The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain
Open accessAbstract
High-resolution optical imaging is critical to understanding brain function. We demonstrate that three-photon microscopy at 1,300-nm excitation enables functional imaging of GCaMP6s-labeled neurons beyond the depth limit of two-photon microscopy. We record spontaneous activity from up to 150 neurons in the hippocampal stratum pyramidale at ∼1-mm depth within an intact mouse brain. Our method creates opportunities for noninvasive recording of neuronal activity with high spatial and temporal resolution deep within scattering brain tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Ultrasensitive fluorescent proteins for imaging neuronal activity
Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
Long-term dynamics of CA1 hippocampal place codes
Ziv, Y., Burns, L. D., Cocker, E. D., Hamel, E. O., Ghosh, K. K., Kitch, L. J., Gamal, A. E., & Schnitzer, M. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3329 · Cited by 1,155
Functional imaging of hippocampal place cells at cellular resolution during virtual navigation
Dombeck, D. A., Harvey, C. D., Tian, L., Looger, L. L., & Tank, D. W. (2010) · Nature Neuroscience · doi:10.1038/nn.2648 · Cited by 873
Two-photon microscopy in brain tissue: parameters influencing the imaging depth
Oheim, M., Beaurepaire, E., Chaigneau, E., Mertz, J., & Charpak, S. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00438-1 · Cited by 425
Cited by
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Neuronal cell-type classification: challenges, opportunities and the path forward
Zeng, H., & Sanes, J. R. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.85 · Cited by 841
Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex
Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J., & Bergles, D. E. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0121-5 · Cited by 540
In vivo imaging of neural activity
Yang, W., & Yuste, R. (2017) · Nature Methods · doi:10.1038/nmeth.4230 · Cited by 406
Light-sheet microscopy in the near-infrared II window
Wang, F., Wan, H., Ma, Z., Zhong, Y., Sun, Q., Tian, Y., Qu, L., Du, H., Zhang, M., Li, L., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0398-7 · Cited by 237
Metadata
- Authors
- Ouzounov, D. G., Wang, T., Wang, M., Feng, D. D., Horton, N. G., Cruz-Hernández, J. C., Cheng, Y.-T., Reimer, J., Tolias, A. S., Nishimura, N., & Xu, C.
- Venue
- Nature Methods
- Published
- 2017-02-20
- Volume
- 14
- Issue
- 4
- Pages
- 388-390
- ISSN
- 1548-7091 (ISSN-L)
- 1548-7105
- OpenAlex
- W2589689453
- Cited by
- 511
- References
- 4
- FWCI
- 34.92
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain. https://app.cochat.ai/papers/10.1038/nmeth.4183
- The paper
- Ouzounov, D. G., Wang, T., Wang, M., Feng, D. D., Horton, N. G., Cruz-Hernández, J. C., Cheng, Y.-T., Reimer, J., Tolias, A. S., Nishimura, N., & Xu, C. (2017). In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain. Nature Methods. https://doi.org/10.1038/nmeth.4183
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
