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Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Open accessAbstract
Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.
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Citations
Cited by
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
Ji, R.-R., Nackley, A., Huh, Y., Terrando, N., & Maixner, W. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002130 · Cited by 1,630
Pain regulation by non-neuronal cells and inflammation
Ji, R.-R., Chamessian, A., & Zhang, Y.-Q. (2016) · Science · doi:10.1126/science.aaf8924 · Cited by 1,314
Acupuncture analgesia: Areas of consensus and controversy
Han, J.-S. (2011) · Pain · doi:10.1016/j.pain.2010.10.012 · Cited by 294
Acupuncture for Chronic Low Back Pain
Berman, B. M., Langevin, H. M., Witt, C. M., & Dubner, R. (2010) · New England Journal of Medicine · doi:10.1056/nejmct0806114 · Cited by 273
Acupuncture for chronic nonspecific low back pain
Mu, J., Furlan, A. D., Lam, W. Y., Hsu, M. Y., Ning, Z., & Lao, L. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013814 · Cited by 169
Metadata
- Authors
- Goldman, N., Chen, M., Fujita, T., Xu, Q., Peng, W., Liu, W., Jensen, T. K., Pei, Y., Wang, F., Han, X., Chen, J.-F., Schnermann, J., Takano, T., Bekar, L., Tieu, K., & Nedergaard, M.
- Venue
- Nature Neuroscience
- Published
- 2010-05-30
- Volume
- 13
- Issue
- 7
- Pages
- 883-888
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2116863239
- Cited by
- 807
- References
- 0
- FWCI
- 135.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldman, N., Chen, M., Fujita, T., Xu, Q., Peng, W., Liu, W., Jensen, T. K., Pei, Y., Wang, F., Han, X., Chen, J.-F., Schnermann, J., Takano, T., Bekar, L., Tieu, K., & Nedergaard, M. (2010). Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nature Neuroscience. https://doi.org/10.1038/nn.2562
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