The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Endocytic reawakening of motility in jammed epithelia
Open accessAbstract
Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or rigidity transition. How cells control such phase transitions is, however, unknown. Here we show that RAB5A, a key endocytic protein, is sufficient to induce large-scale, coordinated motility over tens of cells and ballistic motion in otherwise kinetically-arrested monolayers. This is linked to increased traction forces and to the extension of cell protrusions, which align with local velocity. Molecularly, impairing endocytosis, macropinocytosis or increasing fluid efflux abrogates RAB5A-induced collective motility. A simple model based on mechanical junctional tension and an active cell reorientation mechanism for the velocity of self-propelled cells identifies regimes of monolayer dynamics that explain endocytic reawakening of locomotion in terms of a combination of large-scale directed migration and local unjamming. These changes in multicellular dynamics enable collectives to migrate under physical constraints and may be exploited by tumors for interstitial dissemination.
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Self-citationCollective cell guidance by cooperative intercellular forces
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Self-citationA density-independent rigidity transition in biological tissues
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Self-citationUnjamming and cell shape in the asthmatic airway epithelium
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Motility-Driven Glass and Jamming Transitions in Biological Tissues
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Mechanisms and impact of altered tumour mechanics
Mohammadi, H., & Sahai, E. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0131-2 · Cited by 336
Adherens junctions as molecular regulators of emergent tissue mechanics
Campàs, O., Noordstra, I., & Yap, A. S. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00688-7 · Cited by 149
Endocytosis in the context-dependent regulation of individual and collective cell properties
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Self-citationJamming and arrest of cell motion in biological tissues
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Rigidity transitions in development and disease
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Metadata
- Authors
- Malinverno, C., Corallino, S., Giavazzi, F., Bergert, M., Li, Q., Leoni, M., Disanza, A., Frittoli, E., Oldani, A., Martini, E., Lendenmann, T., Deflorian, G., Beznoussenko, G. V., Poulikakos, D., Ong, K. H., Uroz, M., Trepat, X., Parazzoli, D., Maiuri, P., Yu, W., Ferrari, A., Cerbino, R., & Scita, G.
- Venue
- Nature Materials
- Published
- 2017-01-30
- Volume
- 16
- Issue
- 5
- Pages
- 587-596
- ISSN
- 1476-1122 (ISSN-L)
- 1476-4660
- OpenAlex
- W2581589183
- Cited by
- 308
- References
- 38
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Malinverno, C., Corallino, S., Giavazzi, F., Bergert, M., Li, Q., Leoni, M., Disanza, A., Frittoli, E., Oldani, A., Martini, E., Lendenmann, T., Deflorian, G., Beznoussenko, G. V., Poulikakos, D., Ong, K. H., Uroz, M., Trepat, X., Parazzoli, D., Maiuri, P., . . . Scita, G. (2017). Endocytic reawakening of motility in jammed epithelia. Nature Materials. https://doi.org/10.1038/nmat4848
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