The amygdala encodes specific sensory features of an aversive reinforcer
Open accessAbstract
Studies of reconsolidation, in which retrieved memories are altered and restored, offer an approach for exploring the associative structure of fear memory. We found that exposure to the unconditioned stimulus initiates an unconditioned stimulus-specific reconsolidation of learned fear in rats that depended on the amygdala. Thus, specific features of the unconditioned stimulus appear to be encoded in the amygdala as part of fear memories stored there.
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Context-associated memory deficit is typical in AD patients and manifested as dysfunction of fear conditioning involving neural circuits of the amygdala, hippocampus, and prefrontal cortex.
“Context-associated memory: This deficit is typical in AD patients [128][129][130] and manifested as dysfunction of fear conditioning 82 involving neural circuits of the amygdala, hippocampus, and prefrontal cortex 131,132 .”
From NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease (2025) · cites this paper as [132]
The paper’s Abstract (page unavailable) links fear conditioning and fear-memory reconsolidation to the lateral amygdala in rats. It does not establish the involvement of the hippocampus or prefrontal cortex in the stated circuit. The AD-patient deficit is attached to different citations in the citing sentence, so it is not assessed against this source. (LLM, conf=0.87)
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Cites
The Neuroscience of Mammalian Associative Learning
Fanselow, M. S., & Poulos, A. M. (2005) · Annual Review of Psychology · doi:10.1146/annurev.psych.56.091103.070213 · Cited by 683 · see citing works
Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala
Doyère, V., Dębiec, J., Monfils, M.-H., Schafe, G. E., & LeDoux, J. E. (2007) · Nature Neuroscience · doi:10.1038/nn1871 · Cited by 200 · see citing works
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Cited by
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Optimizing exposure therapy with an inhibitory retrieval approach and the OptEx Nexus
Craske, M. G., Treanor, M., Zbozinek, T. D., & Vervliet, B. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104069 · Cited by 195 · see citing works
Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Torregrossa, M. M., & Taylor, J. R. (2013) · Psychopharmacology · doi:10.1007/s00213-012-2750-9 · Cited by 172 · see citing works
Szeleszczuk, Ł., & Frączkowski, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710099 · Cited by 46 · see citing works
NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease
Fan, F., Joshi, P., Liu, X., Kotturu, S. K., Abiola, M., Liu, Q., & Lou, X. (2025) · doi:10.64898/2025.12.21.695860
- Authors
- Dębiec, J., Díaz-Mataix, L., Bush, D. E. A., Doyère, V., & LeDoux, J. E.
- Affiliations
- W. M. Keck Foundation (US)
- Université Paris-Sud (FR)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Dębiec, Jacek
- Venue
- Nature Neuroscience
- Published
- 2010-03-28
- Volume
- 13
- Issue
- 5
- Pages
- 536-537
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC2860669
- OpenAlex
- W2169803233
- Cited by
- 104
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 10
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Science Foundation
- National Institute of Mental Health (R37MH038774, P50MH058911, R01MH046516)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amygdala, fear memory, memory reconsolidation, unconditioned stimulus, sensory features, aversive reinforcement, associative learning
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Anisomycin, Avoidance Learning, Behavior, Animal, Conditioning, Classical, Cues, Fear, Male, Memory, Protein Synthesis Inhibitors, Reinforcement, Psychology, Time Factors, Rats, Sprague-Dawley, Rats
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