Learning to forget: manipulating extinction and reconsolidation processes to treat addiction

Torregrossa, Mary M.; Taylor, Jane R.

doi:10.1007/s00213-012-2750-9

Cited by 172Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorMemory Processes and Influences

Learning to forget: manipulating extinction and reconsolidation processes to treat addiction

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Torregrossa, Mary M., Taylor, Jane R.·2013·Psychopharmacology

DOI 10.1007/s00213-012-2750-9PMC PMC3466391

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Abstract

Finding effective long-lasting treatments for drug addiction has been an elusive goal. Consequently, researchers are beginning to investigate novel treatment strategies including manipulations of drug-associated memories. When environmental stimuli (cues) become associated with drug use, they become powerful motivators of continued drug use and relapse after abstinence. Reducing the strength of these cue-drug memories could decrease the number of factors that induce craving and relapse to aid in the treatment of addiction. Enhancing the consolidation of extinction learning and/or disrupting cue-drug memory reconsolidation are two strategies that have been proposed to reduce the strength of cues in motivating drug-seeking and drug-taking behavior. Here, we review the latest basic and clinical research elucidating the mechanisms underlying consolidation of extinction and reconsolidation of cue-drug memories in the hopes of developing pharmacological tools that exploit these signaling systems to treat addiction.

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Research supports CBT effectiveness for a wide range of people trying to quit smoking, including PTSD patients, people with HIV, individuals with mental illness, low socioeconomic smokers, adults with chronic pain, overweight and disadvantaged smokers, and youth.
“Research supports that CBT is effective for a wide range of individuals who are trying to quit smoking, including PTSD patients,63 people living with HIV,66 individuals with mental illness,67 low socioeconomic smokers,57 adults with chronic pain,68 overweight and disadvantaged smokers,61 and youth.65”
From Are smoking cessation treatments associated with suicidality risk? An overview (2016) · cites this paper as [63]
The section 'Clinical use of extinction and reconsolidation based therapies' discusses cue exposure therapy and preliminary findings involving cigarette smokers, not CBT for smoking cessation. Searches for CBT, youth, and the listed populations found no passage establishing the attributed effectiveness claim. Page numbers are not available in our copy. (LLM, conf=0.76)
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Postretrieval propranolol disrupts a cocaine conditioned place preference
Bernardi, R. E., Lattal, K. M., & Berger, S. P. (2006) · Neuroreport · doi:10.1097/01.wnr.0000233098.20655.26 · Cited by 118 · see citing works
The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in ratsPreprint
Brown, T. E., Lee, B. R., & Sorg, B. A. (2008) · Learning & Memory · doi:10.1101/lm.1152808 · Cited by 117 · see citing works
Cue Exposure Therapy for the Treatment of Opiate Addiction: Results of a Randomized Controlled Clinical Trial
Marissen, M. A. E., Franken, I. H. A., Blanken, P., van den Brink, W., & Hendriks, V. M. (2007) · Psychotherapy and Psychosomatics · doi:10.1159/000097968 · Cited by 109 · see citing works
Inhibition of PKMζ in Nucleus Accumbens Core Abolishes Long-Term Drug Reward Memory
Li, Y.-Q., Xue, Y.-X., He, Y., Li, F., Xue, L., Xu, C., Sacktor, T. C., Shaham, Y., & Lü, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5884-10.2011 · Cited by 104 · see citing works
Behavioural memory reconsolidation of food and fear memories
Flavell, C. R., Barber, D. J., & Lee, J. L. C. (2011) · Nature Communications · doi:10.1038/ncomms1515 · Cited by 104 · see citing works
Activation of the transcription factor NF-κB by retrieval is required for long-term memory reconsolidationPreprint
Merlo, E., Freudenthal, R., Maldonado, H., & Romano, A. G. (2005) · Learning & Memory · doi:10.1101/lm.82705 · Cited by 104 · see citing works
Cue-Exposure Therapy to Decrease Alcohol Craving in Virtual Environment
Lee, J.-H., Kwon, H., Choi, J., & Yang, B. (2007) · CyberPsychology & Behavior · doi:10.1089/cpb.2007.9978 · Cited by 104 · see citing works
The amygdala encodes specific sensory features of an aversive reinforcer
Dębiec, J., Díaz-Mataix, L., Bush, D. E. A., Doyère, V., & LeDoux, J. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2520 · Cited by 104 · see citing works
Animal Models and Brain Circuits in Drug Addiction
Kalivas, P. W., Peters, J., & Knackstedt, L. A. (2006) · Molecular Interventions · doi:10.1124/mi.6.6.7 · Cited by 103 · see citing works
d-Cycloserine Reduces the Context Specificity of Pavlovian Extinction of Cocaine Cues through Actions in the Nucleus Accumbens
Torregrossa, M. M., Sanchez, H., & Taylor, J. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2523-10.2010 · Cited by 100 · see citing works
Self-citation
Cues paired with a low dose of alcohol acquire conditioned incentive properties in social drinkers
Field, M., & Duka, T. (2001) · Psychopharmacology · doi:10.1007/s00213-001-0923-z · Cited by 99 · see citing works
Reconsolidation of a morphine place preference: Impact of the strength and age of memory on disruption by propranolol and midazolam
Robinson, M. J. F., & Franklin, K. B. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.04.056 · Cited by 99 · see citing works
The facilitative effects of d-cycloserine on extinction of a cocaine-induced conditioned place preference can be long lasting and resistant to reinstatement
Paolone, G., Botreau, F., & Stewart, J. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1280-y · Cited by 96 · see citing works
Antagonism at NMDA receptors, but not β-adrenergic receptors, disrupts the reconsolidation of pavlovian conditioned approach and instrumental transfer for ethanol-associated conditioned stimuli
Milton, A. L., Schramm, M. J. W., Wawrzynski, J. R., Gore, F., Oikonomou-Mpegeti, F., Wang, N. Q., Samuel, D., Economidou, D., & Everitt, B. J. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2399-9 · Cited by 96 · see citing works
Reconsolidation or extinction: transcription factor switch in the determination of memory course after retrieval
de la Fuente, V., Freudenthal, R., & Romano, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6066-10.2011 · Cited by 94 · see citing works
D-cycloserine Deters Reacquisition of Cocaine Self-Administration by Augmenting Extinction Learning
Dhonnchadha, B. Á. N., Szalay, J. J., Achat‐Mendes, C., Platt, D. M., Otto, M. W., Spealman, R. D., & Kantak, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.139 · Cited by 93 · see citing works
The role of the basolateral amygdala in stimulus–reward memory and extinction memory consolidation and in subsequent conditioned cued reinstatement of cocaine seeking
Fuchs, R. A., Feltenstein, M. W., & See, R. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04806.x · Cited by 91 · see citing works
Context-Induced Relapse of Conditioned Behavioral Responding to Ethanol Cues in Rats
Chaudhri, N., Sahuque, L. L., & Janak, P. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.007 · Cited by 91 · see citing works
Long-term memory of cocaine-associated context: disruption and reinstatement
Kelley, J. B., Anderson, K. L., & Itzhak, Y. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280c1e2e7 · Cited by 89 · see citing works
Extinction learning, reconsolidation and the internal reinforcement hypothesis
Eisenhardt, D., & Menzel, R. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.09.005 · Cited by 89 · see citing works
Reconsolidation of a Cocaine-Associated Stimulus Requires Amygdalar Protein Kinase A
Sanchez, H., Quinn, J. J., Torregrossa, M. M., & Taylor, J. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3149-09.2010 · Cited by 88 · see citing works
Self-citation
d-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: A pilot investigation
Ana, E. J. S., Rounsaville, B. J., Frankforter, T. L., Nich, C., Babuscio, T. A., Poling, J. C., Gonsai, K., Hill, K. P., & Carroll, K. M. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.04.023 · Cited by 88 · see citing works
Immersive Virtual Environments in Cue Exposure
Kuntze, M. F., Stoermer, R., Mager, R., Roessler, A., Müller-Spahn, F., & Bullinger, A. H. (2001) · CyberPsychology & Behavior · doi:10.1089/109493101750527051 · Cited by 87 · see citing works
NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse
Feltenstein, M. W., & See, R. E. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.006 · Cited by 83 · see citing works
Cocaine withdrawal enhances long‐term potentiation induced by corticotropin‐releasing factor at central amygdala glutamatergic synapses via CRF1, NMDA receptors and PKA
Pollandt, S., Liu, J., Orozco-Cabal, L. F., Grigoriadis, D. E., Vale, W., Gallagher, J. P., & Shinnick‐Gallagher, P. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05049.x · Cited by 82 · see citing works
Basolateral amygdala involvement in memory reconsolidation processes that facilitate drug context‐induced cocaine seeking
Fuchs, R. A., Bell, G. H., Ramirez, D. R., Eaddy, J. L., & Su, Z. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06888.x · Cited by 81 · see citing works
Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context‐induced cocaine‐seeking behavior in rats
Ramirez, D. R., Bell, G. H., Lasseter, H. C., Xie, X., Traina, S. A., & Fuchs, R. A. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06889.x · Cited by 77 · see citing works
Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories
von der Goltz, C., Vengeliene, V., Bilbao, A., Perreau‐Lenz, S., Pawlak, C. R., Kiefer, F., & Spanagel, R. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1544-1 · Cited by 76 · see citing works
Basolateral Amygdala Cdk5 Activity Mediates Consolidation and Reconsolidation of Memories for Cocaine Cues
Li, F., Xue, Y.-X., Wang, J., Fang, Q., Li, Y.-Q., Zhu, W., He, Y., Liu, J., Xue, L., Shaham, Y., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2112-10.2010 · Cited by 73 · see citing works
Systemic or intra‐amygdala injections of glucose facilitate memory consolidation for extinction of drug‐induced conditioned reward
Schroeder, J. P., & Packard, M. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02578.x · Cited by 73 · see citing works
Psychosocial stress after reactivation of drug-related memory impairs later recall in abstinent heroin addicts
Zhao, L., Zhang, X., Shi, J., Epstein, D. H., & Lü, L. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1406-2 · Cited by 73 · see citing works
Central but not peripheral beta-adrenergic antagonism blocks reconsolidation for a morphine place preference
ROBINSON, M., & Franklin, K. B. J. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.05.023 · Cited by 72 · see citing works
Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD
de Quervain, D. J. ‐. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67017-4 · Cited by 71 · see citing works
D-cycloserine potentiates the reconsolidation of cocaine-associated memories
Lee, J. L. C., Gardner, R. J., Butler, V. J., & Everitt, B. J. (2009) · Learning & Memory · doi:10.1101/lm.1186609 · Cited by 70 · see citing works
Repeated treatment with the NMDA antagonist MK-801 disrupts reconsolidation of memory for amphetamine-conditioned place preference
Sadler, R., Herzig, V., & Schmidt, W. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282effb81 · Cited by 68 · see citing works
Integration of psychological and biological approaches to trauma memory: Implications for pharmacological prevention of PTSD
McCleery, J. M., & Harvey, A. G. (2004) · Journal of Traumatic Stress · doi:10.1007/s10960-004-5797-5 · Cited by 66 · see citing works
Microdialysis and the neurochemistry of addiction
Torregrossa, M. M., & Kalivas, P. W. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.001 · Cited by 65 · see citing works
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Effects of scopolamine and ketamine on reconsolidation of morphine conditioned place preference in rats
Zhai, H., Wu, P., Chen, S., Li, F., Liu, Y., & Lü, L. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282fe88a0 · Cited by 65 · see citing works
Inhibition of β-Adrenergic Receptors Induces a Persistent Deficit in Retrieval of a Cocaine-Associated Memory Providing Protection against Reinstatement
Otis, J. M., & Mueller, D. T. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.77 · Cited by 64 · see citing works
Facilitation of Memory for Extinction of Drug-Induced Conditioned Reward: Role of Amygdala and AcetylcholinePreprint
Schroeder, J. P., & Packard, M. G. (2004) · Learning & Memory · doi:10.1101/lm.78504 · Cited by 63 · see citing works
Post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference in rats dependent on the retrieval-extinction interval
Ma, X., Zhang, J., & Yu, L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2545-4 · Cited by 60 · see citing works
Contextual renewal of cocaine seeking in rats and its attenuation by the conditioned effects of an alternative reinforcer
Kearns, D. N., & Weiss, S. J. (2007) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2007.03.006 · Cited by 58 · see citing works
Disruption of Long-Term Alcohol-Related Memory Reconsolidation: Role of β-Adrenoceptors and NMDA Receptors
Wouda, J. A., Diergaarde, L., Riga, D., van Mourik, Y., Schoffelmeer, A. N. M., & Vries, T. J. D. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00179 · Cited by 56 · see citing works
Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory
Wu, P., Xue, Y.-X., Ding, Z., Xue, L., Xu, C., & Lü, L. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07277.x · Cited by 53 · see citing works
A randomized, placebo-controlled laboratory study of the effects of d-cycloserine on craving in cocaine-dependent individuals
Price, K. L., Baker, N. L., McRae‐Clark, A. L., Saladin, M. E., DeSantis, S. M., Ana, E. J. S., & Brady, K. T. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2592-x · Cited by 53 · see citing works
Long-Term Memory
(2013) · Psychology Press eBooks · doi:10.4324/9781315871554-14 · Cited by 53 · see citing works
Persistent changes in motivation to self‐administer cocaine following modulation of cyclic AMP‐dependent protein kinase A (PKA) activity in the nucleus accumbens
Lynch, W. J., & Taylor, J. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04305.x · Cited by 51 · see citing works
Self-citation
Effects of β-adrenergic receptor blockade on drug-related memory reconsolidation in abstinent heroin addicts
Zhao, L., Sun, L.-L., Shi, J., Li, P., Zhang, Y., & Lü, L. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.03.025 · Cited by 50 · see citing works
Roles of hippocampal N-methyl-D-aspartate receptors and calcium/calmodulin-dependent protein kinase II in amphetamine-produced conditioned place preference in rats
Sakurai, S., Yu, L., & Tan, S.-E. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee7b62 · Cited by 48 · see citing works
Memory extinction entails the inhibition of the transcription factor NF-κB
Merlo, E., & Romano, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003687 · Cited by 47 · see citing works
Cue exposure and response prevention with heavy smokers: a laboratory-based randomised placebo-controlled trial examining the effects of D-cycloserine on cue reactivity and attentional bias
Kamboj, S. K., Joye, A., Das, R. K., Gibson, A. J. W., Morgan, C. J. A., & Curran, H. V. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2571-2 · Cited by 44 · see citing works
Lesions of basolateral amygdala impair extinction of CS motivational value, but not of explicit conditioned responses, in Pavlovian appetitive second‐order conditioning
Lindgren, J. L., Gallagher, M., & Holland, P. C. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02421.x · Cited by 43 · see citing works
Neuronal responses of the rat amygdala during extinction and reassociation learning in elementary and configural associative tasks
Toyomitsu, Y., Nishijo, H., Uwano, T., Kuratsu, J., & Ono, T. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01889.x · Cited by 43 · see citing works
Changes in cue reactivity and attentional bias following experimental cue exposure and response prevention: a laboratory study of the effects of d-cycloserine in heavy drinkers
Kamboj, S. K., Massey-Chase, R. A., Rodney, L., Das, R., Almahdi, B., Curran, H. V., & Morgan, C. J. A. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2254-z · Cited by 39 · see citing works
Extinction-induced Neuroplasticity Attenuates Stress-induced Cocaine Seeking: A State-dependent Learning Hypothesis
Self, D. W., & Choi, K.-H. (2004) · Stress · doi:10.1080/10253890400012677 · Cited by 38 · see citing works
Post-retrieval propranolol treatment does not modulate reconsolidation or extinction of ethanol-induced conditioned place preference
Font, L., & Cunningham, C. L. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.01.009 · Cited by 35 · see citing works
The consequences of different "lapses" on relapse to heroin seeking in rats.
Leri, F., & Stewart, J. (2002) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.10.4.339 · Cited by 35 · see citing works
A pilot study of the effectiveness of d-cycloserine during cue-exposure therapy in abstinent alcohol-dependent subjects
Watson, B. J., Wilson, S., Griffin, L., Kalk, N. J., Taylor, L. G., Munafo, M. R., Lingford-Hughes, A. R., & Nutt, D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2199-2 · Cited by 33 · see citing works
Inactivation of PKMζ in the NAc Shell Abolished Cocaine-Conditioned Reward
Shabashov, D., Shohami, E., & Yaka, R. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9671-7 · Cited by 33 · see citing works
Memory reconsolidation of cocaine‐associated context requires nitric oxide signaling
Itzhak, Y., & Anderson, K. L. (2007) · Synapse · doi:10.1002/syn.20446 · Cited by 33 · see citing works
Drug cue induced overshadowing: selective disruption of natural reward processing by cigarette cues amongst abstinent but not satiated smokers
Freeman, T. P., Morgan, C. J. A., Beesley, T., & Curran, H. V. (2011) · Psychological Medicine · doi:10.1017/s0033291711001139 · Cited by 32 · see citing works
The effect of propranolol dose and novelty of the reactivation procedure on the reconsolidation of a morphine place preference
Robinson, M. J. F., Ross, E. C., & Franklin, K. B. J. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.08.009 · Cited by 32 · see citing works
d-Serine facilitates the effects of extinction to reduce cocaine-primed reinstatement of drug-seeking behavior
Kelamangalath, L., Seymour, C. M., & Wagner, J. J. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.07.004 · Cited by 30 · see citing works
Effects of d -Cycloserine on Craving to Alcohol Cues in Problem Drinkers: Preliminary Findings
Hofmann, S. G., Hüweler, R., MacKillop, J., & Kantak, K. M. (2011) · The American Journal of Drug and Alcohol Abuse · doi:10.3109/00952990.2011.600396 · Cited by 29 · see citing works
The Effect of Propranolol and Midazolam on the Reconsolidation of a Morphine Place Preference in Chronically Treated Rats
Robinson, M. J., Armson, M. J., & Franklin, K. B. J. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00042 · Cited by 28 · see citing works
Effects of D-cycloserine on the extinction of appetitive operant learning
Vurbic, D., Gold, B., & Bouton, M. (2011) · Behavioral Neuroscience · doi:10.1037/a0024403 · Cited by 27 · see citing works
Preclinical Validation of a Novel Cocaine Exposure Therapy for Relapse Prevention
Mihindou, C., Vouillac‐Mendoza, C., Koob, G. F., & Ahmed, S. H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.036 · Cited by 25 · see citing works
NMDA receptor glycine modulatory site in the ventral tegmental area regulates the acquisition, retrieval, and reconsolidation of cocaine reward memory
Zhou, S., Xue, L., Wang, X., Jiang, W., Xue, Y.-X., Liu, J., He, Y.-Y., Luo, Y., & Lü, L. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2551-6 · Cited by 18 · see citing works
Renewal effect: context-dependent extinction of a cocaine- and a morphine-induced conditioned floor preference
Parker, L. A., Limebeer, C. L., & Slomke, J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0422-3 · Cited by 18 · see citing works
Disruption of memory reconsolidation impairs storage of other, non-reactivated memory
Tzeng, W.-Y., Chang, W.-T., Chuang, J., Lin, K.-Y., Cherng, C. G., & Yu, L. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.01.001 · Cited by 11 · see citing works

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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research
Bossert, J. M., Marchant, N. J., Calu, D. J., & Shaham, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3120-y · Cited by 453 · see citing works
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction
Everitt, B. J. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12644 · Cited by 318 · see citing works
Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research
McKendrick, G., & Graziane, N. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.582147 · Cited by 203 · see citing works
Reconsolidation of memory: A decade of debate
Besnard, A., Caboche, J., & Laroche, S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.07.002 · Cited by 168 · see citing works
Harnessing reconsolidation to weaken fear and appetitive memories: A meta-analysis of post-retrieval extinction effects.
Kredlow, M. A., Unger, L. D., & Otto, M. W. (2016) · Psychological Bulletin · doi:10.1037/bul0000034 · Cited by 130 · see citing works
Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories
Das, R. K., Gale, G., Walsh, K., Hennessy, V. E., Iskandar, G., Mordecai, L. A., Brandner, B., Kindt, M., Curran, H. V., & Kamboj, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-13162-w · Cited by 122 · see citing works
Epigenetics and persistent memory: implications for reconsolidation and silent extinction beyond the zero
Lattal, K. M., & Wood, M. A. (2013) · Nature Neuroscience · doi:10.1038/nn.3302 · Cited by 116 · see citing works
A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis
Castilla‐Ortega, E., Serrano, A., Blanco, E., Araos, P. F., Suárez, J., Pavón, F. J., de Fonseca, F. R., & Santín, L. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.030 · Cited by 100 · see citing works
A double blind, placebo-controlled study of the effects of post-retrieval propranolol on reconsolidation of memory for craving and cue reactivity in cocaine dependent humans
Saladin, M. E., Gray, K. M., McRae‐Clark, A. L., LaRowe, S. D., Yeatts, S. D., Baker, N. L., Hartwell, K. J., & Brady, K. T. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3039-3 · Cited by 93 · see citing works
Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving
Xue, Y.-X., Deng, J., Chen, Y., Zhang, L., Wu, P., Huang, G.-D., Luo, Y., Bao, Y., Wang, Y., Shaham, Y., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.3907 · Cited by 92 · see citing works
Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking
Barker, J. M., Taylor, J. R., Vries, T. J. D., & Peters, J. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.058 · Cited by 86 · see citing works
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Addiction: a drug-induced disorder of memory reconsolidation
Tronson, N. C., & Taylor, J. R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.022 · Cited by 83 · see citing works
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Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms
Farrell, M. R., Schoch, H., & Mahler, S. V. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.002 · Cited by 85 · see citing works
Two weeks of image-guided left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation improves smoking cessation: A double-blind, sham-controlled, randomized clinical trial
Li, X., Hartwell, K. J., Henderson, S., Badran, B. W., Brady, K. T., & George, M. S. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.06.007 · Cited by 79 · see citing works
The role of progesterone in memory: An overview of three decades
Barros, L. A., Tufik, S. B., & Andersen, M. L. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.015 · Cited by 78 · see citing works
Long-term parental methamphetamine exposure of mice influences behavior and hippocampal DNA methylation of the offspring
Itzhak, Y., Ergui, I., & Young, J. I. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.7 · Cited by 72 · see citing works
Linking Social Cognition to Learning and Memory
Leblanc, H., & Ramirez, S. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.1280-20.2020 · Cited by 69 · see citing works
A randomized clinical trial of cue exposure treatment through virtual reality for smoking cessation
Pericot‐Valverde, I., Secades‐Villa, R., & Gutiérrez‐Maldonado, J. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.10.003 · Cited by 67 · see citing works
Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments
Dunbar, A. B., & Taylor, J. R. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.11.005 · Cited by 66 · see citing works
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Epigenetic Mechanisms in Drug Relapse
Werner, C. T., Altshuler, R. D., Shaham, Y., & Li, X. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.08.005 · Cited by 61 · see citing works
Selective Inhibition of Amygdala Neuronal Ensembles Encoding Nicotine-Associated Memories Inhibits Nicotine Preference and Relapse
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REVIEW Learning to forget: manipulating extinction and reconsolidation processes to treat addiction
Torregrossa, M. M., & Taylor, J. R. (2012)
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Authors: Torregrossa, M. M., & Taylor, J. R.
Affiliations: Yale University (US)
Corresponding author: Torregrossa, Mary M.
ORCID: Torregrossa, Mary M.
Taylor, Jane R.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2012-05-26
Volume: 226
Issue: 4
Pages: 659-672
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-012-2750-9
PMC: PMC3466391
OpenAlex: W2043662856
Cited by: 172
References: 157
Citations by year: 2026: 7 · 2025: 9 · 2024: 12 · 2023: 11 · 2022: 5 · 2021: 13 · 2020: 23 · 2019: 18 · 2018: 11 · 2017: 8 · 2016: 17 · 2015: 12 · 2014: 13 · 2013: 11 · 2012: 2
FWCI: 0.96
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Drug Abuse (K01DA031745, P20DA027844, R01DA011717, R01DA015222)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: drug addiction, extinction learning, memory reconsolidation, relapse, craving, memory consolidation, pharmacological treatment of addiction, drug-seeking behavior
MeSH terms: Animals, Cues, Extinction, Psychological, Humans, Memory, Motivation, Time Factors, Behavior, Addictive, Substance-Related Disorders, Secondary Prevention

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Learning to forget: manipulating extinction and reconsolidation processes to treat addiction

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