The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

Khanna, Chand, Wan, Xiaolin, Bose, Seuli, Cassaday, Ryan, Olomu, Osarenoma, Mendoza, Arnulfo, Yeung, Choh, Gorlick, Richard +2 more·2004·Nature Medicine
DOI 10.1038/nm982

Cited by (707)

Items 601–700 of 707

  1. Diagnostic and prognostic aspects in soft tissue sarcomas
    Suzan E. ten Heuvel · 2014
  2. Biofabricated Nano-Cerium Oxide Loaded Polycaprolactone with Resveratrol Improves Repair of Spinal Cord Injury Through the PTEN/AKT Pathway
    En-Jia Wang, Deng-Yan Bai, Xu-Sheng Zhang, Chun-Fa Su, Guan Wang · 2022 · Science of Advanced Materials
  3. Specific Subcellular Localization of Phosphoinositide-Specific Phospholipase C enzymes in Different Human Osteosarcoma Cell Lines
    Matteo Corradini, Marta Checchi, Marta Benincasa, Marzia Ferretti, Francesco Cavani, Carla Palumbo, Vincenza Rita Lo Vasco · 2024 · Journal of Cellular Signaling
  4. UNCOVERING THE BIOLOGICAL FUNCTIONS OF PHOSPHATASE OF REGENERATING LIVER -2
    Yan Wang · 2010 · D-Scholarship@Pitt (University of Pittsburgh)
  5. High ezrin immunoreactivity is an indicator of poor survival in squamous cell carcinoma of uterine cervix
    Tahany M. Shams, HanaaOmar Badr-El-Din, Iman Loay Hussein Abulkheir · 2012 · Clinical Cancer Investigation Journal
  6. Androgen Receptor Regulation of Prostate Cancer Progression and Metastasis
    Randy S. Schrecengost, Michael A. Augello, Karen E. Knudsen · 2011 · Springer eBooks
  7. Sequence and partial functional analysis of canine Bcl-2 family proteins
    Simone de Brot, Benjamin Schade, Martina Croci, Martina Dettwiler, Franco Guscetti · 2015 · Research in Veterinary Science
  8. Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?
    Rosanna J. Ricafort, Richard Greg Gorlick · 2010 · Springer eBooks
  9. Drug Discovery in Pediatric Bone and Soft Tissue Sarcomas Using In Vivo Models
    Jennifer K. Peterson, Peter J. Houghton · 2005 · Springer eBooks
  10. Phosphoinositide Signal Transduction Pathway and Osteosarcoma Metastases
    Vincenza Rita Lo Vasco · 2021 · Jentashapir Journal of Cellular and Molecular Biology
  11. Markers for bone sarcomas
    Matthias Tallegas, Anne Gomez‐Brouchet, Mélanie Legrand, Corinne Bouvier, Gonzague Du Bouexic De Pinieux · 2021 · Elsevier eBooks
  12. Carcinogenesis
    Carlos Muro‐Cacho · 2015 · John Wiley & Sons, Inc. eBooks
  13. Recent Advances in the Biology of Bone Tumors and New Diagnostic Tools
    Gonzague Du Bouexic De Pinieux, Corinne Bouvier · 2010 · Elsevier eBooks
  14. Prognostic factors of primary cutaneous melanoma
    Suvi Ilmonen · 2005 · Työväentutkimus Vuosikirja
  15. THE HISTONE DEACETYLASE INHIBITOR, MS-275, SENSITIZES METASTATIC OSTEOSARCOMA TO FASL-INDUCED CELL DEATH: A ROLE FOR C-FLIP
    Krithi Rao‐Bindal · 2012 · Digital Commons-TMC (Texas Medical Center)
  16. Molecular Pathology of Osteosarcoma
    Walter C. Bell, Gene P. Siegal · 2010 · Elsevier eBooks
  17. Genetic abnormalities in soft tissue sarcomas – implications for treatment
    Robert Lor Randall, David M. Cearley, Brian Johnson, David E. Joyner · 2006 · Current Opinion in Orthopedics
  18. Molecular and cellular mechanisms of osteosarcoma metastasis: current knowledge and perspectives
    Bruno Fuchs, Walter Born · 2009 · Current Orthopaedic Practice
  19. Estudo da associação das variáveis clínico-patológicas com a expressão imunoistoquímica de Ezrin e CD44 em pacientes portadores de osteossarcoma
    Érica Boldrini · 2010
  20. WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer
    Szymon Janczar · 2010 · Spiral (Imperial College London)
  21. The Ezrin Signalling Network as a Potential Novel Marker in Breast Cancer Metastasis
    Hannah Mak · 2010 · QSpace (Queen's University Library)
  22. A Novel Regulatory Role of Ezrin in Promoting Breast Cancer Cell Invasion and Metastasis
    Victoria Hoskin · 2015 · QSpace (Queen's University Library)
  23. A key to metastasis
    Emma Greenwood · 2004 · Nature reviews. Cancer
  24. Ezrin
    Neetu Gupta, Mala Upadhyay, Michael Cheung, Nabanita Bhunia · 2017 · Springer eBooks
  25. Correlação da expressão de podoplanina, ezrina e Rho-A em carcinomas espinocelulares de lábio inferior
    Agnes Assáo · 2015
  26. Functions of human papillomavirus E5 oncogene in epithelial cells and in the onset of cervical cancer
    Niina Kivi · 2011 · Työväentutkimus Vuosikirja
  27. Correlação clínico-patológica da expressão protéica do complexo CD44/ERM (Ezrin/Radixin/Moesin) no carcinoma da próstata
    Francisco Sálvio Cavalcante Pinto · 2010
  28. Liquid Chromatography - Mass Spectrometry for Protein Biomarker Discovery in Pancreatic Adenocarcinoma
    Angela Y. Wehr · 2011 · ScholarlyCommons (University of Pennsylvania)
  29. Biomarkers for pancreatic carcinogenesis
    Steven R. Hustinx · 2007 · Utrecht University Repository (Utrecht University)
  30. Novel functions of the Neurofibromatosis 2 tumour suppressor protein merlin
    Mikaela Grönholm · 2005 · Työväentutkimus Vuosikirja
  31. Doxorrubicina e ifosfamida em dose densa em pacientes com sarcomas de partes moles e expressão de ezrina como fator de prognóstico
    Gustavo Fernandes Godoy Almeida · 2010
  32. Correlação da imunoexpressão de podoplanina e ezrin em carcinomas espinocelulares de lábio
    Alexandre Simões Garcia · 2013
  33. Chapter 81. Osteogenic Osteosarcoma
    Janet M. Hock, Ching C. Lau · 2008 · Primer on the metabolic bone diseases and disorders of mineral metabolism
  34. Molecular cytogenetic studies of soft tissue sarcoma : With focus on prognosis and acquired events
    Wen‐Hui Weng · 2005 · Figshare
  35. Risk Factors of Tumour Recurrence and Reduced Survival in Rectal Cancer
    Fredrik Jörgren · 2010 · Lund University Publications (Lund University)
  36. Role of the lactoferrin-binding protein in pathogenesis of streptococcus uberis
    Igor Moshynskyy · 2005 · University Library - University of Saskatchewan (University of Saskatchewan)
  37. Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors
    David Mark Loeb, Allen R. Chen · 2009
  38. A STUDY OF THE TRANSITION FROM PREMALIGNANCY TO CLINICAL PROSTATE CANCER
    Alexander Valdman · 2005 · Figshare
  39. New Medical/Biologic Paradigms in the Treatment of Bone Tumors
    Peter Choong · 2014 · Current Surgery Reports
  40. Osteosarcoma: Biologic Markers in Its Treatment
    Han‐Soo Kim · 2006 · Journal of the Korean Medical Association
  41. Recurrent Bone Tumors
    Joanne Lagmay, Nicholas D. Yeager · 2015 · Pediatric oncology
  42. Clinical significance of Ezrin expression in ultrasound-guided HCC biopsy
    Lin Lin-juan, Jinhui Zhang, Wang Yan, Jin Zheng, Cai Ying-lan · 2011 · International Conference on Human Health and Biomedical Engineering
  43. Investigating pathways in tumour cell migration and invasion in response to novel isoquinolinone compounds
    Mario De Piano · 2013 · UEA Digital Repository (University of East Anglia)
  44. Activation of the Tumor Suppressor Merlin by Mosin/Moesin Phosphatase
    Wissenschaftliche Berichte · 2004
  45. Functional Regulation of the Neurofibromatosis 2 Tumor Suppressor Merlin
    Minja Pehrsson · 2011 · Työväentutkimus Vuosikirja
  46. The Role of Podocalyxin in Breast and Prostate Cancer Aggressiveness
    Steven T. Sizemore · 2008 · OhioLink ETD Center (Ohio Library and Information Network)
  47. Gene and proteomic profiling of osteosarcoma
    Ana Patiño‐García, Fernando Lecanda · 2014 · Elsevier eBooks
  48. The role of podocalyxin in breast cancer progression and metastasis
    Kimberly Snyder · 2015 · cIRcle (University of British Columbia)
  49. Elucidation of the Molecular Mechanisms of Malignant Bone Tumors: Refining Diagnosis and Identifying Novel Targets for Treatment
    Jorge E. Casas-Ganem, John H. Healey · 2005 · Journal of the National Comprehensive Cancer Network
  50. Cancer - From Mechanisms of Invasion to Targeted Therapy
    Philosophisch-Naturwissenschaftlichen Fakultät · 2007
  51. Activation of the tumor suppressor merlin by myosin/moesin phosphatase
    Hongchuan H. Jin · 2004 · Repository KITopen (Karlsruhe Institute of Technology)
  52. Pediatric solid tumors: embryonal cell oncogenesis
    Jeffrey A. Toretsky, AeRang Kim · 2013 · Cambridge University Press eBooks
  53. G-Protein-Coupled Receptors, Signal Fidelity, and Cell Transformation
    Todd R. Palmby, Hans M. Rosenfeldt, Jorge Silvio Gutkind · 2010 · Elsevier eBooks
  54. Cell and cell-MATRIX INTERACTIONS IN TUMORS: CURRENT STATE OF THE PROBLEM
    Maxim V. Mnikhovich · 2013 · I P Pavlov Russian Medical Biological Herald
  55. Uncovering Mechanisms of Osteosarcoma Metastasis
    Tracy A. Marko · 2016 · University of Minnesota Digital Conservancy (University of Minnesota)
  56. Alterations in Tgf-β Signaling Mediate the Biologic Behaviour of Osteosarcoma Cell Lines
    Benjamin M. Deheshi · 2010 · TSpace (University of Toronto)
  57. Preoperative radiotherapy modulates ezrin expression and its value as a predictive marker in patients with
    Eija A. Korkeila, Kari Juhani Syrjänen, Riyad Bendardaf, Minja Laulajainen, Seppo O Pyrhönen, J. C. Sundström · 2011
  58. Contribuição das células-tronco mesenquimais para as propriedades tumorigênicas de células de glioblastoma humano
    Carolina de Oliveira Rodini · 2016
  59. Involvement and Targeted Intervention of Deregulated Hedgehog Pathway in Osteosarcoma
    Winnie W. Lo · 2012 · TSpace (University of Toronto)
  60. Breast Cancer Stem Cells: Tumourspheres and Implications for Therapy
    Brian J. Morrison · 2011 · Griffith Research Online
  61. 부인암의 전이에 중요인자로 작용하는 Ezrin
    최승도 · 2012 · Journal of Menopausal Medicine
  62. Genotype-phenotype correlations in mouse musculoskeletal development and disease
    Alice Fiona Ford-Hutchinson · 2006 · Libraries and Cultural Resources (University of Calgary)
  63. Metastatic Disease to the Lung
    Annikka Weissferdt · 2020 · Springer eBooks
  64. Role of β-catenin and Active Beta Catenin in Osteosarcoma Progression
    Geetha Venkateswaran · 2016 · ERA: Education and Research Archive (University of Alberta)
  65. Importancia de los receptores híbridos receptor de insulina/receptor del factor de crecimiento similar a la insulina tipo I (InsR/IGF-1R) en las redes de señalización del sistema IGF
    Vallejo Pulido, Andrés Felipe · 2010
  66. Global Research on Osteosarcoma, 1999–2019: A Bibliometric and Visual Analysis
    Han Jiang Wu, Baixing Wei, Yuanpei Cheng, Yongbo Li · 2020
  67. Studies on relationships between malignant behaviors and ezrin activity in tissues of canine osteosarcoma patients and a xenograft nude mouse model
    Tassanee Jaroensong · 2011 · Institutional Repositories DataBase (IRDB)
  68. Genomic and proteomic profiling of osteosarcoma
    Ana Patiño‐García, Fernando Lecanda · 2021 · Elsevier eBooks
  69. Faculty Opinions recommendation of Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group.
    Nathalie Gaspar · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  70. Ezrin
    Neetu Gupta, Mala Upadhyay, Michael B. Cheung, Nabanita Bhunia · 2016 · Springer eBooks
  71. The Discovery of Cancer Tissue Specific Proteins in Serum: Case Studies on Prostate Cancer
    D. Spiros, A. Paul · 2012 · InTech eBooks
  72. Proteomic profiling of canine osteosarcoma patients
    Tassanee Jaroensong, Sittiruk Roytrakul, Chaiyakorn Thitiyanaporn · 2019
  73. Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors
    Masanori Hayashi, David Mark Loeb, Allen R. Chen · 2015
  74. A zebrafish embryo screen utilizing gastrulation for identification of anti-metastasis drugs
    Joji Nakayama, Hideki Makinoshima, Zhiyuan Gong · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Effects of miR-32 on Proliferation, Apoptosis, Invasion and Migration of Osteosarcoma Cells by Targeting PTEN
    Jun Wang, Yumin Zhang, Pengfei Wen, Tao Ma, Tao Wang, Wei Song, BinFei Zhang · 2022 · Journal of Biomaterials and Tissue Engineering
  76. Global Research on Osteosarcoma, 1999–2019: A Bibliometric and Visual Analysis
    Jixiang Zhang, Yongbo Li, Han Wu · 2022 · Research Square
  77. The G protein-coupled receptor TBXA2R activates ERMs to control cell motility and invasion of triple-negative breast cancer cells.
    Kévin Leguay, Omaima Naffati, Yu Yan He, Mireille Rogue, Chloé Tesnière, Melania Gombos, Hellen Kuasne, Louis Arthur Gaboury, Christian Le Gouill, Sylvain Meloche et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  78. Data from Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton
    Dalit Barkan, Hynda K. Kleinman, Justin L. Simmons, Holly Asmussen, Anil K. Kamaraju, Mark J. Hoenorhoff, Zi-yao Liu, Sylvain V. Costes, Edward H. Cho, Stephen Lockett et al. · 2023
  79. Data from Alterations in Gemin5 Expression Contribute to Alternative mRNA Splicing Patterns and Tumor Cell Motility
    Jong‐Heun Lee, Christine E. Horak, Chand Khanna, Zhaojing Meng, Li‐Rong Yu, Timothy D. Veenstra, Patricia Schriver Steeg · 2023
  80. Data from Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma
    Eisuke Kobayashi, Mari Masuda, Robert T. Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi et al. · 2023
  81. Data from Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma
    Eisuke Kobayashi, Mari Masuda, Robert T. Nakayama, Hitoshi Ichikawa, Reiko Satow, Miki Shitashige, Kazufumi Honda, Umio Yamaguchi, Ayako Shoji, Naobumi Tochigi et al. · 2023
  82. Supplementary Data from Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
    Marcin Tomasz Skrzypski, Ewa Jassem, Miquel Tarón, José Javier Sánchez, Pedro Méndez, Witold Rzyman, Grazyna K. Gulida, Dan J. Raz, David M. Jablons, Mariano Provencio et al. · 2023
  83. Data from Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis
    Pingyu Zhang, Yanwen Yang, Patrick A. Zweidler‐McKay, Dennis P.M. Hughes · 2023
  84. Data from Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis
    Pingyu Zhang, Yanwen Yang, Patrick A. Zweidler‐McKay, Dennis P.M. Hughes · 2023
  85. Supplementary Data from Three-Gene Expression Signature Predicts Survival in Early-Stage Squamous Cell Carcinoma of the Lung
    Marcin Tomasz Skrzypski, Ewa Jassem, Miquel Tarón, José Javier Sánchez, Pedro Méndez, Witold Rzyman, Grazyna K. Gulida, Dan J. Raz, David M. Jablons, Mariano Provencio et al. · 2023
  86. Data from Genomic Analysis of a Spontaneous Model of Breast Cancer Metastasis to Bone Reveals a Role for the Extracellular Matrix1
    Bedrich L. Eckhardt, Belinda S. Parker, Ryan K. van Laar, Christina M. Restall, Anthony L. Natoli, Michael D. Tavaria, Kym L. Stanley, Erica K. Sloan, Jane M. Moseley, Robin L. Anderson · 2023
  87. Supplementary Data 1 from Genomic Analysis of a Spontaneous Model of Breast Cancer Metastasis to Bone Reveals a Role for the Extracellular Matrix1
    Bedrich L. Eckhardt, Belinda S. Parker, Ryan K. van Laar, Christina M. Restall, Anthony L. Natoli, Michael D. Tavaria, Kym L. Stanley, Erica K. Sloan, Jane M. Moseley, Robin L. Anderson · 2023
  88. Ezrin Immunoexpression in Prostate Adenocarcinomas.
    Tudor Cristian Timotei Popescu, Alex Emilian Stepan, Mirela Marinela Florescu, Cristiana Eugenia Simionescu · 2022 · PubMed Central
  89. The role of pulmonary metastasectomy (PM) for non-primary lung cancer: Umbrella review of meta-analyses
    Wongi Woo, B. Kevin Park, Awranoos Ahadi, Liam Il‐Young Chung, Chan Mi Jung, Ankit Bharat, Young Kwang Chae · 2024 · medRxiv
  90. Additional file 3 of CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
    Hu, Song, Shi, Xiaoxing, Liu, Yiwen, He, Yiqing, Yan Du, Guoliang Zhang, Cuixia Yang, Gao, Feng · 2020 · Figshare
  91. Additional file 2 of System analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy
    Wu, Zhouwei, Yu, Jiapei, Han, Tao, Yiting Tu, Fang Su, Li, Shi, Huang, Yixing · 2024 · Figshare
  92. Additional file 2 of CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
    Hu, Song, Shi, Xiaoxing, Yiwen Liu, He, Yiqing, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao · 2020 · Figshare
  93. Additional file 5 of CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
    Hu, Song, Shi, Xiaoxing, Liu, Yiwen, He, Yiqing, Yan Du, Guoliang Zhang, Cuixia Yang, Gao, Feng · 2020 · Figshare
  94. Additional file 1 of System analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy
    Wu, Zhouwei, Yu, Jiapei, Han, Tao, Yiting Tu, Fang Su, Li, Shi, Huang, Yixing · 2024 · Figshare
  95. Additional file 3 of System analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy
    Wu, Zhouwei, Yu, Jiapei, Han, Tao, Yiting Tu, Fang Su, Li, Shi, Huang, Yixing · 2024 · Figshare
  96. Additional file 4 of CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
    Hu, Song, Shi, Xiaoxing, Liu, Yiwen, He, Yiqing, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao · 2020 · Figshare
  97. Additional file 1 of CD44 cross-linking increases malignancy of breast cancer via upregulation of p-Moesin
    Hu, Song, Shi, Xiaoxing, Liu, Yiwen, He, Yiqing, Yan Du, Guoliang Zhang, Cuixia Yang, Feng Gao · 2020 · Figshare
  98. Structural and Dynamic Insights into Podocalyxin–Ezrin Interaction as a Target in Cancer Progression
    Mila Milutinovic, Stuart Lutimba, Mohammed Awad Mansour · 2026 · Journal of Xenobiotics
  99. TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells
    Kévin Leguay, Omaima Naffati, C. L. Kiyan, Yu-Yang He, M. Hogue, Chloé Tesnière, Mélania Gombos, H. Kuasne, L. Gaboury, C. Le Gouill et al. · 2026 · Life Science Alliance
  100. TRAIL signalling regulation by ezrin
    Elisabetta Iessi · 2011 · theses.fr (ABES)