Mapping the genomic landscape of CRISPR-Cas9 cleavage

Cameron, Peter, Fuller, Chris K, Donohoue, Paul D, Jones, Brittnee N, Thompson, Matthew S, Carter, Matthew M, Gradia, Scott, Vidal, Bastien +13 more·2017·Nature Methods

DOI 10.1038/nmeth.4284

Cited by (454)

Items 301–400 of 454

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The effect of sequence mismatches on binding affinity and endonuclease activity are decoupled throughout the Cas9 binding site
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Sylvie Mireille Guichard · 2017 · Annual reports in medicinal chemistry
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A kinetic model improves off-target predictions and reveals the physical basis of Sp Cas9 fidelity
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Negative DNA Supercoiling Induces Genome Wide Cas9 Off-Target Activity
Matthew D. Newton, Marialucrezia Losito, Quentin M. Smith, Nishita Parnandi, Benjamin J. Taylor, Pınar Akçakaya, Marcello Maresca, Yi-Fang Wang, Simon J. Boulton, Graeme A. King et al. · 2022 · SSRN Electronic Journal
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Off-target interactions in the CRISPR-Cas9 Machinery: mechanisms and outcomes
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Alieh Fazeli, Evelyn Ullrich, Toni Cathomen, Tobias Bexte · 2025 · Frontiers in Immunology
Phage homing endonuclease amplifies anti-defense genes to evade bacterial immunity
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Feature representation for explainable CRISPR off-target prediction and base editing efficiency
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A bioinformatic analysis of gene editing off‐target loci altered by common polymorphisms, using ‘PopOff’
Christopher Samson, Alex du Rand, John Hunt, Whitney Whitford, Jessie C. Jacobsen, Hilary M. Sheppard · 2024 · Journal of the Royal Society of New Zealand
A systematic method for solving data imbalance in CRISPR off-target prediction tasks
Zengrui Guan, Zhenran Jiang · 2024 · Computers in Biology and Medicine
CRISPert: A Transformer-Based Model for CRISPR-Cas Off-Target Prediction
William Jobson Pargeter, Rolf Backofen, Van Dinh Tran · 2024 · Lecture notes in computer science
Predicting CRISPR Cas9 Off-Target Activities With a Two-Stage Deep Learning Framework
Tianshan Zhang, Bei Jiang, Guang Yang, Zhijie Bao, Jiajie Peng · 2025 · IEEE Transactions on Computational Biology and Bioinformatics
Strategies for Optimization of the Clustered Regularly Interspaced Short Palindromic Repeat-Based Genome Editing System for Enhanced Editing Specificity
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Mechanism of the CRISPR/Cas9 System Specificity in Genome Editing
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Deciphering Cas9 specificity: Role of domain dynamics and RNA:DNA hybrid interactions revealed through machine learning and accelerated molecular simulations
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Off-target detection of CRISPR-Cas9 nuclease in vitro with CROFT-Seq
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Massively Targeted Evaluation of Therapeutic CRISPR Off-Targets in Cells
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Off-Target Effects of Crop Genome Editing and Its Minimization
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