Physiology of cell volume regulation in vertebrates
Abstract
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adaptive (e.g., altered expression of osmolyte transporters and heat shock proteins) measures and, in most cases, activation of volume regulatory osmolyte transport. After acute swelling, cell volume is regulated by the process of regulatory volume decrease (RVD), which involves the activation of KCl cotransport and of channels mediating K(+), Cl(-), and taurine efflux. Conversely, after acute shrinkage, cell volume is regulated by the process of regulatory volume increase (RVI), which is mediated primarily by Na(+)/H(+) exchange, Na(+)-K(+)-2Cl(-) cotransport, and Na(+) channels. Here, we review in detail the current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species, upon changes in cell volume. We also discuss the nature of the upstream elements in volume sensing in vertebrate organisms. Importantly, cell volume impacts on a wide array of physiological processes, including transepithelial transport; cell migration, proliferation, and death; and changes in cell volume function as specific signals regulating these processes. A discussion of this issue concludes the rev…
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Several carriers, such as NHE, NKCC or SMIT, could contribute to regulatory cell volume increase (RVI).
“Several of the carriers could contribute to regulatory cell volume increase (RVI), such as NHE, NKCC or SMIT (Lang et al. 1998;Hoffmann et al. 2009).”
From Significance of SGK1 in the regulation of neuronal function (2010) · cites this paper as Hoffmann et al. 2009
Stimulation of K+ channels and Cl- channels would counteract RVI and rather support regulatory cell volume decrease (RVD).
“Stimulation of K + channels and Cl -channels, however, would counteract RVI and rather support regulatory cell volume decrease (RVD) (Lang et al. 1998;Hoffmann et al. 2009).”
From Significance of SGK1 in the regulation of neuronal function (2010) · cites this paper as Hoffmann et al. 2009
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- Authors
- Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F.
- Affiliations
- University of Copenhagen (DK)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2009-01
- Volume
- 89
- Issue
- 1
- Pages
- 193-277
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2125588561
- Cited by
- 1,441
- References
- 8
- Citations by year
- 2026: 54 · 2025: 64 · 2024: 79 · 2023: 81 · 2022: 106 · 2021: 90 · 2020: 82 · 2019: 74 · 2018: 87 · 2017: 74 · 2016: 85 · 2015: 93 · 2014: 95 · 2013: 82 · 2012: 105
- FWCI
- 7.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- cell volume regulation, regulatory volume decrease, regulatory volume increase, Na+/H+ exchange, Na+-K+-2Cl- cotransport, sodium channels, taurine efflux, osmolyte transport, membrane deformation, ionic strength, calcium signaling, cytoskeleton, G proteins, lipid mediators, reactive oxygen species, transepithelial transport, cell migration, cell proliferation, cell death, vertebrates
- MeSH terms
- Animals, Cell Movement, Humans, Osmosis, Vertebrates, Signal Transduction, Cell Death, Cell Size, Cell Proliferation
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