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Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers
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“In addition, P–Xn–G motifs in intrinsically disordered peptides and proteins encode LCST behavior45.”
From Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) · cites this paper as [45]
In the citing paper
“While a high content of arginine residues favours phase separation below a critical temperature, as observed for FUS, the presence of lysine residues has been associated with LCST45.”
From Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) · cites this paper as [45]
In the citing paper
“The dependence of LLPS on temperature is governed by the protein’s amino acid composition45.”
From Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) · cites this paper as [45]
In the citing paper
“Thus, the repeat region of Tau undergoes a so-called LCST45.”
From Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau (2017) · cites this paper as [45]
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Ambadipudi, S., Biernat, J., Riedel, D., Mandelkow, E., & Zweckstetter, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00480-0 · Cited by 782
Relationship of sequence and phase separation in protein low-complexity regions
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Population-based heteropolymer design to mimic protein mixtures
Ruan, Z., Li, S., Grigoropoulos, A., Amiri, H., Hilburg, S. L., Chen, H., Jayapurna, I., Jiang, T., Gu, Z., Alexander-Katz, A., et al. (2023) · Nature · doi:10.1038/s41586-022-05675-0 · Cited by 64
Metadata
- Authors
- Quiroz, F. G., & Chilkoti, A.
- Venue
- Nature Materials
- Published
- 2015-09-21
- Volume
- 14
- Issue
- 11
- Pages
- 1164-1171
- ISSN
- 1476-1122
- 1476-4660
- PMC
- PMC4618764
- Cited by
- 505
- References
- 4
- Language
- en
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