The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The cytoplasm of living cells behaves as a poroelastic material
Open accessAbstract
The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at which cellular shape changes can occur. Recent experimental evidence suggests that cytoplasmic rheology can be described by a poroelastic model, in which the cytoplasm is treated as a biphasic material consisting of a porous elastic solid meshwork (cytoskeleton, organelles, macromolecules) bathed in an interstitial fluid (cytosol). In this picture, the rate of cellular deformation is limited by the rate at which intracellular water can redistribute within the cytoplasm. However, direct supporting evidence for the model is lacking. Here we directly validate the poroelastic model to explain cellular rheology at physiologically relevant timescales using microindentation tests in conjunction with mechanical, chemical and genetic treatments. Our results show that water redistribution through the solid phase of the cytoplasm (cytoskeleton and macromolecular crowders) plays a fundamental role in setting cellular rheology.
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Cites
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Diffusion of a small molecule in the cytoplasm of mammalian cells
Mastro, A. M., Babich, M. A., Taylor, W. D., & Keith, A. D. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.11.3414 · Cited by 228
Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Scarcelli, G., Polacheck, W. J., Nia, H. T., Patel, K., Grodzinsky, A. J., Kamm, R. D., & Yun, S. H. (2015) · Nature Methods · doi:10.1038/nmeth.3616 · Cited by 432
Investigating cell mechanics with atomic force microscopy
Haase, K., & Pelling, A. E. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0970 · Cited by 396
Cell mechanics: principles, practices, and prospects
Moeendarbary, E., & Harris, A. R. (2014) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1275 · Cited by 342
Self-citationFrom mechanical resilience to active material properties in biopolymer networks
Burla, F., Mulla, Y., Vos, B. E., Aufderhorst-Roberts, A., & Koenderink, G. H. (2019) · Nature Reviews Physics · doi:10.1038/s42254-019-0036-4 · Cited by 224
Metadata
- Authors
- Moeendarbary, E., Valon, L., Fritzsche, M., Harris, A. R., Moulding, D. A., Thrasher, A. J., Stride, E., Mahadevan, L., & Charras, G. T.
- Venue
- Nature Materials
- Published
- 2013-01-06
- Volume
- 12
- Issue
- 3
- Pages
- 253-261
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2142677837
- Cited by
- 686
- References
- 2
- FWCI
- 23.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Moeendarbary, E., Valon, L., Fritzsche, M., Harris, A. R., Moulding, D. A., Thrasher, A. J., Stride, E., Mahadevan, L., & Charras, G. T. (2013). The cytoplasm of living cells behaves as a poroelastic material. Nature Materials. https://doi.org/10.1038/nmat3517
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