The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy–treated macaques
Open accessAbstract
The detection of viral dynamics and localization in the context of controlled HIV infection remains a challenge and is limited to blood and biopsies. We developed a method to capture total-body simian immunodeficiency virus (SIV) replication using immunoPET (antibody-targeted positron emission tomography). The administration of a poly(ethylene glycol)-modified, 64Cu-labeled SIV Gp120–specific antibody led to readily detectable signals in the gastrointestinal and respiratory tract, lymphoid tissues and reproductive organs of viremic monkeys. Viral signals were reduced in aviremic antiretroviral-treated monkeys but detectable in colon, select lymph nodes, small bowel, nasal turbinates, the genital tract and lung. In elite controllers, virus was detected primarily in foci in the small bowel, select lymphoid areas and the male reproductive tract, as confirmed by quantitative reverse-transcription PCR (qRT-PCR) and immunohistochemistry. This real-time, in vivo viral imaging method has broad applications to the study of immunodeficiency virus pathogenesis, drug and vaccine development, and the potential for clinical translation.
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Textural Features for Image Classification
Haralick, R. M., Shanmugam, K., & Dinstein, I. (1973) · IEEE Transactions on Systems, Man, and Cybernetics · doi:10.1109/tsmc.1973.4309314 · Cited by 22,886
HIV reservoirs: pathogenesis and obstacles to viral eradication and cure
Chun, T.-W., & Fauci, A. S. (2012) · AIDS · doi:10.1097/qad.0b013e328353f3f1 · Cited by 175
Cited by
Cherry, S. R., Jones, T., Karp, J. S., Qi, J., Moses, W. W., & Badawi, R. D. (2018) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.184028 · Cited by 763
International AIDS Society global scientific strategy: towards an HIV cure 2016
International AIDS Society Towards a Cure Working Group, Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4108 · Cited by 425
Research priorities for an HIV cure: International AIDS Society Global Scientific Strategy 2021
Deeks, S. G., Archin, N., Cannon, P., Collins, S., Jones, R. B., de Jong, M. A. W. P., Lambotte, O., Lamplough, R., Ndung’u, T., Sugarman, J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01590-5 · Cited by 377
ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo
Rolle, A.-M., Hasenberg, M., Thornton, C. R., Solouk-Saran, D., Männ, L., Weski, J., Maurer, A., Fischer, E., Spycher, P. R., Schibli, R., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518836113 · Cited by 134
Davies, G., Rolle, A.-M., Maurer, A., Spycher, P. R., Schillinger, C., Solouk-Saran, D., Hasenberg, M., Weski, J., Fonslet, J., Dubois, A., et al. (2017) · Theranostics · doi:10.7150/thno.20919 · Cited by 63
Molecular Imaging of Invasive Pulmonary Aspergillosis Using ImmunoPET/MRI: The Future Looks Bright
Thornton, C. R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00691 · Cited by 47
Metadata
- Authors
- Santangelo, P. J., Rogers, K. A., Zurla, C., Blanchard, E. L., Gumber, S., Strait, K., Connor-Stroud, F., Schuster, D. M., Amancha, P. K., Hong, J. J., Byrareddy, S. N., Hoxie, J. A., Vidakovic, B., Ansari, A. A., Hunter, E., & Villinger, F.
- Venue
- Nature Methods
- Published
- 2015-03-09
- Volume
- 12
- Issue
- 5
- Pages
- 427-432
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2036468349
- Cited by
- 167
- References
- 2
- FWCI
- 11.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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