The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
The corticothalamocortical circuit drives higher-order cortex in the mouse
Open accessAbstract
An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B are involved in information transfer through the cortical hierarchy. Using a new form of optical imaging in a brain slice preparation, we found that the corticothalamocortical pathway drove robust activity in higher-order somatosensory cortex. When the direct corticocortical pathway was interrupted, secondary somatosensory cortex showed robust activity in response to stimulation of the barrel field in primary somatosensory cortex (S1BF), which was eliminated after subsequently cutting the somatosensory thalamus, suggesting a highly efficacious corticothalamocortical circuit. Furthermore, after chemically inhibiting the thalamus, activation in secondary somatosensory cortex was eliminated, with a subsequent return after washout. Finally, stimulation of layer 5B in S1BF, and not layer 6, drove corticothalamocortical activation. These findings suggest that the corticothalamocortical circuit is a physiologically viable candidate for information transfer to higher-order cortical areas.
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“Similarly, cortico-fugal (61, 62) and cortico-thalamo-cortical (57, 58) organization is also mainly ipsilateral and known to form feedback control loops.”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [57]
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“The strongest evidence for this claim comes from the somatosensory system, where it was shown recently that the posterior medial nucleus of the thalamus (POm) – a higher-order thalamic nucleus that receives direct input from cortex – can relay information between S1 and S2 (Theyel et al., 2009).”
From Canonical Microcircuits for Predictive Coding (2012) · cites this paper as Theyel et al., 2009
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“For example, posterior thalamic nucleus (POm) may provide a thalamic relay for cortico-cortical information flow between S1 and S2 sensory areas (57) and was shown recently to be indispensable in whisker-based texture discrimination tasks (58).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [57]
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Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
Information processing in the primate visual system: an integrated systems perspective
Van Essen, D. C., Anderson, C. H., & Felleman, D. J. (1992) · Science · doi:10.1126/science.1734518 · Cited by 1,266
The role of the thalamus in the flow of information to the cortex
Sherman, S. M., & Guillery, R. W. (2002) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1161 · Cited by 938 · cited 1×
“However, a recent hypothesis suggests that much, and perhaps the vast majority of, information flow between cortical areas involves higher-order thalamic nuclei in the form of corticothalamocortical circuit”
BackgroundSelf-citationOlshausen, B., Anderson, C., & Van Essen, D. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-11-04700.1993 · Cited by 908
Functional organization of thalamocortical relays
Sherman, S. M., & Guillery, R. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1367 · Cited by 762
Self-citationOn the actions that one nerve cell can have on another: distinguishing “drivers” from “modulators”
Sherman, S. M., & Guillery, R. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7121 · Cited by 746 · cited 1×
“This latter hypothesis is based partly on the idea that many brain circuits can be divided into 'drivers', which represent the main information routes, and 'modulators', which serve to modulate information flo”
BackgroundSelf-citationThalamocortical responses of mouse somatosensory (barrel) cortexin vitro
Agmon, A., & Connors, B. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90333-j · Cited by 673
Exploring the Thalamus and Its Role in Cortical Function
Sherman, S. M., & Guillery, R. W. (2005) · The MIT Press eBooks · doi:10.7551/mitpress/2940.001.0001 · Cited by 646
Self-citationThalamic Relay Functions and Their Role in Corticocortical Communication
Guillery, R. W., & Sherman, S. M. (2002) · Neuron · doi:10.1016/s0896-6273(01)00582-7 · Cited by 637
Self-citationBourassa, J., Pinault, D., & Deschênes, M. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01016.x · Cited by 405
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Canonical Microcircuits for Predictive Coding
Bastos, A. M., Usrey, W. M., Adams, R. A., Mangun, G. R., Fries, P., & Friston, K. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.038 · Cited by 2,421
“The strongest evidence for this claim comes from the somatosensory system, where it was shown recently that the posterior medial nucleus of the thalamus (POm) – a higher-order thalamic nucleus that receives direct input from cortex – can relay information between S1 and S2 (Theyel et al., 2009).”
Neural correlates of consciousness: progress and problems
Koch, C., Massimini, M., Boly, M., & Tononi, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.22 · Cited by 1,600
Spectral fingerprints of large-scale neuronal interactions
Siegel, M., Donner, T. H., & Engel, A. K. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3137 · Cited by 1,295
The neocortical circuit: themes and variations
Harris, K. D., & Shepherd, G. M. G. (2015) · Nature Neuroscience · doi:10.1038/nn.3917 · Cited by 1,215
The pulvinar regulates information transmission between cortical areas based on attention demands
Saalmann, Y. B., Pinsk, M. A., Wang, L., Li, X., & Kastner, S. (2012) · Science · doi:10.1126/science.1223082 · Cited by 1,016
Metadata
- Authors
- Theyel, B. B., Llano, D. A., & Sherman, S. M.
- Affiliations
- University of Chicago (US)
- University of Chicago Medical Center (US)
- Corresponding author
- Theyel, Brian B
- Venue
- Nature Neuroscience
- Published
- 2009-12-06
- Volume
- 13
- Issue
- 1
- Pages
- 84-88
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2846438
- OpenAlex
- W2011102093
- Cited by
- 366
- References
- 45
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 23 · 2023: 23 · 2022: 21 · 2021: 42 · 2020: 28 · 2019: 19 · 2018: 21 · 2017: 16 · 2016: 25 · 2015: 27 · 2014: 20 · 2013: 16 · 2012: 25
- FWCI
- 9.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (EY 03038, R01EY003038)
- National Institute on Deafness and Other Communication Disorders (R01DC008794, DC008320, DC-008794, K08DC008320)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- somatosensory cortex, secondary somatosensory cortex, primary somatosensory cortex, barrel cortex, thalamus, cortical hierarchy, corticocortical connections
- MeSH terms
- Afferent Pathways, Animals, Animals, Newborn, Biophysics, Brain Mapping, Cerebral Cortex, Diagnostic Imaging, Electric Stimulation, Female, Flavoproteins, Male, Membrane Potentials, Mice, Inbred BALB C, Neural Inhibition, Quinoxalines, Thalamus, Time Factors, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Mice, In Vitro Techniques
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