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock
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7. β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner
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10. S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll‐like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis
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13. Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion
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14. Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells
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15. Calcium-Binding Proteins S100A8 and S100A9: Investigation of Their Immune Regulatory Effect in Myeloid Cells
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18. IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases
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19. Inhibition of TLR4 signalling to dampen joint inflammation in osteoarthritis
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20. Myeloid-related protein 8 induces self-tolerance and cross-tolerance to bacterial infection via TLR4- and TLR2-mediated signal pathways
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21. Psoriasis and extra domain A fibronectin loops
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22. DNAX-activating Protein 10 (DAP10) Membrane Adaptor Associates with Receptor for Advanced Glycation End Products (RAGE) and Modulates the RAGE-triggered Signaling Pathway in Human Keratinocytes
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23. S100-alarmins: potential therapeutic targets for arthritis
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24. Differences in lipopolysaccharide-induced signaling between conventional dendritic cells and macrophages
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25. The roles of toll-like receptor 4, CD33, CD68, CD69, or CD147/EMMPRIN for monocyte activation by the DAMP S100A8/S100A9
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26. S100A8/A9-alarmin promotes local myeloid-derived suppressor cell activation restricting severe autoimmune arthritis
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27. Role of toll-like receptors in systemic sclerosis
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28. TNFα ‐ and IL ‐17A‐mediated S100 A 8 expression is regulated by p38 MAPK
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29. S100A9 Knockout Decreases the Memory Impairment and Neuropathology in Crossbreed Mice of Tg2576 and S100A9 Knockout Mice Model
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31. Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
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32. The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2–mediated Allergic Airway Inflammation
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36. SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice via NF-ĸB Activation
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37. A role for neutrophils in early enthesitis in spondyloarthritis
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38. Anti-inflammatory and gut microbiota modulatory effects of polysaccharides from Fuzhuan brick tea on colitis in mice induced by dextran sulfate sodium
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39. The anti-oxidative, anti-inflammatory, and protective effect of S100A8 in endotoxemic mice
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40. Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation
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45. Role of the Receptor for Advanced Glycation End Products (RAGE) and Its Ligands in Inflammatory Responses
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46. Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity?
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48. Role of S100 Proteins in Colorectal Carcinogenesis
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49. EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation
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50. TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still’s Disease and Their Association with Disease Activity and Clinical Manifestations
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51. The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness
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52. Neuroplastin‐β mediates S100A8/A9‐induced lung cancer disseminative progression
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56. High density of S100A9 positive inflammatory cells in prostate cancer stroma is associated with poor outcome
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57. Klotho and S100A8/A9 as Discriminative Markers between Pre-Renal and Intrinsic Acute Kidney Injury
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68. Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia
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71. Differential expression of alarmins—S100A9, IL-33, HMGB1 and HIF-1α in supraspinatus tendinopathy before and after treatment
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74. S100A proteins in the pathogenesis of experimental corneal neovascularization.
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75. Human S100A9 potentiates IL‐8 production in response to GM‐CSF or fMLP via activation of a different set of transcription factors in neutrophils
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77. TLR9 Ligands Induce S100A8 in Macrophages via a STAT3-Dependent Pathway which Requires IL-10 and PGE2
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80. -1,3-Galactosyl-O-Glycosyl-Glycoprotein -1,6-N-Acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility
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81. Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease
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84. Loss of Myeloid Related Protein-8/14 Exacerbates Cardiac Allograft Rejection
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85. High Amounts of S100-Alarmins Confer Antimicrobial Activity on Human Breast Milk Targeting Pathogens Relevant in Neonatal Sepsis
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86. Role of alarmins in poststroke inflammation and neuronal repair
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87. Impact of S100A8/A9 Expression on Prostate Cancer Progression In Vitro and In Vivo
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88. RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells
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89. Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-γ Agonist Rivoglitazone
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90. A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury
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91. Platelet activation and platelet–leukocyte interaction in generalized aggressive periodontitis
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92. Association Between Serum S100A8/S100A9 Heterodimer and Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease
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93. Inflammation in the brain and periphery found in animal models of depression and its behavioral relevance
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94. Neutrophil Extracellular Traps: Inflammation and Biomaterial Preconditioning for Tissue Engineering
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95. S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
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96. Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer
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97. Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis
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98. Myeloid-related protein-14 regulates deep vein thrombosis
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99. Galectin-3 and S100A9: Novel Diabetogenic Factors Mediating Pancreatic Cancer–Associated Diabetes
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100. Salivary calprotectin is elevated in patients with active inflammatory bowel disease
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