Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Danial, Nika N, Walensky, Loren D, Zhang, Chen-Yu, Choi, Cheol Soo, Fisher, Jill K, Molina, Anthony J A, Datta, Sandeep Robert, Pitter, Kenneth L +14 more·2008·Nature Medicine

Cited by (314)

Items 101–200 of 314

  1. Insulin Signaling Regulates Mitochondrial Function in Pancreatic β-Cells
    Liu, Siming, Okada, Terumasa, Assmann, Anke, Soto, Jamie, Liew, Chong Wee, Bugger, Heiko, Shirihai, Orian S., Abel, E. Dale, Kulkarni, Rohit N. · 2009 · PLoS ONE
  2. Glucose metabolism and programmed cell death: an evolutionary and mechanistic perspective
    Ayala King, Eyal Gottlieb · 2009 · Current Opinion in Cell Biology
  3. Changing appetites: the adaptive advantages of fuel choice
    Illana A. Stanley, Sofia M. Ribeiro, Alfredo Giménez-Cassina, Erik Norberg, Nika N. Danial · 2013 · Trends in Cell Biology
  4. A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators
    Benjamin Szlyk, Craig R. Braun, Sanda Ljubicic, Elaura Patton, Gregory H. Bird, Mayowa A. Osundiji, Franz M. Matschinsky, Loren D. Walensky, Nika N. Danial · 2013 · Nature Structural & Molecular Biology
  5. Non-Canonical Roles of Apoptotic Caspases in the Nervous System
    Mahshid H. Dehkordi, Robert G.K. Munn, Howard O. Fearnhead · 2022 · Frontiers in Cell and Developmental Biology
  6. Investigating Endogenous Peptides and Peptidases Using Peptidomics
    Arthur D. Tinoco, Alan Saghatelian · 2011 · Biochemistry
  7. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP
    Elizabeth A. Lane, Dong Wook Choi, Luisa García-Haro, Zebulon G. Levine, Meghan Tedoldi, Suzanne Walker, Nika N. Danial · 2019 · Molecular Cell
  8. Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics
    Franz M. Matschinsky, Daniel Porte · 2010 · F1000 Medicine Reports
  9. Photoreactive Stapled BH3 Peptides to Dissect the BCL-2 Family Interactome
    Craig R. Braun, Julian Mintseris, Evripidis Gavathiotis, Gregory H. Bird, Steven P. Gygi, Loren D. Walensky · 2010 · Chemistry & Biology
  10. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
    Liansheng Zhang, Yun Qian, Jie Li, Xuan Zhou, He Jax Xu, Jie Yan, Jialing Xiang, Xiang Yuan, Beicheng Sun, Sangram S. Sisodia et al. · 2021 · iScience
  11. Mitochondria mediated cell death in diabetes
    György Szabadkai, Michael R. Duchen · 2009 · APOPTOSIS
  12. Research and Development of Glucokinase Activators for Diabetes Therapy: Theoretical and Practical Aspects
    Franz M. Matschinsky, Bogumił Zelent, Nicolai M. Doliba, Klaus H. Kaestner, Jane M. Vanderkooi, Joseph S. Grimsby, Steven J. Berthel, Ramakanth Sarabu · 2011 · Handbook of experimental pharmacology
  13. Death by Committee: Organellar Trafficking and Communication in Apoptosis
    Joseph E. Aslan, Gary Thomas · 2009 · Traffic
  14. Expression of the Bcl-2 Protein BAD Promotes Prostate Cancer Growth
    Adrienne J. Smith, Yelena Karpova, Ralph D'Agostino, Mark C. Willingham, George Kulik · 2009 · PLoS ONE
  15. 14-3-3 proteins are essential signalling hubs for beta cell survival
    Gareth E. Lim, Micah Piske, James D. Johnson · 2013 · Diabetologia
  16. Different downstream signalling of CCK1receptors regulates distinct functions of CCK in pancreatic beta cells
    Shanglei Ning, Wenshuai Zheng, Jing Su, Nan Liang, Hui zi Li, Daolai Zhang, Chunhua Liu, Junhong Dong, Zheng‐kui Zhang, Min Cui et al. · 2015 · British Journal of Pharmacology
  17. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
    Accalia Fu, Lara van Rooyen, Lindsay Evans, Nina Armstrong, Daina Zofija Avizonis, Tatsuya Kin, Gregory H. Bird, Anita Reddy, Edward T. Chouchani, Marc Liesa et al. · 2021 · Cell Reports
  18. Bcl-2 family proteins, beyond the veil
    Jason Glab, Zhipeng Cao, Hamsa Puthalakath · 2020 · International review of cytology
  19. Homeostatic Functions of BCL-2 Proteins beyond Apoptosis
    Nika N. Danial, Alfredo Giménez-Cassina, Daniel Tondera · 2010 · Advances in experimental medicine and biology
  20. Direct targeting of β-catenin: Inhibition of protein–protein interactions for the inactivation of Wnt signaling
    Hahne, Gernot, Grossmann, Tom N. · 2013 · Bioorganic & Medicinal Chemistry
  21. Upregulation of BAD, a pro-apoptotic protein of the BCL2 family, in vascular smooth muscle cells exposed to uremic conditions
    E. Trécherel, Corinne Godin, Christophe Louandre, Joyce Benchitrit, Sabrina Poirot, Jean‐Claude Mazière, Ziad A. Massy, Antoine Galmiche · 2011 · Biochemical and Biophysical Research Communications
  22. Can 14-3-3 proteins serve as therapeutic targets for the treatment of metabolic diseases?
    Kadidia Diallo, Abel K. Oppong, Gareth E. Lim · 2018 · Pharmacological Research
  23. Bis‐Azobenzene Crosslinkers for Photocontrol of Peptide Structure
    Subhas Samanta, G. Andrew Woolley · 2011 · ChemBioChem
  24. Anti-incretin, Anti-proliferative Action of Dopamine on β-Cells
    Antonella Maffei, Ann Marie Segal, Juan Carlos Álvarez-Pérez, Adolfo Garcı́a-Ocaña, Paul E. Harris · 2015 · Molecular Endocrinology
  25. Getting away with murder: how does the BCL‐2 family of proteins kill with immunity?
    Thibaud T. Renault, Jerry E. Chipuk · 2013 · Annals of the New York Academy of Sciences
  26. The apoptotic members CD95, BclxL, and Bcl-2 cooperate to promote cell migration by inducing Ca2+ flux from the endoplasmic reticulum to mitochondria
    Amélie Fouqué, Eléonore Lepvrier, Laure Debure, Y Gouriou, Marine Malleter, Vanessa Delcroix, Michel Ovize, Thomas Ducret, Chenqi Li, Mehdi Hammadi et al. · 2016 · Cell Death and Differentiation
  27. BAD and KATP channels regulate neuron excitability and epileptiform activity
    Juan Ramón Martínez‐François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N. Danial, Gary Yellen · 2018 · eLife
  28. Chapter 23 Dissection of the BCL‐2 Family Signaling Network with Stabilized α‐Helices of BCL‐2 Domains
    Kenneth L. Pitter, Federico Bernal, James L. LaBelle, Loren D. Walensky · 2008 · Methods in enzymology on CD-ROM/Methods in enzymology
  29. A New i, i + 3 Peptide Stapling System for α‐Helix Stabilization
    So Youn Shim, Young‐Woo Kim, Gregory L. Verdine · 2013 · Chemical Biology & Drug Design
  30. Small‐Molecule and Peptide Inhibitors of the Pro‐Survival Protein Mcl‐1
    Andrew Michael Beekman, Lesley A. Howell · 2015 · ChemMedChem
  31. Dying for Something to Eat: How Cells Respond to Starvation
    Alfredo Caro‐Maldonado, Cristina Muñoz‐Pinedo · 2011 · The Open Cell Signaling Journal
  32. Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2Agonism and Glucose-Dependent Insulin Secretion
    Fabrizio Giordanetto, Jefferson D. Revell, Laurent Knerr, Marie Hostettler, Amalia Paunovic, Claire Priest, Annika Janefeldt, Adrian L. Gill · 2013 · ACS Medicinal Chemistry Letters
  33. Acute Insulin Signaling in Pancreatic Beta-Cells Is Mediated by Multiple Raf-1 Dependent Pathways
    Emilyn U. Alejandro, Tatyana B. Kalynyak, Farnaz Taghizadeh, Kamila Gwiazda, Erin K. Rawstron, Karen J. Jacob, James D. Johnson · 2010 · Endocrinology
  34. How does metabolism affect cell death in cancer?
    Elodie Villa, Jean‐Ehrland Ricci · 2015 · FEBS Journal
  35. Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia
    Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Monica Piedimonte, Agostino Tafuri · 2017 · Advances in Biological Regulation
  36. Targeting Protein–Protein Interfaces with Peptides: The Contribution of Chemical Combinatorial Peptide Library Approaches
    Alessandra Monti, Luigi Vitagliano, Andrea Caporale, Menotti Ruvo, Nunzianna Doti · 2023 · International Journal of Molecular Sciences
  37. Truncated and constrained helical analogs of antimicrobial esculentin-2EM
    Thanh K. Pham, Do-Hee Kim, Bong‐Jin Lee, Young‐Woo Kim · 2013 · Bioorganic & Medicinal Chemistry Letters
  38. Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice
    Antoine Rohrbach, Émilie Caron, Rafik Dali, Maxime Brunner, Roxane Pasquettaz, Irina Kolotuev, Federico Andrea Santoni, Bernard Thorens, Fanny Langlet · 2021 · Molecular Metabolism
  39. Pancreatic β‐cell Raf‐1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription
    Emilyn U. Alejandro, Gareth E. Lim, Arya E. Mehran, Xiaoke Hu, Farnaz Taghizadeh, Dmytro Pelipeychenko, Manuela Baccarini, James D. Johnson · 2011 · The FASEB Journal
  40. Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism
    Jasdeep K. Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Hélène Lemieux et al. · 2019 · Oncogene
  41. Procaspase-3 regulates fibronectin secretion and influences adhesion, migration and survival independent of catalytic function
    Matthew Brentnall, David B. Weir, Anthony Rongvaux, Adam I. Marcus, Lawrence Boise · 2014 · Journal of Cell Science
  42. New Modalities in Conformationally Constrained Peptides for Potency, Selectivity and Cell Permeation
    Ram Dharanipragada · 2013 · Future Medicinal Chemistry
  43. G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment
    Pallabi Sengupta, Samit Chattopadhyay, Subhrangsu Chatterjee · 2017 · Drug Discovery Today
  44. Phospho-BAD BH3 Mimicry Protects β Cells and Restores Functional β Cell Mass in Diabetes
    Sanda Ljubicic, Klaudia Z. Polak, Accalia Fu, Jessica M. Wiwczar, Benjamin Szlyk, Yigang Chang, Juan Carlos Álvarez-Pérez, Gregory H. Bird, Loren D. Walensky, Adolfo Garcı́a-Ocaña et al. · 2015 · Cell Reports
  45. BH3-Only Proteins in Health and Disease
    Jason Glab, George Williams Mbogo, Hamsa Puthalakath · 2016 · International review of cytology
  46. The BH3-only protein Bad confers breast cancer taxane sensitivity through a nonapoptotic mechanism
    Alison C Craik, Richard A. Veldhoen, Matt Czernick, Timothy W. Buckland, K Kyselytzia, Sunita Ghosh, Raymond L. Lai, Swathi Damaraju, D. Alan Underhill, John Robert Mackey et al. · 2010 · Oncogene
  47. MISC-1/OGC Links Mitochondrial Metabolism, Apoptosis and Insulin Secretion
    Marco Gallo, Donha Park, Dan S. Luciani, Katarzyna Kida, Ferdinando Palmieri, Oliver E. Blacque, James D. Johnson, Donald L Riddle · 2011 · PLoS ONE
  48. Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress
    Yihao Liu, Clinton C. Bertram, Q Shi, Sandra S. Zinkel · 2010 · Cell Death and Differentiation
  49. Automated Design of Macrocycles for Therapeutic Applications: From Small Molecules to Peptides and Proteins
    Dan Sindhikara, Michael Wagner, Paraskevi Gkeka, Stefan Güssregen, Garima Tiwari, Gerhard Heßler, Engin Yapici, Ziyu Li, Andreas Evers · 2020 · Journal of Medicinal Chemistry
  50. Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic Reprogramming
    Zeenat Farooq, Hagar Ismail, Sheraz Ahmad Bhat, Brian Thomas Layden, Md. Wasim Khan · 2023 · Life
  51. Emerging roles for β-arrestin-1 in the control of the pancreatic β-cell function and mass: New therapeutic strategies and consequences for drug screening
    Stéphane Dalle, Magalie A. Ravier, Gyslaine Bertrand · 2010 · Cellular Signalling
  52. Human Embryonic Stem Cells Express Elevated Levels of Multiple Pro-Apoptotic BCL-2 Family Members
    David T. Madden, Diana Davila-Kruger, Simon Melov, Dale E. Bredesen · 2011 · PLoS ONE
  53. Mutational analysis of allosteric activation and inhibition of glucokinase
    Bogumił Zelent, Stella Odili, Carol W. Buettger, Dorothy Zelent, Pan Chen, Deborah Fenner, Joseph T. Bass, Charles A. Stanley, Monique Laberge, Jane M. Vanderkooi et al. · 2011 · Biochemical Journal
  54. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions
    Yaw Sing Tan, David R. Spring, Chris Abell, Chandra Shekhar Verma · 2015 · Journal of Chemical Theory and Computation
  55. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX
    Daniel T. Cohen, Thomas E. Wales, Matthew W. McHenry, John R. Engen, Loren D. Walensky · 2020 · Cell Reports
  56. Defining the role of the Bcl-2 family proteins in Huntington’s disease
    Jenny Sassone, AnnaMaria Maraschi, Fabiana Sassone, Vincenzo Silani, Andrea Ciammola · 2013 · Cell Death and Disease
  57. The Bcl-2 family in autoimmune and degenerative disorders
    Delphine Mérino, Philippe Bouillet · 2009 · APOPTOSIS
  58. Transcriptome Profiling of m6A mRNA Modification in Bovine Mammary Epithelial Cells Treated with Escherichia coli
    Ting Li, Changjie Lin, Yifan Zhu, Haojun Xu, Yiya Yin, Chaohao Wang, Xin Tang, Tongxing Song, Aizhen Guo, Yingyu Chen et al. · 2021 · International Journal of Molecular Sciences
  59. JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity
    Sara A. Litwak, Lokman Pang, Sandra Galić, Mariana Igoillo‐Esteve, William J. Stanley, Jean‐Valéry Turatsinze, Kim Loh, Helen E. Thomas, Arpeeta Sharma, Eric Trépo et al. · 2017 · Diabetes
  60. Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
    Yohannes Afework Mebratu, Ivan Leyva-Baca, Marc G. Wathelet, Neal E. Lacey, Hitendra Singh Chand, Augustine M.K. Choi, Yohannes Tesfaigzi · 2017 · Nature Communications
  61. Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation
    P. Campbell, A. Weinberg, Jonathan Chee, L. Mariana, Rochelle Ayala, W. Hawthorne, P. O'Connell, T. Loudovaris, M. Cowley, T. Kay et al. · 2012 · Cell Transplantation
  62. Discovery of a Novel Site Regulating Glucokinase Activity following Characterization of a New Mutation Causing Hyperinsulinemic Hypoglycemia in Humans
    Nicola L. Beer, Martijn van de Bunt, Kevin Colclough, Christine Lukacs, Paul Arundel, Constance L. Chik, Joseph S. Grimsby, Sian Ellard, Anna L. Gloyn · 2011 · Journal of Biological Chemistry
  63. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family
    Tejia Zhang, Lauren A. Barclay, Loren D. Walensky, Alan Saghatelian · 2015 · Journal of Lipid Research
  64. Activation of NFκB dependent apoptotic pathway in pancreatic islet cells by hypoxia
    Yi Lai, Heide Brandhorst, Hamid Hossain, Angelika Bierhaus, Chunguang Chen, Reinhard G. Bretzel, Thomas Linn · 2009 · Islets
  65. Intermediary metabolism: An intricate network at the crossroads of cell fate and function
    Leonardo M. R. Ferreira, Albert Mao Li, Teresa L. Serafim, Margarida C.M. Sobral, Maria Carmen Alpoim, Ana M. Urbano · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  66. Gating of the Mitochondrial Permeability Transition Pore by Long Chain Fatty Acyl Analogs in Vivo
    Dmitri Samovski, Bella Kalderon, Einav Yehuda‐Shnaidman, Jacob Bar‐Tana · 2009 · Journal of Biological Chemistry
  67. Repair of diverse diabetic defects of β‐cells in man and mouse by pharmacological glucokinase activation
    Nicolai M. Doliba, Deborah Fenner, Bogumił Zelent, Joseph T. Bass, Ramakanth Sarabu, Franz M. Matschinsky · 2012 · Diabetes Obesity and Metabolism
  68. Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction
    Yue Wang, Quan Liu, Yi Huan, Rongcui Li, Caina Li, Sujuan Sun, Nan Guo, Miaomiao Yang, Shuainan Liu, Zhufang Shen · 2018 · Experimental Cell Research
  69. Understanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine
    Vasileios A. Stamelos, Charles W. E. Redman, Alan Richardson · 2012 · Journal of Molecular Signaling
  70. A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential
    Bird, Gregory H., Patten, J. J., Zavadoski, William, Barucci, Nicole, Godes, Marina, Moyer, Benjamin M., Owen, Callum D., DaSilva-Jardine, Paul, Neuberg, Donna S., Bowen, Richard A. et al. · 2024 · Nature Communications
  71. Regulation of protein–protein interactions using stapled peptides
    Andrew G. Jamieson, Naomi Robertson · 2015 · Reports in Organic Chemistry
  72. The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet
    Caroline Treins, Samira Alliouachene, Rim Hassouna, Yun Xie, Morris J. Birnbaum, Mario Pende · 2012 · Molecular and Cellular Biology
  73. Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide‑1 Receptor
    Gregory H. Bird, Accalia Fu, Silvia Escudero, Marina Godes, Kwadwo Opoku-Nsiah, Thomas E. Wales, Michael D. Cameron, John R. Engen, Nika N. Danial, Loren D. Walensky · 2020 · ACS Chemical Biology
  74. Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells
    Qifan Yang, Xianxiu Qiu, Xiaozhe Zhang, Yingting Yu, Na Li, Xing Wei, Guoqin Feng, Yan Li, Yanxiang Zhao, Renxiao Wang · 2021 · Journal of Medicinal Chemistry
  75. Endogenous and imposed determinants of apoptotic vulnerabilities in cancer
    Kristopher A. Sarosiek, Kris C. Wood · 2022 · Trends in cancer
  76. Stapling Mimics Noncovalent Interactions of γ-Carboxyglutamates in Conantokins, Peptidic Antagonists of N-Methyl-d-Aspartic Acid Receptors
    Randall J. Platt, Tiffany Han, Brad R. Green, Misty D. Smith, Jack J. Skalicky, Paweł Gruszczyński, H. Steve White, Baldomero M. Olivera, Grzegorz W. Bulaj, Joanna Gajewiak · 2012 · Journal of Biological Chemistry
  77. Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38δ MAPK-dependent exocytosis in pancreatic β-cells
    Jizheng Chen, Fang Wang, Yue Zhou, Jing Jiang, Sulaiman Ksimu, Xu Zhang, John Zhong Li, Junqi Niu, Qian Wang · 2020 · Clinical Science
  78. Pim3 negatively regulates glucose-stimulated insulin secretion
    Gregory Riccardo Vlacich, Martijn C. Nawijn, Gene C. Webb, Donald F. Steiner · 2010 · Islets
  79. Molecular modeling of BAD complex resided in a mitochondrion integrating glycolysis and apoptosis
    Jie Yang, Jiahuang Li, Jin Wang, Chen‐Yu Zhang · 2010 · Journal of Theoretical Biology
  80. Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors
    Jade England, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Maja Krajinović, Caroline Laverdière, Emile H. Levy, Valérie Marcil, Daniel Sinnett · 2017 · BMC Cancer
  81. Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes
    Umberto De Marchi, Silvia Fernandez‐Martinez, Sergio de la Fuente, Andreas Wiederkehr, Jaime Santo Domingo · 2020 · British Journal of Pharmacology
  82. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages
    Jie Li, Liansheng Zhang, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang et al. · 2020 · eLife
  83. Control of Insulin Secretion by Cytochrome c and Calcium Signaling in Islets with Impaired Metabolism
    Austin M. Rountree, Adam S. Neal, Mark Lisowski, Norma O. Rizzo, Jared R. Radtke, Sarah White, Dan S. Luciani, Francis Kim, Christiane S. Hampe, Ian R. Sweet · 2014 · Journal of Biological Chemistry
  84. Comparison of hydrocarbon-and lactam-bridged cyclic peptides as dimerization inhibitors of Leishmania infantum trypanothione reductase
    Pedro A. Sánchez‐Murcia, Marta Ruiz‐Santaquiteria, Miguel Toro-Londoño, Héctor de Lucio, María Angeles Jiménez, Federico Gago, Antonio Jiménez-Ruı́z, María‐José Camarasa, Sonsoles Velázquez · 2015 · RSC Advances
  85. Discovery of Novel PTP1B Inhibitors with Once-Weekly Therapeutic Potential for Type 2 Diabetes: Design, Synthesis, and In Vitro and In Vivo Investigations of BimBH3 Peptide Analogues
    Chuanliang Zhang, Xianmin Yang, Xinjia Meng, Lijuan Wu, Xiaochun Liu, Jiangming Gao, Shan Liu, Juan Wu, Dingmin Huang, Zhenwei Wang et al. · 2023 · Journal of Medicinal Chemistry
  86. Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress
    Sarah A. White, Lisa S. Zhang, Daniel J. Pasula, Yu Hsuan Carol Yang, Dan S. Luciani · 2020 · Scientific Reports
  87. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus
    Kota Nishihama, Taro Yasuma, Yutaka Yano, Corina N. D’ Alessandro‐Gabazza, Masaaki Toda, Josephine A. Hinneh, Prince Baffour Tonto, Atsuro Takeshita, Toshiaki Totoki, Rumi Mifuji‐Moroka et al. · 2018 · Metabolism
  88. AILERON Therapeutics
    Tomi K. Sawyer · 2008 · Chemical Biology & Drug Design
  89. Discovery of Novel PTP1B Inhibitors Derived from the BH3 Domain of Proapoptotic Bcl-2 Proteins with Antidiabetic Potency
    Chuanliang Zhang, Lijuan Wu, Xiaochun Liu, Jiangming Gao, Shan Liu, Juan Wu, Dingmin Huang, Zhenwei Wang, Xianbin Su · 2021 · ACS Medicinal Chemistry Letters
  90. RNA-seq analysis of the hypothalamic transcriptome reveals the networks regulating physiopathological progress in the diabetic GK rat
    Yuhuan Meng, Yujia Guan, Wenlu Zhang, Yue Wu, Huanhuan Jia, Yu Zhang, Xiuqing Zhang, Hongli Du, Xiaoning Wang · 2016 · Scientific Reports
  91. Newer perspective on the coupling between glucose-mediated signaling and β-cell functionality
    Jun Shirakawa, Yasuo Terauchi · 2019 · Endocrine Journal
  92. IKKγ-Mimetic Peptides Block the Resistance to Apoptosis Associated with Kaposi's Sarcoma-Associated Herpesvirus Infection
    Louise C. Briggs, A. W. Edith Chan, Christopher A. Davis, Nicholas Whitelock, Hajira Ahmed Hotiana, Mehdi Baratchian, Claire Bagnéris, David L. Selwood, Mary K. Collins, Tracey E. Barrett · 2017 · Journal of Virology
  93. Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea in diabetes
    Hitoshi Watanabe, Wen Juan Du, Jinsook Son, Lina Sui, Shun‐ichiro Asahara, Irwin J. Kurland, Taiyi Kuo, Takumi Kitamoto, Yasutaka Miyachi, Rafael de Cabo et al. · 2023 · Science Translational Medicine
  94. Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells
    Christoph Küper, Helmut Bartels, Franz-Xaver Beck, Wolfgang Neuhofer · 2011 · Kidney International
  95. Bcl-XL mediates epidermal growth factor dependent cell survival in HC11 mammary epithelial cells
    Leonardo Romorini, Omar A. Coso, Adalı́ Pecci · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  96. Bad News for β-Cell Apoptosis
    Helen E. Thomas, Trevor J. Biden · 2009 · Diabetes
  97. Drugging the “Undruggable”
    Gregory L. Verdine · 2010 · Wiley eBooks
  98. A Peptidomics Strategy To Elucidate the Proteolytic Pathways That Inactivate Peptide Hormones
    Arthur D. Tinoco, Yun‐Gon Kim, Debarati Mazumder Tagore, Jessica M. Wiwczar, William S. Lane, Nika N. Danial, Alan Saghatelian · 2011 · Biochemistry
  99. Susceptibility of Glucokinase-MODY Mutants to Inactivation by Oxidative Stress in Pancreatic β-Cells
    Kirsty S. Cullen, Franz M. Matschinsky, Loranne Agius, Catherine Arden · 2011 · Diabetes
  100. Targeting metabolic vulnerabilities to overcome resistance to therapy in acute myeloid leukemia
    Priyanka Sharma, Gautam M. Borthakur · 2023 · Cancer Drug Resistance