Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Woolfrey, Kevin M, Srivastava, Deepak P, Photowala, Huzefa, Yamashita, Megumi, Barbolina, Maria V, Cahill, Michael E, Xie, Zhong, Jones, Kelly A +3 more·2009·Nature Neuroscience
DOI 10.1038/nn.2386

Cited by (161)

Items 101–161 of 161

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  5. Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy
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  7. Connecting the Neurobiology of Developmental Brain Injury: Neuronal Arborisation as a Regulator of Dysfunction and Potential Therapeutic Target
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  8. Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release
    Xiaojie Liu, Casey R. Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J. Kelly, David L. Baker et al. · 2022 · eLife
  9. A subpopulation of serotonin1B receptors colocalize with the AMPA receptor subunit GluR2 in the hippocampal dentate gyrus
    Christopher J. Peddie, Heather A. Davies, Frances M. Colyer, Michael G. Stewart, J.J. Rodríguez · 2010 · Neuroscience Letters
  10. Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density
    Kelly A. Jones, Michiko Sumiya, Kevin M. Woolfrey, Deepak P. Srivastava, Peter Penzes · 2019 · Molecular and Cellular Neuroscience
  11. Novel crosstalk mechanisms between GluA3 and Epac2 in synaptic plasticity and memory in Alzheimer's disease
    Tong Zhang, Amalia M. Dolga, Ulrich L.M. Eisel, Martina Schmidt · 2023 · Neurobiology of Disease
  12. Epac activation sensitizes rat sensory neurons through activation of Ras
    Behzad Shariati, Eric L. Thompson, G. D. Nicol, Michael R. Vasko · 2015 · Molecular and Cellular Neuroscience
  13. Plk2 Raps up Ras to subdue synapses
    Kea Joo Lee, Hyang‐Sook Hoe, Daniel T.S. Pak · 2011 · Small GTPases
  14. Regulation of Rap GTPases in mammalian neurons
    Bhavin Shah, Andreas W. Püschel · 2016 · Biological Chemistry
  15. Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice
    Reidun Aesöy, Haruna Muwonge, Kathrine Sivertsen Nordhus, Misbah Sabir, Solveig L. Witsoe, Ronja Bjørnstad, Reidun Kristin Kopperud, Erling André Høivik, Stein Ove Døskeland, Marit Bakke · 2018 · PLoS ONE
  16. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry
    Jan-Philip Schülke, Nicholas J. Brandon · 2017 · Advances in neurobiology
  17. Interactions between Ras and Rap signaling pathways during neurodevelopment in health and disease
    Salvatore J. Cherra, Reagan Lamb · 2024 · Frontiers in Molecular Neuroscience
  18. Modulation of Angiopoietin 2 release from endothelial cells and angiogenesis by the synaptic protein Neuroligin 2
    Margherita Pergolizzi, Laura Bizzozero, E. Riccitelli, Davide Pascal, Anna Valeria Samarelli, Federico Bussolino, Marco Arese · 2018 · Biochemical and Biophysical Research Communications
  19. Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function
    Kathryn J. Bjornson, Amanda M. Vanderplow, Yezi Yang, Danielle R. Anderson, Bailey A. Kermath, Michael E. Cahill · 2023 · iScience
  20. Over-expression of the DCLK gene transcript CARP decreases CA3/CA1 network excitability
    Geert J. Schenk, Taco R. Werkman, Wytse Jan Wadman, Barbera Veldhuisen, Thomas F. Dijkmans, Eva Blaas, Linde Kegel, E. R. de Kloet, Erno Vreugdenhil · 2010 · Brain Research
  21. Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis
    Reham Alharatani, John N. Griffin, Karen J. Liu · 2019 · Gene Expression Patterns
  22. Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis
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  26. 8-pCPT, an Epac activator, impairs conditioned place preference based on nucleus accumbens amphetamine in rats
    Sung Woo Park, Ali Roohbakhsh, Richard J Beninger · 2013 · Acta Neuropsychiatrica
  27. Aberrant gene expression yet undiminished retinal ganglion cell genesis in iPSC-derived models of optic nerve hypoplasia
    Jennifer G. Aparicio, Hanno Hopp, Narine Harutyunyan, Carly Stewart, David E. Cobrinik, Mark Borchert · 2023 · Ophthalmic Genetics
  28. Epac2-mediated synaptic insertion of Ca2+-permeable AMPARs in the nucleus accumbens contributes to incubation of cocaine craving
    Xiaojie Liu, Yao Huang, Lianwei Mu, Vladislav Friedman, Thomas J. Kelly, Ying Chuan Hu, Dong Yuan, Qing-song Liu · 2024 · Neuropsychopharmacology
  29. The Relevance of Subplate Modifications to Connectivity in the Cerebral Cortex of Individuals with Autism Spectrum Disorders
    Jeffrey J. Hutsler, Thomas A. Avino · 2015 · Springer eBooks
  30. MicroRNAs
    Ghiabe-Henri Guibinga · 2015 · Advances in genetics
  31. Trafficking of Glutamate Receptors and Associated Proteins in Synaptic Plasticity
    Martin Hořák, Gail K. Seabold, Ronald S. Petralia · 2014 · Elsevier eBooks
  32. Spine Homeostasis as a Novel Therapeutic Target for Schizophrenia
    Satoru Yamagishi · 2013 · Clinical Pharmacology & Biopharmaceutics
  33. 3D culture of the spinal cord with roots as an ex vivo model for comparative studies of motor and sensory nerve regeneration
    Li‐Kang Zhang, Jia-Hui Sun, Sheng Liu, Wenliang Zhang, Jianlong Zou · 2023 · Experimental Neurology
  34. Genetic manipulation of cyclic nucleotide signaling during hippocampal neuroplasticity and memory formation
    Michy P. Kelly, Pim R.A. Heckman, Robbert Havekes · 2020 · Progress in Neurobiology
  35. Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target
    Anand Suresh, Nazim Kourdougli, Toshihiro Nomura, Jessie E. Buth, Soledad Miranda‐Rottmann, Carlos Andrés Sánchez-León, Michelle W. Wu, Sofia M. Nelson, Lauren T. Wall, Anne Tran et al. · 2026 · Neuron
  36. Interaction of Epac with Non-canonical Cyclic Nucleotides
    Holger Rehmann · 2015 · Handbook of experimental pharmacology
  37. Alleviation of thalamic pain by cilostazol administration: a case report
    Ayaka Haruta‐Tsukamoto, Hideki Funahashi, Yu Miyahara, Tomoko Matsuo, Toshikazu Nishimori, Yasushi Ishida · 2018 · Clinical Case Reports
  38. Dendritic spine pathology in neuropsychiatric
    Michael E. Cahill, Kelly A. Jones, Jon‐Eric VanLeeuwen, Kevin M. Woolfrey · 2011
  39. cAMP Sensor Epac and Gastrointestinal Function
    Oleg G. Chepurny, Colin A. Leech, Xiaodong Cheng, George G. Holz · 2012 · Elsevier eBooks
  40. Exchange protein directly activated by cAMP 2 is required for corticotropin‐releasing hormone‐mediated spine loss
    Zhong Xie, Peter Penzes, Deepak P. Srivastava · 2019 · European Journal of Neuroscience
  41. Dendritic Spines
    Dominique Müller, Irina Nikonenko · 2013 · Elsevier eBooks
  42. Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders
    Peter Penzes, Christine L. Remmers, Michael E. Cahill, Kelly A. Jones, Jon‐Eric VanLeeuwen, Kevin M. Woolfrey · 2014 · Elsevier eBooks
  43. Mutations in Synaptic Adhesion Molecules
    Jaewon Ko, Caterina Montani, Eunjoon Kim, Carlo Sala · 2016 · Elsevier eBooks
  44. Activity-Mediated Structural Plasticity of Dendritic Spines
    Dominique Müller, Mathias De Roo, Irina Nikonenko · 2014 · Elsevier eBooks
  45. The role of filopodia in the formation of spine synapses
    Pamela Arstikaitis · 2011 · cIRcle (University of British Columbia)
  46. Nanoscale organization and dynamics of SNARE proteins in the presynaptic membranes
    Dragomir Milovanović · 2015
  47. Role of EPAC in axon determination
    Pablo Muñoz-LLancao · 2015
  48. Illuminating cAMP dynamics at the synapse with multiphoton FLIM-FRET Imaging
    Lucien West · 2016
  49. Mechanism of Training Induced Functional Gains and CST Sprouting after SCI: The role of PKA Signaling
    David Wei · 2015 · ERA: Education and Research Archive (University of Alberta)
  50. Loss of EPAC2 results in altered synaptic composition of dendritic spines and excitatory and inhibitory balance
    Kelly A. Jones, Michiko Sumiya, Kevin M. Woolfrey, Deepak P. Srivastava, Peter Penzes · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  51. EPAC2 is required for corticotropin-releasing hormone-mediated spine loss
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  52. Rapid Modulation of Spinogenesis by Estradiol in the Neocortex
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  53. The Epac2 coding gene (RAPGEF4) rs3769219 polymorphism is associated with protection against major depressive disorder in the Chinese Han population
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  54. Aberrant regulation of the Rap1 small GTPase in response to escalating, intermittent stress produces hippocampal synaptic and cognitive dysfunction
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  55. Additional file 1 of Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus
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