The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis

A molecular signature of metastasis in primary solid tumors

Ramaswamy, S., Ross, K. N., Lander, E. S., & Golub, T. R. (2002) · Nature Genetics · doi:10.1038/ng1060 · Cited by 2,448 · see citing works

Genomic analysis of metastasis reveals an essential role for RhoC

Clark, E. A., Golub, T. R., Lander, E. S., & Hynes, R. O. (2000) · Nature · doi:10.1038/35020106 · Cited by 1,444 · see citing works

ERM proteins and merlin: integrators at the cell cortex

Bretscher, A., Edwards, K., & Fehon, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm882 · Cited by 1,306 · see citing works

Multistep Nature of Metastatic Inefficiency

Luzzi, K. J., MacDonald, I. C., Schmidt, E. E., Kerkvliet, N. I., Morris, V. L., Chambers, A. F., & Groom, A. C. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65628-3 · Cited by 1,246 · see citing works

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

Wang, T., Niu, G., Kortylewski, M., Burdelya, L. G., Shain, K. H., Zhang, S., Bhattacharya, R., Gabrilovich, D. I., Heller, R. F., Coppola, D., et al. (2003) · Nature Medicine · doi:10.1038/nm976 · Cited by 1,159 · see citing works

Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer

Vail, D. M., & MacEwen, E. G. (2000) · Cancer Investigation · doi:10.3109/07357900009012210 · Cited by 533 · see citing works

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

Yu, Y., Khan, J. I., Khanna, C., Helman, L. J., Meltzer, P. S., & Merlino, G. T. (2004) · Nature Medicine · doi:10.1038/nm966 · Cited by 525 · see citing works

Role of MAP kinase in tumor progression and invasion

Reddy, K. B., Nabha, S. M., & Atanaskova, N. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023781114568 · Cited by 511 · see citing works

Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker.

Algrain, M., Turunen, O., Vaheri, A. I., Louvard, D., & Arpin, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.1.129 · Cited by 424 · see citing works

Ezrin, a plasma membrane–microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

Gautreau, A. M., Poullet, P., Louvard, D., & Arpin, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7300 · Cited by 331 · see citing works

Ezrin Is an Effector of Hepatocyte Growth Factor–mediated Migration and Morphogenesis in Epithelial Cells

Crepaldi, T., Gautreau, A. M., Comoglio, P. M., Louvard, D., & Arpin, M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.423 · Cited by 321 · see citing works

Metastasis-associated differences in gene expression in a murine model of osteosarcoma.

Khanna, C., Khan, J. I., Nguyen, P., Prehn, J., Caylor, J., Yeung, C. L., Trepel, J. B., Meltzer, P. S., & Helman, L. J. (2001) · PubMed · Cited by 282 · see citing works

Morphogenic Effects of Ezrin Require a Phosphorylation-Induced Transition from Oligomers to Monomers at the Plasma Membrane

Gautreau, A. M., Louvard, D., & Arpin, M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.193 · Cited by 280 · see citing works

Apoptosis: an early event in metastatic inefficiency.

Wong, C. W., Lee, A., Shientag, L., Yu, J. H., Dong, Y., Kao, G., Al‐Mehdi, A. B., Bernhard, E. J., & Muschel, R. J. (2001) · PubMed · Cited by 276 · see citing works

The role of the CD44/ezrin complex in cancer metastasis

Martin, T. A., Harrison, G. M., Mansel, R. E., & Jiang, W. G. (2003) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(02)00172-5 · Cited by 251 · see citing works

Comparative Aspects of Osteosarcoma

Withrow, S. J., Powers, B. E., Straw, R. C., & Wilkins, R. M. (1991) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199109000-00023 · Cited by 239 · see citing works

Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts

Lamb, R. F., Ozanne, B. W., Roy, C., McGarry, L., Stipp, C. S., Mangeat, P. H., & Jay, D. G. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00295-8 · Cited by 211 · see citing works

Critical Steps in Hematogenous Metastasis

Chambers, A. F., Naumov, G. N., Varghese, H. J., Nadkarni, K. V., MacDonald, I. C., & Groom, A. C. (2001) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30063-2 · Cited by 210 · see citing works

An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential

Khanna, C., Prehn, J., Yeung, C., Caylor, J., Tsokos, M., & Helman, L. (2000) · Clinical & Experimental Metastasis · doi:10.1023/a:1006767007547 · Cited by 207 · see citing works

Critical steps in hematogenous metastasis: an overview.

Chambers, A. F., Naumov, G. N., Varghese, H. J., Nadkarni, K. V., MacDonald, I. C., & Groom, A. C. (2001) · PubMed · Cited by 191 · see citing works

Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin/β-catenin

Hiscox, S., & Jiang, W. G. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.18.3081 · Cited by 169 · see citing works

Signal Pathways Which Promote Invasion and Metastasis: Critical and Distinct Contributions of Extracellular Signal-Regulated Kinase and Ral-Specific Guanine Exchange Factor Pathways

Ward, Y., Wang, W., Woodhouse, E. C., Linnoila, I. R., Liotta, L. A., & Kelly, K. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5958-5969.2001 · Cited by 161 · see citing works

Molecular biology of breast cancer metastasis Clinical implications of experimental studies on metastatic inefficiency

Chambers, A. F., Naumov, G. N., Vantyghem, S. A., & Tuck, A. B. (2000) · Breast Cancer Research · doi:10.1186/bcr86 · Cited by 137 · see citing works

Intravascular Location of Breast Cancer Cells after Spontaneous Metastasis to the Lung

Wong, C. W., Song, C. H., Grimes, M., Fu, W., Dewhirst, M. W., Muschel, R. J., & Al‐Mehdi, A. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64233-2 · Cited by 123 · see citing works

Ezrin as a prognostic indicator and its relationship to tumor characteristics in uveal malignant melanoma.

Mäkitie, T., Carpén, O., Vaheri, A. I., & Kivelä, T. (2001) · PubMed · Cited by 112 · see citing works

Hierarchy of Merlin and Ezrin N- and C-terminal Domain Interactions in Homo- and Heterotypic Associations and Their Relationship to Binding of Scaffolding Proteins EBP50 and E3KARP

Nguyen, R., Reczek, D., & Bretscher, A. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006708200 · Cited by 103 · see citing works

Ezrin, a membrane-cytoskeletal linking protein, is highly expressed in atypical endometrial hyperplasia and uterine endometrioid adenocarcinoma

Ohtani, K., Sakamoto, H., Rutherford, T., Chen, Z., Kikuchi, A., Yamamoto, T., Satoh, K., & Naftolin, F. N. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00857-6 · Cited by 88 · see citing works

A randomized controlled trial of octreotide pamoate long-acting release and carboplatin versus carboplatin alone in dogs with naturally occurring osteosarcoma: evaluation of insulin-like growth factor suppression and chemotherapy.

Khanna, C., Prehn, J., Hayden, D. W., Cassaday, R. D., Caylor, J., Jacob, S. T., Bose, S., Hong, S. H., Hewitt, S. M., & Helman, L. J. (2002) · PubMed · Cited by 56 · see citing works

Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway.

Wan, X., & Helman, L. (2002) · Neoplasia · doi:10.1038/sj.neo.7900242 · Cited by 51 · see citing works

Cancer Metastasis: Building a Framework

Gupta, G. P., & Massagué, J. (2006) · Cell · doi:10.1016/j.cell.2006.11.001 · Cited by 4,230 · see citing works

Tumor metastasis: mechanistic insights and clinical challenges

Steeg, P. S. (2006) · Nature Medicine · doi:10.1038/nm1469 · Cited by 2,135 · see citing works

Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6

Lee, R. H., Pulin, A. A., Seo, M. J., Kota, D. J., Ylostalo, J., Larson, B. L., Semprun-Prieto, L., Delafontaine, P., & Prockop, D. J. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.05.003 · Cited by 1,898 · see citing works

Molecular Basis of Metastasis

Chiang, A. C., & Massagué, J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0805239 · Cited by 1,049 · see citing works

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Lee, J., Heo, J., Libbrecht, L. J., Chu, I., Kaposi-Novák, P., Calvisi, D. F., Mikaelyan, A. S., Roberts, L. R., Demetris, A. J., Sun, Z., et al. (2006) · Nature Medicine · doi:10.1038/nm1377 · Cited by 953 · see citing works

Actin and Actin-Binding ProteinsPreprint

Pollard, T. D. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018226 · Cited by 929 · see citing works

Genetic determinants of cancer metastasis

Nguyen, D. X., & Massagué, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2101 · Cited by 796 · see citing works

CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer

Smith, M. C. P., Luker, K. E., Garbow, J. R., Prior, J. L., Jackson, E. N., Piwnica-Worms, D. R., & Luker, G. D. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1844 · Cited by 715 · see citing works

Osteosarcoma

Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works

Expression of Notch-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation

Purow, B. W., Haque, R. M., Noel, M. W., Su, Q., Burdick, M. J., Lee, J., Sundaresan, T. K., Pastorino, S., Park, J. K., Mikolaenko, I., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1890 · Cited by 583 · see citing works

Movers and shakers: cell cytoskeleton in cancer metastasis

Fife, C. M., McCarroll, J. A., & Kavallaris, M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12704 · Cited by 552 · see citing works

Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators

Yu, Y., Khan, J. I., Khanna, C., Helman, L. J., Meltzer, P. S., & Merlino, G. T. (2004) · Nature Medicine · doi:10.1038/nm966 · Cited by 525 · see citing works

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

Gianferante, D. M., Mirabello, L. J., & Savage, S. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.16 · Cited by 470 · see citing works

Modeling metastasis in vivo

Khanna, C. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh261 · Cited by 466 · see citing works

Metastasis mechanisms

Geiger, T. R., & Peeper, D. S. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.07.006 · Cited by 443 · see citing works

Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton

Barkan, D., Kleinman, H. K., Simmons, J. L., Asmussen, H., Kamaraju, A. K., Hoenorhoff, M. J., Liu, Z.-Y., Costes, S. V., Cho, E. H., Lockett, S., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6849 · Cited by 426 · see citing works

Metastatic Growth from Dormant Cells Induced by a Col-I–Enriched Fibrotic Environment

Barkan, D., Touny, L. H. E., Michalowski, A. M., Smith, J. A., Chu, I. M., Davis, A. S., Webster, J. D., Hoover, S. B., Simpson, R. M., Gauldie, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2356 · Cited by 395 · see citing works

Osteosarcoma Development and Stem Cell Differentiation

Tang, N., Song, W., Luo, J., Haydon, R. C., & He, T. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0335-z · Cited by 355 · see citing works

The Molecular Pathogenesis of Osteosarcoma: A Review

Broadhead, M. L., Clark, J. C. M., Myers, D. E., Dass, C. R., & Choong, P. (2011) · Sarcoma · doi:10.1155/2011/959248 · Cited by 347 · see citing works

Breed-Predispositions to Cancer in Pedigree Dogs

Dobson, J. M. (2013) · ISRN Veterinary Science · doi:10.1155/2013/941275 · Cited by 340 · see citing works

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

Taylor, J. G., Cheuk, A., Tsang, P. S., Chung, J., Song, Y., Desai, K. D., Yu, Y., Chen, Q., Shah, K. J., Youngblood, V., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39703 · Cited by 317 · see citing works

Osteosarcoma treatment: state of the art

Ta, H. T., Dass, C. R., Choong, P., & Dunstan, D. E. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-009-9186-7 · Cited by 311 · see citing works

Dissecting lipid raft facilitated cell signaling pathways in cancer

Patra, S. K. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.11.002 · Cited by 307 · see citing works

Cannibalism of Live Lymphocytes by Human Metastatic but Not Primary Melanoma Cells

Lugini, L., Matarrese, P., Tinari, A., Lozupone, F., Federici, C., Iessi, E., Gentile, M., Luciani, F., Parmiani, G., Rivoltini, L., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3204 · Cited by 289 · see citing works

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics

Simpson, S., Dunning, M., de Brot, S., Grau‐Roma, L., Mongan, N. P., & Rutland, C. S. (2017) · Acta veterinaria Scandinavica · doi:10.1186/s13028-017-0341-9 · Cited by 294 · see citing works

MicroRNA miR-183 Functions as an Oncogene by Targeting the Transcription Factor EGR1 and Promoting Tumor Cell Migration

Sarver, A. L., Li, L., & Subramanian, S. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2074 · Cited by 278 · see citing works

Molecular Pathogenesis of Osteosarcoma

Kansara, M., & Thomas, D. M. (2007) · DNA and Cell Biology · doi:10.1089/dna.2006.0505 · Cited by 273 · see citing works

ERM proteins in cancer progression

Clucas, J., & Valderrama, F. (2014) · Journal of Cell Science · doi:10.1242/jcs.133108 · Cited by 261 · see citing works

Canine Osteosarcoma: A Naturally Occurring Disease to Inform Pediatric Oncology

Fenger, J. M., London, C. A., & Kisseberth, W. C. (2014) · ILAR Journal · doi:10.1093/ilar/ilu009 · Cited by 248 · see citing works

A review of clinical and molecular prognostic factors in osteosarcoma

Clark, J. C. M., Dass, C. R., & Choong, P. (2007) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-007-0330-x · Cited by 250 · see citing works

Distinct mechanisms of tumor invasion and metastasis

Yilmaz, M., Christofori, G., & Lehembre, F. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.10.004 · Cited by 245 · see citing works

Osteosarcoma: Accelerating Progress Makes for a Hopeful Future

Saraf, A. J., Fenger, J. M., & Roberts, R. D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00004 · Cited by 237 · see citing works

An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis

Luu, H. H., Kang, Q., Park, J. K., Si, W., Luo, Q., Jiang, W., Yin, H. X., MONTAG, A. G., Simon, M. A., Peabody, T. D., et al. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-005-0365-9 · Cited by 233 · see citing works

Ezrin, a key component in tumor metastasis

Hunter, K. W. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.03.001 · Cited by 229 · see citing works

Bone microenvironment signals in osteosarcoma development

Alfranca, A., Martínez-Cruzado, L., Tornín, J., Abarrategi, A., Amaral, A. T., de Álava, E., Menéndez, P. R., Garcı́a-Castro, J., & Rodrı́guez, R. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1918-y · Cited by 225 · see citing works

Genomic Analysis of a Spontaneous Model of Breast Cancer Metastasis to Bone Reveals a Role for the Extracellular Matrix

Eckhardt, B. L., Parker, B. S., van Laar, R. K., Restall, C. M., Natoli, A. L., Tavaria, M. D., Stanley, K. L., Sloan, E. K., Moseley, J. M., & Anderson, R. L. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.1.3.1 · Cited by 224 · see citing works

Spontaneous and genetically engineered animal models

Hansen, K., & Khanna, C. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2003.11.031 · Cited by 223 · see citing works

Rapamycin Inhibits Ezrin-Mediated Metastatic Behavior in a Murine Model of Osteosarcoma

Wan, X., Mendoza, A., Khanna, C., & Helman, L. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3135 · Cited by 215 · see citing works

Genetically Engineered Mouse Models in Cancer Research

Walrath, J. C., Hawes, J. J., Dyke, T. V., & Reilly, K. M. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)06004-5 · Cited by 210 · see citing works

Comparative biology of human and canine osteosarcoma.

Mueller, F., Fuchs, B., & Kaser‐Hotz, B. (2007) · PubMed · Cited by 203 · see citing works

Osteosarcoma and Metastasis

Sheng, G., Gao, Y., Yong, Y., & Wu, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.780264 · Cited by 202 · see citing works

The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells

Elliott, B. E., Meens, J., Sengupta, S., Louvard, D., & Arpin, M. (2005) · Breast Cancer Research · doi:10.1186/bcr1006 · Cited by 198 · see citing works

Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

PosthumaDeBoer, J., Witlox, A. M. A., Kaspers, G. J. L., & van Royen, B. J. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9384-x · Cited by 192 · see citing works

Hepatocyte Growth Factor-induced Ras Activation Requires ERM Proteins Linked to Both CD44v6 and F-Actin

Orian‐Rousseau, V., Morrison, H., Matzke, A., Kastilan, T., Pace, G., Herrlich, P. A., & Ponta, H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0674 · Cited by 189 · see citing works

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

Tsai, Y. C., Mendoza, A., Mariano, J. M., Zhou, M., Kostova, Z., Chen, B., Veenstra, T., Hewitt, S. M., Helman, L. J., Khanna, C., et al. (2007) · Nature Medicine · doi:10.1038/nm1686 · Cited by 186 · see citing works

The CD34-like protein PODXL and α6-integrin (CD49f) identify early progenitor MSCs with increased clonogenicity and migration to infarcted heart in mice

Lee, R. H., Seo, M. J., Pulin, A. A., Gregory, C. A., Ylöstalo, J., & Prockop, D. J. (2008) · Blood · doi:10.1182/blood-2007-12-128702 · Cited by 182 · see citing works

Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways

Pignochino, Y., Grignani, G., Cavalloni, G., Motta, M., Tapparo, M., Bruno, S., Bottos, A., Gammaitoni, L., Migliardi, G., Camussi, G., et al. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-118 · Cited by 180 · see citing works

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

Bulut, G., Hong, S.-H., Chen, K., Beauchamp, E. M., Rahim, S., Kosturko, G. W., Glasgow, E., Dakshanamurthy, S., Lee, H.-S., Daar, I., et al. (2012) · Oncogene · doi:10.1038/onc.2011.245 · Cited by 179 · see citing works

Tumors of the Skeletal System

Ehrhart, N. P., Ryan, S. D., & Fan, T. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2362-5.00024-4 · Cited by 178 · see citing works

Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway

Qureshi-Baig, K., Kuhn, D., Viry, E., Pozdeev, V. I., Schmitz, M., Rodriguez, F., Ullmann, P., Koncina, E., Nurmik, M., Frasquilho, S., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1687213 · Cited by 178 · see citing works

Biology, diagnosis and treatment of canine appendicular osteosarcoma: Similarities and differences with human osteosarcoma

Morello, E. M., Martano, M., & Buracco, P. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.08.014 · Cited by 174 · see citing works

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies

Morrow, J. J., & Khanna, C. (2015) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2015013713 · Cited by 171 · see citing works

Dynamic cortical actin remodeling by ERM proteins controls BCR microcluster organization and integrity

Treanor, B., Depoil, D., Bruckbauer, A., & Batista, F. D. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101125 · Cited by 172 · see citing works

Conditional ROCK Activation In vivo Induces Tumor Cell Dissemination and Angiogenesis

Croft, D. R., Sahai, E. A., Mavria, G., Li, S., Tsai, J. H., Lee, W. M. F., Marshall, C. J., & Olson, M. F. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2052 · Cited by 165 · see citing works

Osteosarcoma.

Gorlick, R., & Khanna, C. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.77 · Cited by 157 · see citing works

Down-Regulation of miR-183 Promotes Migration and Invasion of Osteosarcoma by Targeting Ezrin

Zhu, J., Feng, Y., Ke, Z., Yang, Z., Zhou, J., Huang, X., & Wang, L. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.02.023 · Cited by 155 · see citing works

Metastasis: the seed and soil theory gains identity

Fokas, E., Engenhart‐Cabillic, R., Daniilidis, K., Rose, F., & An, H. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9088-5 · Cited by 149 · see citing works

Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles

Subramanian, S., West, R. B., Corless, C. L., Ou, W., Rubin, B. P., Chu, K., Leung, S. Y., Yuen, S. T., Zhu, S., Hernandez‐Boussard, T., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208056 · Cited by 148 · see citing works

Cannibalism: A way to feed on metastatic tumors

Fais, S. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.09.014 · Cited by 146 · see citing works

Nf2/Merlin: a coordinator of receptor signalling and intercellular contact

Curto, M., & McClatchey, A. I. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6604002 · Cited by 145 · see citing works

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells

Touny, L. H. E., Vieira, A., Mendoza, A., Khanna, C., Hoenerhoff, M. J., & Green, J. E. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70259 · Cited by 144 · see citing works

The Homeoprotein Six1 Transcriptionally Activates Multiple Protumorigenic Genes but Requires Ezrin to Promote Metastasis

Yu, Y., Davicioni, E., Triche, T. J., & Merlino, G. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2360 · Cited by 142 · see citing works

Podocalyxin Increases the Aggressive Phenotype of Breast and Prostate Cancer Cells In vitro through Its Interaction with Ezrin

Sizemore, S. T., Cicek, M., Sizemore, N., Ng, K. P., & Casey, G. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3575 · Cited by 141 · see citing works

Mechanisms of Resistance to Conventional Therapies for Osteosarcoma

Marchandet, L., Lallier, M., Charrier, C., Baud’huin, M., Ory, B., & Lamoureux, F. (2021) · Cancers · doi:10.3390/cancers13040683 · Cited by 137 · see citing works

Proteins MOVE! Protein dynamics and long-range allostery in cell signaling

Bu, Z., & Callaway, D. J. E. (2011) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-381262-9.00005-7 · Cited by 139 · see citing works

Osteosarcoma: Basic Science and Clinical Implications

Hayden, J. B., & Hoang, B. H. (2006) · Orthopedic Clinics of North America · doi:10.1016/j.ocl.2005.06.004 · Cited by 136 · see citing works

Expression of the cytoskeleton linker protein ezrin in human cancers

Bruce, B. G., Khanna, G., Ren, L., Landberg, G., Jirström, K., Powell, C. A., Borczuk, A., Keller, E. T., Wojno, K. J., Meltzer, P. S., et al. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-006-9050-x · Cited by 133 · see citing works

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC

Ren, L., Hong, S., Cassavaugh, J. M., Osborne, T. S., Chou, A. J., Kim, S. Y., Gorlick, R. G., Hewitt, S. M., & Khanna, C. (2008) · Oncogene · doi:10.1038/onc.2008.437 · Cited by 131 · see citing works

Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group

Roberts, R. D., Lizardo, M. M., Reed, D. R., Hingorani, P., Glover, J., Allen‐Rhoades, W., Fan, T., Khanna, C., Sweet‐Cordero, E. A., Cash, T., et al. (2019) · Cancer · doi:10.1002/cncr.32351 · Cited by 127 · see citing works

Biology of Osteogenic Sarcoma

Wang, L. L. (2005) · The Cancer Journal · doi:10.1097/00130404-200507000-00005 · Cited by 126 · see citing works

An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells

Lorentzen, A., Bamber, J. C., Sadok, A., Elson‐Schwab, I., & Marshall, C. J. (2011) · Journal of Cell Science · doi:10.1242/jcs.074849 · Cited by 126 · see citing works

Extra-Nuclear Signalling of Estrogen Receptor to Breast Cancer Cytoskeletal Remodelling, Migration and Invasion

Giretti, M. S., Fu, X.-D., Rosa, G. D., Sarotto, I., Baldacci, C., Garibaldi, S., Mannella, P., Biglia, N., Sismondi, P., Genazzani, A. R., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002238 · Cited by 125 · see citing works

Prognostic factors in canine appendicular osteosarcoma – a meta-analysis

Boerman, I., Selvarajah, G. T., Nielen, M., & Kirpensteijn, J. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-56 · Cited by 123 · see citing works

Revisiting the seed and soil in cancer metastasis

Mendoza, M., & Khanna, C. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.01.015 · Cited by 122 · see citing works

Reduced Argininosuccinate Synthetase Is a Predictive Biomarker for the Development of Pulmonary Metastasis in Patients with Osteosarcoma

Kobayashi, E., Masuda, M., Nakayama, R. T., Ichikawa, H., Satow, R., Shitashige, M., Honda, K., Yamaguchi, U., Shoji, A., Tochigi, N., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0774 · Cited by 120 · see citing works

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells

Ren, L., Mendoza, A., Zhu, J., Briggs, J., Halsey, C., Hong, E. S., Burkett, S. S., Morrow, J. J., Lizardo, M. M., Osborne, T. S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5177 · Cited by 119 · see citing works

Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas

Sarrió, D., Rodríguez-Pinilla, S. M., Dotor, A. M., Calero, F., Hardisson, D., & Palacios, J. (2006) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-9133-4 · Cited by 118 · see citing works

Peroxisome proliferator-activated receptor-γ (PPARγ) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC)

Bren‐Mattison, Y., Putten, V. V., Chan, D. C. F., Winn, R. A., Geraci, M. W., & Nemenoff, R. A. (2004) · Oncogene · doi:10.1038/sj.onc.1208333 · Cited by 117 · see citing works

Molecular mechanisms of the PRL phosphatases

Ríos, P., Li, X., & Köhn, M. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08565.x · Cited by 116 · see citing works

An Ezrin/Calpain/PI3K/AMPK/eNOS s1179 Signaling Cascade Mediating VEGF-Dependent Endothelial Nitric Oxide Production

Youn, J. Y., Wang, T., & Cai, H. “. (2008) · Circulation Research · doi:10.1161/circresaha.108.178467 · Cited by 116 · see citing works

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

Fossey, S. L., Bear, M. D., Kisseberth, W. C., Pennell, M. L., & London, C. A. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-125 · Cited by 115 · see citing works

Shedding light on Merlin's wizardry

Okada, T., You, L., & Giancotti, F. G. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.03.006 · Cited by 113 · see citing works

Characterization of STAT3 activation and expression in canine and human osteosarcoma

Fossey, S. L., Liao, A. T., McCleese, J., Bear, M. D., Lin, J., Li, P., Kisseberth, W. C., & London, C. A. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-81 · Cited by 112 · see citing works

Prognostic Impact of Immunohistochemical Expression of Ezrin in Highly Malignant Soft Tissue Sarcomas

Weng, W., Åhlén, J., Åström, K., Lui, W., & Larsson, C. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0548 · Cited by 111 · see citing works

mTOR Regulates the Invasive Properties of Synovial Fibroblasts in Rheumatoid Arthritis

Laragione, T., & Gulko, P. S. (2010) · Molecular Medicine · doi:10.2119/molmed.2010.00049 · Cited by 111 · see citing works

Emerging Treatment Strategies for Adrenocortical Carcinoma: A New Hope

Kirschner, L. S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1739 · Cited by 110 · see citing works

The Adolescent and Young Adult with Cancer: State of the Art - Bone Tumors

Rainusso, N. C., Wang, L. L., & Yustein, J. T. (2013) · Current Oncology Reports · doi:10.1007/s11912-013-0321-9 · Cited by 108 · see citing works

The interaction of lncRNA EZR-AS1 with SMYD3 maintains overexpression of EZR in ESCC cells

Zhang, X., Huang, G.-W., Xie, Y.-H., He, J., Guo, J., Xu, X., Liao, L., Xie, Y., Song, Y., Li, E., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1259 · Cited by 108 · see citing works

Credentialing Preclinical Pediatric Xenograft Models Using Gene Expression and Tissue Microarray Analysis

Whiteford, C. C., Bilke, S., Greer, B. T., Chen, Q., Braunschweig, T. A., Cenacchi, N., Wei, J. S., Smith, M. A., Houghton, P. J., Morton, C. L., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-0610 · Cited by 108 · see citing works

Moesin orchestrates cortical polarity of melanoma tumour cells to initiate 3D invasion

Estecha, A., Sánchez-Martı́n, L., Puig‐Kröger, A., Bartolomé, R. A., Teixidó, J., Samaniego, R., & Sánchez‐Mateos, P. (2009) · Journal of Cell Science · doi:10.1242/jcs.053157 · Cited by 106 · see citing works

Pathology of primary malignant bone and cartilage tumours

Rozeman, L. B., Cleton-Jansen, A., & Hogendoorn, P. C. W. (2006) · International Orthopaedics · doi:10.1007/s00264-006-0212-x · Cited by 106 · see citing works

Establishment and characterization of a new highly metastatic human osteosarcoma cell line

Su, Y., Luo, X., He, B., Wang, Y., Liang, C., Zuo, G., Liu, B., Bi, Y., Huang, J., Zhu, G., et al. (2009) · Clinical & Experimental Metastasis · doi:10.1007/s10585-009-9259-6 · Cited by 104 · see citing works

Ezrin in primary cutaneous melanoma

Ilmonen, S., Vaheri, A. I., Asko-Seljavaara, S. L., & Carpén, O. (2004) · Modern Pathology · doi:10.1038/modpathol.3800300 · Cited by 104 · see citing works

Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma

Kunita, A., Kashima, T. G., Ohazama, A., Grigoriadis, A. E., & Fukayama, M. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.027 · Cited by 103 · see citing works

The role of osteoclasts and tumour-associated macrophages in osteosarcoma metastasis

Endo‐Munoz, L., Evdokiou, A., & Saunders, N. A. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.07.003 · Cited by 103 · see citing works

Ezrin… a metastatic detERMinant?

Curto, M., & McClatchey, A. I. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00031-5 · Cited by 102 · see citing works

WWOX Gene and Gene Product: Tumor Suppression Through Specific Protein Interactions

Salah, Z., Aqeilan, R. I., & Huebner, K. (2010) · Future Oncology · doi:10.2217/fon.09.152 · Cited by 101 · see citing works

Berberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho Kinase-mediated Ezrin Phosphorylation at Threonine 567

Tang, F., Wang, D., Duan, C., Huang, D., Wu, Y. Q., Chen, Y. Z., Wang, W., Xie, C., Meng, J., Wang, L., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033795 · Cited by 100 · see citing works

Intense cytoplasmic ezrin immunoreactivity predicts poor survival in colorectal cancer

Elzagheid, A. I., Korkeila, E. A., Bendardaf, R., Buhmeida, A. S., Heikkilä, S., Vaheri, A. I., Syrjänen, K. J., Pyrhönen, S. O., & Carpén, O. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.04.020 · Cited by 100 · see citing works

The membrane-cytoskeleton linker ezrin provides a survival advantage to metastatic osteosarcoma cells that reach in the lung

Hong, S.-H., Mendoza, A., Ren, L., & Khanna, C. (2005) · Cancer Research

Osteosarcoma metastasis: prospective role of ezrin

Zhang, Y., Zhang, L., Zhang, G., Li, S., Duan, J., Cheng, J., Ding, G., Zhou, C., Zhang, J., Luo, P., et al. (2014) · Tumor Biology · doi:10.1007/s13277-014-1799-y · Cited by 45 · see citing works

Role of Ezrin in Osteosarcoma Metastasis

Ren, L., & Khanna, C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_10 · Cited by 52 · see citing works

The role of ezrin in osteosarcoma metastasis and its potential use in early identification of metastases

Stitzlein, R. N. (2007) · OhioLink ETD Center (Ohio Library and Information Network)

Ezrin enhances survival of single metastatic osteosarcoma cells that reach the lung in an AKT‐independent manner

Hong, S., Ren, L., & Khanna, C. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.238.5 · Cited by 1 · see citing works