The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Gold nanocages covered by smart polymers for controlled release with near-infrared light
Open accessAbstract
Photosensitive caged compounds have enhanced our ability to address the complexity of biological systems by generating effectors with remarkable spatial/temporal resolutions1-3. The caging effect is typically removed by photolysis with ultraviolet light to liberate the bioactive species. Although this technique has been successfully applied to many biological problems, it suffers from a number of intrinsic drawbacks. For example, it requires dedicated efforts to design and synthesize a precursor compound to the effector. The ultraviolet light may cause damage to biological samples and is only suitable for in vitro studies because of its quick attenuation in tissue4. Here we address these issues by developing a platform based on the photothermal effect of gold nanocages. Gold nanocages represent a class of nanostructures with hollow interiors and porous walls5. They can have strong absorption (for the photothermal effect) in the near-infrared (NIR) while maintaining a compact size. When the surface of a gold nanocage is covered with a smart polymer, the pre-loaded effector can be released in a controllable fashion using a NIR laser. This system works well with various effectors without involving sophiscated syntheses, and is well-suited for in vivo studies due to the high transparency of soft tissue in NIR6.
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Cites
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839
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Huang, X., Tang, S., Mu, X., Dai, Y., Chen, G., Zhou, Z., Ruan, F., Yang, Z., & Zheng, N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2010.235 · Cited by 1,602
Metadata
- Authors
- Yavuz, M. S., Cheng, Y., Chen, J., Cobley, C. M., Zhang, Q., Rycenga, M., Xie, J., Kim, C., Song, K. H., Schwartz, A. G., Wang, L. V., & Xia, Y.
- Venue
- Nature Materials
- Published
- 2009-11-01
- Volume
- 8
- Issue
- 12
- Pages
- 935-939
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2112227276
- Cited by
- 1,405
- References
- 2
- FWCI
- 45.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Yavuz, M. S., Cheng, Y., Chen, J., Cobley, C. M., Zhang, Q., Rycenga, M., Xie, J., Kim, C., Song, K. H., Schwartz, A. G., Wang, L. V., & Xia, Y. (2009). Gold nanocages covered by smart polymers for controlled release with near-infrared light. Nature Materials. https://doi.org/10.1038/nmat2564
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