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Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioxime β-Catenin Pathway Inhibitors

Soldi, R., Horrigan, S. K., Chołody, M., Padia, J. K., Sorna, V., Bearss, J. J., Gilcrease, G. W., Bhalla, K. N., Verma, A. R., Vankayalapati, H., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00460 · Cited by 25 · see citing works

An engineered antibody fragment targeting mutant β-catenin via major histocompatibility complex I neoantigen presentation

Miller, M. S., Douglass, J., Hwang, M. S., Skora, A. D., Murphy, M. B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Zhou, S., & Gabelli, S. B. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010251 · Cited by 24 · see citing works

Medicinal Chemistry Approaches to Heart Regeneration

Schade, D., & Plowright, A. T. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00446 · Cited by 20 · see citing works

Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners

Zhang, H., Liu, C., Zhu, D., Zhang, Q., & Li, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01016 · Cited by 15 · see citing works

Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction

Low, J.-L., Du, W., Gocha, T., Oguz, G., Zhang, X., Chen, M., Masirevic, S., Yim, D., Tan, I. B. H., Ramasamy, A., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102544 · Cited by 13 · see citing works

Wnt/β-Catenin Signaling Modulates Human Airway Sensitization Induced by β2-Adrenoceptor Stimulation

Faisy, C., Grassin‐Delyle, S., Blouquit‐Laye, S., Brollo, M., Naline, E., Chapelier, A. R., & Devillier, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111350 · Cited by 12 · see citing works

Structure‐Based Design of Bicyclic Helical Peptides That Target the Oncogene β‐Catenin

Yeste‐Vázquez, A., Paulussen, F. M., Wendt, M., Klintrot, R., Schulte, C., Wallraven, K., van Gijzel, L., Simeonov, B., van der Gaag, M., Gerber, A., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202411749 · Cited by 10 · see citing works

Regulatory mechanisms of signaling pathways in liver cancer treatment with traditional Chinese medicine

Zheng, S., Xue, T., Xue, C., Li, S., Zao, X., Li, X., Cao, X., Du, H., Qi, W., Seetoh, W. S., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119386 · Cited by 10 · see citing works

A Dominant Negative Antisense Approach Targeting β-Catenin

Vonbrüll, M., Riegel, E., Halter, C., Aigner, M., Bock, H., Werner, B., Lindhorst, T., & Czerny, T. (2018) · Molecular Biotechnology · doi:10.1007/s12033-018-0058-7 · Cited by 10 · see citing works

Synthesis of a Bcl9 Alpha-Helix Mimetic for Inhibition of PPIs by a Combination of Electrooxidative Phenol Coupling and Pd-Catalyzed Cross Coupling

Vareka, M., Dahms, B., Lang, M., Hoang, M. H., Trobe, M., Weber, H., Hielscher, M. M., Waldvogel, S. R., & Breinbauer, R. (2020) · Catalysts · doi:10.3390/catal10030340 · Cited by 9 · see citing works

Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles

Lai, K. K. Y., & Kahn, M. (2021) · Handbook of experimental pharmacology · doi:10.1007/164_2021_523 · Cited by 6 · see citing works

Development of structure-based pharmacophore to target the β-catenin-TCF protein–protein interaction

Pagare, P. P., Morris, A., Li, J., & Zhang, Y. (2021) · Medicinal Chemistry Research · doi:10.1007/s00044-020-02693-3 · Cited by 5 · see citing works

Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling

Wendt, M., Bellavita, R., Gerber, A., Efrém, N., van Ramshorst, T., Pearce, N. M., Davey, P. R. J., Everard, I., Vázquez–Chantada, M., Chiarparin, E., et al. (2021) · Angewandte Chemie · doi:10.1002/ange.202102082 · Cited by 5 · see citing works

Synthetic polyphenol compounds inhibit β-catenin/Tcf signaling: Structure-activity relationship

Ahn, S., Ahn, E.-S., Sung, J., Koh, D., Lim, Y., & Park, S. (2017) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2017.07.018 · Cited by 5 · see citing works

Wnt Pathway: A Hallmark of Drug Discovery Challenge

Babić, I., Yenugonda, V. M., Kesari, S., & Nurmemmedov, E. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0084 · Cited by 4 · see citing works

Structure‐Based Design of Bicyclic Helical Peptides That Target the Oncogene β‐Catenin

Yeste‐Vázquez, A., Paulussen, F. M., Wendt, M., Klintrot, R., Schulte, C., Wallraven, K., van Gijzel, L., Simeonov, B., van der Gaag, M., Gerber, A., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202411749 · Cited by 2 · see citing works

Combinatorial Effects of 5-Fluorouracil and Menadione on Wnt/β-Catenin Pathway in Human Colorectal Cancer Cells

Warrier, V. P., Venkatachalam, S., Sakthivel, R., Gromiha, M. M., & Karunagaran, D. (2024) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-024-05072-5 · Cited by 2 · see citing works

Peptide Therapeutics for Solid Tumors: Functional Classes, AI‐Enhanced Discovery and Clinical Advances

Liang, J., Tang, X., Li, H., Fang, Y., & Jiang, F. (2026) · Journal of Peptide Science · doi:10.1002/psc.70119 · Cited by 1 · see citing works

From Protein Structures to Functional Biomimetics

Grossmann, T. N., & Durukan, C. (2024) · Synlett · doi:10.1055/a-2308-1795 · Cited by 1 · see citing works

Targeting the Transcriptional Hub β‐Catenin Using Stapled Peptides

Grossmann, T. N., & Verdine, G. L. (2014) · Wiley eBooks · doi:10.1002/9783527687503.ch25

Remote Residue Substitution and Macrocyclization Preorganize a β ‐Hairpin Peptide and Enhance β ‐Catenin Binding

Meulendijks, M. H. N., Li, Y., Steiner, F. J., Klintrot, R., Schulte, C., Roose, S., Yeste‐Vázquez, A., Maric, H. M., Hennig, S., Paulussen, F. M., et al. (2026) · ChemistryEurope · doi:10.1002/ceur.70357

BindingDB Entry 50015737: Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.

BindingDB (2023) · UC San Diego · doi:10.7270/q2gq72q3

BindingDB Entry 50046360: Design, Synthesis, and Biological Evaluation of a Series of Anthracene-9,10-dione Dioximeß-Catenin Pathway Inhibitors.

BindingDB (2016) · UC San Diego · doi:10.7270/q2cz38zp

BindingDB Entry 50015754: Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling.

BindingDB (2023) · UC San Diego · doi:10.7270/q2t157m8

BindingDB Entry 50006478: Medicinal Chemistry Approaches to Heart Regeneration.

BindingDB (2020) · UC San Diego · doi:10.7270/q2125wns

Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin

Grossmann, T. N., Yeh, J. T.-H., Bowman, B. R., Chu, Q., Moellering, R. E., & Verdine, G. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208396109 · Cited by 268 · see citing works

Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein–protein interfaces of nuclear factors

Zimmerli, D., Hausmann, G., Cantù, C., & Basler, K. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13864 · Cited by 66 · see citing works

Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling

Koelman, E. M. R., Yeste-Vázquez, A., & Grossmann, T. N. (2022) · Bioorganic &amp; Medicinal Chemistry · doi:10.1016/j.bmc.2022.116920 · Cited by 63 · see citing works

Direct targeting of β ‐catenin in the Wnt signaling pathway: Current progress and perspectives

Wang, Z., Li, Z., & Ji, H. (2021) · Medicinal Research Reviews · doi:10.1002/med.21787 · Cited by 144 · see citing works

Medicinal Chemistry Strategies for the Development of Inhibitors Disrupting β-Catenin’s Interactions with Its Nuclear Partners

Zhang, H., Liu, C., Zhu, D., Zhang, Q., & Li, J. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01016 · Cited by 15 · see citing works