Acupuncture for Chronic Low Back Pain
Abstract
A 45-year-old man with a 7-year history of low back pain asks his physician for a referral to a licensed acupuncturist. Acupuncture involves the insertion of fine metallic needles into the body at specific sites. Clinical trials of acupuncture for chronic low back pain have shown higher rates of symptom improvement with either acupuncture or sham acupuncture than with usual care.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Positron emission tomography has shown an increase in μ-opioid binding potential in several brain areas.
“Positron emission tomography has shown an increase in μ-opioid binding potential in several brain areas. 19”
The adverse events of acupuncture may include needle-site pain, nausea, vomiting, light headedness, or fainting.
“The adverse events may include needle-site pain, nausea, vomiting, light headedness, or fainting.”
Functional magnetic resonance imaging has shown prolonged stimulations in the limbic systems and basal forebrain.
“Functional magnetic resonance imaging has shown prolonged stimulations in the limbic systems and basal forebrain.”
Major adverse events related to acupuncture are rare, with significant adverse events occurring in less than 0.1% of cases.
“Major adverse events related to acupuncture are reported to be rare, with significant adverse events occurring in less than 0.1% of cases. 19”
It has been demonstrated that acupuncture induces the release of endogenous opioids in the brain stem, subcortical, and limbic structures, modulating pain perception.
“It has been demonstrated that acupuncture induces the release of endogenous opioids in the brain stem, subcortical, and limbic structures, modulating pain perception.”
Given various physiological bases and mechanisms for pain modulation, it is likely that acupuncture produces a real therapeutic effect.
“Given various physiological bases and mechanisms for pain modulation, it is likely that acupuncture produces real therapeutic effect.”
Cites
Epidemiological features of chronic low-back pain
Andersson, G. B. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01312-4 · Cited by 3,181 · see citing works
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126 · see citing works
Chou, R., Qaseem, A., Snow, V., Casey, D., Cross, J. T., Shekelle, P., Owens, D. K., & for the Clinical Efficacy Assessment Subcommittee of the American College of Physicians and the American College of Physicians/American Pain Society Low Back Pain Guidelines Panel* (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-7-200710020-00006 · Cited by 2,718 · see citing works
Magnetic Resonance Imaging of the Lumbar Spine in People without Back Pain
Jensen, M. C., Brant-Zawadzki, M. N., Obuchowski, N. A., Modic, M. T., Malkasian, D. R., & Ross, J. S. (1994) · New England Journal of Medicine · doi:10.1056/nejm199407143310201 · Cited by 2,381 · see citing works
Deyo, R. A., & Weinstein, J. N. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440508 · Cited by 1,675 · see citing works
Pincus, T., Burton, A. K., Vogel, S., & Field, A. P. (2002) · Spine · doi:10.1097/00007632-200203010-00017 · Cited by 1,633 · see citing works
Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., & Gitelman, D. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2541-04.2004 · Cited by 1,434 · see citing works
Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome
Kaptchuk, T. J., Kelley, J. M., Conboy, L. A., Davis, R. B., Kerr, C. E., Jacobson, E. E., Kirsch, I., Schyner, R. N., Nam, B. H., Nguyen, L. T., et al. (2008) · BMJ · doi:10.1136/bmj.39524.439618.25 · Cited by 1,196 · see citing works
Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies
Han, J. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00006-1 · Cited by 1,088 · see citing works
Chou, R., & Huffman, L. H. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-7-200710020-00007 · Cited by 1,045 · see citing works
Back Pain Prevalence and Visit Rates
Deyo, R. A., Mirza, S. K., & Martin, B. I. (2006) · Spine · doi:10.1097/01.brs.0000244618.06877.cd · Cited by 987 · see citing works
Physician Office Visits for Low Back Pain
Hart, L. G., Deyo, R. A., & Cherkin, D. C. (1995) · Spine · doi:10.1097/00007632-199501000-00003 · Cited by 889 · see citing works
Luo, X., Pietrobon, R. S., Sun, S. X., Liu, G. G., & Hey, L. A. (2003) · Spine · doi:10.1097/01.brs.0000105527.13866.0f · Cited by 838 · see citing works
Evidence of augmented central pain processing in idiopathic chronic low back pain
Giesecke, T., Gracely, R. H., Grant, M. A. B., NACHEMSON, A. L., Petzke, F. W., Williams, D. A., & Clauw, D. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20063 · Cited by 816 · see citing works
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Goldman, N., Chen, M. J., Fujita, T., Xu, Q., Peng, W., Liu, W., Jensen, T. K., Pei, Y., Wang, F., Han, X., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2562 · Cited by 810 · see citing works
Baliki, M. N., Chialvo, D. R., Geha, P. Y., Levy, R. M., Harden, R. N., Parrish, T. B., & Apkarian, A. V. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3576-06.2006 · Cited by 756 · see citing works
Haake, M. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.17.1892 · Cited by 725 · see citing works
Diagnostic Evaluation of Low Back Pain with Emphasis on Imaging
Jarvik, J. G., & Deyo, R. A. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-7-200210010-00010 · Cited by 696 · see citing works
Chinese acupuncture and moxibustion
Cheng, X., & Deng, L.-Y. (1987) · Medical Entomology and Zoology · Cited by 640 · see citing works
Linde, K., Witt, C. M., Streng, A., Weidenhammer, W., Wagenpfeil, S., Brinkhaus, B., Willich, S. N., & Melchart, D. (2007) · Pain · doi:10.1016/j.pain.2006.12.006 · Cited by 548 · see citing works
Self-citationWitt, C. M., Pach, D., Brinkhaus, B., Wruck, K., Tag, B., Mank, S., & Willich, S. N. (2009) · Complementary Medicine Research · doi:10.1159/000209315 · Cited by 510 · see citing works
Self-citationCharacteristic and incidental (placebo) effects in complex interventions such as acupuncture
Paterson, C., & Dieppe, P. A. (2005) · BMJ · doi:10.1136/bmj.330.7501.1202 · Cited by 478 · see citing works
Langevin, H. M., Churchill, D. L., & Cipolla, M. J. (2001) · The FASEB Journal · doi:10.1096/fj.01-0015hyp · Cited by 477 · see citing works
Self-citationTsao, H., Galea, M. P., & Hodges, P. W. (2008) · Brain · doi:10.1093/brain/awn154 · Cited by 458 · see citing works
Cherkin, D. C., Sherman, K. J., Avins, A. L., Erro, J. H., Ichikawa, L., Barlow, W. E., Delaney, K. M., Hawkes, R. J., Hamilton, L., Pressman, A. R., et al. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.65 · Cited by 439 · see citing works
MacPherson, H., Thomas, K. J., Walters, S. J., & FITTER, M. J. (2001) · BMJ · doi:10.1136/bmj.323.7311.486 · Cited by 423 · see citing works
White, A. R., Hayhoe, S., Hart, A., & Ernst, E. (2001) · BMJ · doi:10.1136/bmj.323.7311.485 · Cited by 421 · see citing works
Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture
Pariente, J., White, P. D., Frackowiak, R. S. J., & Lewith, G. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.016 · Cited by 418 · see citing works
Schmidt-Wilcke, T., Leinisch, E., Gänbauer, S., Draganski, B., Bogdahn, U., Altmeppen, J., & May, A. (2006) · Pain · doi:10.1016/j.pain.2006.05.004 · Cited by 413 · see citing works
Carragee, E. J., Alamin, T. F., Miller, J. L., & Carragee, J. M. (2005) · The Spine Journal · doi:10.1016/j.spinee.2004.05.250 · Cited by 409 · see citing works
Dagenais, S., Tricco, A. C., & Haldeman, S. (2010) · The Spine Journal · doi:10.1016/j.spinee.2010.03.032 · Cited by 404 · see citing works
Prospective Investigation of Adverse Effects of Acupuncture in 97 733 Patients
Melchart, D., Weidenhammer, W., Streng, A., Reitmayr, S., Hoppe, A., Ernst, E., & Linde, K. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.1.104 · Cited by 361 · see citing works
Witt, C. M., Jena, S., Selim, D., Brinkhaus, B., Reinhold, T., Wruck, K., Liecker, B., Linde, K., Wegscheider, K., & Willich, S. N. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj224 · Cited by 319 · see citing works
Self-citationEvidence of Connective Tissue Involvement in Acupuncture
Langevin, H. M., Churchill, D. L., Wu, J., Badger, G. J., Yandow, J. A., Fox, J. R., & Krag, M. H. (2002) · The FASEB Journal · doi:10.1096/fj.01-0925fje · Cited by 311 · see citing works
Self-citationThree-Year Incidence of Low Back Pain in an Initially Asymptomatic Cohort
Jarvik, J. G., Hollingworth, W., Heagerty, P. J., Haynor, D. R., Boyko, E. J., & Deyo, R. A. (2005) · Spine · doi:10.1097/01.brs.0000167536.60002.87 · Cited by 303 · see citing works
The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study
Jarvik, J. J., Hollingworth, W., Heagerty, P. J., Haynor, D. R., & Deyo, R. A. (2001) · Spine · doi:10.1097/00007632-200105150-00014 · Cited by 297 · see citing works
Harris, R. E., Zubieta, J.-K., Scott, D. J., Napadow, V., Gracely, R. H., & Clauw, D. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.083 · Cited by 296 · see citing works
Acupuncture in Patients With Chronic Low Back Pain: A Randomized Controlled Trial
Brinkhaus, B. (2006) · Archives of Internal Medicine · doi:10.1001/.450 · Cited by 285 · see citing works
Acupuncture Analgesia: I. The Scientific Basis
Wang, S., Kain, Z. N., & White, P. F. (2008) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000277493.42335.7b · Cited by 275 · see citing works
A brief history of acupuncture
White, A. (2004) · British journal of rheumatology · doi:10.1093/rheumatology/keg005 · Cited by 269 · see citing works
Neuroimaging Acupuncture Effects in the Human Brain
Dhond, R. P., Kettner, N. W., & Napadow, V. (2007) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.7040 · Cited by 254 · see citing works
Thomas, K. J., MacPherson, H., Thorpe, L., Brazier, J. E., FITTER, M. J., Campbell, M. J., Roman, M., Walters, S. J., & Nicholl, J. P. (2006) · BMJ · doi:10.1136/bmj.38878.907361.7c · Cited by 240 · see citing works
Stanton, T. R., Henschke, N., Maher, C. G., Refshauge, K. M., Latimer, J., & McAuley, J. H. (2008) · Spine · doi:10.1097/brs.0b013e31818a3167 · Cited by 235 · see citing works
Langevin, H. M., Stevens‐Tuttle, D., Fox, J. R., Badger, G. J., Bouffard, N. A., Krag, M. H., Wu, J., & Henry, S. M. (2009) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-10-151 · Cited by 231 · see citing works
Self-citationCherkin, D. C., Deyo, R. A., Sherman, K. J., Hart, L. G., Street, J. H., Hrbek, A. L., Davis, R. B., Cramer, E. H., Milliman, B., Booker, J., et al. (2002) · PubMed · Cited by 228 · see citing works
Effects of acupuncture on skin and muscle blood flow in healthy subjects
Sandberg, M., Lundeberg, T., Lindberg, L., & Gerdle, B. U. C. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0825-3 · Cited by 209 · see citing works
Effectiveness of Acupuncture for Low Back Pain
Yuan, J., Purepong, N., Kerr, D. P., Park, J., Bradbury, I., & McDonough, S. (2008) · Spine · doi:10.1097/brs.0b013e318186b276 · Cited by 177 · see citing works
Chronic Pain Is Associated with Brain Volume Loss in Older Adults: Preliminary Evidence
Buckalew, N. A., Haut, M. W., Morrow, L. A., & Weiner, D. K. (2008) · Pain Medicine · doi:10.1111/j.1526-4637.2008.00412.x · Cited by 161 · see citing works
Kong, J., Kaptchuk, T. J., Polich, G. R., Kirsch, I., Vangel, M. G., Zyloney, C. E., Rosen, B. R., & Gollub, R. L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.025 · Cited by 158 · see citing works
Rubinstein, S. M., van Middelkoop, M., Kuijpers, T., Ostelo, R., Verhagen, A. P., de Boer, M. R., Koes, B. W., & van Tulder, M. W. (2010) · European Spine Journal · doi:10.1007/s00586-010-1356-3 · Cited by 153 · see citing works
Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture
Napadow, V., Liu, J., Li, M., Kettner, N. W., Ryan, A., Kwong, K. K., Hui, K. K. S., & Audette, J. F. (2006) · Human Brain Mapping · doi:10.1002/hbm.20261 · Cited by 151 · see citing works
Spinal muscle evaluation in healthy individuals and low-back-pain patients: a literature review
Demoulin, C., Crielaard, J.-M., & Vanderthommen, M. (2006) · Joint Bone Spine · doi:10.1016/j.jbspin.2006.02.013 · Cited by 148 · see citing works
Woby, S. R., Watson, P., Roach, N. K., & Urmston, M. (2003) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(03)00195-5 · Cited by 128 · see citing works
Augmented Cerebral Activation by Lumbar Mechanical Stimulus in Chronic Low Back Pain Patients
Kobayashi, Y., Kurata, J., Sekiguchi, M., Kokubun, M., Akaishizawa, T., Chiba, Y., Konno, S., & Kikuchi, S. (2009) · Spine · doi:10.1097/brs.0b013e3181b1fb76 · Cited by 105 · see citing works
Hurwitz, E. L., Morgenstern, H., & Yu, F. (2003) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(03)00010-6 · Cited by 102 · see citing works
Scientific Research into Acupuncture for the Relief of Pain
Pomeranz, B. H. (1996) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.1996.2.53 · Cited by 91 · see citing works
Neuroimaging Revolutionizes Therapeutic Approaches to Chronic Pain
Borsook, D., Moulton, E. A., Schmidt, K. F., & Becerra, L. R. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-25 · Cited by 85 · see citing works
Speed, C. A. (2004) · BMJ · doi:10.1136/bmj.328.7448.1119 · Cited by 76 · see citing works
Acupuncture for pelvic and back pain in pregnancy: a systematic review
Ee, C., Manheimer, E. W., Pirotta, M. V., & White, A. R. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2007.11.008 · Cited by 76 · see citing works
Adverse effects of acupuncture. Which are clinically significant?
Chung, A., Bui, L., & Mills, E. J. (2003) · PubMed Central · Cited by 70 · see citing works
Derbyshire, S. W. G. (1999) · Current Review of Pain · doi:10.1007/s11916-999-0044-7 · Cited by 69 · see citing works
Li, A., Lao, L., Wang, Y., Xin, J., Ren, K., Berman, B., Tan, M. T., & Zhang, R.-X. (2008) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-8-20 · Cited by 65 · see citing works
Self-citationEvidence-informed management of chronic low back pain with needle acupuncture
Ammendolia, C., Furlan, A. D., Imamura, M., Irvin, E., & van Tulder, M. W. (2008) · The Spine Journal · doi:10.1016/j.spinee.2007.10.014 · Cited by 61 · see citing works
Dionne, C. E. (2005) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.12.005 · Cited by 51 · see citing works
Acupuncture: What Underlies Needle Administration?
Liu, T. (2007) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen002 · Cited by 41 · see citing works
Sherman, K. J., & Cherkin, D. C. (2003) · PubMed · Cited by 32 · see citing works
Acupuncture for Lower Back Pain
Lewis, K., & Abdi, S. (2009) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181bad71e · Cited by 31 · see citing works
Kovacs, F. M., & Zanoli, G. A. (2009) · Spine · doi:10.1097/brs.0b013e31819d070a · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
RELIEVING PAIN IN AMERICA: A BLUEPRINT FOR TRANSFORMING PREVENTION, CARE, EDUCATION, AND RESEARCH
Simon, L. S. (2012) · Journal of Pain & Palliative Care Pharmacotherapy · doi:10.3109/15360288.2012.678473 · Cited by 2,185 · see citing works
Guidelines for Recognition, Assessment and Treatment of Pain
Mathews, K. A., Kronen, P., Lascelles, B. D. X., Nolan, A. M., Robertson, S. A., Steagall, P. V. M., Wright, B. D., & YAMASHITA, K. (2014) · Journal of Small Animal Practice · doi:10.1111/jsap.12200 · Cited by 380 · see citing works
Chae, Y., Chang, D.-S., Lee, S.-H., Jung, W.-M., Lee, I., Jackson, S. R., Kong, J., Lee, H., Park, H., Lee, H., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.11.011 · Cited by 200 · see citing works
Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed
Ma, Y., Dong, M., Zhou, K., Mita, C., Liu, J., & Wayne, P. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168123 · Cited by 177 · see citing works
Acupuncture for chronic nonspecific low back pain
Mu, J., Furlan, A. D., Lam, W. Y., Hsu, M. Y., Ning, Z., & Lao, L. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013814 · Cited by 169 · see citing works
Nonnarcotic Methods of Pain Management
Finnerup, N. B. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1807061 · Cited by 153 · see citing works
Wang, L., He, T., Liu, J., Tai, J., Wang, B., Zhang, L., & Quan, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.666355 · Cited by 124 · see citing works
Applications of Acupuncture Therapy in Modulating Plasticity of Central Nervous System
Xiao, L., Wang, X., Yang, Y., Yang, J., Cao, Y., Ma, S., Li, T., & Liu, C. (2017) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.12724 · Cited by 118 · see citing works
Acupuncture for Chronic Low Back Pain
Cho, Y.-J., Song, Y.-K., Cha, Y.-Y., Shin, B., Shin, I.-H., Park, H., Lee, H., Kim, K., Cho, J., Chung, W., et al. (2012) · Spine · doi:10.1097/brs.0b013e318275e601 · Cited by 106 · see citing works
Endometriosis, an Ongoing Pain—Step-by-Step Treatment
Mechsner, S. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020467 · Cited by 103 · see citing works
“It is assumed that the release of endogenous opioids (pain reduction) and endogenous cortisol (anti-inflammatory), deactivation of brain areas linked to pain perception and local effects such as adenosine release and local blood flow modulate the pain [42].”
BackgroundLee, I., Lee, H., Chen, Y., & Chae, Y. (2020) · Journal of Pain Research · doi:10.2147/jpr.s235047 · Cited by 98 · see citing works
Implementation of the Veterans Health Administration National Pain Management Strategy
Kerns, R. D., Philip, E. J., Lee, A. W., & Rosenberger, P. H. (2011) · Translational Behavioral Medicine · doi:10.1007/s13142-011-0094-3 · Cited by 98 · see citing works
Hutchinson, A. J. P., Ball, S. V., Andrews, J. C. H., & Jones, G. G. (2012) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-7-36 · Cited by 97 · see citing works
Tang, Y., Yin, H., Rubini, P., & Illés, P. (2016) · The Neuroscientist · doi:10.1177/1073858416654453 · Cited by 95 · see citing works
The model of western integrative medicine: The role of Chinese medicine
Dobos, G. J., & Tao, I. F. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0601-x · Cited by 95 · see citing works
Revealing the magic of acupuncture based on biological mechanisms: A literature review
Zhang, B., Shi, H., Cao, S., Xie, L., Ren, P., Wang, J., & Shi, B. (2022) · BioScience Trends · doi:10.5582/bst.2022.01039 · Cited by 93 · see citing works
Li, J., Zhang, J., Yi, T., Tang, W.-J., Wang, S., & Dong, J. (2013) · Acupuncture in Medicine · doi:10.1136/acupmed-2013-010423 · Cited by 91 · see citing works
Kim, H., Mawla, I., Lee, J., Gerber, J. A., Walker, K. L., Kim, J., Ortiz, A., Chan, S., Loggia, M. L., Wasan, A. D., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116899 · Cited by 88 · see citing works
Paul, C. P. L., Zuiderbaan, H. A., Zandieh‐Doulabi, B., van der Veen, A. J., van de Ven, P. M., Smit, T. H., Helder, M. N., van Royen, B. J., & Mullender, M. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033147 · Cited by 87 · see citing works
Buggio, L., Barbara, G., Facchin, F., Frattaruolo, M. P., Aimi, G., & Berlanda, N. (2017) · International Journal of Women's Health · doi:10.2147/ijwh.s119724 · Cited by 85 · see citing works
Gendelman, O., Itzhaki, D., Makarov, S., Bennun, M., & Amital, H. (2015) · Lupus · doi:10.1177/0961203314558676 · Cited by 85 · see citing works
Tao, J., Zheng, Y., Liu, W., Yang, S., Huang, J., Xue, X., Shang, G., Wang, X., Lin, R., & Chen, L. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.10.011 · Cited by 83 · see citing works
The treatment of intervertebral disc degeneration using Traditional Chinese Medicine
Zhu, L., Yu, C., Zhang, X., Yu, Z., Zhan, F., Yu, X., Wang, S., He, F., Han, Y., & Zhao, H. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113117 · Cited by 83 · see citing works
Kim, T., Kang, J. W., Kim, K. H., Kang, K., Shin, M., Jung, S., Kim, A., Jung, H., Choi, J.-B., Hong, K. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036638 · Cited by 81 · see citing works
Loeser, J. D. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318230f6c1 · Cited by 78 · see citing works
Wang, Q., Liang, D., Wang, F., Li, W., Han, Y., Zhang, W., Xie, Y., Xin, W., Zhou, B., Sun, D., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.043 · Cited by 77 · see citing works
Kong, J., Wang, Z.-J., Leiser, J., Minicucci, D., Edwards, R., Kirsch, I., Wasan, A., Lang, C., Gerber, J., Yu, S.-Y., et al. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.01.021 · Cited by 77 · see citing works
The neuro-immune microenvironment of acupoints—initiation of acupuncture effectiveness
Gong, Y., Li, N., Lv, Z., Zhang, K., Zhang, Y., Yang, T., Wang, H., Zhao, X., Chen, Z., Dou, B., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ab0420-361rr · Cited by 73 · see citing works
Chen, C., Liu, J., Sun, M., Liu, W., Han, J., & Wang, H. (2019) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2019.04.004 · Cited by 72 · see citing works
Hurt, J. K., & Zylka, M. J. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-28 · Cited by 69 · see citing works
Kong, J., Puetz, C., Tian, L., Haynes, I., Lee, E., Stafford, R. S., Manber, R., & Mackey, S. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.22787 · Cited by 71 · see citing works
From Peripheral to Central: The Role of ERK Signaling Pathway in Acupuncture Analgesia
Park, J.-Y., Park, J. J., Jeon, S., Doo, A.-R., Kim, S., Lee, H., Chae, Y., Maixner, W. D., Lee, H., & Park, H. (2014) · Journal of Pain · doi:10.1016/j.jpain.2014.01.498 · Cited by 67 · see citing works
Chen, X.-M., Xu, J., Song, J., Zheng, B.-J., & Wang, X.-R. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu199 · Cited by 67 · see citing works
Shih, C., Liao, C., Sun, M.-F., Su, Y.-C., Wen, C. P., Morisky, D., Sung, F., Hsu, C. Y., & Lin, J.-G. (2015) · Medicine · doi:10.1097/md.0000000000001572 · Cited by 66 · see citing works
Acupuncture for Cancer Pain and Symptom Management in a Palliative Medicine Clinic
Miller, K., Patel, J. N., Symanowski, J. T., Edelen, C., & Walsh, D. (2018) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909118804464 · Cited by 62 · see citing works
Yang, L., Yu, C., Fan, X., Zeng, T., Yang, W., Xia, J., Wang, J., Yao, L., Hu, C., Yang, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01633-0 · Cited by 61 · see citing works
Steel, A., Foley, H., Bradley, R. D., Venter, C. V. D., Lloyd, I., Schloss, J. M., Wardle, J., & Reid, R. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-2851-7 · Cited by 60 · see citing works
Liao, H.-Y., Satyanarayanan, S. K., Lin, Y.-W., & Su, K.-P. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.03.016 · Cited by 53 · see citing works
Seo, B.-K., Han, K., Kwon, O., Jo, D.-J., & Lee, J. (2017) · Toxins · doi:10.3390/toxins9110361 · Cited by 53 · see citing works
P2X receptors and acupuncture analgesia
Tang, Y., Yin, H., Liu, J., Rubini, P., & Illés, P. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.015 · Cited by 53 · see citing works
Use of Acupuncture as a Treatment Method for Chronic Prostatitis/Chronic Pelvic Pain Syndromes
Lee, S., & Lee, B.-C. (2011) · Current Urology Reports · doi:10.1007/s11934-011-0186-0 · Cited by 51 · see citing works
Clinical research on acupuncture — Concepts and guidance on efficacy and effectiveness research
Witt, C. M. (2011) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-011-0662-x · Cited by 49 · see citing works
Self-citationWitt, C. M., Manheimer, E. W., Hammerschlag, R., Lüdtke, R., Lao, L., Tunis, S., & Berman, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032399 · Cited by 47 · see citing works
Self-citationNierhaus, T., Pach, D., Huang, W., Long, X., Napadow, V., Roll, S., Liang, F., Pleger, B., Villringer, A., & Witt, C. M. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00074 · Cited by 46 · see citing works
Self-citationAcupuncture for lumbar spinal stenosis: A systematic review and meta-analysis
Kim, K. H., Kim, T., Lee, B.-R., Kim, J. K., Son, D. W., Lee, S. W., & Yang, G. Y. (2013) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2013.08.007 · Cited by 45 · see citing works
Kong, J., Schnyer, R. N., Johnson, K. A., & Mackey, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/187182 · Cited by 45 · see citing works
Huang, Y., Wang, L., Zeng, X., Chen, J., Zhang, Z., Jiang, Y., Nie, L., Cheng, X., & He, B. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.792819 · Cited by 42 · see citing works
Xu, W., Ran, B., Luo, W., Li, Z., & Gu, R. (2020) · World Neurosurgery · doi:10.1016/j.wneu.2020.11.121 · Cited by 40 · see citing works
Kim, K., & Lee, S. (2018) · Integrative Cancer Therapies · doi:10.1177/1534735418786797 · Cited by 39 · see citing works
Wu, Y., Jiang, Y., He, X., Zhao, X., Shao, X., Sun, J., Shen, Z., Shou, S.-Y., Wei, J., Ye, J., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4479 · Cited by 39 · see citing works
Integrative oncology: really the best of both worlds?
Gorski, D. H. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3822 · Cited by 38 · see citing works
The Effect of Topical Rosa damascena (Rose) Oil on Pregnancy-Related Low Back Pain
Shirazi, M., Mohebitabar, S., Bioos, S., Yekaninejad, M. S., Rahimi, R., Shahpiri, Z., Malekshahi, F., & Nejatbakhsh, F. (2016) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587216654601 · Cited by 38 · see citing works
Cesare, A. D., Giombini, A., Cesare, M. D., Ripani, M., Vulpiani, M. C., & Saraceni, V. M. (2010) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2010.11.002 · Cited by 38 · see citing works
Acupuncture for Pain in Chronic Pancreatitis
Juel, J., Liguori, S., Liguori, A., Poulsen, J. L., Valeriani, M., Graversen, C., Olesen, S. S., & Drewes, A. M. (2017) · Pancreas · doi:10.1097/mpa.0000000000000749 · Cited by 37 · see citing works
Zhang, X., Tian, R., Yang, Z., Zhao, C., Yao, L., Lau, C. T., Wu, T., Shang, H., Zhang, X., Lü, A., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-025218 · Cited by 37 · see citing works
Tang, H.-Y., Wang, F., Ma, J., Wang, H., Shen, G.-M., & Jiang, A. (2020) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00769-8 · Cited by 37 · see citing works
Magnetic resonance imaging for chronic pain: diagnosis, manipulation, and biomarkers
Tu, Y., Cao, J., Bi, Y., & Hu, L. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1822-4 · Cited by 37 · see citing works
Acupuncture for treating acute ankle sprains in adults
Kim, T., Lee, M. S., Kim, K. H., Kang, J. W., Choi, T., & Ernst, E. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009065.pub2 · Cited by 37 · see citing works
Pach, D., Yang-Strobel, X., Lüdtke, R., Roll, S., Icke, K., Brinkhaus, B., & Witt, C. M. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/125937 · Cited by 36 · see citing works
Self-citationFrom stress to functional syndromes: An internist's point of view
Lucini, D., & Pagani, M. (2011) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2011.11.016 · Cited by 35 · see citing works
Hegu Acupuncture for Chronic Low-Back Pain: A Randomized Controlled Trial
Mingdong, Y., Shao, Y., Zhang, Y., he, S. T., Xiong, N., Zhang, J., Guo, M., Liu, D., Luo, Y. M., Guo, L., et al. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2010.0779 · Cited by 34 · see citing works
Yoon, S. W., Jeong, J. S., Kim, J. H., & Aggarwal, B. B. (2013) · Integrative Cancer Therapies · doi:10.1177/1534735413510023 · Cited by 33 · see citing works
Visualization of the Meridian System Based on Biomedical Information about Acupuncture Treatment
Lee, I., Lee, S. H., Kim, S., Lee, H., Park, H., & Chae, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/872142 · Cited by 32 · see citing works
Systems biology approach opens door to essence of acupuncture
Zhang, A., Sun, H. J., Yan, G., Cheng, W., & Wang, X. (2013) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2013.03.002 · Cited by 31 · see citing works
Gao, Y.-H., Chen, S., Wang, J.-Y., Qiao, L.-N., Meng, F., Xu, Q., & Liu, J. (2012) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-12-241 · Cited by 30 · see citing works
Efferth, T., Xu, A., & Lee, D. Y. W. (2019) · Phytomedicine · doi:10.1016/j.phymed.2019.153078 · Cited by 29 · see citing works
Huang, H., Liao, H.-Y., & Lin, Y. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/4951591 · Cited by 30 · see citing works
Effects of Acupuncture on 1-Chloro-2,4-dinitrochlorobenzene-Induced Atopic Dermatitis
Park, J.-Y., Park, H., Choi, Y. Y., Kim, M. H., Kim, S., & Yang, W. M. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/982095 · Cited by 27 · see citing works
Radossi, A. L., Taromina, K., Marjerrison, S., Diorio, C. J., Similio, R., Njuguna, F. M., Afungchwi, G. M., & Ladas, E. J. (2017) · Supportive Care in Cancer · doi:10.1007/s00520-017-3908-0 · Cited by 27 · see citing works
Lin, Y., Li, X., Huang, L., Xie, X., Luo, T., & Tian, G. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-088898 · Cited by 26 · see citing works
Cortical remodeling after electroacupuncture therapy in peripheral nerve repairing model
Wu, J., Lu, Y.-C., Hua, X., Ma, S., Shan, C., & Xu, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.009 · Cited by 26 · see citing works
The role of nitric oxide in portal hypertensive systemic and portal vascular pathology.
Hartleb, M., Michielsen, P. P., & Dziurkowska-Marek, A. (1997) · PubMed · Cited by 26 · see citing works
Rand, S. E., Fishman, L. M., Halstead-Kenny, J., & Wainapel, S. F. (2015) · International Journal of General Medicine · doi:10.2147/ijgm.s66290 · Cited by 25 · see citing works
Bergenstrahle, A., & Nielsen, B. D. (2016) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2016.05.019 · Cited by 27 · see citing works
Kienle, G. S., Ben‐Arye, E., Berger, B., Nahum, C. C., Falkenberg, T., Kapócs, G., Kiene, H., Martin, D., Wolf, U., & Szőke, H. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3706143 · Cited by 25 · see citing works
Highfield, E. S., Lama, P., Grodin, M. A., Kaptchuk, T. J., & Crosby, S. S. (2011) · Journal of Immigrant and Minority Health · doi:10.1007/s10903-011-9538-6 · Cited by 24 · see citing works
Cary, D., Briffa, K., & McKenna, L. J. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-027633 · Cited by 23 · see citing works
Wang, Y., Lei, J., Gupta, M., Peng, F., Lam, S., Jha, R., Raduenz, E., Beitz, A. J., & Gupta, K. (2016) · Scientific Reports · doi:10.1038/srep34493 · Cited by 23 · see citing works
Medical indications for acupuncture: Systematic review
Muñoz-Ortego, J., Solans‐Domènech, M., & Carrión, C. (2016) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.10.006 · Cited by 22 · see citing works
Guo, L., Hu, H., Jiang, N., Yang, H., Sun, X., Xia, H., Ma, J., & Liu, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30819 · Cited by 23 · see citing works
Wang, X.-Q., Pi, Y.-L., Chen, P.-J., Chen, B.-L., Liang, L.-C., Li, X., Wang, X., & Zhang, J. (2014) · Trials · doi:10.1186/1745-6215-15-104 · Cited by 21 · see citing works
KCC2-GABAA pathway correlates with the analgesic effect of electro-acupuncture in CCI rats
Li, S., Tu, W., Jia, C., Jiang, X., Qian, X., Yang, G., Hu, Q., Chen, W., Lü, B., & Jiang, S. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8766 · Cited by 22 · see citing works
Efficacy of acupressure on quality of recovery after surgery
Noll, É., Shodhan, S., Romeiser, J. L., Madariaga, M. C., Page, C. R., Santangelo, D., Guo, X., Pryor, A. D., Gan, T. J., & Bennett‐Guerrero, E. (2019) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000001001 · Cited by 22 · see citing works
Liu, Y., Chen, F., Qin, P., Zhao, L., Li, X., Han, J., Ke, Z., Zhu, H.-H., & Wu, B. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1035125 · Cited by 21 · see citing works
Tian, X., Zhang, Y., Shen, L., Pan, G., Yang, H., Jiang, Z., Zhu, X., & He, F. (2023) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2023.07.002 · Cited by 20 · see citing works
The influence of different methods of acupuncture on skin surface perfusion
Huang, T., Wang, R.-H., Zhang, W., Han, B., Wang, G., Tian, Y., & Zhang, Y. (2012) · 中医杂志:英文版 · doi:10.1016/s0254-6272(12)60029-6 · Cited by 20 · see citing works
Endometrioseschmerz beherrschen: Stufenschema und klinische Erfahrungen
Mechsner, S. (2021) · Der Schmerz · doi:10.1007/s00482-021-00543-8 · Cited by 19 · see citing works
Effects of Dry Needling on Spasticity and Range of Motion: A Systematic Review
Bynum, R., García, O. G., Herbst, E., Kossa, M., Liou, K., Cowan, A. C., & Hilton, C. L. (2020) · American Journal of Occupational Therapy · doi:10.5014/ajot.2021.041798 · Cited by 19 · see citing works
Traditional Chinese medicine for cardiovascular disease: efficacy and safety
Lin, Y., Han, Y., & Wang, Y. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1419169 · Cited by 18 · see citing works
Wu, J., Lu, Y.-C., Hua, X., Ma, S., & Xu, J. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.02.173 · Cited by 18 · see citing works
Acu Glass: Quantifying Acupuncture Therapy using Google Glass
Jiang, H., Starkman, J., Kuo, C.-H., & Huang, M.-C. (2015) · EAI Endorsed Transactions on Pervasive Health and Technology · doi:10.4108/eai.28-9-2015.2261520 · Cited by 18 · see citing works
Pediatric Headache Clinic Model: Implementation of Integrative Therapies in Practice
Esparham, A. E., Herbert, A., Pierzchalski, E., Tran, C., Dilts, J. J., Boorigie, M. E., Wingert, T., Connelly, M. A., & Bickel, J. (2018) · Children · doi:10.3390/children5060074 · Cited by 18 · see citing works
Zhao, Z., Li, J., Wen, J., He, Y., & Sun, Z. (2023) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s429469 · Cited by 17 · see citing works
Lin, W.-C., Liu, C.-Y., Tang, C.-L., & Hsu, C.-H. (2012) · Acupuncture in Medicine · doi:10.1136/acupmed-2012-010149 · Cited by 17 · see citing works
Reduced Health Resource Use After Acupuncture for Low-Back Pain
Moritz, S., Liu, M. F., Rickhi, B., Xu, T. J., Paccagnan, P., & Quan, H. (2011) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2010.0619 · Cited by 17 · see citing works
An Overview of Systematic Reviews of Randomized Controlled Trials on Acupuncture Treating Migraine
Zhang, X., Li, X., Zhao, C., Hu, Y., Lin, Y., Chen, H., Shi, Z., Zhang, X., Shang, H., & Tian, G. (2019) · Pain Research and Management · doi:10.1155/2019/5930627 · Cited by 17 · see citing works
Individual characteristics of reliable lumbar coupling motions
Yun, W.-S., Kim, H., Ahn, J. H., Park, Y.-B., & Park, Y.-J. (2015) · European Spine Journal · doi:10.1007/s00586-015-4081-0 · Cited by 16 · see citing works
Yan, L., Zhang, J., Wang, X., Zhou, Q., Wen, J., Zhao, H., Guo, K., & Zeng, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1467769 · Cited by 16 · see citing works
Graded brain fMRI response to somatic and visual acupuncture stimulation
Yoon, D.-E., Lee, S., Kim, J., Kim, K., Park, H., Napadow, V., Lee, I., & Chae, Y. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad364 · Cited by 16 · see citing works
Fu, T.-C., Wang, G.-R., Li, Y., Xu, Z., Wang, C., Zhang, R.-C., Ma, Q.-T., Ma, Y.-J., Guo, Y., Dai, X.-Y., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1181670 · Cited by 15 · see citing works
- Authors
- Berman, B. M., Langevin, H. M., Witt, C. M., & Dubner, R.
- Affiliations
- University of Maryland, Baltimore (US)
- Charité – Universitätsmedizin Berlin (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2010-07-29
- Volume
- 363
- Issue
- 5
- Pages
- 454-461
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2152751399
- Cited by
- 273
- References
- 68
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 17 · 2023: 23 · 2022: 25 · 2021: 16 · 2020: 19 · 2019: 15 · 2018: 17 · 2017: 17 · 2016: 12 · 2015: 18 · 2014: 11 · 2013: 20 · 2012: 20
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Acupuncture Treatment Research Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Myofascial pain diagnosis and treatment
- Keywords
- acupuncture, chronic low back pain, sham acupuncture, acupuncture needles, symptom improvement, usual care comparison
- MeSH terms
- Contraindications, Chronic Disease, Humans, Intervertebral Disc Displacement, Lumbar Vertebrae, Male, Middle Aged, Acupuncture Therapy, Low Back Pain, Practice Guidelines as Topic, Intervertebral Disc Degeneration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review