Mechanisms and impact of altered tumour mechanics
Abstract
The physical characteristics of tumours are intricately linked to the tumour phenotype and difficulties during treatment. Many factors contribute to the increased stiffness of tumours; from increased matrix deposition, matrix remodelling by forces from cancer cells and stromal fibroblasts, matrix crosslinking, increased cellularity, and the build-up of both solid and interstitial pressure. Increased stiffness then feeds back to increase tumour invasiveness and reduce therapy efficacy. Increased understanding of this interplay is offering new therapeutic avenues.
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Increased mechanical stress can collapse blood vessels, leading to hypoxia, thereby promoting more aggressive cancer phenotypes and reducing drug delivery.
“Increased mechanical stress can collapse blood vessels, leading to hypoxia, thereby promoting more aggressive cancer phenotypes, and reducing drug delivery89,100–105.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [89]
CAFs produce matrix-crosslinking enzymes and, together with force-mediated ECM remodelling, these contribute to increased stiffness of tumour tissue.
“CAFs also produce matrix-crosslinking enzymes and, together with force-mediated ECM remodelling (reviewed in detail85,86), these contribute to the increased stiffness of tumour tissue87–89.”
From A framework for advancing our understanding of cancer-associated fibroblasts (2020) · cites this paper as [89]
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- Authors
- Mohammadi, H., & Sahai, E.
- Affiliations
- The Francis Crick Institute (GB)
- Corresponding author
- Sahai, Erik
- Venue
- Nature Cell Biology
- Published
- 2018-06-27
- Volume
- 20
- Issue
- 7
- Pages
- 766-774
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2809059040
- Cited by
- 336
- References
- 145
- Citations by year
- 2026: 25 · 2025: 52 · 2024: 41 · 2023: 63 · 2022: 44 · 2021: 54 · 2020: 36 · 2019: 18 · 2018: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Update notices
- correction (2018-07-10)
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute (10144)
- Cancer Research UK
- Canadian Institutes of Health Research
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- tumor stiffness, extracellular matrix, matrix remodeling, stromal fibroblasts, interstitial fluid pressure, solid pressure, tumour invasiveness, carcinogenesis, mechanotherapy
- MeSH terms
- Animals, Antineoplastic Agents, Cell Communication, Elasticity, Extracellular Matrix, Humans, Neoplasms, Phenotype, Pressure, Stress, Mechanical, Stromal Cells, Mechanotransduction, Cellular, Tumor Microenvironment
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