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The development of cryo-EM into a mainstream structural biology technique
Open accessAbstract
Single-particle cryo-electron microscopy (cryo-EM) has emerged over the last two decades as a technique capable of studying challenging systems that otherwise defy structural characterization. Recent technical advances have resulted in a 'quantum leap' in applicability, throughput and achievable resolution that has gained this technique worldwide attention. Here I discuss some of the major historical landmarks in the development of the cryo-EM field, ultimately leading to its present success.
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Cited by
Wang, X., Zhang, M., Alvarado, J., Wang, S., Sina, M., Lu, B., Bouwer, J., Xu, W., Xiao, J., Zhang, J.-G., et al. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b03606 · Cited by 409
Palermo, G., Chen, J. S., Ricci, C. G., Rivalta, I., Jinek, M., Batista, V. S., Doudna, J. A., & McCammon, J. A. (2018) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583518000070 · Cited by 123
Labeling and Single-Molecule Methods To Monitor G Protein-Coupled Receptor Dynamics
Tian, H., Fürstenberg, A., & Huber, T. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00084 · Cited by 114
The evolving contribution of mass spectrometry to integrative structural biology
Faini, M., Stengel, F., & Aebersold, R. (2016) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-016-1382-4 · Cited by 44
The Role of Mass Spectrometry in Structural Studies of Flavin-Based Electron Bifurcating Enzymes
Tokmina-Lukaszewska, M., Patterson, A., Berry, L., Scott, L., Balasubramanian, N., & Bothner, B. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01397 · Cited by 15
Metadata
- Authors
- Nogales, E.
- Venue
- Nature Methods
- Published
- 2015-12-30
- Volume
- 13
- Issue
- 1
- Pages
- 24-27
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2212589734
- Cited by
- 432
- References
- 0
- FWCI
- 19.24
- Type
- journal article
- Language
- en
- Open access
- green
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