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Degradation of Misfolded Proteins by Autophagy: Is it a Strategy for Huntington's Disease Treatment?

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Huntingtin facilitates selective autophagy

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Acute manganese treatment restores defective autophagic cargo loading in Huntington’s disease cell lines

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Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient‐induced pluripotent stem cell‐derived retinal pigment epithelium cells

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Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

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Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

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Network analysis of human post-mortem microarrays reveals novel genes, microRNAs, and mechanistic scenarios of potential importance in fighting huntington's disease

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Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration

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HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation

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Induction of Autophagy and Its Role in Peripheral Nerve Regeneration after Peripheral Nerve Injury

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Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux

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Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy–lysosome-dependent way

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Drugging unconventional targets: insights from Huntington's disease

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Changes in the Striatal Proteome of YAC128Q Mice Exhibit Gene–Environment Interactions between Mutant Huntingtin and Manganese

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The In Vitro Effects of Enzymatic Digested Gliadin on the Functionality of the Autophagy Process

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Clinical and Functional Characterization of a Missense ELF2 Variant in a CANVAS Family

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Killing Two Angry Birds with One Stone: Autophagy Activation by Inhibiting Calpains in Neurodegenerative Diseases and Beyond

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Pramipexole reduces soluble mutant huntingtin and protects striatal neurons through dopamine D3 receptors in a genetic model of Huntington's disease

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Pathogenic Single Nucleotide Polymorphisms on Autophagy-Related Genes

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Site-specific mitochondrial dysfunction in neurodegeneration

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The regulatory mechanism and therapeutic potential of transcription factor EB in neurodegenerative diseases

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Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies

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Early Delivery of Misfolded PrP from ER to Lysosomes by Autophagy

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Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

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Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction

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New opportunities for antioxidants in amelioration of neurodegenerative diseases

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Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders

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Spermidine and Rapamycin Reveal Distinct Autophagy Flux Response and Cargo Receptor Clearance Profile

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Targeting the autophagy-lysosomal pathway in Huntington disease: a pharmacological perspective

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Mitophagy and long-term neuronal homeostasis

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Neurotropic virus infection and neurodegenerative diseases: Potential roles of autophagy pathway

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Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis

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Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease

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Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica)

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Impairment of Autophagic Flux Promotes Glucose Reperfusion-Induced Neuro2A Cell Death after Glucose Deprivation

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Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD

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Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy

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Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans

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Scaffold proteins in bulk and selective autophagy

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The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux

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Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain

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The Role of Mitophagy in Various Neurological Diseases as a Therapeutic Approach

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Cleaning up Epilepsy and Neurodegeneration: The Role of Autophagy in Epileptogenesis

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Role of Autophagy in HIV Pathogenesis and Drug Abuse

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Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington’s Disease Knock-In Mouse Models

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Mitophagy mechanisms in neuronal physiology and pathology during ageing

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A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

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Hypothalamic lipophagy and energetic balance

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Opportunities and Challenges for Molecular Chaperone Modulation to Treat Protein-Conformational Brain Diseases

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A role of cellular translation regulation associated with toxic Huntingtin protein

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FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates

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Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

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Macroautophagy Abnormality in Essential Tremor

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SQSTM1/p62 droplet -mediated autophagosome formation:insights into Huntington disease

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Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

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Stochastics of degradation: the autophagic-lysosomal system of the cell

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Dietary and nutraceutical-based therapeutic approaches to combat the pathogenesis of Huntington’s disease

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HSF1 and Its Role in Huntington’s Disease Pathology

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Up-regulation of Sirtuin-1/autophagy signaling in human cerebral ischemia: possible role in caspase-3 mediated apoptosis

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Vitamin B6, B12 and folate modulate deregulated pathways and protein aggregation in yeast model of Huntington disease

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Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders

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Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures

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A phenolic-rich extract from Ugni molinae berries reduces abnormal protein aggregation in a cellular model of Huntington’s disease

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Autophagy Modulation by Lanthionine Ketimine Ethyl Ester Improves Long-Term Outcome after Central Fluid Percussion Injury in the Mouse

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The Precision Control of Autophagic Flux and Vesicle Dynamics—A Micropattern Approach

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Potential role of modulating autophagy levels in sensorineural hearing loss

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