The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis
Open accessAbstract
The transcriptional state of a cell reflects a variety of biological factors, from cell-type-specific features to transient processes such as the cell cycle, all of which may be of interest. However, identifying such aspects from noisy single-cell RNA-seq data remains challenging. We developed pathway and gene set overdispersion analysis (PAGODA) to resolve multiple, potentially overlapping aspects of transcriptional heterogeneity by testing gene sets for coordinated variability among measured cells.
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Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314
Spatial reconstruction of single-cell gene expression data
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Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
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Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
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Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
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Smart-seq2 for sensitive full-length transcriptome profiling in single cells
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Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
Self-citationMassively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M.-J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J.-R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.006 · Cited by 1,429
Metadata
- Authors
- Fan, J., Salathia, N., Liu, R., Kaeser, G. E., Yung, Y. C., Herman, J. L., Kaper, F., Fan, J.-B., Zhang, K., Chun, J., & Kharchenko, P. V.
- Venue
- Nature Methods
- Published
- 2016-01-18
- Volume
- 13
- Issue
- 3
- Pages
- 241-244
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2273101790
- Cited by
- 392
- References
- 21
- FWCI
- 26.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fan, J., Salathia, N., Liu, R., Kaeser, G. E., Yung, Y. C., Herman, J. L., Kaper, F., Fan, J.-B., Zhang, K., Chun, J., & Kharchenko, P. V. (2016). Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis. Nature Methods. https://doi.org/10.1038/nmeth.3734
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