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Neurexins and neuroligins: synapses look out of the nervous system

Bottos, A., Rissone, A., Bussolino, F., & Arese, M. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0664-z · Cited by 70 · see citing works

Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus

Fernandes, H. B., Riordan, S. M., Nomura, T., Remmers, C. L., Kraniotis, S., Marshall, J. J., Kukreja, L., Vassar, R. J., & Contractor, A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0314-14.2015 · Cited by 71 · see citing works

SynArfGEF is a guanine nucleotide exchange factor for Arf6 and localizes preferentially at post‐synaptic specializations of inhibitory synapses

Fukaya, M., Kamata, A., Hara, Y., Tamaki, H., Katsumata, O., Ito, N., Takeda, S., Hata, Y., Suzuki, T., Watanabe, M., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07167.x · Cited by 70 · see citing works

PH‐Domain‐driven targeting of collybistin but not Cdc42 activation is required for synaptic gephyrin clustering

Reddy-Alla, S., Schmitt, B., Birkenfeld, J., Eulenburg, V., Dutertre, S., Böhringer, C., Götz, M., Betz, H., & Papadopoulos, T. G. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07149.x · Cited by 69 · see citing works

Analysis of Dendritic Spine Morphology in Cultured CNS Neurons

Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2011) · Journal of Visualized Experiments · doi:10.3791/2794 · Cited by 67 · see citing works

Lateral organization of the postsynaptic density

MacGillavry, H. D., Kerr, J. M., & Blanpied, T. A. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.09.001 · Cited by 64 · see citing works

Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot

Argyrousi, E. K., Heckman, P. R. A., & Prickaerts, J. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.004 · Cited by 64 · see citing works

NPY Y1 Receptors Differentially Modulate GABAA and NMDA Receptors via Divergent Signal-Transduction Pathways to Reduce Excitability of Amygdala Neurons

Molosh, A. I., Sajdyk, T. J., Truitt, W. A., Zhu, W., Oxford, G. S., & Shekhar, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.33 · Cited by 60 · see citing works

Structure and functional roles of Epac2 (Rapgef4)

Sugawara, K., Shibasaki, T., Takahashi, H., & Seino, S. (2015) · Gene · doi:10.1016/j.gene.2015.09.029 · Cited by 63 · see citing works

Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines

Penzes, P., & Cahill, M. E. (2012) · Cytoskeleton · doi:10.1002/cm.21015 · Cited by 57 · see citing works

Novel candidate genes and regions for childhood apraxia of speech identified by array comparative genomic hybridization

Laffin, J. J. S., Raca, G., Jackson, C. A., Strand, E. A., Jakielski, K. J., & Shriberg, L. D. (2012) · Genetics in Medicine · doi:10.1038/gim.2012.72 · Cited by 59 · see citing works

WASP family proteins: Molecular mechanisms and implications in human disease

Kramer, D. A., Piper, H. K., & Chen, B. (2022) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2022.151244 · Cited by 57 · see citing works

Signaling mechanisms regulating synapse formation and function in mental retardation

Boda, B., Dubos, A., & Müller, D. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.03.012 · Cited by 57 · see citing works

Synaptic Cell Adhesion Molecules

Bukalo, O., & Dityatev, A. E. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_5 · Cited by 57 · see citing works

New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels

Podda, M. V., & Grassi, C. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1373-2 · Cited by 53 · see citing works

Epac2-mediated dendritic spine remodeling: Implications for disease

Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 47 · see citing works

Antidiabetic Sulfonylureas and cAMP Cooperatively Activate Epac2A

Takahashi, T., Shibasaki, T., Takahashi, H., Sugawara, K., Ono, A., Inoue, N., Furuya, T., & Seino, S. (2013) · Science Signaling · doi:10.1126/scisignal.2004581 · Cited by 48 · see citing works

Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling

Fields, D. P., Springborn, S., & Mitchell, G. S. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00374.2015 · Cited by 47 · see citing works

Actin-Dependent Alterations of Dendritic Spine Morphology in Shankopathies

Sarowar, T., & Grabrucker, A. M. (2016) · Neural Plasticity · doi:10.1155/2016/8051861 · Cited by 46 · see citing works

Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease

Srivastava, D. P., & Penzes, P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00077 · Cited by 44 · see citing works

Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac

Zhou, L., Ma, S. L., Yeung, P. K. K., Wong, Y. H., Tsim, K. W. K., So, K., LAM, L. C. W., & Chung, S. K. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.129 · Cited by 44 · see citing works

Organization of central synapses by adhesion molecules

Tallafuß, A., Constable, J. R. L., & Washbourne, P. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07340.x · Cited by 42 · see citing works

New perspectives in cyclic AMP-mediated axon growth and guidance: The emerging epoch of Epac

Peace, A. G., & Shewan, D. A. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.09.002 · Cited by 41 · see citing works

Epac: new emerging cAMP-binding protein

Lee, K. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.3.233 · Cited by 41 · see citing works

Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome

Mironov, S. L., Skorova, E., & Kügler, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.002 · Cited by 39 · see citing works

Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility

Lee, K., Kobayashi, Y., Seo, H., Kwak, J., Masuda, A., Lim, C., Lee, H., Kang, S. J., Park, P., Sim, S.-E., et al. (2015) · Molecular Brain · doi:10.1186/s13041-015-0130-1 · Cited by 39 · see citing works

A Schizophrenia-Linked KALRN Coding Variant Alters Neuron Morphology, Protein Function, and Transcript Stability

Russell, T. A., Grubisha, M. J., Remmers, C. L., Kang, S. K., Forrest, M. P., Smith, K. R., Kopeikina, K. J., Gao, R., Sweet, R. A., & Penzes, P. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.024 · Cited by 38 · see citing works

Two-Step Wiring Plasticity – A mechanism for estrogen-induced rewiring of cortical circuits

Srivastava, D. P. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.01.006 · Cited by 37 · see citing works

Long-term depression-associated signaling is required for an in vitro model of NMDA receptor-dependent synapse pruning

Henson, M. A., Tucker, C. J., Zhao, M., & Dudek, S. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.013 · Cited by 34 · see citing works

PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain

Hegde, S., Ji, H., Oliver, D., Patel, N. S., Poupore, N. S., Shtutman, M. S., & Kelly, M. P. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.08.019 · Cited by 33 · see citing works

Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B

Muñoz-LLancao, P., Henríquez, D. R., Wilson, C., Bodaleo, F. J., Boddeke, E., Lezoualc’h, F., Schmidt, M., & González-Billault, C. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3645-14.2015 · Cited by 32 · see citing works

Role of Epac in brain and heart

Laurent, A., Breckler, M., Berthouze, M., & Lezoualc’h, F. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110642 · Cited by 31 · see citing works

Ubiquitination

de la Vega, M., Burrows, J. F., & Johnston, J. A. (2011) · Small GTPases · doi:10.4161/sgtp.2.4.16707 · Cited by 31 · see citing works

Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia

Chen, B. H., Park, J. H., Kim, D. W., Park, J., Choi, S. Y., Kim, I. H., Cho, J.-H., Lee, T.-K., Lee, J. C., Lee, C. H., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00278 · Cited by 31 · see citing works

Afadin Is Required for Maintenance of Dendritic Structure and Excitatory Tone

Srivastava, D. P., Copits, B. A., Xie, Z., Huda, R., Jones, K. A., Mukherji, S., Cahill, M. E., VanLeeuwen, J., Woolfrey, K. M., Rafalovich, I., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363358 · Cited by 30 · see citing works

A Kinase Anchor Protein 150 (AKAP150)-associated Protein Kinase A Limits Dendritic Spine Density

Lü, Y., Zha, X., Kim, E. Y., Schachtele, S. J., Dailey, M. E., Hall, D. D., Strack, S., Green, S. H., Hoffman, D. A., & Hell, J. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254912 · Cited by 29 · see citing works

The role of melanocortins and Neuropeptide Y in food reward

Pandit, R., la Fleur, S. E., & Adan, R. A. H. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.059 · Cited by 29 · see citing works

Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area

Liu, X., Chen, Y., Tong, J., Reynolds, A., Proudfoot, S. C., Qi, J., Penzes, P., Lu, Y., & Liu, Q.-S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3186-15.2016 · Cited by 27 · see citing works

Cyclic AMP and the regeneration of retinal ganglion cell axons

Hellström, M., & Harvey, A. R. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.04.018 · Cited by 27 · see citing works

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons

Tong, J., Liu, X.-J., Vickstrom, C. R., Li, Y., Yu, L., Lu, Y.-M., Smrcka, A., & Liu, Q.-S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2810-16.2017 · Cited by 25 · see citing works

Activation of Exchange Protein Activated by cAMP in the Rat Basolateral Amygdala Impairs Reconsolidation of a Memory Associated with Self-Administered Cocaine

Wan, X., Torregrossa, M. M., Sanchez, H., Nairn, A. C., & Taylor, J. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107359 · Cited by 25 · see citing works

The dual role of dopamine in the modulation of information processing in the prefrontal cortex underlying social behavior

Sotoyama, H., Inaba, H., Iwakura, Y., Namba, H., Takei, N., Sasaoka, T., & Nawa, H. (2022) · The FASEB Journal · doi:10.1096/fj.202101637r · Cited by 25 · see citing works

A Bright, Nontoxic, and Non-aggregating red Fluorescent Protein for Long-Term Labeling of Fine Structures in Neurons

Lin, N., Geng, Y., Lovett-Barron, M., Niu, X., Deng, M., Wang, L., Ataie, N., Sens, A., Ng, H. L., Chen, S., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.893468 · Cited by 25 · see citing works

Guanine nucleotide exchange factor Epac2–dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells

Emery, A. C., Xu, W., Eiden, M. V., & Eiden, L. E. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.790329 · Cited by 25 · see citing works

Advances in Discovery of PDE10A Inhibitors for CNS-Related Disorders. Part 1: Overview of the Chemical and Biological Research

Jankowska, A., Świerczek, A., Wyska, E., Gawalska, A., Bucki, A., Pawłowski, M., & Chłoń‐Rzepa, G. (2018) · Current Drug Targets · doi:10.2174/1389450119666180808105056 · Cited by 25 · see citing works

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Maeta, K., Hattori, S., Ikutomo, J., Edamatsu, H., Bilasy, S. E., Miyakawa, T., & Kataoka, T. (2018) · Molecular Brain · doi:10.1186/s13041-018-0370-y · Cited by 24 · see citing works

Aggression based genome-wide, glutamatergic, dopaminergic and neuroendocrine polygenic risk scores predict callous-unemotional traits

Ruisch, I. H., Dietrich, A., Klein, M., Faraone, S. V., Oosterlaan, J., Buitelaar, J. K., & Hoekstra, P. J. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0608-0 · Cited by 23 · see citing works

Modelling intracellular competition for calcium: kinetic and thermodynamic control of different molecular modes of signal decoding

Antunes, G., Roque, A. C., & de Souza, F. M. S. (2016) · Scientific Reports · doi:10.1038/srep23730 · Cited by 22 · see citing works

Common pathways for growth and for plasticity

Knafo, S., & Esteban, J. A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.008 · Cited by 21 · see citing works

Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking

Argyrousi, E. K., Heckman, P. R. A., van Hagen, B. T. J., Muysers, H., van Goethem, N. P., & Prickaerts, J. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119885262 · Cited by 21 · see citing works

Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus

Nia, F. H., Woike, D., Martens, V., Klüssendorf, M., Hönck, H., Harder, S., & Kreienkamp, H. (2020) · Molecular Autism · doi:10.1186/s13229-020-00385-8 · Cited by 21 · see citing works

EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability

Zhao, K., Wen, R., Wang, X., Pei, L., Yang, Y., Shang, Y., Bazan, N. G., Zhu, L., Tian, Q., & Lu, Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5686-12.2013 · Cited by 21 · see citing works

The Rap1 small GTPase is a critical mediator of the effects of stress on prefrontal cortical dysfunction

Kermath, B. A., Vanderplow, A. M., Bjornson, K. J., Seablom, E. N., Novak, A., Bernhardt, C. R., & Cahill, M. E. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0835-0 · Cited by 17 · see citing works

Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells

Lewis, A. E., Aesöy, R., & Bakke, M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00063 · Cited by 19 · see citing works

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortex

Gao, Y., Dong, Q., Arachchilage, K. H., Risgaard, R. D., Syed, M., Sheng, J., Schmidt, D. K., Jin, T., Liu, S., Sandoval, S. O., et al. (2023) · Neuron · doi:10.1016/j.neuron.2025.04.025 · Cited by 18 · see citing works

Dopamine Promotes Ascorbate Release from Retinal Neurons: Role of D1 Receptors and the Exchange Protein Directly Activated by cAMP type 2 (EPAC2)

da Encarnação, T. G., Portugal, C. C., Nogueira, C. E., Santiago, F. N., Socodato, R., & Paes‐de‐Carvalho, R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0962-7 · Cited by 18 · see citing works

Functional Relevance of Missense Mutations Affecting the N-Terminal Part of Shank3 Found in Autistic Patients

Nia, F. H., & Kreienkamp, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00268 · Cited by 19 · see citing works

Epac activation initiates associative odor preference memories in the rat pupPreprint

Grimes, M. T., Powell, M. F., Gutierrez, S. M., Darby‐King, A., Harley, C. W., & McLean, J. H. (2015) · Learning & Memory · doi:10.1101/lm.037101.114 · Cited by 18 · see citing works

Epac2-mediated dendritic spine remodeling: Implications for disease

Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 47 · see citing works

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density

Jones, K. A., Sumiya, M., Woolfrey, K. M., Srivastava, D. P., & Penzes, P. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.05.001 · Cited by 15 · see citing works

Loss of EPAC2 results in altered synaptic composition of dendritic spines and excitatory and inhibitory balancePreprint

Jones, K. A., Sumiya, M., Woolfrey, K. M., Srivastava, D. P., & Penzes, P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/526772

An Autism-Associated Variant of Epac2 Reveals a Role for Ras/Epac2 Signaling in Controlling Basal Dendrite Maintenance in Mice

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Özdi̇nler, P. H., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001350 · Cited by 85 · see citing works

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol

Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Ozdinler, E., et al. (2012)