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In vivo fluorescence imaging with high-resolution microlenses
Open accessAbstract
Micro-optics are increasingly used for minimally invasive in vivo imaging, in miniaturized microscopes and in lab-on-a-chip devices. Owing to optical aberrations and lower numerical apertures, a main class of microlens, gradient refractive index lenses, has not achieved resolution comparable to conventional microscopy. Here we describe high-resolution microlenses, and illustrate two-photon imaging of dendritic spines on hippocampal neurons and dual-color nonlinear optical imaging of neuromuscular junctions in live mice.
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Cited by
Long-term dynamics of CA1 hippocampal place codes
Ziv, Y., Burns, L. D., Cocker, E. D., Hamel, E. O., Ghosh, K. K., Kitch, L. J., Gamal, A. E., & Schnitzer, M. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3329 · Cited by 1,155
Self-citationMiniaturized integration of a fluorescence microscope
Ghosh, K. K., Burns, L. D., Cocker, E. D., Nimmerjahn, A., Ziv, Y., Gamal, A. E., & Schnitzer, M. J. (2011) · Nature Methods · doi:10.1038/nmeth.1694 · Cited by 1,120
Self-citationSpecialized coding of sensory, motor and cognitive variables in VTA dopamine neurons
Engelhard, B., Finkelstein, J., Cox, J., Fleming, W., Jang, H. J., Ornelas, S., Koay, S. A., Thiberge, S. Y., Daw, N. D., Tank, D. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1261-9 · Cited by 544
Impermanence of dendritic spines in live adult CA1 hippocampus
Attardo, A., Fitzgerald, J. E., & Schnitzer, M. J. (2015) · Nature · doi:10.1038/nature14467 · Cited by 399
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Metadata
- Authors
- Barretto, R. P. J., Messerschmidt, B., & Schnitzer, M. J.
- Venue
- Nature Methods
- Published
- 2009-06-14
- Volume
- 6
- Issue
- 7
- Pages
- 511-512
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W1975668440
- Cited by
- 274
- References
- 0
- FWCI
- 12.62
- Type
- journal article
- Language
- en
- Open access
- green
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